Synthesis of new pyrimidine-fused derivatives as potent and selective antidiabetic α-glucosidase inhibitors

Carbohydrate Research

Volumn 380, Issue , 2013, Pages 81-91

  Panahi, Farhad ^a   Yousefi, Reza ^a   Mehraban, Mohammad Hossein ^a   Khalafi Nezhad, Ali ^a  

^a SHIRAZ UNIVERSITY   (Iran)

Author keywords

Antidiabetic; Inhibitors; Pyrimidine fused heterocycles; Glucosidase

Indexed keywords

CORROSION INHIBITORS; DRUG INTERACTIONS; LIGANDS;

ANTI DIABETICS; ANTI-DIABETIC DRUGS; GLUCOSIDASE; GLUCOSIDASE INHIBITORS; HETEROCYCLES; HETEROCYCLIC RINGS; INHIBITORY ACTIVITY; THERAPEUTIC STRATEGY;

AROMATIC COMPOUNDS;

9 (4 BROMO PHENYL) 10 (1H INDOL 3 YL) 2,7 DITHIOXO 2,3,7,8,9,10 HEXAHYDRO 1H,6H 1,3,6,8,9 PENTAAZA ANTHRACENE 4,5 DIONE; 9 (4 BROMO PHENYL) 10 (1H INDOL 3 YL) 9,10 DIHYDRO 1H,8H 1,3,6,8,9 PENTAAZA ANTHRACENE 2,4,5,7 TETRAONE; 9 (4 BROMO PHENYL) 10 (3 HYDROXY 4 METHOXY PHENYL) 9,10 DIHYDRO 1H,8H 1,3,6,8,9 PENTAAZA ANTHRACENE 2,4,5,7 TETRAONE; 9 [4 (4 AMINO BENZENESULFONYL)PHENYL] 10 (3 HYDROXY 4 METHOXY PHENYL) 9,10 DIHYDRO 1H,8H 1,3,6,8,9 PENTAAZA ANTHRACENE 2,4,5,7 TETRAONE; 9 [4 (4 AMINO BENZOYL)PHENYL] 10 (3 HYDROXY 4 METHOXY PHENYL) 9,10 DIHYDRO 1H,8H 1,3,6,8,9 PENTAAZA ANTHRACENE 2,4,5,7 TETRAONE; 9 [4 (4 AMINO BENZYL)PHENYL] 10 (3 HYDROXY 4 METHOXY PHENYL) 9,10 DIHYDRO 1H,8H 1,3,6,8,9 PENTAAZA ANTHRACENE 2,4,5,7 TETRAONE; 9 [4 (4 AMINO PHENOXY)PHENYL] 10 (3 HYDROXY 4 METHOXY PHENYL) 9,10 DIHYDRO 1H,8H 1,3,6,8,9 PENTAAZA ANTHRACENE 2,4,5,7 TETRAONE; ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; AMYLASE; ANTIDIABETIC AGENT; HETEROCYCLIC COMPOUND; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORESCENCE SPECTROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

SUS;

ANTIDIABETIC; INHIBITORS; PYRIMIDINE-FUSED HETEROCYCLES; Α-GLUCOSIDASE;

ALPHA-AMYLASES; ALPHA-GLUCOSIDASES; ANIMALS; CHEMISTRY TECHNIQUES, SYNTHETIC; HYPOGLYCEMIC AGENTS; LIGANDS; MICE; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; PYRIMIDINES; SACCHAROMYCES CEREVISIAE; SWINE;

EID: 84884491862     PISSN: 00086215     EISSN: 1873426X     Source Type: Journal    
DOI: 10.1016/j.carres.2013.07.008     Document Type: Article

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