Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents

European Journal of Medicinal Chemistry

Volumn 43, Issue 12, 2008, Pages 2717-2723

  Singh, B K ^a   Mishra, Mridul ^a   Saxena, Nisha ^a   Yadav, G P ^a   Maulik, P R ^a   Sahoo, M K ^a   Gaur, R L ^a   Murthy, P K ^a   Tripathi, R P ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

1,4 Dihydropyrimidines; Antifilarial; Brugia malayi; Dihydropyrimidines; Tetrabutyl ammonium bromide

Indexed keywords

2 SULFANYL 6 METHYL 1,4 DIHYDROPYRIMIDINE DERIVATIVE; 4 (4 FLUOROPHENYL) 6 METHYL 2 PENTYLSULFANYL 1,4 DIHYDROPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 5 METHYL 6 PHENYL 2 THIOXO 1,2,3,6 TETRAHYDROPYRIMIDINE 4 CARBOXYLIC ACID ETHYL ESTER DERIVATIVE; ANTIFILARIAL AGENT; CARBOXYLIC ACID DERIVATIVE; HALIDE; POTASSIUM CARBONATE; PYRIMIDINE DERIVATIVE; TETRABUTYLAMMONIUM; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRUGIA MALAYI; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; FILARIASIS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRODUCT RECOVERY;

ALKYLATION; ANIMALS; BRUGIA MALAYI; DOSE-RESPONSE RELATIONSHIP, DRUG; FILARICIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PYRIMIDINES; STEREOISOMERISM;

EID: 56949084919     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.01.038     Document Type: Article

References (29)

1. Fischer P., Manoempil P., Supali T., Servais G., and Rücker P. Trans. R. Soc. Trop. Med. Hyg. 11 (2006) 464-469
2. Galvez T.J.Z. Filaria J. 2 12 (2003) 1-5 10.1186/1475-2883-2-12 and references cited therein
3. Thomas P.A. Parasitology 122 (2001) S65-S71
4. Molyneux D. Filaria J. 2 (2003) 13 10.1186/1475-2883-2-13
5. Ottesen E.A. Trop. Med. Int. Health 5 (2000) 591-594
6. Ottesen E.A. Am. J. Trop. Med. Hyg. 41 (1989) S9-S17
7. Michael E., and Bundy D.A.P. Parasitol. Today 13 (1997) 472-476
8. Khan A.M., and Mahanta J. Curr. Sci. 88 (2005) 1718-1719
9. Das P.K., and Pani S.P. Int. Med. Sci. Acad. 13 (2000) 18-26
10. Hoerauf A., Volkmann L., Hamelmann C., Adjei O., Autenrieth I.B., Fleischer B., and Buttner D.W. Lancet 35 (2000) 1242-1243
11. Tripathi R.P., Katiyar D., Dwivedi N., Singh B.K., and Pandey J. Curr. Med. Chem. 13 (2006) 3319-3334
12. Collier L., Balows A., and Sussman M. Parasitology 5 (1998) 349-359
13. Bose C., Agarwal S.K., Chatterjee R.K., Srivastava V.M., Chauhan P.M., and Chatterjee R.K. Indian J. Chem. 33B (1994) 32-37
14. Srivastava S., Chauhan P.M., Bhaduri A.P., Murthy P.K., and Chatterjee R.K. Bioorg. Med. Chem. Lett. 10 (2000) 313-314
15. Matthews J.M., Liotta F., Hageman W., Rivero R.A., Westover L., Yang M., Xu J., and Demarest K. Bioorg. Med. Chem. Lett. 14 (2004) 1155-1159
16. Atwal K.S., Rovnyak G.C., Kimball S.D., Floyd D.M., Moreland S., Swanson B.N., Gougoutas J.Z., Schwartz J., Smillie K.M., and Malley M.F. J. Med. Chem. 33 (1990) 2629-2635
17. Kappe C.O. Molecules 3 (1998) 1-9
18. Tramontano E., Marongiu M.E., De Montis A., Loi A.G., Artico M., Massa S., Mai A., and La Colla P. Microbiologica 17 (1994) 269-276
19. Mai A., Artico M., Sbardella G., Massa S., Loi A.G., Tramontano E., Scano P., and La Colla P.J. J. Med. Chem. 38 (1995) 3258-3263
20. Ji L., Chen F.-E., Clercq E.D., Balzarini J., and Pannecouque C. J. Med. Chem. 50 (2007) 1778-1786
21. Mishra R.C., Tewari N., Arora K., Ahmad R., Tripathi R.P., Tiwari V.K., Walter R.D., and Srivatava A.K. Comb. Chem. High Throughtput Screen. 6 (2003) 37-51
22. Dwivedi N., Mishra R.C., and Tripathi R.P. Lett. Org. Chem. 2 (2005) 450-457
23. Viedma C. Phys. Rev. Lett. 95 (2005) 65504
24. Viedma C. Astrobiology 7 (2007) 312-319
25. Blackmond D.G. Chem.-Eur. J. 13 (2007) 3290-3295
26. Murthy P.K., and Chatterjee R.K. Curr. Sci. 77 (1999) 1084-1089
27. Lammler G., and Wolf E. Tropenmed. Parasitol. 28 (1977) 205-225
28. Chatterjee R.K., Fatima N., Murthy P.K., Sinha P., Kulshrestha D.K., and Dhawan B.N. Drug Dev. Res. 26 (1992) 67-78
29. Gaur R.L., Dixit S., Sahoo M.K., Khanna M., Singh S., and Murthy P.K. Parasitology 2 (2006) 1-8