Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa

PLoS Genetics

Volumn 10, Issue 2, 2014, Pages

  Engelken, Johannes ^a,b   Carnero Montoro, Elena ^a   Pybus, Marc ^a   Andrews, Glen K ^c   Lalueza Fox, Carles ^a   Comas, David ^a   Sekler, Israel ^d   de la Rasilla, Marco ^e   Rosas, Antonio ^f   Stoneking, Mark ^b   Valverde, Miguel A ^a   Vicente, Rubén ^a   Bosch, Elena ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b MAX PLANCK INSTITUTE FOR EVOLUTIONARY ANTHROPOLOGY   (Germany)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^e UNIVERSITY OF OVIEDO   (Spain)

^f MUSEO NACIONAL DE CIENCIAS NATURALES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; PROTEIN ZIP4; UNCLASSIFIED DRUG; ZINC TRANSPORTER; CATION TRANSPORT PROTEIN; SLC39A4 PROTEIN, HUMAN; ZINC;

ACRODERMATITIS ENTEROPATHICA; AFRICA SOUTH OF THE SAHARA; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CELL LEVEL; CODON; CONTROLLED STUDY; DNA SEQUENCE; GENE FREQUENCY; GENE MUTATION; GENE OVEREXPRESSION; GENETIC SELECTION; GENETIC VARIABILITY; HOMEOSTASIS; HOMO NEANDERTHALENSIS; HUMAN; HUMAN CELL; PHENOTYPE; POPULATION DIFFERENTIATION; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; ZINC DEFICIENCY; ZIP4 GENE; ACRODERMATITIS; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; MUTATION; PATHOLOGY; POPULATION GENETICS;

ACRODERMATITIS; AFRICA SOUTH OF THE SAHARA; CATION TRANSPORT PROTEINS; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETICS, POPULATION; HELA CELLS; HUMANS; MUTATION; SELECTION, GENETIC; ZINC;

EID: 84901743813     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004128     Document Type: Article

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