A mouse model of acrodermatitis enteropathica: Loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity

PLoS Genetics

Volumn 8, Issue 6, 2012, Pages

  Geiser, Jim ^a   Venken, Koen J T ^b   de Lisle, Robert C ^a   Andrews, Glen K ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; IRON; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MANGANESE; MUCIN; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZIP4 PROTEIN; CATION TRANSPORT PROTEIN; METAL; MTOR PROTEIN, MOUSE; SLC39A4 PROTEIN, MOUSE; SOX9 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; ZINC;

ACRODERMATITIS ENTEROPATHICA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DIVISION; CELL FUNCTION; CONTROLLED STUDY; DYSPLASIA; GENE; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GOBLET CELL; INTESTINE CELL; INTESTINE MUCOSA; KNOCKOUT MOUSE; LOSS OF FUNCTION MUTATION; LYSOSOME; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PANETH CELL; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; STEM CELL NICHE; WEIGHT REDUCTION; ZIP4 GENE; ACRODERMATITIS; ANIMAL; DISEASE MODEL; GENETICS; HUMAN; INTESTINE; METABOLISM; MOUSE MUTANT; PATHOLOGY;

MUS;

ACRODERMATITIS; ANIMALS; CATION TRANSPORT PROTEINS; DISEASE MODELS, ANIMAL; ENTEROCYTES; GENE EXPRESSION REGULATION; HUMANS; INTESTINES; METALS; MICE; MICE, KNOCKOUT; PANETH CELLS; SOX9 TRANSCRIPTION FACTOR; STEM CELL NICHE; TOR SERINE-THREONINE KINASES; ZINC;

EID: 84864057714     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002766     Document Type: Article

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