Modulation of angiotensin II-induced inflammatory cytokines by the Epac1-Rap1A-NHE3 pathway: Implications in renal tubular pathobiology

American Journal of Physiology - Renal Physiology

Volumn 306, Issue 11, 2014, Pages

  Xie, Ping ^a   Joladarashi, Darukeshwara ^a   Dudeja, Pradeep ^b   Sun, Lin ^a   Kanwar, Yashpal S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

AKI; Angiotensin II; Cytokines; Diabetic nephropathy; Epac1 Rap1a; Inflammation; NHE3; Tubulointerstitium

Indexed keywords

ANGIOTENSIN II; CYCLIC AMP; EPAC1 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; RAP1 PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GLOMERULUS FILTRATION RATE; HOMEOSTASIS; KIDNEY SLICE; KIDNEY TUBULE DISORDER; KIDNEY TUBULE EPITHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIGNAL TRANSDUCTION; UPREGULATION;

AKI; ANGIOTENSIN II; CYTOKINES; DIABETIC NEPHROPATHY; EPAC1-RAP1A; INFLAMMATION; NHE3; TUBULOINTERSTITIUM;

ANGIOTENSIN II; ANIMALS; CELL LINE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INFLAMMATION; KIDNEY TUBULES; MALE; PROTEIN TRANSPORT; RAP1 GTP-BINDING PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RENIN-ANGIOTENSIN SYSTEM; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER; SWINE;

EID: 84901701308     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00069.2014     Document Type: Article

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