-
1
-
-
2342466734
-
Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
-
Wild, S., Roglic, G., Green, A., Sicree, R. & King, H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 1047-1053 (2004).
-
(2004)
Diabetes Care
, vol.27
, pp. 1047-1053
-
-
Wild, S.1
Roglic, G.2
Green, A.3
Sicree, R.4
King, H.5
-
2
-
-
33847748973
-
Prevalence of chronic kidney disease and associated risk factors: United States, 1999-2004
-
Centers for Disease Control and Prevention (CDC). Prevalence of chronic kidney disease and associated risk factors: United States, 1999-2004. MMWR Morb. Mortal. Wkly Rep. 56, 161-165 (2007).
-
(2007)
MMWR Morb. Mortal. Wkly Rep
, vol.56
, pp. 161-165
-
-
-
3
-
-
0142182724
-
Racial differences in the progression from chronic renal insufficiency to end-stage renal disease in the United States
-
Hsu, C. Y, Lin, F., Vittinghoff, E. & Shlipak, M. G. Racial differences in the progression from chronic renal insufficiency to end-stage renal disease in the United States. J. Am. Soc. Nephrol. 14, 2902-2907 (2003).
-
(2003)
J. Am. Soc. Nephrol
, vol.14
, pp. 2902-2907
-
-
Hsu, C.Y.1
Lin, F.2
Vittinghoff, E.3
Shlipak, M.G.4
-
4
-
-
63549094143
-
The effect of ethnicity on the prevalence of diabetes and associated chronic kidney disease
-
Dreyer, G., Hull, S., Aitken, Z., Chesser, A. & Yaqoob, M. M. The effect of ethnicity on the prevalence of diabetes and associated chronic kidney disease. QJM 102, 261-269 (2009).
-
(2009)
QJM
, vol.102
, pp. 261-269
-
-
Dreyer, G.1
Hull, S.2
Aitken, Z.3
Chesser, A.4
Yaqoob, M.M.5
-
5
-
-
34250361947
-
Cellular and molecular mechanisms of proteinuria in diabetic nephropathy
-
Wolf, G. & Ziyadeh, F. N. Cellular and molecular mechanisms of proteinuria in diabetic nephropathy. Nephron Physiol. 106, 26-31 (2007).
-
(2007)
Nephron Physiol
, vol.106
, pp. 26-31
-
-
Wolf, G.1
Ziyadeh, F.N.2
-
6
-
-
0030377443
-
Effect of duration of type I diabetes on the prevalence of stages of diabetic nephropathy defined by urinary albumin/creatinine ratio
-
Warram, J. H., Gearin, G., Laffel, L. & Krolewski, A. S. Effect of duration of type I diabetes on the prevalence of stages of diabetic nephropathy defined by urinary albumin/creatinine ratio. J. Am. Soc. Nephrol. 7, 930-937 (1996).
-
(1996)
J. Am. Soc. Nephrol
, vol.7
, pp. 930-937
-
-
Warram, J.H.1
Gearin, G.2
Laffel, L.3
Krolewski, A.S.4
-
7
-
-
0028438760
-
Epidemiology of microalbuminuria in diabetes and in the background population
-
Mogensen, C. E. & Poulsen, P L. Epidemiology of microalbuminuria in diabetes and in the background population. Curr. Opin. Nephrol. Hypertens. 3, 248-256 (1994).
-
(1994)
Curr. Opin. Nephrol. Hypertens
, vol.3
, pp. 248-256
-
-
Mogensen, C.E.1
Poulsen, P.L.2
-
8
-
-
47949127622
-
The pathogenesis of diabetic nephropathy
-
Dronavalli, S., Duka, I. & Bakris, G. L. The pathogenesis of diabetic nephropathy. Nat. Clin. Pract. Endocrinol. Metab. 4, 444-452 (2008).
-
(2008)
Nat. Clin. Pract. Endocrinol. Metab
, vol.4
, pp. 444-452
-
-
Dronavalli, S.1
Duka, I.2
Bakris, G.L.3
-
9
-
-
0027525040
-
Renal renin-angiotensin system in diabetes: Functional, immunohistochemical, and molecular biological correlations
-
Anderson, S., Jung, F. F. & Ingelfinger, J. R. Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations. Am. J. Physiol. 265, F477-F486 (1993).
-
(1993)
Am. J. Physiol
, vol.265
, pp. F477-F486
-
-
Anderson, S.1
Jung, F.F.2
Ingelfinger, J.R.3
-
10
-
-
58149247936
-
Angiotensin-converting enzyme 2: Implications for blood pressure and kidney disease
-
Ingelfinger, J. R. Angiotensin-converting enzyme 2: implications for blood pressure and kidney disease. Curr. Opin. Nephrol. Hypertens. 18, 79-84 (2009).
-
(2009)
Curr. Opin. Nephrol. Hypertens
, vol.18
, pp. 79-84
-
-
Ingelfinger, J.R.1
-
11
-
-
33645741235
-
Angiotensin II compartmentalization within the kidney: Effect of salt diet and blood pressure alterations
-
Siragy, H. M. Angiotensin II compartmentalization within the kidney: effect of salt diet and blood pressure alterations. Curr. Opin. Nephrol. Hypertens. 15, 50-53 (2006).
-
(2006)
Curr. Opin. Nephrol. Hypertens
, vol.15
, pp. 50-53
-
-
Siragy, H.M.1
-
12
-
-
0026083978
-
Angiotensin and cell growth: A link to cardiovascular hypertrophy
-
Schelling, P, Fischer, H. & Ganten, D. Angiotensin and cell growth: a link to cardiovascular hypertrophy. J. Hypertens. 9, 3-15 (1991).
-
(1991)
J. Hypertens
, vol.9
, pp. 3-15
-
-
Schelling, P.1
Fischer, H.2
Ganten, D.3
-
13
-
-
0033538649
-
Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension
-
Fukai, T., Siegfried, M. R., Ushio-Fukai, M., Griendling, K. K. & Harrison, D. G. Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension. Circ. Res. 85, 23-28 (1999).
-
(1999)
Circ. Res
, vol.85
, pp. 23-28
-
-
Fukai, T.1
Siegfried, M.R.2
Ushio-Fukai, M.3
Griendling, K.K.4
Harrison, D.G.5
-
14
-
-
0033586639
-
Increased NADH-oxidase- mediated superoxide production in the early stages of atherosclerosis: Evidence for involvement of the renin-angiotensin system
-
Warnholtz, A. et al. Increased NADH-oxidase- mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation 99, 2027-2033 (1999).
-
(1999)
Circulation
, vol.99
, pp. 2027-2033
-
-
Warnholtz, A.1
-
15
-
-
0031708389
-
Angiotensin II induces superoxide anion production by mesangial cells
-
Jaimes, E. A., Galceran, J. M. & Raij, L. Angiotensin II induces superoxide anion production by mesangial cells. Kidney Int. 54, 775-784 (1998).
-
(1998)
Kidney Int
, vol.54
, pp. 775-784
-
-
Jaimes, E.A.1
Galceran, J.M.2
Raij, L.3
-
16
-
-
0028987941
-
Transforming growth factor-beta and angiotensin II: The missing link from glomerular hyperfiltration to glomerulosclerosis?
-
Ketteler, M., Noble, N. A. & Border, W. A. Transforming growth factor-beta and angiotensin II: the missing link from glomerular hyperfiltration to glomerulosclerosis? Annu. Rev. Physiol. 57, 279-295 (1995).
-
(1995)
Annu. Rev. Physiol
, vol.57
, pp. 279-295
-
-
Ketteler, M.1
Noble, N.A.2
Border, W.A.3
-
17
-
-
0035462888
-
Angiotensin II and renal fibrosis
-
Mezzano, S. A., Ruiz-Ortega, M. & Egido, J. Angiotensin II and renal fibrosis. Hypertension 38, 635-638 (2001).
-
(2001)
Hypertension
, vol.38
, pp. 635-638
-
-
Mezzano, S.A.1
Ruiz-Ortega, M.2
Egido, J.3
-
18
-
-
0347986777
-
NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis
-
Bataller, R. et al. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J. Clin. Invest. 112, 1383-1394 (2003).
-
(2003)
J. Clin. Invest
, vol.112
, pp. 1383-1394
-
-
Bataller, R.1
-
20
-
-
70349756901
-
Effects of losartan on hepatic expression of non-phagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C
-
Colmenero, J. et al. Effects of losartan on hepatic expression of non-phagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am. J. Physiol. Gastrointest. Liver Physiol. 297, G726-G734 (2009).
-
(2009)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.297
, pp. G726-G734
-
-
Colmenero, J.1
-
21
-
-
33845603497
-
Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase
-
Johar, S., Cave, A. C., Narayanapanicker, A., Grieve, D. J. & Shah, A. M. Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J. 20, 1546-1548 (2006).
-
(2006)
FASEB J
, vol.20
, pp. 1546-1548
-
-
Johar, S.1
Cave, A.C.2
Narayanapanicker, A.3
Grieve, D.J.4
Shah, A.M.5
-
22
-
-
0036596686
-
Urinary transforming-beta excretion in patients with hypertension, type 2 diabetes, and elevated albumin excretion rate: Effects of angiotensin receptor blockade and sodium restriction
-
Houlihan, C. A. et al. Urinary transforming-beta excretion in patients with hypertension, type 2 diabetes, and elevated albumin excretion rate: effects of angiotensin receptor blockade and sodium restriction. Diabetes Care 25, 1072-1077 (2002).
-
(2002)
Diabetes Care
, vol.25
, pp. 1072-1077
-
-
Houlihan, C.A.1
-
23
-
-
0031252397
-
Role of angiotensin II and bradykinin in experimental diabetic nephropathy. Functional and structural studies
-
Allen, T. J., Cao, Z., Youssef, S., Hulthen, U. L. & Cooper, M. E. Role of angiotensin II and bradykinin in experimental diabetic nephropathy. Functional and structural studies. Diabetes 46, 1612-1618 (1997).
-
(1997)
Diabetes
, vol.46
, pp. 1612-1618
-
-
Allen, T.J.1
Cao, Z.2
Youssef, S.3
Hulthen, U.L.4
Cooper, M.E.5
-
24
-
-
0027517659
-
The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group
-
Lewis, E. J., Hunsicker, L. G., Bain, R. P & Rhohde, R. D. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N. Engl. J. Med. 329, 1456-1462 (1993).
-
(1993)
N. Engl. J. Med
, vol.329
, pp. 1456-1462
-
-
Lewis, E.J.1
Hunsicker, L.G.2
Bain, R.P.3
Rhohde, R.D.4
-
25
-
-
0035922447
-
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
-
Lewis, E. J. et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N. Engl. J. Med. 345, 851-860 (2001).
-
(2001)
N. Engl. J. Med
, vol.345
, pp. 851-860
-
-
Lewis, E.J.1
-
26
-
-
0035922444
-
The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
-
Parving, H. H. et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N. Engl. J. Med. 345, 870-878 (2001).
-
(2001)
N. Engl. J. Med
, vol.345
, pp. 870-878
-
-
Parving, H.H.1
-
27
-
-
67649635807
-
Renal and retinal effects of enalapril and losartan in type 1 diabetes
-
Mauer, M. et al. Renal and retinal effects of enalapril and losartan in type 1 diabetes. N. Engl. J. Med. 361, 40-51 (2009).
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 40-51
-
-
Mauer, M.1
-
28
-
-
84984752936
-
The renin-angiotensin-aldosterone system in the onset and progression of diabetic nephropathy
-
Ruggenenti, P., Cravedi, P. & Remuzzi, G. The renin-angiotensin-aldosterone system in the onset and progression of diabetic nephropathy. Nat. Rev. Nephrol. doi:10.1038/nrneph.2010.58.
-
Nat. Rev. Nephrol
-
-
Ruggenenti, P.1
Cravedi, P.2
Remuzzi, G.3
-
29
-
-
0037967318
-
Chymase is upregulated in diabetic nephropathy: Implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease
-
Huang, X. R., Chen, W. Y, Truong, L. D. & Lan, H. Y. Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease. J. Am. Soc. Nephrol. 14, 1738-1747 (2003).
-
(2003)
J. Am. Soc. Nephrol
, vol.14
, pp. 1738-1747
-
-
Huang, X.R.1
Chen, W.Y.2
Truong, L.D.3
Lan, H.Y.4
-
30
-
-
49149087718
-
Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (The ONTARGET study): A multicentre, randomised, double-blind, controlled trial
-
Mann, J. F. et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 372, 547-553 (2008).
-
(2008)
Lancet
, vol.372
, pp. 547-553
-
-
Mann, J.F.1
-
31
-
-
0029853814
-
Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen
-
Nguyen, G., Delarue, F., Berrou, J., Rondeau, E. & Sraer, J. D. Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int. 50, 1897-1903 (1996).
-
(1996)
Kidney Int
, vol.50
, pp. 1897-1903
-
-
Nguyen, G.1
Delarue, F.2
Berrou, J.3
Rondeau, E.4
Sraer, J.D.5
-
32
-
-
0036266596
-
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
-
Nguyen, G. et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J. Clin. Invest. 109, 1417-1427 (2002).
-
(2002)
J. Clin. Invest
, vol.109
, pp. 1417-1427
-
-
Nguyen, G.1
-
33
-
-
30944469631
-
Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
-
Huang, Y et al. Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int. 69, 105-113 (2006).
-
(2006)
Kidney Int
, vol.69
, pp. 105-113
-
-
Huang, Y.1
-
34
-
-
0036126348
-
Tissue activity of circulating prorenin
-
Prescott, G., Silversides, D. W. & Reudelhuber, T. L. Tissue activity of circulating prorenin. Am. J. Hypertens. 15, 280-285 (2002).
-
(2002)
Am. J. Hypertens
, vol.15
, pp. 280-285
-
-
Prescott, G.1
Silversides, D.W.2
Reudelhuber, T.L.3
-
35
-
-
0024268789
-
Human prorenin: Pathophysiology and clinical implications
-
Derkx, F. H. & Schalekamp, M. A. Human prorenin: pathophysiology and clinical implications. Clin. Exp. Hypertens. A 10, 1213-1225 (1988).
-
(1988)
Clin. Exp. Hypertens. A
, vol.10
, pp. 1213-1225
-
-
Derkx, F.H.1
Schalekamp, M.A.2
-
36
-
-
0021889169
-
Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications
-
Luetscher, J. A., Kraemer, F. B., Wilson, D. M., Schwartz, H. C. & Bryer-Ash, M. Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications. N. Engl. J. Med. 312, 1412-1417 (1985).
-
(1985)
N. Engl. J. Med
, vol.312
, pp. 1412-1417
-
-
Luetscher, J.A.1
Kraemer, F.B.2
Wilson, D.M.3
Schwartz, H.C.4
Bryer-Ash, M.5
-
37
-
-
67049100691
-
Chronic increases in circulating prorenin are not associated with renal or cardiac pathologies
-
Mercure, C., Prescott, G., Lacombe, M. J., Silversides, D. W. & Reudelhuber, T. L. Chronic increases in circulating prorenin are not associated with renal or cardiac pathologies. Hypertension 53, 1062-1069 (2009).
-
(2009)
Hypertension
, vol.53
, pp. 1062-1069
-
-
Mercure, C.1
Prescott, G.2
Lacombe, M.J.3
Silversides, D.W.4
Reudelhuber, T.L.5
-
38
-
-
42649140868
-
Renal (Pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity
-
Siragy, H. M. & Huang, J. Renal (pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity. Exp. Physiol. 93, 709-714 (2008).
-
(2008)
Exp. Physiol
, vol.93
, pp. 709-714
-
-
Siragy, H.M.1
Huang, J.2
-
39
-
-
33745824649
-
Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice
-
Ichihara, A. et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. J. Am. Soc. Nephrol. 17, 1950-1961 (2006).
-
(2006)
J. Am. Soc. Nephrol
, vol.17
, pp. 1950-1961
-
-
Ichihara, A.1
-
40
-
-
34249881320
-
Slowly progressive, angiotensin II-independent glomerulosclerosis in human (Pro)renin receptor-transgenic rats
-
Kaneshiro, Y et al. Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats. J. Am. Soc. Nephrol. 18, 1789-1795 (2007).
-
(2007)
J. Am. Soc. Nephrol
, vol.18
, pp. 1789-1795
-
-
Kaneshiro, Y.1
-
41
-
-
34447272037
-
Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade
-
Takahashi, H. et al. Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade. J. Am. Soc. Nephrol. 18, 2054-2061 (2007).
-
(2007)
J. Am. Soc. Nephrol
, vol.18
, pp. 2054-2061
-
-
Takahashi, H.1
-
42
-
-
0022409744
-
Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine
-
Boger, J. et al. Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine. J. Med. Chem. 28, 1779-1790 (1985).
-
(1985)
J. Med. Chem
, vol.28
, pp. 1779-1790
-
-
Boger, J.1
-
43
-
-
0023235966
-
Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides
-
Hui, K. Y, Carlson, W. D., Bernatowicz, M. S. & Haber, E. J. Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides. J. Med. Chem. 30, 1287-1295 (1987).
-
(1987)
J. Med. Chem
, vol.30
, pp. 1287-1295
-
-
Hui, K.Y.1
Carlson, W.D.2
Bernatowicz, M.S.3
Haber, E.J.4
-
44
-
-
33749985149
-
Oral renin inhibitors
-
Staessen, J. A., Li, Y. & Richart, T. Oral renin inhibitors. Lancet 368, 1449-1456 (2006).
-
(2006)
Lancet
, vol.368
, pp. 1449-1456
-
-
Staessen, J.A.1
Li, Y.2
Richart, T.3
-
45
-
-
0033941893
-
Structure-based drug design: The discovery of novel nonpeptide orally active inhibitors of human renin
-
Rahuel, J. et al. Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin. Chem. Biol. 7, 493-504 (2000).
-
(2000)
Chem. Biol
, vol.7
, pp. 493-504
-
-
Rahuel, J.1
-
46
-
-
0042661157
-
Structure-based design of aliskiren, a novel orally effective renin inhibitor
-
Wood, J. M. et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem. Biophys. Res. Commun. 308, 698-705 (2003).
-
(2003)
Biochem. Biophys. Res. Commun
, vol.308
, pp. 698-705
-
-
Wood, J.M.1
-
47
-
-
0036372173
-
Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): Comparison with enalapril
-
Nussberger, J., Wuerzner, G., Jensen, C. & Brunner, H. R. Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril. Hypertension 39, E1-E8 (2002).
-
(2002)
Hypertension
, vol.39
, pp. E1-E8
-
-
Nussberger, J.1
Wuerzner, G.2
Jensen, C.3
Brunner, H.R.4
-
48
-
-
14044271546
-
Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats
-
Wood, J. M., Schnell, C. R., Cumin, F., Menard, J. & Webb, R. L. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J. Hypertens. 23, 417-426 (2005).
-
(2005)
J. Hypertens
, vol.23
, pp. 417-426
-
-
Wood, J.M.1
Schnell, C.R.2
Cumin, F.3
Menard, J.4
Webb, R.L.5
-
49
-
-
0026753520
-
Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes
-
Ganten, D. et al. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. Proc. Natl Acad. Sci. USA 89, 7806-7810 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 7806-7810
-
-
Ganten, D.1
-
50
-
-
25444454353
-
Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double- transgenic rats
-
Pilz, B. et al. Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double- transgenic rats. Hypertension 46, 569-576 (2005).
-
(2005)
Hypertension
, vol.46
, pp. 569-576
-
-
Pilz, B.1
-
51
-
-
34848907212
-
Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats
-
Kelly, D. J., Zhang, Y., Moe, G., Naik, G. & Gilbert, R. E. Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats. Diabetologia 50, 2398-2404 (2007).
-
(2007)
Diabetologia
, vol.50
, pp. 2398-2404
-
-
Kelly, D.J.1
Zhang, Y.2
Moe, G.3
Naik, G.4
Gilbert, R.E.5
-
52
-
-
46449118638
-
Effect of aliskiren on blood pressure, albuminuria and (Pro)renin receptor expression in diabetic TG(mRen-2)27 rats
-
Feldman, D. L. et al. Effect of aliskiren on blood pressure, albuminuria and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats. Hypertension 52, 130-136 (2008).
-
(2008)
Hypertension
, vol.52
, pp. 130-136
-
-
Feldman, D.L.1
-
53
-
-
36248994286
-
Direct renin inhibitor: Focus on aliskiren
-
Pool, J. L. Direct renin inhibitor: focus on aliskiren. J. Manag. Care Pharm. 13 (Suppl. B), S21-S33 (2007).
-
(2007)
J. Manag. Care Pharm
, vol.13
, pp. S21-S33
-
-
Pool, J.L.1
-
54
-
-
56549103332
-
First renin inhibitor, aliskiren, for the treatment of hypertension
-
Triller, D. M., Evang, S. D., Tadrous, M. & Yoo, B. K. First renin inhibitor, aliskiren, for the treatment of hypertension. Pharm. World Sci. 30, 741-749 (2008).
-
(2008)
Pharm. World Sci
, vol.30
, pp. 741-749
-
-
Triller, D.M.1
Evang, S.D.2
Tadrous, M.3
Yoo, B.K.4
-
55
-
-
43449139264
-
Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes
-
Persson, F. et al. Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes. Kidney Int. 73, 1419-1425 (2008).
-
(2008)
Kidney Int
, vol.73
, pp. 1419-1425
-
-
Persson, F.1
-
56
-
-
70349690296
-
Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension, and albuminuria
-
Persson, F. et al. Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension, and albuminuria. Diabetes Care 32, 1873-1879 (2009).
-
(2009)
Diabetes Care
, vol.32
, pp. 1873-1879
-
-
Persson, F.1
-
57
-
-
44849114597
-
Aliskiren combined with losartan in type 2 diabetes and nephropathy
-
Parving, H. H., Persson, F., Lewis, J. B., Lewis, E. J. & Hollenberg, N. K. Aliskiren combined with losartan in type 2 diabetes and nephropathy. N. Engl. J. Med. 358, 2433-2446 (2008).
-
(2008)
N. Engl. J. Med
, vol.358
, pp. 2433-2446
-
-
Parving, H.H.1
Persson, F.2
Lewis, J.B.3
Lewis, E.J.4
Hollenberg, N.K.5
-
58
-
-
65249182083
-
Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): Rationale and study design
-
Parving, H. H. et al. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrol. Dial. Transplant. 24, 1663-1671 (2009).
-
(2009)
Nephrol. Dial. Transplant
, vol.24
, pp. 1663-1671
-
-
Parving, H.H.1
-
59
-
-
61349170589
-
Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
-
Solomon, S. D. et al. Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 119, 530-537 (2009).
-
(2009)
Circulation
, vol.119
, pp. 530-537
-
-
Solomon, S.D.1
-
60
-
-
0024520864
-
Induction of glomerulosclerosis by dietary lipids. A functional and morphologic study in the rat
-
Grone, H. J. et al. Induction of glomerulosclerosis by dietary lipids. A functional and morphologic study in the rat. Lab. Invest. 60, 433-446 (1989).
-
(1989)
Lab. Invest
, vol.60
, pp. 433-446
-
-
Grone, H.J.1
-
61
-
-
0025019741
-
The role of lipids in the pathogenesis of glomerulosclerosis in the rat following subtotal nephrectomy
-
Rayner, H. C., Ross-Gilbertson, V. L. & Walls, J. The role of lipids in the pathogenesis of glomerulosclerosis in the rat following subtotal nephrectomy. Eur. J. Clin. Invest. 20, 97-104 (1990).
-
(1990)
Eur. J. Clin. Invest
, vol.20
, pp. 97-104
-
-
Rayner, H.C.1
Ross-Gilbertson, V.L.2
Walls, J.3
-
62
-
-
0027280249
-
LDL stimulates mesangial fibronectin production and chemoattractant expression
-
Rovin, B. H. & Tan, L. C. LDL stimulates mesangial fibronectin production and chemoattractant expression. Kidney Int. 43, 218-225 (1993).
-
(1993)
Kidney Int
, vol.43
, pp. 218-225
-
-
Rovin, B.H.1
Tan, L.C.2
-
63
-
-
0029130495
-
Low-density lipoprotein stimulates the expression of macrophage colony-stimulating factor in glomerular mesangial cells
-
Pai, R., Kirschenbaum, M. A. & Kamanna, V. S. Low-density lipoprotein stimulates the expression of macrophage colony-stimulating factor in glomerular mesangial cells. Kidney Int. 48, 1254-1262 (1995).
-
(1995)
Kidney Int
, vol.48
, pp. 1254-1262
-
-
Pai, R.1
Kirschenbaum, M.A.2
Kamanna, V.S.3
-
64
-
-
0029995774
-
Oxidative modification of low-density lipoprotein enhances the murine mesangial cell cytokines associated with monocyte migration, differentiation, and proliferation
-
Kamanna, V. S., Pai, R., Roh, D. D. & Kirschenbaum, M. A. Oxidative modification of low-density lipoprotein enhances the murine mesangial cell cytokines associated with monocyte migration, differentiation, and proliferation. Lab. Invest. 74, 1067-1079 (1996).
-
(1996)
Lab. Invest
, vol.74
, pp. 1067-1079
-
-
Kamanna, V.S.1
Pai, R.2
Roh, D.D.3
Kirschenbaum, M.A.4
-
65
-
-
0031780731
-
Oxidative modification of low-density lipoprotein enhances mesangial cell protein synthesis and gene expression of extracellular matrix proteins
-
Roh, D. D., Kamanna, V. S. & Kirschenbaum, M. A. Oxidative modification of low-density lipoprotein enhances mesangial cell protein synthesis and gene expression of extracellular matrix proteins. Am. J. Nephrol. 18, 344-350 (1998).
-
(1998)
Am. J. Nephrol
, vol.18
, pp. 344-350
-
-
Roh, D.D.1
Kamanna, V.S.2
Kirschenbaum, M.A.3
-
66
-
-
0033998369
-
Early events leading to renal injury in obese Zucker (Fatty) rats with type II diabetes
-
Coimbra, T. M. et al. Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes. Kidney Int. 57, 167-182 (2000).
-
(2000)
Kidney Int
, vol.57
, pp. 167-182
-
-
Coimbra, T.M.1
-
67
-
-
0031869430
-
Interstitial fibrosis in hypercholesterolemic rats: Role of oxidation, matrix synthesis, and proteolytic cascades
-
Eddy, A. A. Interstitial fibrosis in hypercholesterolemic rats: role of oxidation, matrix synthesis, and proteolytic cascades. Kidney Int. 53, 1182-1189 (1998).
-
(1998)
Kidney Int
, vol.53
, pp. 1182-1189
-
-
Eddy, A.A.1
-
68
-
-
0032507776
-
Main risk factors for nephropathy in type 2 diabetes mellitus are plasma cholesterol levels, mean blood pressure, and hyperglycemia
-
Ravid, M., Brosh, D., Ravid-Safran, D., Levy, Z. & Rachmani, R. Main risk factors for nephropathy in type 2 diabetes mellitus are plasma cholesterol levels, mean blood pressure, and hyperglycemia. Arch. Intern. Med. 158, 998-1004 (1998).
-
(1998)
Arch. Intern. Med
, vol.158
, pp. 998-1004
-
-
Ravid, M.1
Brosh, D.2
Ravid-Safran, D.3
Levy, Z.4
Rachmani, R.5
-
69
-
-
0037560304
-
Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model
-
Ota, T et al. Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model. Diabetologia 46, 843-851 (2003).
-
(2003)
Diabetologia
, vol.46
, pp. 843-851
-
-
Ota, T.1
-
70
-
-
0033014894
-
Role of hyperlipidemia in progressive renal disease: Focus on diabetic nephropathy
-
Jandeleit-Dahm, K. et al. Role of hyperlipidemia in progressive renal disease: focus on diabetic nephropathy. Kidney Int. Suppl. 71, S31-S36 (1999).
-
(1999)
Kidney Int. Suppl
, vol.71
, pp. S31-S36
-
-
Jandeleit-Dahm, K.1
-
71
-
-
70350146802
-
Effect of the HMG-CoA reductase inhibitor rosuvastatin on early chronic kidney injury in obese zucker rats fed with an atherogenic diet
-
Reisin, E. et al. Effect of the HMG-CoA reductase inhibitor rosuvastatin on early chronic kidney injury in obese zucker rats fed with an atherogenic diet. Am. J. Med. Sci. 338, 301-309 (2009).
-
(2009)
Am. J. Med. Sci
, vol.338
, pp. 301-309
-
-
Reisin, E.1
-
72
-
-
0036322869
-
Isoprenoids as mediators of the biological effects of statins
-
Liao, J. K. Isoprenoids as mediators of the biological effects of statins. J. Clin. Invest. 110, 285-288 (2002).
-
(2002)
J. Clin. Invest
, vol.110
, pp. 285-288
-
-
Liao, J.K.1
-
73
-
-
11144322775
-
Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on renal function
-
Epstein, M. & Campese, V. M. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on renal function. Am. J. Kidney Dis. 45, 2-14 (2005).
-
(2005)
Am. J. Kidney Dis
, vol.45
, pp. 2-14
-
-
Epstein, M.1
Campese, V.M.2
-
74
-
-
0037315103
-
HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats
-
Usui, H. et al. HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats. Nephrol. Dial. Transplant. 18, 265-272 (2003).
-
(2003)
Nephrol. Dial. Transplant
, vol.18
, pp. 265-272
-
-
Usui, H.1
-
75
-
-
0033802611
-
Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects
-
Park, J. K. et al. Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects. Kidney Int. 58, 1420-1430 (2000).
-
(2000)
Kidney Int
, vol.58
, pp. 1420-1430
-
-
Park, J.K.1
-
76
-
-
42949130547
-
Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice
-
Matsumoto, M. et al. Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice. Metabolism 57, 691-697 (2008).
-
(2008)
Metabolism
, vol.57
, pp. 691-697
-
-
Matsumoto, M.1
-
77
-
-
34547743999
-
Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice
-
Fujii, M. et al. Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice. Kidney Int. 72, 473-480 (2007).
-
(2007)
Kidney Int
, vol.72
, pp. 473-480
-
-
Fujii, M.1
-
78
-
-
0037062481
-
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose- induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy
-
Danesh, F. R. et al. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose- induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: implications for diabetic nephropathy. Proc. Natl Acad. Sci. USA 99, 8301-8305 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 8301-8305
-
-
Danesh, F.R.1
-
79
-
-
0030820468
-
Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21ras activated, AP-1-dependent pathway
-
Vrtovsnik, F., Couette, S., Prie, D., Lallemand, D. & Friedlander, G. Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21ras activated, AP-1-dependent pathway. Kidney Int. 52, 1016-1027 (1997).
-
(1997)
Kidney Int
, vol.52
, pp. 1016-1027
-
-
Vrtovsnik, F.1
Couette, S.2
Prie, D.3
Lallemand, D.4
Friedlander, G.5
-
80
-
-
26244432388
-
Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins
-
Baigent, C. et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins. Lancet 366, 1267-1278 (2005).
-
(2005)
Lancet
, vol.366
, pp. 1267-1278
-
-
Baigent, C.1
-
81
-
-
70350121639
-
Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes: An analysis from the Collaborative Atorvastatin Diabetes Study (CARDS)
-
Colhoun, H. M. et al. Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes: an analysis from the Collaborative Atorvastatin Diabetes Study (CARDS). Am. J. Kidney Dis. 54, 810-819 (2009).
-
(2009)
Am. J. Kidney Dis
, vol.54
, pp. 810-819
-
-
Colhoun, H.M.1
-
82
-
-
22344458137
-
Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
-
Wanner, C. et al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N. Engl. J. Med. 353, 238-248 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 238-248
-
-
Wanner, C.1
-
83
-
-
63849163945
-
Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
-
Fellstrom, B. C. et al. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N. Engl. J. Med. 360, 1395-1407 (2009).
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 1395-1407
-
-
Fellstrom, B.C.1
-
84
-
-
0037458229
-
Cholesterol and Recurrent Events (CARE) Trial Investigators. Pravastatin for secondary prevention of cardiovascular events in persons with mild chronic renal insufficiency
-
Tonelli, M., Moye, L., Sacks, F. M., Kiberd, B. & Curhan, G. Cholesterol and Recurrent Events (CARE) Trial Investigators. Pravastatin for secondary prevention of cardiovascular events in persons with mild chronic renal insufficiency. Ann. Intern. Med. 138, 98-104 (2003).
-
(2003)
Ann. Intern. Med
, vol.138
, pp. 98-104
-
-
Tonelli, M.1
Moye, L.2
Sacks, F.M.3
Kiberd, B.4
Curhan, G.5
-
85
-
-
33745836406
-
Statins for improving renal outcomes: A meta- analysis
-
Sandhu, S., Wiebe, N., Fried, L. F. & Tonelli, M. Statins for improving renal outcomes: a meta- analysis. J. Am. Soc. Nephrol. 17, 2006-2016 (2006).
-
(2006)
J. Am. Soc. Nephrol
, vol.17
, pp. 2006-2016
-
-
Sandhu, S.1
Wiebe, N.2
Fried, L.F.3
Tonelli, M.4
-
86
-
-
41549125948
-
The Lipid lowering and Onset of Renal Disease (LORD) Trial: A randomized double blind placebo controlled trial assessing the effect of atorvastatin on the progression of kidney disease
-
Fassett, R. G., Ball, M. J., Robertson, I. K., Geraghty, D. P. & Coombes, J. S. The Lipid lowering and Onset of Renal Disease (LORD) Trial: a randomized double blind placebo controlled trial assessing the effect of atorvastatin on the progression of kidney disease. BMC Nephrol. 9, 4 (2008).
-
(2008)
BMC Nephrol
, vol.9
, pp. 4
-
-
Fassett, R.G.1
Ball, M.J.2
Robertson, I.K.3
Geraghty, D.P.4
Coombes, J.S.5
-
87
-
-
0037407617
-
Study of Heart and Renal Protection (SHARP)
-
Baigent, C. & Landry, M. Study of Heart and Renal Protection (SHARP). Kidney Int. Suppl. 84, S207-S210 (2003).
-
(2003)
Kidney Int. Suppl
, vol.84
, pp. S207-S210
-
-
Baigent, C.1
Landry, M.2
-
89
-
-
0033638127
-
Molecular basis of renal fibrosis
-
Eddy, A. A. Molecular basis of renal fibrosis. Pediatr. Nephrol. 15, 290-301 (2000).
-
(2000)
Pediatr. Nephrol
, vol.15
, pp. 290-301
-
-
Eddy, A.A.1
-
90
-
-
55249104964
-
Interstitial fibrosis: Tubular hypothesis versus glomerular hypothesis
-
Christensen, E. I. & Verroust, P J. Interstitial fibrosis: tubular hypothesis versus glomerular hypothesis. Kidney Int. 74, 1233-1236 (2008).
-
(2008)
Kidney Int
, vol.74
, pp. 1233-1236
-
-
Christensen, E.I.1
Verroust, P.J.2
-
91
-
-
0029076281
-
Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator
-
Sharma, K. & Ziyadeh, F. N. Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator. Diabetes 44, 1139-1146 (1995).
-
(1995)
Diabetes
, vol.44
, pp. 1139-1146
-
-
Sharma, K.1
Ziyadeh, F.N.2
-
92
-
-
0031883395
-
Potential role of TGF-beta in diabetic nephropathy
-
Hoffman, B. B., Sharma, K. & Ziyadeh, F. N. Potential role of TGF-beta in diabetic nephropathy. Miner. Electrolyte Metab. 24, 190-196 (1998).
-
(1998)
Miner. Electrolyte Metab
, vol.24
, pp. 190-196
-
-
Hoffman, B.B.1
Sharma, K.2
Ziyadeh, F.N.3
-
93
-
-
0036375448
-
Novel aspects of transforming growth factor-beta in diabetic kidney disease
-
Tsuchida, K., Cronin, B. & Sharma, K. Novel aspects of transforming growth factor-beta in diabetic kidney disease. Nephron 92, 7-21 (2002).
-
(2002)
Nephron
, vol.92
, pp. 7-21
-
-
Tsuchida, K.1
Cronin, B.2
Sharma, K.3
-
94
-
-
0034106182
-
TGF-beta in diabetic kidney disease: Role of novel signaling pathways
-
Sharma, K. & McGowan, T. A. TGF-beta in diabetic kidney disease: role of novel signaling pathways. Cytokine Growth Factor Rev. 11, 115-123 (2000).
-
(2000)
Cytokine Growth Factor Rev
, vol.11
, pp. 115-123
-
-
Sharma, K.1
McGowan, T.A.2
-
95
-
-
70349263307
-
Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy
-
Yamaguchi, Y. et al. Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy. Am. J. Kidney Dis. 54, 653-664 (2009).
-
(2009)
Am. J. Kidney Dis
, vol.54
, pp. 653-664
-
-
Yamaguchi, Y.1
-
96
-
-
36148979331
-
Epithelial to mesenchymal transition in the progression of tubulointerstitial fibrosis
-
Li, M. X. & Liu, B. C. Epithelial to mesenchymal transition in the progression of tubulointerstitial fibrosis. Chin. Med. J. (Engl.) 120, 1925-1930 (2007).
-
(2007)
Chin. Med. J. (Engl.)
, vol.120
, pp. 1925-1930
-
-
Li, M.X.1
Liu, B.C.2
-
97
-
-
70350545853
-
TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy
-
Hills, C. E. & Squires, P. E. TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy. Am. J. Nephrol. 31, 68-74 (2009).
-
(2009)
Am. J. Nephrol
, vol.31
, pp. 68-74
-
-
Hills, C.E.1
Squires, P.E.2
-
98
-
-
0029924637
-
Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
-
Sharma, K., Jin, Y, Guo, J. & Ziyadeh, F. N. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45, 522-530 (1996).
-
(1996)
Diabetes
, vol.45
, pp. 522-530
-
-
Sharma, K.1
Jin, Y.2
Guo, J.3
Ziyadeh, F.N.4
-
99
-
-
0242665667
-
Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells
-
Sharma, K. et al. Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. Am. J. Physiol. Renal Physiol. 285, 1258-1270 (2003).
-
(2003)
Am. J. Physiol. Renal Physiol
, vol.285
, pp. 1258-1270
-
-
Sharma, K.1
-
100
-
-
17644408006
-
TGF-beta impairs renal autoregulation via generation of ROS
-
Sharma, K., Cook, A., Smith, M., Valancius, C. & Inscho, E. W. TGF-beta impairs renal autoregulation via generation of ROS. Am. J. Physiol. Renal Physiol. 288, 1069-1077 (2005).
-
(2005)
Am. J. Physiol. Renal Physiol
, vol.288
, pp. 1069-1077
-
-
Sharma, K.1
Cook, A.2
Smith, M.3
Valancius, C.4
Inscho, E.W.5
-
101
-
-
0034608948
-
Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
-
Ziyadeh, F. N. et al. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proc. Natl Acad. Sci. USA 97, 8015-8020 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 8015-8020
-
-
Ziyadeh, F.N.1
-
102
-
-
0037229517
-
Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice
-
Chen, S. et al. Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice. Biochem. Biophys. Res. Commun. 300, 16-22 (2003).
-
(2003)
Biochem. Biophys. Res. Commun
, vol.300
, pp. 16-22
-
-
Chen, S.1
-
103
-
-
33846187695
-
Soluble betaglycan reduces renal damage progression in db/db mice
-
Juarez, P et al. Soluble betaglycan reduces renal damage progression in db/db mice. Am. J. Physiol. Renal Physiol. 292, F321-F329 (2007).
-
(2007)
Am. J. Physiol. Renal Physiol
, vol.292
, pp. F321-F329
-
-
Juarez, P.1
-
104
-
-
21744440388
-
Delivery of plasmid DNA expressing small interference RNA for TGF-beta type II receptor by cationized gelatin to prevent interstitial renal fibrosis
-
Kushibiki, T, Nagata-Nakajima, N., Sugai, M., Shimizu, A. & Tabata, Y. Delivery of plasmid DNA expressing small interference RNA for TGF-beta type II receptor by cationized gelatin to prevent interstitial renal fibrosis. J. Control. Release 105, 318-331 (2005).
-
(2005)
J. Control. Release
, vol.105
, pp. 318-331
-
-
Kushibiki, T.1
Nagata-Nakajima, N.2
Sugai, M.3
Shimizu, A.4
Tabata, Y.5
-
105
-
-
0036191924
-
Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels
-
Agarwal, R., Siva, S., Dunn, S. R. & Sharma, K. Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels. Am. J. Kidney Dis. 39, 486-492 (2002).
-
(2002)
Am. J. Kidney Dis
, vol.39
, pp. 486-492
-
-
Agarwal, R.1
Siva, S.2
Dunn, S.R.3
Sharma, K.4
-
106
-
-
0032737429
-
Captopril-induced reduction of serum levels of transforming growth factor-beta1 correlates with long-term renoprotection in insulin-dependent diabetic patients
-
Sharma, K. et al. Captopril-induced reduction of serum levels of transforming growth factor-beta1 correlates with long-term renoprotection in insulin-dependent diabetic patients. Am. J. Kidney Dis. 34, 818-823 (1999).
-
(1999)
Am. J. Kidney Dis
, vol.34
, pp. 818-823
-
-
Sharma, K.1
-
107
-
-
0038205926
-
Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat
-
Benigni, A. et al. Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat. J. Am. Soc. Nephrol. 14, 1816-1824 (2003).
-
(2003)
J. Am. Soc. Nephrol
, vol.14
, pp. 1816-1824
-
-
Benigni, A.1
-
108
-
-
0038031720
-
Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritis
-
Peters, H. et al. Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritis. J. Hypertens. 21, 771-780 (2003).
-
(2003)
J. Hypertens
, vol.21
, pp. 771-780
-
-
Peters, H.1
-
109
-
-
0343114434
-
Lovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells
-
Kim, S. I., Han, D. C. & Lee, H. B. Lovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells. J.Am. Soc. Nephrol. 11, 80-87 (2000).
-
(2000)
J.Am. Soc. Nephrol
, vol.11
, pp. 80-87
-
-
Kim, S.I.1
Han, D.C.2
Lee, H.B.3
-
110
-
-
26444478235
-
Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction
-
Vieira, J. M. Jr et al. Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction. Nephrol. Dial. Transplant. 20, 1582-1591 (2005).
-
(2005)
Nephrol. Dial. Transplant
, vol.20
, pp. 1582-1591
-
-
Vieira, J.M.1
-
111
-
-
51549098456
-
Simvastatin abates development of renal fibrosis in experimental renovascular disease
-
Chade, A. R. et al. Simvastatin abates development of renal fibrosis in experimental renovascular disease. J. Hypertens. 26, 1651-1660 (2008).
-
(2008)
J. Hypertens
, vol.26
, pp. 1651-1660
-
-
Chade, A.R.1
-
112
-
-
33846250366
-
Recombinant human anti- transforming growth factor beta1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
-
Denton, C. P. et al. Recombinant human anti- transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum. 56, 323-333 (2007).
-
(2007)
Arthritis Rheum
, vol.56
, pp. 323-333
-
-
Denton, C.P.1
-
113
-
-
70350173934
-
The treatment of liver fibrosis induced by hepatocyte growth factor-directed, ultrasound-targeted microbubble destruction in rats
-
Wang, Z. X. et al. The treatment of liver fibrosis induced by hepatocyte growth factor-directed, ultrasound-targeted microbubble destruction in rats. Clin. Imaging 33, 454-461 (2009).
-
(2009)
Clin. Imaging
, vol.33
, pp. 454-461
-
-
Wang, Z.X.1
-
114
-
-
0034782480
-
Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice
-
Yang, J., Dai, C. & Liu, Y. Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice. Gene Ther. 8, 1470-1479 (2001).
-
(2001)
Gene Ther
, vol.8
, pp. 1470-1479
-
-
Yang, J.1
Dai, C.2
Liu, Y.3
-
115
-
-
0035070420
-
Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy
-
Mizuno, S., Matsumoto, K. & Nakamura, T. Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. Kidney Int. 59, 1304-1314 (2001).
-
(2001)
Kidney Int
, vol.59
, pp. 1304-1314
-
-
Mizuno, S.1
Matsumoto, K.2
Nakamura, T.3
-
116
-
-
0035023230
-
Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases
-
Matsumoto, K. & Nakamura, T. Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases. Kidney Int. 59, 2023-2038 (2001).
-
(2001)
Kidney Int
, vol.59
, pp. 2023-2038
-
-
Matsumoto, K.1
Nakamura, T.2
-
117
-
-
0032080835
-
Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease
-
Mizuno, S. et al. Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. J. Clin. Invest. 101, 1827-1834 (1998).
-
(1998)
J. Clin. Invest
, vol.101
, pp. 1827-1834
-
-
Mizuno, S.1
-
118
-
-
0036785218
-
Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice
-
Yang, J., Dai, C. & Liu, Y. Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. J. Am. Soc. Nephrol. 13, 2464-2477 (2002).
-
(2002)
J. Am. Soc. Nephrol
, vol.13
, pp. 2464-2477
-
-
Yang, J.1
Dai, C.2
Liu, Y.3
-
119
-
-
72949121314
-
Connective tissue growth factor (CTGF): A key factor in the onset and progression of kidney damage [Spanish]
-
Sanchez-Lopez, E. et al. Connective tissue growth factor (CTGF): a key factor in the onset and progression of kidney damage [Spanish]. Nefrologia 29, 382-391 (2009).
-
(2009)
Nefrologia
, vol.29
, pp. 382-391
-
-
Sanchez-Lopez, E.1
-
120
-
-
48649102468
-
Plasma connective tissue growth factor is an independent predictor of end- stage renal disease and mortality in type 1 diabetic nephropathy
-
Nguyen, T. Q. et al. Plasma connective tissue growth factor is an independent predictor of end- stage renal disease and mortality in type 1 diabetic nephropathy. Diabetes Care 31, 1177-1182 (2008).
-
(2008)
Diabetes Care
, vol.31
, pp. 1177-1182
-
-
Nguyen, T.Q.1
-
121
-
-
35248841125
-
Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes
-
Guha, M., Xu, Z. G., Tung, D., Lanting, L. & Natarajan, R. Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes. FASEB J. 21, 3355-3368 (2007).
-
(2007)
FASEB J
, vol.21
, pp. 3355-3368
-
-
Guha, M.1
Xu, Z.G.2
Tung, D.3
Lanting, L.4
Natarajan, R.5
-
122
-
-
51249090127
-
Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy
-
Luo, G. H. et al. Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy. Transplant. Proc. 40, 2365-2369 (2008).
-
(2008)
Transplant. Proc
, vol.40
, pp. 2365-2369
-
-
Luo, G.H.1
-
123
-
-
84984768064
-
Dose-escalation phase I study of FG-3019 anti-connective tissue growth factor (CTGF) monoclonal antibody, in subjects with type I/II diabetes mellitus (DM) and microalbuminuria (MalbU) [abstract]
-
Adler, S. G. et al. Dose-escalation phase I study of FG-3019 anti-connective tissue growth factor (CTGF) monoclonal antibody, in subjects with type I/II diabetes mellitus (DM) and microalbuminuria (MalbU) [abstract]. J. Am. Soc. Nephrol. 17, 157A (2007).
-
(2007)
J. Am. Soc. Nephrol
, vol.157A
, pp. 17
-
-
Adler, S.G.1
-
124
-
-
0034946204
-
Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats
-
Miric, G. et al. Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats. Br. J. Pharmacol. 133, 687-694 (2001).
-
(2001)
Br. J. Pharmacol
, vol.133
, pp. 687-694
-
-
Miric, G.1
-
125
-
-
0031474029
-
Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy
-
Shimizu, T. et al. Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy. Kidney Int. Suppl. 63, S239-S243 (1997).
-
(1997)
Kidney Int. Suppl
, vol.63
, pp. S239-S243
-
-
Shimizu, T.1
-
126
-
-
0031834709
-
Pirfenidone improves renal function and fibrosis in the post-obstructed kidney
-
Shimizu, T. et al. Pirfenidone improves renal function and fibrosis in the post-obstructed kidney. Kidney Int. 54, 99-109 (1998).
-
(1998)
Kidney Int
, vol.54
, pp. 99-109
-
-
Shimizu, T.1
-
127
-
-
0034004098
-
Pirfenidone inhibits NADPH-dependent microsomal lipid peroxidation and scavenges hydroxyl radicals
-
Misra, H. P & Rabideau, C. Pirfenidone inhibits NADPH-dependent microsomal lipid peroxidation and scavenges hydroxyl radicals. Mol. Cell. Biochem. 204, 119-126 (2000).
-
(2000)
Mol. Cell. Biochem
, vol.204
, pp. 119-126
-
-
Misra, H.P.1
Rabideau, C.2
-
128
-
-
34548834734
-
Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis
-
Cho, M. E., Smith, D. C., Branton, M. H., Penzak, S. R. & Kopp, J. B. Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis. Clin. J. Am. Soc. Nephrol. 2, 906-913 (2007).
-
(2007)
Clin. J. Am. Soc. Nephrol
, vol.2
, pp. 906-913
-
-
Cho, M.E.1
Smith, D.C.2
Branton, M.H.3
Penzak, S.R.4
Kopp, J.B.5
-
129
-
-
20944434994
-
Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis
-
Azuma, A. et al. Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 171, 1040-1047 (2005).
-
(2005)
Am. J. Respir. Crit. Care Med
, vol.171
, pp. 1040-1047
-
-
Azuma, A.1
-
130
-
-
68149178848
-
Pirfenidone is renoprotective in diabetic kidney disease
-
RamachandraRao, S. P et al. Pirfenidone is renoprotective in diabetic kidney disease. J. Am. Soc. Nephrol. 20, 1765-1775 (2009).
-
(2009)
J. Am. Soc. Nephrol
, vol.20
, pp. 1765-1775
-
-
Ramachandrarao, S.P.1
-
131
-
-
69549110735
-
Fluorofenidone attenuates collagen I and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells
-
Peng, Z. Z. et al. Fluorofenidone attenuates collagen I and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells. Nephrology (Carlton) 14, 565-572 (2009).
-
(2009)
Nephrology (Carlton)
, vol.14
, pp. 565-572
-
-
Peng, Z.Z.1
-
132
-
-
0031128130
-
Albuminuria is directly associated with increased plasma PAI-1 and factor VII levels in NIDDM patients
-
Hirano, T., Kashiwazaki, K., Moritomo, Y, Nagano, S. & Adachi, M. Albuminuria is directly associated with increased plasma PAI-1 and factor VII levels in NIDDM patients. Diabetes Res. Clin. Pract. 36, 11-18 (1997).
-
(1997)
Diabetes Res. Clin. Pract
, vol.36
, pp. 11-18
-
-
Hirano, T.1
Kashiwazaki, K.2
Moritomo, Y.3
Nagano, S.4
Adachi, M.5
-
133
-
-
20144386753
-
Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy
-
Nicholas, S. B. et al. Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy. Kidney Int. 67, 1297-1307 (2005).
-
(2005)
Kidney Int
, vol.67
, pp. 1297-1307
-
-
Nicholas, S.B.1
-
134
-
-
39049153080
-
A PAI-1 mutant, PAI-1R, slows progression of diabetic nephropathy
-
Huang, Y. et al. A PAI-1 mutant, PAI-1R, slows progression of diabetic nephropathy. J. Am. Soc. Nephrol. 19, 329-338 (2008).
-
(2008)
J. Am. Soc. Nephrol
, vol.19
, pp. 329-338
-
-
Huang, Y.1
-
135
-
-
63849095053
-
PAI-1 and kidney fibrosis
-
Ma, L. J. & Fogo, A. B. PAI-1 and kidney fibrosis. Front. Biosci. 14, 2028-2041 (2009).
-
(2009)
Front. Biosci
, vol.14
, pp. 2028-2041
-
-
Ma, L.J.1
Fogo, A.B.2
-
136
-
-
70349409438
-
Positive feedback loop between plasminogen activator inhibitor-1 and transforming growth factor-beta1 during renal fibrosis in diabetes
-
Seo, J. Y et al. Positive feedback loop between plasminogen activator inhibitor-1 and transforming growth factor-beta1 during renal fibrosis in diabetes. Am. J. Nephrol. 30, 481-490 (2009).
-
(2009)
Am. J. Nephrol
, vol.30
, pp. 481-490
-
-
Seo, J.Y.1
-
137
-
-
41649096963
-
Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway
-
Zheng, J. M., Zhu, J. M., Li, L. S. & Liu, Z. H. Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway. Br. J. Pharmacol. 153, 1456-1464 (2008).
-
(2008)
Br. J. Pharmacol
, vol.153
, pp. 1456-1464
-
-
Zheng, J.M.1
Zhu, J.M.2
Li, L.S.3
Liu, Z.H.4
-
138
-
-
74349098549
-
Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy
-
Gao, Q. et al. Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy. Planta Med. 76, 27-33 (2010).
-
(2010)
Planta Med
, vol.76
, pp. 27-33
-
-
Gao, Q.1
-
139
-
-
0033996388
-
AGEs induce oxidative stress and activate protein kinase C-beta(II) in neonatal mesangial cells
-
Scivittaro, V., Ganz, M. B. & Weiss, M. F. AGEs induce oxidative stress and activate protein kinase C-beta(II) in neonatal mesangial cells. Am. J. Physiol. Renal Physiol. 278, F676-F683 (2000).
-
(2000)
Am. J. Physiol. Renal Physiol
, vol.278
, pp. F676-F683
-
-
Scivittaro, V.1
Ganz, M.B.2
Weiss, M.F.3
-
140
-
-
0032704786
-
Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats
-
Kang, N. et al. Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats. Kidney Int. 56, 1737-1750 (1999).
-
(1999)
Kidney Int
, vol.56
, pp. 1737-1750
-
-
Kang, N.1
-
141
-
-
0031860340
-
Protein kinase C activation and the development of diabetic complications
-
Koya, D. & King, G. L. Protein kinase C activation and the development of diabetic complications. Diabetes 47, 859-866 (1998).
-
(1998)
Diabetes
, vol.47
, pp. 859-866
-
-
Koya, D.1
King, G.L.2
-
142
-
-
0037315791
-
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension
-
Kelly, D. J. et al. Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Diabetes 52, 512-518 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 512-518
-
-
Kelly, D.J.1
-
143
-
-
28644442122
-
The effect of ruboxistaurin on nephropathy in type 2 diabetes
-
Tuttle, K. R. et al. The effect of ruboxistaurin on nephropathy in type 2 diabetes. Diabetes Care 28, 2686-2690 (2005).
-
(2005)
Diabetes Care
, vol.28
, pp. 2686-2690
-
-
Tuttle, K.R.1
-
144
-
-
34147151265
-
Effect of ruboxistaurin on urinary transforming growth factor-beta in patients with diabetic nephropathy and type 2 diabetes
-
Gilbert, R. E. et al. Effect of ruboxistaurin on urinary transforming growth factor-beta in patients with diabetic nephropathy and type 2 diabetes. Diabetes Care 30, 995-996 (2007).
-
(2007)
Diabetes Care
, vol.30
, pp. 995-996
-
-
Gilbert, R.E.1
-
145
-
-
0024559825
-
Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy
-
Seaquist, E. R., Goetz, F. C., Rich, S. S. & Barboso, J. Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N. Engl. J. Med. 320, 1161-1165 (1989).
-
(1989)
N. Engl. J. Med
, vol.320
, pp. 1161-1165
-
-
Seaquist, E.R.1
Goetz, F.C.2
Rich, S.S.3
Barboso, J.4
-
146
-
-
67449113446
-
Genetics of diabetic nephropathy: Are there clues to the understanding of common kidney diseases?
-
Conway, B. R. & Maxwell, A. P. Genetics of diabetic nephropathy: are there clues to the understanding of common kidney diseases? Nephron Clin. Pract. 112, c213-c221 (2009).
-
(2009)
Nephron Clin. Pract
, vol.112
, pp. c213-c221
-
-
Conway, B.R.1
Maxwell, A.P.2
-
147
-
-
0042867398
-
Genomic strategies for diabetic nephropathy
-
Susztak, K. et al. Genomic strategies for diabetic nephropathy. J.Am.Soc. Nephrol. 14 (Suppl. 3), S271-S278 (2003).
-
(2003)
J.Am.Soc. Nephrol
, vol.14
, pp. S271-S278
-
-
Susztak, K.1
-
148
-
-
73849127049
-
Application of proteomic analysis to the study of renal diseases
-
Smith, M. P., Banks, R. E., Wood, S. L., Lewington, A. J. & Selby, P. J. Application of proteomic analysis to the study of renal diseases. Nat. Rev. Nephrol. 5, 701-712 (2009)
-
(2009)
Nat. Rev. Nephrol
, vol.5
, pp. 701-712
-
-
Smith, M.P.1
Banks, R.E.2
Wood, S.L.3
Lewington, A.J.4
Selby, P.J.5
|