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Volumn 6, Issue 6, 2010, Pages 371-380

New pharmacological treatments for improving renal outcomes in diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ALISKIREN; AMIDE; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BIOLOGICAL MARKER; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FUMARIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PIRFENIDONE; PROTEIN KINASE C; PYRIDONE DERIVATIVE; RENIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 77956628272     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2010.57     Document Type: Article
Times cited : (105)

References (148)
  • 1
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild, S., Roglic, G., Green, A., Sicree, R. & King, H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 1047-1053 (2004).
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 2
    • 33847748973 scopus 로고    scopus 로고
    • Prevalence of chronic kidney disease and associated risk factors: United States, 1999-2004
    • Centers for Disease Control and Prevention (CDC). Prevalence of chronic kidney disease and associated risk factors: United States, 1999-2004. MMWR Morb. Mortal. Wkly Rep. 56, 161-165 (2007).
    • (2007) MMWR Morb. Mortal. Wkly Rep , vol.56 , pp. 161-165
  • 3
    • 0142182724 scopus 로고    scopus 로고
    • Racial differences in the progression from chronic renal insufficiency to end-stage renal disease in the United States
    • Hsu, C. Y, Lin, F., Vittinghoff, E. & Shlipak, M. G. Racial differences in the progression from chronic renal insufficiency to end-stage renal disease in the United States. J. Am. Soc. Nephrol. 14, 2902-2907 (2003).
    • (2003) J. Am. Soc. Nephrol , vol.14 , pp. 2902-2907
    • Hsu, C.Y.1    Lin, F.2    Vittinghoff, E.3    Shlipak, M.G.4
  • 4
    • 63549094143 scopus 로고    scopus 로고
    • The effect of ethnicity on the prevalence of diabetes and associated chronic kidney disease
    • Dreyer, G., Hull, S., Aitken, Z., Chesser, A. & Yaqoob, M. M. The effect of ethnicity on the prevalence of diabetes and associated chronic kidney disease. QJM 102, 261-269 (2009).
    • (2009) QJM , vol.102 , pp. 261-269
    • Dreyer, G.1    Hull, S.2    Aitken, Z.3    Chesser, A.4    Yaqoob, M.M.5
  • 5
    • 34250361947 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of proteinuria in diabetic nephropathy
    • Wolf, G. & Ziyadeh, F. N. Cellular and molecular mechanisms of proteinuria in diabetic nephropathy. Nephron Physiol. 106, 26-31 (2007).
    • (2007) Nephron Physiol , vol.106 , pp. 26-31
    • Wolf, G.1    Ziyadeh, F.N.2
  • 6
    • 0030377443 scopus 로고    scopus 로고
    • Effect of duration of type I diabetes on the prevalence of stages of diabetic nephropathy defined by urinary albumin/creatinine ratio
    • Warram, J. H., Gearin, G., Laffel, L. & Krolewski, A. S. Effect of duration of type I diabetes on the prevalence of stages of diabetic nephropathy defined by urinary albumin/creatinine ratio. J. Am. Soc. Nephrol. 7, 930-937 (1996).
    • (1996) J. Am. Soc. Nephrol , vol.7 , pp. 930-937
    • Warram, J.H.1    Gearin, G.2    Laffel, L.3    Krolewski, A.S.4
  • 7
    • 0028438760 scopus 로고
    • Epidemiology of microalbuminuria in diabetes and in the background population
    • Mogensen, C. E. & Poulsen, P L. Epidemiology of microalbuminuria in diabetes and in the background population. Curr. Opin. Nephrol. Hypertens. 3, 248-256 (1994).
    • (1994) Curr. Opin. Nephrol. Hypertens , vol.3 , pp. 248-256
    • Mogensen, C.E.1    Poulsen, P.L.2
  • 9
    • 0027525040 scopus 로고
    • Renal renin-angiotensin system in diabetes: Functional, immunohistochemical, and molecular biological correlations
    • Anderson, S., Jung, F. F. & Ingelfinger, J. R. Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations. Am. J. Physiol. 265, F477-F486 (1993).
    • (1993) Am. J. Physiol , vol.265 , pp. F477-F486
    • Anderson, S.1    Jung, F.F.2    Ingelfinger, J.R.3
  • 10
    • 58149247936 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2: Implications for blood pressure and kidney disease
    • Ingelfinger, J. R. Angiotensin-converting enzyme 2: implications for blood pressure and kidney disease. Curr. Opin. Nephrol. Hypertens. 18, 79-84 (2009).
    • (2009) Curr. Opin. Nephrol. Hypertens , vol.18 , pp. 79-84
    • Ingelfinger, J.R.1
  • 11
    • 33645741235 scopus 로고    scopus 로고
    • Angiotensin II compartmentalization within the kidney: Effect of salt diet and blood pressure alterations
    • Siragy, H. M. Angiotensin II compartmentalization within the kidney: effect of salt diet and blood pressure alterations. Curr. Opin. Nephrol. Hypertens. 15, 50-53 (2006).
    • (2006) Curr. Opin. Nephrol. Hypertens , vol.15 , pp. 50-53
    • Siragy, H.M.1
  • 12
    • 0026083978 scopus 로고
    • Angiotensin and cell growth: A link to cardiovascular hypertrophy
    • Schelling, P, Fischer, H. & Ganten, D. Angiotensin and cell growth: a link to cardiovascular hypertrophy. J. Hypertens. 9, 3-15 (1991).
    • (1991) J. Hypertens , vol.9 , pp. 3-15
    • Schelling, P.1    Fischer, H.2    Ganten, D.3
  • 13
    • 0033538649 scopus 로고    scopus 로고
    • Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension
    • Fukai, T., Siegfried, M. R., Ushio-Fukai, M., Griendling, K. K. & Harrison, D. G. Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension. Circ. Res. 85, 23-28 (1999).
    • (1999) Circ. Res , vol.85 , pp. 23-28
    • Fukai, T.1    Siegfried, M.R.2    Ushio-Fukai, M.3    Griendling, K.K.4    Harrison, D.G.5
  • 14
    • 0033586639 scopus 로고    scopus 로고
    • Increased NADH-oxidase- mediated superoxide production in the early stages of atherosclerosis: Evidence for involvement of the renin-angiotensin system
    • Warnholtz, A. et al. Increased NADH-oxidase- mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation 99, 2027-2033 (1999).
    • (1999) Circulation , vol.99 , pp. 2027-2033
    • Warnholtz, A.1
  • 15
    • 0031708389 scopus 로고    scopus 로고
    • Angiotensin II induces superoxide anion production by mesangial cells
    • Jaimes, E. A., Galceran, J. M. & Raij, L. Angiotensin II induces superoxide anion production by mesangial cells. Kidney Int. 54, 775-784 (1998).
    • (1998) Kidney Int , vol.54 , pp. 775-784
    • Jaimes, E.A.1    Galceran, J.M.2    Raij, L.3
  • 16
    • 0028987941 scopus 로고
    • Transforming growth factor-beta and angiotensin II: The missing link from glomerular hyperfiltration to glomerulosclerosis?
    • Ketteler, M., Noble, N. A. & Border, W. A. Transforming growth factor-beta and angiotensin II: the missing link from glomerular hyperfiltration to glomerulosclerosis? Annu. Rev. Physiol. 57, 279-295 (1995).
    • (1995) Annu. Rev. Physiol , vol.57 , pp. 279-295
    • Ketteler, M.1    Noble, N.A.2    Border, W.A.3
  • 18
    • 0347986777 scopus 로고    scopus 로고
    • NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis
    • Bataller, R. et al. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J. Clin. Invest. 112, 1383-1394 (2003).
    • (2003) J. Clin. Invest , vol.112 , pp. 1383-1394
    • Bataller, R.1
  • 20
    • 70349756901 scopus 로고    scopus 로고
    • Effects of losartan on hepatic expression of non-phagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C
    • Colmenero, J. et al. Effects of losartan on hepatic expression of non-phagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am. J. Physiol. Gastrointest. Liver Physiol. 297, G726-G734 (2009).
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol , vol.297 , pp. G726-G734
    • Colmenero, J.1
  • 21
    • 33845603497 scopus 로고    scopus 로고
    • Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase
    • Johar, S., Cave, A. C., Narayanapanicker, A., Grieve, D. J. & Shah, A. M. Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J. 20, 1546-1548 (2006).
    • (2006) FASEB J , vol.20 , pp. 1546-1548
    • Johar, S.1    Cave, A.C.2    Narayanapanicker, A.3    Grieve, D.J.4    Shah, A.M.5
  • 22
    • 0036596686 scopus 로고    scopus 로고
    • Urinary transforming-beta excretion in patients with hypertension, type 2 diabetes, and elevated albumin excretion rate: Effects of angiotensin receptor blockade and sodium restriction
    • Houlihan, C. A. et al. Urinary transforming-beta excretion in patients with hypertension, type 2 diabetes, and elevated albumin excretion rate: effects of angiotensin receptor blockade and sodium restriction. Diabetes Care 25, 1072-1077 (2002).
    • (2002) Diabetes Care , vol.25 , pp. 1072-1077
    • Houlihan, C.A.1
  • 23
    • 0031252397 scopus 로고    scopus 로고
    • Role of angiotensin II and bradykinin in experimental diabetic nephropathy. Functional and structural studies
    • Allen, T. J., Cao, Z., Youssef, S., Hulthen, U. L. & Cooper, M. E. Role of angiotensin II and bradykinin in experimental diabetic nephropathy. Functional and structural studies. Diabetes 46, 1612-1618 (1997).
    • (1997) Diabetes , vol.46 , pp. 1612-1618
    • Allen, T.J.1    Cao, Z.2    Youssef, S.3    Hulthen, U.L.4    Cooper, M.E.5
  • 24
    • 0027517659 scopus 로고
    • The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group
    • Lewis, E. J., Hunsicker, L. G., Bain, R. P & Rhohde, R. D. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N. Engl. J. Med. 329, 1456-1462 (1993).
    • (1993) N. Engl. J. Med , vol.329 , pp. 1456-1462
    • Lewis, E.J.1    Hunsicker, L.G.2    Bain, R.P.3    Rhohde, R.D.4
  • 25
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    • Lewis, E. J. et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N. Engl. J. Med. 345, 851-860 (2001).
    • (2001) N. Engl. J. Med , vol.345 , pp. 851-860
    • Lewis, E.J.1
  • 26
    • 0035922444 scopus 로고    scopus 로고
    • The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    • Parving, H. H. et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N. Engl. J. Med. 345, 870-878 (2001).
    • (2001) N. Engl. J. Med , vol.345 , pp. 870-878
    • Parving, H.H.1
  • 27
    • 67649635807 scopus 로고    scopus 로고
    • Renal and retinal effects of enalapril and losartan in type 1 diabetes
    • Mauer, M. et al. Renal and retinal effects of enalapril and losartan in type 1 diabetes. N. Engl. J. Med. 361, 40-51 (2009).
    • (2009) N. Engl. J. Med , vol.361 , pp. 40-51
    • Mauer, M.1
  • 28
    • 84984752936 scopus 로고    scopus 로고
    • The renin-angiotensin-aldosterone system in the onset and progression of diabetic nephropathy
    • Ruggenenti, P., Cravedi, P. & Remuzzi, G. The renin-angiotensin-aldosterone system in the onset and progression of diabetic nephropathy. Nat. Rev. Nephrol. doi:10.1038/nrneph.2010.58.
    • Nat. Rev. Nephrol
    • Ruggenenti, P.1    Cravedi, P.2    Remuzzi, G.3
  • 29
    • 0037967318 scopus 로고    scopus 로고
    • Chymase is upregulated in diabetic nephropathy: Implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease
    • Huang, X. R., Chen, W. Y, Truong, L. D. & Lan, H. Y. Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease. J. Am. Soc. Nephrol. 14, 1738-1747 (2003).
    • (2003) J. Am. Soc. Nephrol , vol.14 , pp. 1738-1747
    • Huang, X.R.1    Chen, W.Y.2    Truong, L.D.3    Lan, H.Y.4
  • 30
    • 49149087718 scopus 로고    scopus 로고
    • Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (The ONTARGET study): A multicentre, randomised, double-blind, controlled trial
    • Mann, J. F. et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 372, 547-553 (2008).
    • (2008) Lancet , vol.372 , pp. 547-553
    • Mann, J.F.1
  • 31
    • 0029853814 scopus 로고    scopus 로고
    • Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen
    • Nguyen, G., Delarue, F., Berrou, J., Rondeau, E. & Sraer, J. D. Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int. 50, 1897-1903 (1996).
    • (1996) Kidney Int , vol.50 , pp. 1897-1903
    • Nguyen, G.1    Delarue, F.2    Berrou, J.3    Rondeau, E.4    Sraer, J.D.5
  • 32
    • 0036266596 scopus 로고    scopus 로고
    • Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    • Nguyen, G. et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J. Clin. Invest. 109, 1417-1427 (2002).
    • (2002) J. Clin. Invest , vol.109 , pp. 1417-1427
    • Nguyen, G.1
  • 33
    • 30944469631 scopus 로고    scopus 로고
    • Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
    • Huang, Y et al. Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int. 69, 105-113 (2006).
    • (2006) Kidney Int , vol.69 , pp. 105-113
    • Huang, Y.1
  • 35
    • 0024268789 scopus 로고
    • Human prorenin: Pathophysiology and clinical implications
    • Derkx, F. H. & Schalekamp, M. A. Human prorenin: pathophysiology and clinical implications. Clin. Exp. Hypertens. A 10, 1213-1225 (1988).
    • (1988) Clin. Exp. Hypertens. A , vol.10 , pp. 1213-1225
    • Derkx, F.H.1    Schalekamp, M.A.2
  • 36
    • 0021889169 scopus 로고
    • Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications
    • Luetscher, J. A., Kraemer, F. B., Wilson, D. M., Schwartz, H. C. & Bryer-Ash, M. Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications. N. Engl. J. Med. 312, 1412-1417 (1985).
    • (1985) N. Engl. J. Med , vol.312 , pp. 1412-1417
    • Luetscher, J.A.1    Kraemer, F.B.2    Wilson, D.M.3    Schwartz, H.C.4    Bryer-Ash, M.5
  • 37
    • 67049100691 scopus 로고    scopus 로고
    • Chronic increases in circulating prorenin are not associated with renal or cardiac pathologies
    • Mercure, C., Prescott, G., Lacombe, M. J., Silversides, D. W. & Reudelhuber, T. L. Chronic increases in circulating prorenin are not associated with renal or cardiac pathologies. Hypertension 53, 1062-1069 (2009).
    • (2009) Hypertension , vol.53 , pp. 1062-1069
    • Mercure, C.1    Prescott, G.2    Lacombe, M.J.3    Silversides, D.W.4    Reudelhuber, T.L.5
  • 38
    • 42649140868 scopus 로고    scopus 로고
    • Renal (Pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity
    • Siragy, H. M. & Huang, J. Renal (pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity. Exp. Physiol. 93, 709-714 (2008).
    • (2008) Exp. Physiol , vol.93 , pp. 709-714
    • Siragy, H.M.1    Huang, J.2
  • 39
    • 33745824649 scopus 로고    scopus 로고
    • Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice
    • Ichihara, A. et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. J. Am. Soc. Nephrol. 17, 1950-1961 (2006).
    • (2006) J. Am. Soc. Nephrol , vol.17 , pp. 1950-1961
    • Ichihara, A.1
  • 40
    • 34249881320 scopus 로고    scopus 로고
    • Slowly progressive, angiotensin II-independent glomerulosclerosis in human (Pro)renin receptor-transgenic rats
    • Kaneshiro, Y et al. Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats. J. Am. Soc. Nephrol. 18, 1789-1795 (2007).
    • (2007) J. Am. Soc. Nephrol , vol.18 , pp. 1789-1795
    • Kaneshiro, Y.1
  • 41
    • 34447272037 scopus 로고    scopus 로고
    • Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade
    • Takahashi, H. et al. Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade. J. Am. Soc. Nephrol. 18, 2054-2061 (2007).
    • (2007) J. Am. Soc. Nephrol , vol.18 , pp. 2054-2061
    • Takahashi, H.1
  • 42
    • 0022409744 scopus 로고
    • Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine
    • Boger, J. et al. Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine. J. Med. Chem. 28, 1779-1790 (1985).
    • (1985) J. Med. Chem , vol.28 , pp. 1779-1790
    • Boger, J.1
  • 43
    • 0023235966 scopus 로고
    • Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides
    • Hui, K. Y, Carlson, W. D., Bernatowicz, M. S. & Haber, E. J. Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides. J. Med. Chem. 30, 1287-1295 (1987).
    • (1987) J. Med. Chem , vol.30 , pp. 1287-1295
    • Hui, K.Y.1    Carlson, W.D.2    Bernatowicz, M.S.3    Haber, E.J.4
  • 44
    • 33749985149 scopus 로고    scopus 로고
    • Oral renin inhibitors
    • Staessen, J. A., Li, Y. & Richart, T. Oral renin inhibitors. Lancet 368, 1449-1456 (2006).
    • (2006) Lancet , vol.368 , pp. 1449-1456
    • Staessen, J.A.1    Li, Y.2    Richart, T.3
  • 45
    • 0033941893 scopus 로고    scopus 로고
    • Structure-based drug design: The discovery of novel nonpeptide orally active inhibitors of human renin
    • Rahuel, J. et al. Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin. Chem. Biol. 7, 493-504 (2000).
    • (2000) Chem. Biol , vol.7 , pp. 493-504
    • Rahuel, J.1
  • 46
    • 0042661157 scopus 로고    scopus 로고
    • Structure-based design of aliskiren, a novel orally effective renin inhibitor
    • Wood, J. M. et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem. Biophys. Res. Commun. 308, 698-705 (2003).
    • (2003) Biochem. Biophys. Res. Commun , vol.308 , pp. 698-705
    • Wood, J.M.1
  • 47
    • 0036372173 scopus 로고    scopus 로고
    • Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): Comparison with enalapril
    • Nussberger, J., Wuerzner, G., Jensen, C. & Brunner, H. R. Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril. Hypertension 39, E1-E8 (2002).
    • (2002) Hypertension , vol.39 , pp. E1-E8
    • Nussberger, J.1    Wuerzner, G.2    Jensen, C.3    Brunner, H.R.4
  • 48
    • 14044271546 scopus 로고    scopus 로고
    • Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats
    • Wood, J. M., Schnell, C. R., Cumin, F., Menard, J. & Webb, R. L. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J. Hypertens. 23, 417-426 (2005).
    • (2005) J. Hypertens , vol.23 , pp. 417-426
    • Wood, J.M.1    Schnell, C.R.2    Cumin, F.3    Menard, J.4    Webb, R.L.5
  • 49
    • 0026753520 scopus 로고
    • Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes
    • Ganten, D. et al. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. Proc. Natl Acad. Sci. USA 89, 7806-7810 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 7806-7810
    • Ganten, D.1
  • 50
    • 25444454353 scopus 로고    scopus 로고
    • Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double- transgenic rats
    • Pilz, B. et al. Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double- transgenic rats. Hypertension 46, 569-576 (2005).
    • (2005) Hypertension , vol.46 , pp. 569-576
    • Pilz, B.1
  • 51
    • 34848907212 scopus 로고    scopus 로고
    • Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats
    • Kelly, D. J., Zhang, Y., Moe, G., Naik, G. & Gilbert, R. E. Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats. Diabetologia 50, 2398-2404 (2007).
    • (2007) Diabetologia , vol.50 , pp. 2398-2404
    • Kelly, D.J.1    Zhang, Y.2    Moe, G.3    Naik, G.4    Gilbert, R.E.5
  • 52
    • 46449118638 scopus 로고    scopus 로고
    • Effect of aliskiren on blood pressure, albuminuria and (Pro)renin receptor expression in diabetic TG(mRen-2)27 rats
    • Feldman, D. L. et al. Effect of aliskiren on blood pressure, albuminuria and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats. Hypertension 52, 130-136 (2008).
    • (2008) Hypertension , vol.52 , pp. 130-136
    • Feldman, D.L.1
  • 53
    • 36248994286 scopus 로고    scopus 로고
    • Direct renin inhibitor: Focus on aliskiren
    • Pool, J. L. Direct renin inhibitor: focus on aliskiren. J. Manag. Care Pharm. 13 (Suppl. B), S21-S33 (2007).
    • (2007) J. Manag. Care Pharm , vol.13 , pp. S21-S33
    • Pool, J.L.1
  • 54
    • 56549103332 scopus 로고    scopus 로고
    • First renin inhibitor, aliskiren, for the treatment of hypertension
    • Triller, D. M., Evang, S. D., Tadrous, M. & Yoo, B. K. First renin inhibitor, aliskiren, for the treatment of hypertension. Pharm. World Sci. 30, 741-749 (2008).
    • (2008) Pharm. World Sci , vol.30 , pp. 741-749
    • Triller, D.M.1    Evang, S.D.2    Tadrous, M.3    Yoo, B.K.4
  • 55
    • 43449139264 scopus 로고    scopus 로고
    • Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes
    • Persson, F. et al. Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes. Kidney Int. 73, 1419-1425 (2008).
    • (2008) Kidney Int , vol.73 , pp. 1419-1425
    • Persson, F.1
  • 56
    • 70349690296 scopus 로고    scopus 로고
    • Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension, and albuminuria
    • Persson, F. et al. Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension, and albuminuria. Diabetes Care 32, 1873-1879 (2009).
    • (2009) Diabetes Care , vol.32 , pp. 1873-1879
    • Persson, F.1
  • 58
    • 65249182083 scopus 로고    scopus 로고
    • Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): Rationale and study design
    • Parving, H. H. et al. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrol. Dial. Transplant. 24, 1663-1671 (2009).
    • (2009) Nephrol. Dial. Transplant , vol.24 , pp. 1663-1671
    • Parving, H.H.1
  • 59
    • 61349170589 scopus 로고    scopus 로고
    • Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
    • Solomon, S. D. et al. Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 119, 530-537 (2009).
    • (2009) Circulation , vol.119 , pp. 530-537
    • Solomon, S.D.1
  • 60
    • 0024520864 scopus 로고
    • Induction of glomerulosclerosis by dietary lipids. A functional and morphologic study in the rat
    • Grone, H. J. et al. Induction of glomerulosclerosis by dietary lipids. A functional and morphologic study in the rat. Lab. Invest. 60, 433-446 (1989).
    • (1989) Lab. Invest , vol.60 , pp. 433-446
    • Grone, H.J.1
  • 61
    • 0025019741 scopus 로고
    • The role of lipids in the pathogenesis of glomerulosclerosis in the rat following subtotal nephrectomy
    • Rayner, H. C., Ross-Gilbertson, V. L. & Walls, J. The role of lipids in the pathogenesis of glomerulosclerosis in the rat following subtotal nephrectomy. Eur. J. Clin. Invest. 20, 97-104 (1990).
    • (1990) Eur. J. Clin. Invest , vol.20 , pp. 97-104
    • Rayner, H.C.1    Ross-Gilbertson, V.L.2    Walls, J.3
  • 62
    • 0027280249 scopus 로고
    • LDL stimulates mesangial fibronectin production and chemoattractant expression
    • Rovin, B. H. & Tan, L. C. LDL stimulates mesangial fibronectin production and chemoattractant expression. Kidney Int. 43, 218-225 (1993).
    • (1993) Kidney Int , vol.43 , pp. 218-225
    • Rovin, B.H.1    Tan, L.C.2
  • 63
    • 0029130495 scopus 로고
    • Low-density lipoprotein stimulates the expression of macrophage colony-stimulating factor in glomerular mesangial cells
    • Pai, R., Kirschenbaum, M. A. & Kamanna, V. S. Low-density lipoprotein stimulates the expression of macrophage colony-stimulating factor in glomerular mesangial cells. Kidney Int. 48, 1254-1262 (1995).
    • (1995) Kidney Int , vol.48 , pp. 1254-1262
    • Pai, R.1    Kirschenbaum, M.A.2    Kamanna, V.S.3
  • 64
    • 0029995774 scopus 로고    scopus 로고
    • Oxidative modification of low-density lipoprotein enhances the murine mesangial cell cytokines associated with monocyte migration, differentiation, and proliferation
    • Kamanna, V. S., Pai, R., Roh, D. D. & Kirschenbaum, M. A. Oxidative modification of low-density lipoprotein enhances the murine mesangial cell cytokines associated with monocyte migration, differentiation, and proliferation. Lab. Invest. 74, 1067-1079 (1996).
    • (1996) Lab. Invest , vol.74 , pp. 1067-1079
    • Kamanna, V.S.1    Pai, R.2    Roh, D.D.3    Kirschenbaum, M.A.4
  • 65
    • 0031780731 scopus 로고    scopus 로고
    • Oxidative modification of low-density lipoprotein enhances mesangial cell protein synthesis and gene expression of extracellular matrix proteins
    • Roh, D. D., Kamanna, V. S. & Kirschenbaum, M. A. Oxidative modification of low-density lipoprotein enhances mesangial cell protein synthesis and gene expression of extracellular matrix proteins. Am. J. Nephrol. 18, 344-350 (1998).
    • (1998) Am. J. Nephrol , vol.18 , pp. 344-350
    • Roh, D.D.1    Kamanna, V.S.2    Kirschenbaum, M.A.3
  • 66
    • 0033998369 scopus 로고    scopus 로고
    • Early events leading to renal injury in obese Zucker (Fatty) rats with type II diabetes
    • Coimbra, T. M. et al. Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes. Kidney Int. 57, 167-182 (2000).
    • (2000) Kidney Int , vol.57 , pp. 167-182
    • Coimbra, T.M.1
  • 67
    • 0031869430 scopus 로고    scopus 로고
    • Interstitial fibrosis in hypercholesterolemic rats: Role of oxidation, matrix synthesis, and proteolytic cascades
    • Eddy, A. A. Interstitial fibrosis in hypercholesterolemic rats: role of oxidation, matrix synthesis, and proteolytic cascades. Kidney Int. 53, 1182-1189 (1998).
    • (1998) Kidney Int , vol.53 , pp. 1182-1189
    • Eddy, A.A.1
  • 68
    • 0032507776 scopus 로고    scopus 로고
    • Main risk factors for nephropathy in type 2 diabetes mellitus are plasma cholesterol levels, mean blood pressure, and hyperglycemia
    • Ravid, M., Brosh, D., Ravid-Safran, D., Levy, Z. & Rachmani, R. Main risk factors for nephropathy in type 2 diabetes mellitus are plasma cholesterol levels, mean blood pressure, and hyperglycemia. Arch. Intern. Med. 158, 998-1004 (1998).
    • (1998) Arch. Intern. Med , vol.158 , pp. 998-1004
    • Ravid, M.1    Brosh, D.2    Ravid-Safran, D.3    Levy, Z.4    Rachmani, R.5
  • 69
    • 0037560304 scopus 로고    scopus 로고
    • Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model
    • Ota, T et al. Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model. Diabetologia 46, 843-851 (2003).
    • (2003) Diabetologia , vol.46 , pp. 843-851
    • Ota, T.1
  • 70
    • 0033014894 scopus 로고    scopus 로고
    • Role of hyperlipidemia in progressive renal disease: Focus on diabetic nephropathy
    • Jandeleit-Dahm, K. et al. Role of hyperlipidemia in progressive renal disease: focus on diabetic nephropathy. Kidney Int. Suppl. 71, S31-S36 (1999).
    • (1999) Kidney Int. Suppl , vol.71 , pp. S31-S36
    • Jandeleit-Dahm, K.1
  • 71
    • 70350146802 scopus 로고    scopus 로고
    • Effect of the HMG-CoA reductase inhibitor rosuvastatin on early chronic kidney injury in obese zucker rats fed with an atherogenic diet
    • Reisin, E. et al. Effect of the HMG-CoA reductase inhibitor rosuvastatin on early chronic kidney injury in obese zucker rats fed with an atherogenic diet. Am. J. Med. Sci. 338, 301-309 (2009).
    • (2009) Am. J. Med. Sci , vol.338 , pp. 301-309
    • Reisin, E.1
  • 72
    • 0036322869 scopus 로고    scopus 로고
    • Isoprenoids as mediators of the biological effects of statins
    • Liao, J. K. Isoprenoids as mediators of the biological effects of statins. J. Clin. Invest. 110, 285-288 (2002).
    • (2002) J. Clin. Invest , vol.110 , pp. 285-288
    • Liao, J.K.1
  • 73
    • 11144322775 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on renal function
    • Epstein, M. & Campese, V. M. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on renal function. Am. J. Kidney Dis. 45, 2-14 (2005).
    • (2005) Am. J. Kidney Dis , vol.45 , pp. 2-14
    • Epstein, M.1    Campese, V.M.2
  • 74
    • 0037315103 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats
    • Usui, H. et al. HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats. Nephrol. Dial. Transplant. 18, 265-272 (2003).
    • (2003) Nephrol. Dial. Transplant , vol.18 , pp. 265-272
    • Usui, H.1
  • 75
    • 0033802611 scopus 로고    scopus 로고
    • Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects
    • Park, J. K. et al. Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects. Kidney Int. 58, 1420-1430 (2000).
    • (2000) Kidney Int , vol.58 , pp. 1420-1430
    • Park, J.K.1
  • 76
    • 42949130547 scopus 로고    scopus 로고
    • Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice
    • Matsumoto, M. et al. Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice. Metabolism 57, 691-697 (2008).
    • (2008) Metabolism , vol.57 , pp. 691-697
    • Matsumoto, M.1
  • 77
    • 34547743999 scopus 로고    scopus 로고
    • Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice
    • Fujii, M. et al. Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice. Kidney Int. 72, 473-480 (2007).
    • (2007) Kidney Int , vol.72 , pp. 473-480
    • Fujii, M.1
  • 78
    • 0037062481 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose- induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy
    • Danesh, F. R. et al. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose- induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: implications for diabetic nephropathy. Proc. Natl Acad. Sci. USA 99, 8301-8305 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 8301-8305
    • Danesh, F.R.1
  • 79
    • 0030820468 scopus 로고    scopus 로고
    • Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21ras activated, AP-1-dependent pathway
    • Vrtovsnik, F., Couette, S., Prie, D., Lallemand, D. & Friedlander, G. Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21ras activated, AP-1-dependent pathway. Kidney Int. 52, 1016-1027 (1997).
    • (1997) Kidney Int , vol.52 , pp. 1016-1027
    • Vrtovsnik, F.1    Couette, S.2    Prie, D.3    Lallemand, D.4    Friedlander, G.5
  • 80
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins
    • Baigent, C. et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins. Lancet 366, 1267-1278 (2005).
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1
  • 81
    • 70350121639 scopus 로고    scopus 로고
    • Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes: An analysis from the Collaborative Atorvastatin Diabetes Study (CARDS)
    • Colhoun, H. M. et al. Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes: an analysis from the Collaborative Atorvastatin Diabetes Study (CARDS). Am. J. Kidney Dis. 54, 810-819 (2009).
    • (2009) Am. J. Kidney Dis , vol.54 , pp. 810-819
    • Colhoun, H.M.1
  • 82
    • 22344458137 scopus 로고    scopus 로고
    • Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    • Wanner, C. et al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N. Engl. J. Med. 353, 238-248 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 238-248
    • Wanner, C.1
  • 83
    • 63849163945 scopus 로고    scopus 로고
    • Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    • Fellstrom, B. C. et al. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N. Engl. J. Med. 360, 1395-1407 (2009).
    • (2009) N. Engl. J. Med , vol.360 , pp. 1395-1407
    • Fellstrom, B.C.1
  • 84
    • 0037458229 scopus 로고    scopus 로고
    • Cholesterol and Recurrent Events (CARE) Trial Investigators. Pravastatin for secondary prevention of cardiovascular events in persons with mild chronic renal insufficiency
    • Tonelli, M., Moye, L., Sacks, F. M., Kiberd, B. & Curhan, G. Cholesterol and Recurrent Events (CARE) Trial Investigators. Pravastatin for secondary prevention of cardiovascular events in persons with mild chronic renal insufficiency. Ann. Intern. Med. 138, 98-104 (2003).
    • (2003) Ann. Intern. Med , vol.138 , pp. 98-104
    • Tonelli, M.1    Moye, L.2    Sacks, F.M.3    Kiberd, B.4    Curhan, G.5
  • 85
    • 33745836406 scopus 로고    scopus 로고
    • Statins for improving renal outcomes: A meta- analysis
    • Sandhu, S., Wiebe, N., Fried, L. F. & Tonelli, M. Statins for improving renal outcomes: a meta- analysis. J. Am. Soc. Nephrol. 17, 2006-2016 (2006).
    • (2006) J. Am. Soc. Nephrol , vol.17 , pp. 2006-2016
    • Sandhu, S.1    Wiebe, N.2    Fried, L.F.3    Tonelli, M.4
  • 86
    • 41549125948 scopus 로고    scopus 로고
    • The Lipid lowering and Onset of Renal Disease (LORD) Trial: A randomized double blind placebo controlled trial assessing the effect of atorvastatin on the progression of kidney disease
    • Fassett, R. G., Ball, M. J., Robertson, I. K., Geraghty, D. P. & Coombes, J. S. The Lipid lowering and Onset of Renal Disease (LORD) Trial: a randomized double blind placebo controlled trial assessing the effect of atorvastatin on the progression of kidney disease. BMC Nephrol. 9, 4 (2008).
    • (2008) BMC Nephrol , vol.9 , pp. 4
    • Fassett, R.G.1    Ball, M.J.2    Robertson, I.K.3    Geraghty, D.P.4    Coombes, J.S.5
  • 87
    • 0037407617 scopus 로고    scopus 로고
    • Study of Heart and Renal Protection (SHARP)
    • Baigent, C. & Landry, M. Study of Heart and Renal Protection (SHARP). Kidney Int. Suppl. 84, S207-S210 (2003).
    • (2003) Kidney Int. Suppl , vol.84 , pp. S207-S210
    • Baigent, C.1    Landry, M.2
  • 89
    • 0033638127 scopus 로고    scopus 로고
    • Molecular basis of renal fibrosis
    • Eddy, A. A. Molecular basis of renal fibrosis. Pediatr. Nephrol. 15, 290-301 (2000).
    • (2000) Pediatr. Nephrol , vol.15 , pp. 290-301
    • Eddy, A.A.1
  • 90
    • 55249104964 scopus 로고    scopus 로고
    • Interstitial fibrosis: Tubular hypothesis versus glomerular hypothesis
    • Christensen, E. I. & Verroust, P J. Interstitial fibrosis: tubular hypothesis versus glomerular hypothesis. Kidney Int. 74, 1233-1236 (2008).
    • (2008) Kidney Int , vol.74 , pp. 1233-1236
    • Christensen, E.I.1    Verroust, P.J.2
  • 91
    • 0029076281 scopus 로고
    • Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator
    • Sharma, K. & Ziyadeh, F. N. Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator. Diabetes 44, 1139-1146 (1995).
    • (1995) Diabetes , vol.44 , pp. 1139-1146
    • Sharma, K.1    Ziyadeh, F.N.2
  • 93
    • 0036375448 scopus 로고    scopus 로고
    • Novel aspects of transforming growth factor-beta in diabetic kidney disease
    • Tsuchida, K., Cronin, B. & Sharma, K. Novel aspects of transforming growth factor-beta in diabetic kidney disease. Nephron 92, 7-21 (2002).
    • (2002) Nephron , vol.92 , pp. 7-21
    • Tsuchida, K.1    Cronin, B.2    Sharma, K.3
  • 94
    • 0034106182 scopus 로고    scopus 로고
    • TGF-beta in diabetic kidney disease: Role of novel signaling pathways
    • Sharma, K. & McGowan, T. A. TGF-beta in diabetic kidney disease: role of novel signaling pathways. Cytokine Growth Factor Rev. 11, 115-123 (2000).
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 115-123
    • Sharma, K.1    McGowan, T.A.2
  • 95
    • 70349263307 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy
    • Yamaguchi, Y. et al. Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy. Am. J. Kidney Dis. 54, 653-664 (2009).
    • (2009) Am. J. Kidney Dis , vol.54 , pp. 653-664
    • Yamaguchi, Y.1
  • 96
    • 36148979331 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in the progression of tubulointerstitial fibrosis
    • Li, M. X. & Liu, B. C. Epithelial to mesenchymal transition in the progression of tubulointerstitial fibrosis. Chin. Med. J. (Engl.) 120, 1925-1930 (2007).
    • (2007) Chin. Med. J. (Engl.) , vol.120 , pp. 1925-1930
    • Li, M.X.1    Liu, B.C.2
  • 97
    • 70350545853 scopus 로고    scopus 로고
    • TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy
    • Hills, C. E. & Squires, P. E. TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy. Am. J. Nephrol. 31, 68-74 (2009).
    • (2009) Am. J. Nephrol , vol.31 , pp. 68-74
    • Hills, C.E.1    Squires, P.E.2
  • 98
    • 0029924637 scopus 로고    scopus 로고
    • Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
    • Sharma, K., Jin, Y, Guo, J. & Ziyadeh, F. N. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45, 522-530 (1996).
    • (1996) Diabetes , vol.45 , pp. 522-530
    • Sharma, K.1    Jin, Y.2    Guo, J.3    Ziyadeh, F.N.4
  • 99
    • 0242665667 scopus 로고    scopus 로고
    • Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells
    • Sharma, K. et al. Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. Am. J. Physiol. Renal Physiol. 285, 1258-1270 (2003).
    • (2003) Am. J. Physiol. Renal Physiol , vol.285 , pp. 1258-1270
    • Sharma, K.1
  • 101
    • 0034608948 scopus 로고    scopus 로고
    • Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
    • Ziyadeh, F. N. et al. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proc. Natl Acad. Sci. USA 97, 8015-8020 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 8015-8020
    • Ziyadeh, F.N.1
  • 102
    • 0037229517 scopus 로고    scopus 로고
    • Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice
    • Chen, S. et al. Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice. Biochem. Biophys. Res. Commun. 300, 16-22 (2003).
    • (2003) Biochem. Biophys. Res. Commun , vol.300 , pp. 16-22
    • Chen, S.1
  • 103
    • 33846187695 scopus 로고    scopus 로고
    • Soluble betaglycan reduces renal damage progression in db/db mice
    • Juarez, P et al. Soluble betaglycan reduces renal damage progression in db/db mice. Am. J. Physiol. Renal Physiol. 292, F321-F329 (2007).
    • (2007) Am. J. Physiol. Renal Physiol , vol.292 , pp. F321-F329
    • Juarez, P.1
  • 104
    • 21744440388 scopus 로고    scopus 로고
    • Delivery of plasmid DNA expressing small interference RNA for TGF-beta type II receptor by cationized gelatin to prevent interstitial renal fibrosis
    • Kushibiki, T, Nagata-Nakajima, N., Sugai, M., Shimizu, A. & Tabata, Y. Delivery of plasmid DNA expressing small interference RNA for TGF-beta type II receptor by cationized gelatin to prevent interstitial renal fibrosis. J. Control. Release 105, 318-331 (2005).
    • (2005) J. Control. Release , vol.105 , pp. 318-331
    • Kushibiki, T.1    Nagata-Nakajima, N.2    Sugai, M.3    Shimizu, A.4    Tabata, Y.5
  • 105
    • 0036191924 scopus 로고    scopus 로고
    • Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels
    • Agarwal, R., Siva, S., Dunn, S. R. & Sharma, K. Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels. Am. J. Kidney Dis. 39, 486-492 (2002).
    • (2002) Am. J. Kidney Dis , vol.39 , pp. 486-492
    • Agarwal, R.1    Siva, S.2    Dunn, S.R.3    Sharma, K.4
  • 106
    • 0032737429 scopus 로고    scopus 로고
    • Captopril-induced reduction of serum levels of transforming growth factor-beta1 correlates with long-term renoprotection in insulin-dependent diabetic patients
    • Sharma, K. et al. Captopril-induced reduction of serum levels of transforming growth factor-beta1 correlates with long-term renoprotection in insulin-dependent diabetic patients. Am. J. Kidney Dis. 34, 818-823 (1999).
    • (1999) Am. J. Kidney Dis , vol.34 , pp. 818-823
    • Sharma, K.1
  • 107
    • 0038205926 scopus 로고    scopus 로고
    • Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat
    • Benigni, A. et al. Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat. J. Am. Soc. Nephrol. 14, 1816-1824 (2003).
    • (2003) J. Am. Soc. Nephrol , vol.14 , pp. 1816-1824
    • Benigni, A.1
  • 108
    • 0038031720 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritis
    • Peters, H. et al. Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritis. J. Hypertens. 21, 771-780 (2003).
    • (2003) J. Hypertens , vol.21 , pp. 771-780
    • Peters, H.1
  • 109
    • 0343114434 scopus 로고    scopus 로고
    • Lovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells
    • Kim, S. I., Han, D. C. & Lee, H. B. Lovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells. J.Am. Soc. Nephrol. 11, 80-87 (2000).
    • (2000) J.Am. Soc. Nephrol , vol.11 , pp. 80-87
    • Kim, S.I.1    Han, D.C.2    Lee, H.B.3
  • 110
    • 26444478235 scopus 로고    scopus 로고
    • Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction
    • Vieira, J. M. Jr et al. Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction. Nephrol. Dial. Transplant. 20, 1582-1591 (2005).
    • (2005) Nephrol. Dial. Transplant , vol.20 , pp. 1582-1591
    • Vieira, J.M.1
  • 111
    • 51549098456 scopus 로고    scopus 로고
    • Simvastatin abates development of renal fibrosis in experimental renovascular disease
    • Chade, A. R. et al. Simvastatin abates development of renal fibrosis in experimental renovascular disease. J. Hypertens. 26, 1651-1660 (2008).
    • (2008) J. Hypertens , vol.26 , pp. 1651-1660
    • Chade, A.R.1
  • 112
    • 33846250366 scopus 로고    scopus 로고
    • Recombinant human anti- transforming growth factor beta1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
    • Denton, C. P. et al. Recombinant human anti- transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum. 56, 323-333 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 323-333
    • Denton, C.P.1
  • 113
    • 70350173934 scopus 로고    scopus 로고
    • The treatment of liver fibrosis induced by hepatocyte growth factor-directed, ultrasound-targeted microbubble destruction in rats
    • Wang, Z. X. et al. The treatment of liver fibrosis induced by hepatocyte growth factor-directed, ultrasound-targeted microbubble destruction in rats. Clin. Imaging 33, 454-461 (2009).
    • (2009) Clin. Imaging , vol.33 , pp. 454-461
    • Wang, Z.X.1
  • 114
    • 0034782480 scopus 로고    scopus 로고
    • Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice
    • Yang, J., Dai, C. & Liu, Y. Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice. Gene Ther. 8, 1470-1479 (2001).
    • (2001) Gene Ther , vol.8 , pp. 1470-1479
    • Yang, J.1    Dai, C.2    Liu, Y.3
  • 115
    • 0035070420 scopus 로고    scopus 로고
    • Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy
    • Mizuno, S., Matsumoto, K. & Nakamura, T. Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. Kidney Int. 59, 1304-1314 (2001).
    • (2001) Kidney Int , vol.59 , pp. 1304-1314
    • Mizuno, S.1    Matsumoto, K.2    Nakamura, T.3
  • 116
    • 0035023230 scopus 로고    scopus 로고
    • Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases
    • Matsumoto, K. & Nakamura, T. Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases. Kidney Int. 59, 2023-2038 (2001).
    • (2001) Kidney Int , vol.59 , pp. 2023-2038
    • Matsumoto, K.1    Nakamura, T.2
  • 117
    • 0032080835 scopus 로고    scopus 로고
    • Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease
    • Mizuno, S. et al. Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. J. Clin. Invest. 101, 1827-1834 (1998).
    • (1998) J. Clin. Invest , vol.101 , pp. 1827-1834
    • Mizuno, S.1
  • 118
    • 0036785218 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice
    • Yang, J., Dai, C. & Liu, Y. Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. J. Am. Soc. Nephrol. 13, 2464-2477 (2002).
    • (2002) J. Am. Soc. Nephrol , vol.13 , pp. 2464-2477
    • Yang, J.1    Dai, C.2    Liu, Y.3
  • 119
    • 72949121314 scopus 로고    scopus 로고
    • Connective tissue growth factor (CTGF): A key factor in the onset and progression of kidney damage [Spanish]
    • Sanchez-Lopez, E. et al. Connective tissue growth factor (CTGF): a key factor in the onset and progression of kidney damage [Spanish]. Nefrologia 29, 382-391 (2009).
    • (2009) Nefrologia , vol.29 , pp. 382-391
    • Sanchez-Lopez, E.1
  • 120
    • 48649102468 scopus 로고    scopus 로고
    • Plasma connective tissue growth factor is an independent predictor of end- stage renal disease and mortality in type 1 diabetic nephropathy
    • Nguyen, T. Q. et al. Plasma connective tissue growth factor is an independent predictor of end- stage renal disease and mortality in type 1 diabetic nephropathy. Diabetes Care 31, 1177-1182 (2008).
    • (2008) Diabetes Care , vol.31 , pp. 1177-1182
    • Nguyen, T.Q.1
  • 121
    • 35248841125 scopus 로고    scopus 로고
    • Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes
    • Guha, M., Xu, Z. G., Tung, D., Lanting, L. & Natarajan, R. Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes. FASEB J. 21, 3355-3368 (2007).
    • (2007) FASEB J , vol.21 , pp. 3355-3368
    • Guha, M.1    Xu, Z.G.2    Tung, D.3    Lanting, L.4    Natarajan, R.5
  • 122
    • 51249090127 scopus 로고    scopus 로고
    • Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy
    • Luo, G. H. et al. Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy. Transplant. Proc. 40, 2365-2369 (2008).
    • (2008) Transplant. Proc , vol.40 , pp. 2365-2369
    • Luo, G.H.1
  • 123
    • 84984768064 scopus 로고    scopus 로고
    • Dose-escalation phase I study of FG-3019 anti-connective tissue growth factor (CTGF) monoclonal antibody, in subjects with type I/II diabetes mellitus (DM) and microalbuminuria (MalbU) [abstract]
    • Adler, S. G. et al. Dose-escalation phase I study of FG-3019 anti-connective tissue growth factor (CTGF) monoclonal antibody, in subjects with type I/II diabetes mellitus (DM) and microalbuminuria (MalbU) [abstract]. J. Am. Soc. Nephrol. 17, 157A (2007).
    • (2007) J. Am. Soc. Nephrol , vol.157A , pp. 17
    • Adler, S.G.1
  • 124
    • 0034946204 scopus 로고    scopus 로고
    • Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats
    • Miric, G. et al. Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats. Br. J. Pharmacol. 133, 687-694 (2001).
    • (2001) Br. J. Pharmacol , vol.133 , pp. 687-694
    • Miric, G.1
  • 125
    • 0031474029 scopus 로고    scopus 로고
    • Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy
    • Shimizu, T. et al. Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy. Kidney Int. Suppl. 63, S239-S243 (1997).
    • (1997) Kidney Int. Suppl , vol.63 , pp. S239-S243
    • Shimizu, T.1
  • 126
    • 0031834709 scopus 로고    scopus 로고
    • Pirfenidone improves renal function and fibrosis in the post-obstructed kidney
    • Shimizu, T. et al. Pirfenidone improves renal function and fibrosis in the post-obstructed kidney. Kidney Int. 54, 99-109 (1998).
    • (1998) Kidney Int , vol.54 , pp. 99-109
    • Shimizu, T.1
  • 127
    • 0034004098 scopus 로고    scopus 로고
    • Pirfenidone inhibits NADPH-dependent microsomal lipid peroxidation and scavenges hydroxyl radicals
    • Misra, H. P & Rabideau, C. Pirfenidone inhibits NADPH-dependent microsomal lipid peroxidation and scavenges hydroxyl radicals. Mol. Cell. Biochem. 204, 119-126 (2000).
    • (2000) Mol. Cell. Biochem , vol.204 , pp. 119-126
    • Misra, H.P.1    Rabideau, C.2
  • 128
    • 34548834734 scopus 로고    scopus 로고
    • Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis
    • Cho, M. E., Smith, D. C., Branton, M. H., Penzak, S. R. & Kopp, J. B. Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis. Clin. J. Am. Soc. Nephrol. 2, 906-913 (2007).
    • (2007) Clin. J. Am. Soc. Nephrol , vol.2 , pp. 906-913
    • Cho, M.E.1    Smith, D.C.2    Branton, M.H.3    Penzak, S.R.4    Kopp, J.B.5
  • 129
    • 20944434994 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis
    • Azuma, A. et al. Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 171, 1040-1047 (2005).
    • (2005) Am. J. Respir. Crit. Care Med , vol.171 , pp. 1040-1047
    • Azuma, A.1
  • 130
    • 68149178848 scopus 로고    scopus 로고
    • Pirfenidone is renoprotective in diabetic kidney disease
    • RamachandraRao, S. P et al. Pirfenidone is renoprotective in diabetic kidney disease. J. Am. Soc. Nephrol. 20, 1765-1775 (2009).
    • (2009) J. Am. Soc. Nephrol , vol.20 , pp. 1765-1775
    • Ramachandrarao, S.P.1
  • 131
    • 69549110735 scopus 로고    scopus 로고
    • Fluorofenidone attenuates collagen I and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells
    • Peng, Z. Z. et al. Fluorofenidone attenuates collagen I and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells. Nephrology (Carlton) 14, 565-572 (2009).
    • (2009) Nephrology (Carlton) , vol.14 , pp. 565-572
    • Peng, Z.Z.1
  • 132
    • 0031128130 scopus 로고    scopus 로고
    • Albuminuria is directly associated with increased plasma PAI-1 and factor VII levels in NIDDM patients
    • Hirano, T., Kashiwazaki, K., Moritomo, Y, Nagano, S. & Adachi, M. Albuminuria is directly associated with increased plasma PAI-1 and factor VII levels in NIDDM patients. Diabetes Res. Clin. Pract. 36, 11-18 (1997).
    • (1997) Diabetes Res. Clin. Pract , vol.36 , pp. 11-18
    • Hirano, T.1    Kashiwazaki, K.2    Moritomo, Y.3    Nagano, S.4    Adachi, M.5
  • 133
    • 20144386753 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy
    • Nicholas, S. B. et al. Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy. Kidney Int. 67, 1297-1307 (2005).
    • (2005) Kidney Int , vol.67 , pp. 1297-1307
    • Nicholas, S.B.1
  • 134
    • 39049153080 scopus 로고    scopus 로고
    • A PAI-1 mutant, PAI-1R, slows progression of diabetic nephropathy
    • Huang, Y. et al. A PAI-1 mutant, PAI-1R, slows progression of diabetic nephropathy. J. Am. Soc. Nephrol. 19, 329-338 (2008).
    • (2008) J. Am. Soc. Nephrol , vol.19 , pp. 329-338
    • Huang, Y.1
  • 135
    • 63849095053 scopus 로고    scopus 로고
    • PAI-1 and kidney fibrosis
    • Ma, L. J. & Fogo, A. B. PAI-1 and kidney fibrosis. Front. Biosci. 14, 2028-2041 (2009).
    • (2009) Front. Biosci , vol.14 , pp. 2028-2041
    • Ma, L.J.1    Fogo, A.B.2
  • 136
    • 70349409438 scopus 로고    scopus 로고
    • Positive feedback loop between plasminogen activator inhibitor-1 and transforming growth factor-beta1 during renal fibrosis in diabetes
    • Seo, J. Y et al. Positive feedback loop between plasminogen activator inhibitor-1 and transforming growth factor-beta1 during renal fibrosis in diabetes. Am. J. Nephrol. 30, 481-490 (2009).
    • (2009) Am. J. Nephrol , vol.30 , pp. 481-490
    • Seo, J.Y.1
  • 137
    • 41649096963 scopus 로고    scopus 로고
    • Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway
    • Zheng, J. M., Zhu, J. M., Li, L. S. & Liu, Z. H. Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway. Br. J. Pharmacol. 153, 1456-1464 (2008).
    • (2008) Br. J. Pharmacol , vol.153 , pp. 1456-1464
    • Zheng, J.M.1    Zhu, J.M.2    Li, L.S.3    Liu, Z.H.4
  • 138
    • 74349098549 scopus 로고    scopus 로고
    • Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy
    • Gao, Q. et al. Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy. Planta Med. 76, 27-33 (2010).
    • (2010) Planta Med , vol.76 , pp. 27-33
    • Gao, Q.1
  • 139
    • 0033996388 scopus 로고    scopus 로고
    • AGEs induce oxidative stress and activate protein kinase C-beta(II) in neonatal mesangial cells
    • Scivittaro, V., Ganz, M. B. & Weiss, M. F. AGEs induce oxidative stress and activate protein kinase C-beta(II) in neonatal mesangial cells. Am. J. Physiol. Renal Physiol. 278, F676-F683 (2000).
    • (2000) Am. J. Physiol. Renal Physiol , vol.278 , pp. F676-F683
    • Scivittaro, V.1    Ganz, M.B.2    Weiss, M.F.3
  • 140
    • 0032704786 scopus 로고    scopus 로고
    • Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats
    • Kang, N. et al. Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats. Kidney Int. 56, 1737-1750 (1999).
    • (1999) Kidney Int , vol.56 , pp. 1737-1750
    • Kang, N.1
  • 141
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya, D. & King, G. L. Protein kinase C activation and the development of diabetic complications. Diabetes 47, 859-866 (1998).
    • (1998) Diabetes , vol.47 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 142
    • 0037315791 scopus 로고    scopus 로고
    • Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension
    • Kelly, D. J. et al. Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Diabetes 52, 512-518 (2003).
    • (2003) Diabetes , vol.52 , pp. 512-518
    • Kelly, D.J.1
  • 143
    • 28644442122 scopus 로고    scopus 로고
    • The effect of ruboxistaurin on nephropathy in type 2 diabetes
    • Tuttle, K. R. et al. The effect of ruboxistaurin on nephropathy in type 2 diabetes. Diabetes Care 28, 2686-2690 (2005).
    • (2005) Diabetes Care , vol.28 , pp. 2686-2690
    • Tuttle, K.R.1
  • 144
    • 34147151265 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on urinary transforming growth factor-beta in patients with diabetic nephropathy and type 2 diabetes
    • Gilbert, R. E. et al. Effect of ruboxistaurin on urinary transforming growth factor-beta in patients with diabetic nephropathy and type 2 diabetes. Diabetes Care 30, 995-996 (2007).
    • (2007) Diabetes Care , vol.30 , pp. 995-996
    • Gilbert, R.E.1
  • 145
    • 0024559825 scopus 로고
    • Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy
    • Seaquist, E. R., Goetz, F. C., Rich, S. S. & Barboso, J. Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N. Engl. J. Med. 320, 1161-1165 (1989).
    • (1989) N. Engl. J. Med , vol.320 , pp. 1161-1165
    • Seaquist, E.R.1    Goetz, F.C.2    Rich, S.S.3    Barboso, J.4
  • 146
    • 67449113446 scopus 로고    scopus 로고
    • Genetics of diabetic nephropathy: Are there clues to the understanding of common kidney diseases?
    • Conway, B. R. & Maxwell, A. P. Genetics of diabetic nephropathy: are there clues to the understanding of common kidney diseases? Nephron Clin. Pract. 112, c213-c221 (2009).
    • (2009) Nephron Clin. Pract , vol.112 , pp. c213-c221
    • Conway, B.R.1    Maxwell, A.P.2
  • 147
    • 0042867398 scopus 로고    scopus 로고
    • Genomic strategies for diabetic nephropathy
    • Susztak, K. et al. Genomic strategies for diabetic nephropathy. J.Am.Soc. Nephrol. 14 (Suppl. 3), S271-S278 (2003).
    • (2003) J.Am.Soc. Nephrol , vol.14 , pp. S271-S278
    • Susztak, K.1


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