Role of dipeptidyl peptidase IV in regulating activity of Na +/H+ exchanger isoform NHE3 in proximal tubule cells

American Journal of Physiology - Cell Physiology

Volumn 287, Issue 5 56-5, 2004, Pages

  Girardi, Adriana C C ^a   Knauf, Felix ^a   Demuth, Hans Ulrich ^b   Aronson, Peter S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PROBIODRUG AG   (Germany)

Author keywords

Diprotin A; P32 98; Sodium hydrogen exchange; Tyrosine kinase

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; DIPEPTIDYL PEPTIDASE IV; DIPROTIN A; ENZYME INHIBITOR; FORSKOLIN; FUMARIC ACID DERIVATIVE; ISOBUTYLMETHYLXANTHINE; ISOLEUCYLTHIAZOLIDINE FUMARATE; PROTEIN TYROSINE KINASE; SODIUM PROTEIN EXCHANGE PROTEIN 3 INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; BRUSH BORDER; COMPETITIVE INHIBITION; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; EVALUATION; INHIBITION KINETICS; KIDNEY PROXIMAL TUBULE; NONHUMAN; OPOSSUM; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD26; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; IMMUNOBLOTTING; KIDNEY TUBULES, PROXIMAL; OPOSSUMS; PROTEIN ISOFORMS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

ANIMALIA; DIDELPHIDAE;

EID: 6044261454     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00186.2004     Document Type: Article

References (56)

1. Adachi M, Kitamura K, Miyoshi T, Narikiyo T, Iwashita K, Shiraishi N, Nonoguchi H, and Tomita K. Activation of epithelial sodium channels by prostasin in Xenopus oocytes. J Am Soc Nephrol 12: 1114-1121, 2001.
2. + exchanger 3 is in large complexes in the center of the apical surface of proximal tubule-derived OK cells. Am J Physiol Cell Physiol 283: C927-C940, 2002.
3. Amemiya M, Loffing J, Lotscher M, Kaissling B, Alpern RJ, and Moe OW. Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb. Kidney Int 48: 1206-1215, 1995.
4. Biemesderfer D, DeGray B, and Aronson PS. Active (9.6 s) and inactive (21 s) oligomers of NHE3 in microdomains of the renal brush border. J Biol Chem 276: 10161-10167, 2001.
5. + exchanger isoform of renal brush border. Am J Physiol Renal Fluid Electrolyte Physiol 265: F736-F742, 1993.
6. + exchanger isoform NHE-1 in rabbit kidney. Am J Physiol Renal Fluid Electrolyte Physiol 263: F833-F840, 1992.
7. Biemesderfer D, Rutherford PA, Nagy T, Pizzonia JH, Abu-Alfa AK, and Aronson PS. Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney. Am J Physiol Renal Physiol 273: F289-F299, 1997.
8. + exchanger NHE3 isoform. J Biol Chem 271: 3590-3599, 1996.
9. + exchanger in rat renal cortical tubules. Am J Physiol Cell Physiol 273: C1064-C1074, 1997.
10. + exchanger isoform NHE2 in rat kidney. Am J Physiol Renal Physiol 275: F379-F386, 1998.
11. Cheng HC, Abdel-Ghany M, Elble RC, and Pauli BU. Lung endothelial dipeptidyl peptidase IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin. J Biol Chem 273: 24207-24215, 1998.
12. Choi JY, Shah M, Lee MG, Schultheis PJ, Shull GE, Muallem S, and Baum M. Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule. J Clin Invest 105: 1141-1146, 2000.
13. Cole JA, Forte LR, Krause WJ, and Thorne PK. Clonal sublines that are morphologically and functionally distinct from parental OK cells. Am J Physiol Renal Fluid Electrolyte Physiol 256: F672-F679, 1989.
14. + exchanger NHE3 by parathyroid hormone via NHE3 phosphorylation and dynamin-dependent endocytosis. J Biol Chem 275: 31601-31608, 2000.
15. + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol 44: 1041-1045, 1993.
16. Cunningham DF and O'Connor B. Proline specific peptidases. Biochim Biophys Acta 1343: 160-186, 1997.
17. + permeability. J Biol Chem 278: 44632-44638, 2003.
18. + exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubule. J Biol Chem 276: 46671-46677, 2001.
19. + exchanger isoform NHE8. Am J Physiol Renal Physiol 284: F467-F473, 2003.
20. Hegen M, Kameoka J, Dong RP, Schlossman SF, and Morimoto C. Cross-linking of CD26 by antibody induces tyrosine phosphorylation and activation of mitogen-activated protein kinase. Immunology 90: 257-264, 1997.
21. Hino M, Fuyamada H, Hayakawa T, Nagatsu T, and Oya H. X-Prolyl dipeptidyl-aminopeptidase activity, with X-proline p-nitroanilides as substrates, in normal and pathological human sera. Clin Chem 22: 1256-1261, 1976.
22. Ishii T, Ohnuma K, Murakami A, Takasawa N, Kobayashi S, Dang NH, Schlossman SF, and Morimoto C. CD26-mediated signaling for T cell activation occurs, in lipid rafts through its association with CD45RO. Proc Natl Acad Sci USA 98: 12138-12143, 2001.
23. Kahne T, Neubert K, and Ansorge S. Enzymatic activity of DPIV/CD26 is involved in PMA-induced hyperphosphorylation of p56lck. Immunol Lett 46: 189-193, 1995.
24. Kahne T, Neubert K, Faust J, and Ansorge S. Early phosphorylation events induced by DPIV/CD26-specific inhibitors. Cell Immunol 189: 60-66, 1998.
25. Kenny AJ, Booth AG, George SG, Ingram J, Kershaw D, Wood EJ, and Young AR. Dipeptidyl peptidase IV, a kidney brush-border serine peptidase. Biochem J 157: 169-182, 1976.
26. + exchange. J Biol Chem 271: 9919-9927, 1996.
27. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
28. Lambeir AM, Durinx C, Scharpe S, and De Meester I. Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci 40: 209-294, 2003.
29. Leiting B, Pryor KD, Wu JK, Marsilio F, Patel RA, Craik CS, Ellman JA, Cummings RT, and Thornberry NA. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. Biochem J 371: 525-532, 2003.
30. Lorenz JN, Schultheis PJ, Traynor T, Shull GE, and Schnermann J. Micropuncture analysis of single-nephron function in NHE3-deficient mice. Am J Physiol Renal Physiol 277: F447-F453, 1999.
31. Loster K, Zeilinger K, Schuppan D, and Reutter W. The cysteine-rich region of dipeptidyl peptidase IV (CD 26) is the collagen-binding site. Biochem Biophys Res Commun 217: 341-348, 1995.
32. Lucci MS, Warnock DG, and Rector FC Jr. Carbonic anhydrase-dependent bicarbonate reabsorption in the rat proximal tubule. Am J Physiol Renal Fluid Electrolyte Physiol 236: F58-F65, 1979.
33. Mentlein R. Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regul Pept 85: 9-24, 1999.
34. Morimoto C and Schlossman SF. The structure and function of CD26 in the T-cell immune response. Immunol Rev 161: 55-70, 1998.
35. Morrison ME, Vijayasaradhi S, Engelstein D, Albino AP, and Houghton AN. A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase. J Exp Med 177: 1135-1143, 1993.
36. Munoz E, Blazquez MV, Madueno JA, Rubio G, and Pena J. CD26 induces T-cell proliferation by tyrosine protein phosphorylation. Immunology 77: 43-50, 1992.
37. Orlowski J. Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger. J Biol Chem 268: 16369-16377, 1993.
38. Pederson RA, White HA, Schlenzig D, Pauly RP, McIntosh CH, and Demuth HU. Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes 47: 1253-1258, 1998.
39. Rahfeld J, Schierhorn M, Hartrodt B, Neubert K, and Heins J. Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV? Biochim Biophys Acta 1076: 314-316, 1991.
40. Reshkin SJ, Forgo J, and Murer H. Functional asymmetry of phosphate transport and its regulation in opossum kidney cells: phosphate transport. Pflügers Arch 416: 554-560, 1990.
41. Stockel-Maschek A, Mrestani-Klaus C, Stiebitz B, Demuth H, and Neubert K. Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases. Biochim Biophys Acta 1479: 15-31, 2000.
42. Tanaka T, Camerini D, Seed B, Torimoto Y, Dang NH, Kameoka J, Dahlberg HN, Schlossman SF, and Morimoto C. Cloning and functional expression of the T cell activation antigen CD26. J Immunol 149: 481-486, 1992.
43. Thoma R, Loffler B, Stihle M, Huber W, Ruf A, and Hennig M. Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV. Structure 11: 947-959, 2003.
44. Torimoto Y, Dang NH, Vivier E, Tanaka T, Schlossman SF, and Morimoto C. Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes. J Immunol 147: 2514-2517, 1991.
45. Tsuganezawa H, Preisig PA, and Alpern RJ. Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cells. Kidney Int 54: 394-398, 1998.
46. Umezawa H, Aoyagi T, Ogawa K, Naganawa H, Hamada M, and Takeuchi T. Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria. J Antibiot (Tokyo) 37: 422-425, 1984.
47. Vallet V, Chraibi A, Gaeggeler HP, Horisberger JD, and Rossier BC. An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature 389: 607-610, 1997.
48. + exchanger NHE3 in nephron function: micropuncture studies with S3226, an inhibitor of NHE3. Am J Physiol Renal Physiol 278: F375-F379, 2000.
49. Vuagniaux G, Vallet V, Jaeger NF, Hummler E, and Rossier BC. Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes. J Gen Physiol 120: 191-201, 2002.
50. + exchangers. Physiol Rev 77: 51-74, 1997.
51. Wang T, Hropot M, Aronson PS, and Giebisch G. Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. Am J Physiol Renal Physiol 281: F1117-F1122, 2001.
52. Wang T, Yang CL, Abbiati T, Schultheis PJ, Shull GE, Giebisch G, and Aronson PS. Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice. Am J Physiol Renal Physiol 277: F298-F302, 1999.
53. - absorption in renal thick ascending limb. J Clin Invest 104: 1593-1602, 1999.
54. Weinman EJ, Minkoff C, and Shenolikar S. Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. Am J Physiol Renal Physiol 279: F393-F399, 2000.
55. + exchange. Adaptation to metabolic acidosis. J Biol Chem 271: 32749-32752, 1996.
56. Yang X, Amemiya M, Peng Y, Moe OW, Preisig PA, and Alpern RJ. Acid incubation causes exocytic insertion of NHE3 in OKP cells. Am J Physiol Cell Physiol 279: C410-C419, 2000.