Molecular basis of the general base catalysis of an α/β- hydrolase catalytic triad

Journal of Biological Chemistry

Volumn 289, Issue 22, 2014, Pages 15867-15879

  Sun, Yueru ^a   Yin, Shuhui ^a   Feng, Yitao ^a   Li, Jie ^b   Zhou, Jiahai ^b   Liu, Changdong ^a   Zhu, Guang ^a   Guo, Zhihong ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS;

CATALYTIC TRIAD; CATALYTIC VERSATILITY; CONFORMATIONAL CHANGE; ENZYME CATALYSIS; GENERAL BASE CATALYSIS; MOLECULAR BASIS;

HYDROLASES;

2 SUCCINYL 6 HYDROXY 2,4 CYCLOHEXADIENE 1 CARBOXYLATE SYNTHASE; ALPHA HYDROLASE; ASPARTIC ACID; BETA HYDROLASE; HISTIDINE; HYDROLASE; SERINE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; STRUCTURE ANALYSIS;

CRYSTAL STRUCTURE; ENZYME MECHANISMS; HYDROLASES; OPEN-CLOSED CONFORMATIONAL CHANGE; PROTEIN CONFORMATION; VITAMIN K;

ASPARTIC ACID; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ESCHERICHIA COLI; HISTIDINE; HYDROGEN BONDING; MUTAGENESIS, SITE-DIRECTED; OXO-ACID-LYASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN K;

EID: 84901700890     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.535641     Document Type: Article

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