Investigation of a general base mechanism for ester hydrolysis in C-C hydrolase enzymes of the α/β-hydrolase superfamily: A novel mechanism for the serine catalytic triad

Organic and Biomolecular Chemistry

Volumn 5, Issue 3, 2007, Pages 507-513

  Li, Jian Jun ^a   Bugg, Timothy D H ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C-C HYDROLASE ENZYMES; GEM-DIOLATE INTERMEDIATE; HAMMETT ANALYSIS; SERINE CATALYTIC TRIAD;

CATALYSIS; ENZYMES; ESTERS; HYDROGEN BONDS; HYDROLYSIS;

REACTION KINETICS;

4 NITROPHENYL ACETATE; 4-NITROPHENYL ACETATE; BENZOIC ACID DERIVATIVE; ESCHERICHIA COLI PROTEIN; ESTER; ESTERASE; HYDROLASE; MHPC PROTEIN, E COLI; NITROPHENOL; SERINE; SERINE PROTEINASE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BURKHOLDERIA; CATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; HYDROLYSIS; KINETICS; METABOLISM; PH;

BENZOATES; BINDING SITES; BURKHOLDERIA; CATALYSIS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ESTERASES; ESTERS; HYDROGEN-ION CONCENTRATION; HYDROLASES; HYDROLYSIS; KINETICS; LIPASE; NITROPHENOLS; SERINE; SUBSTRATE SPECIFICITY;

BURKHOLDERIA; BURKHOLDERIA XENOVORANS; ESCHERICHIA COLI;

EID: 33846527200     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b615605c     Document Type: Article

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