The catalytic serine of meta-cleavage product hydrolases is activated differently for C-O bond cleavage than for C-C bond cleavage

Biochemistry

Volumn 51, Issue 29, 2012, Pages 5831-5840

  Ruzzini, Antonio C ^a   Horsman, Geoff P ^a,b   Eltis, Lindsay D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b WILFRID LAURIER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOIC ACID; C-C BOND FISSION; C-C BONDS; C-O BOND CLEAVAGE; DEACYLATION; DIFFERENT MECHANISMS; ESTER HYDROLYSIS; KINETIC ANALYSIS; META-CLEAVAGE; METHANOL CONCENTRATION; METHANOLYSIS; METHYL BENZOATE; N-PROPANOL; NUCLEOPHILIC CATALYSIS; NUCLEOPHILIC MECHANISMS; ORDERS OF MAGNITUDE; PHYSIOLOGICAL SUBSTRATE; PRIMARY ALCOHOLS; PRODUCT ANALYSIS; RATE LIMITING; STEADY-STATE HYDROLYSIS;

ACYLATION; AEROBIC BACTERIA; AMINO ACIDS; CARBOXYLIC ACIDS; CATALYSIS; DEGRADATION; ESTERIFICATION; ESTERS; ETHANOL; HYDROLASES; METHANOL; NUCLEOPHILES;

HYDROLYSIS;

ALCOHOL; AROMATIC COMPOUND; ASPARAGINE; BENZOIC ACID DERIVATIVE; BIPHENYL DERIVATIVE; CARBON; ESTER DERIVATIVE; HISTIDINE; HYDROLASE; METHANOL; NUCLEOPHILE; OXYGEN; PROPANOL; SERINE;

ACYLATION; ARTICLE; BACTERIUM; CATABOLISM; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION KINETICS; DEACYLATION; DEGRADATION; ENZYME ACTIVATION; HYDROLYSIS; METHANOLYSIS; MODEL; NONHUMAN; PRIORITY JOURNAL; SUBSTITUTION REACTION;

BENZOATES; BURKHOLDERIA; FATTY ACIDS, UNSATURATED; HYDROLASES; HYDROLYSIS; METHANOL; SERINE; SUBSTRATE SPECIFICITY;

KOBUS;

EID: 84864268097     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300663r     Document Type: Article

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