Fortification of Human Milk in Very Low Birth Weight Infants (VLBW <1500 g Birth Weight)

Clinics in Perinatology

Volumn 41, Issue 2, 2014, Pages 405-421

  Adamkin, David H ^a   Radmacher, Paula G ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Human milk fortification; Necrotizing enterocolitis; Neurodevelopment; Postnatal growth restriction; Preterm human milk; Very low birth weight infants

Indexed keywords

ARTICLE; ARTIFICIAL MILK; BREAST MILK; CHILD GROWTH; DIET SUPPLEMENTATION; FOOD ANALYSIS; FOOD PROCESSING; FORTIFICATION; HUMAN; INFANT FEEDING; INFRARED SPECTROSCOPY; MACRONUTRIENT; NECROTIZING ENTEROCOLITIS; NERVOUS SYSTEM DEVELOPMENT; POSTNATAL GROWTH; PREMATURITY; PRIORITY JOURNAL; PROTEIN INTAKE; VERY LOW BIRTH WEIGHT; ENTERIC FEEDING; GROWTH, DEVELOPMENT AND AGING; INFANT NUTRITION; LOW BIRTH WEIGHT; NEWBORN; PHYSIOLOGY; PROCEDURES; WEIGHT GAIN;

ENTERAL NUTRITION; HUMANS; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; MILK, HUMAN; WEIGHT GAIN;

EID: 84901642722     PISSN: 00955108     EISSN: 15579840     Source Type: Journal    
DOI: 10.1016/j.clp.2014.02.010     Document Type: Review

References (75)

1. American Academy of Pediatrics Section on Breastfeeding Breastfeeding and the use of human milk. Pediatrics 2012, 129(3):e827-e841.
2. Furman L., Taylor G., Minich N., et al. The effect of maternal milk on neonatal morbidity of very low-birth-weight infants. Arch Pediatr Adolesc Med 2003, 157(1):66-71.
3. Patel A.L., Johnson T.J., Engstrom J.L., et al. Impact of early human milk on sepsis and health-care costs in very low birth weight infants. J Perinatol 2013, 33:514-519.
4. Schanler R.J. The use of human milk for premature infants. Pediatr Clin North Am 2001, 48(1):207-219.
5. Schanler R.J., Shulman R.J., Lau C. Feeding strategies for premature infants: beneficial outcomes of feeding fortified human milk versus preterm formula. Pediatrics 1999, 103(6 Pt 1):1150-1157.
6. Sisk P.M., Lovelady C.A., Dillard R.G., et al. Early human milk feeding is associated with a lower risk of necrotizing enterocolitis in very low birth weight infants. J Perinatol 2007, 27(7):428-433.
7. Sullivan S., Schanler R.J., Kim J.H., et al. An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products. J Pediatr 2010, 156(4):562-567.e1.
8. Vohr B.R., Poindexter B.B., Dusick A.M., et al. Persistent beneficial effects of breast milk ingested in the neonatal intensive care unit on outcomes of extremely low birth weight infants at 30 months of age. Pediatrics 2007, 120(4):e953-e959.
9. Schanler R. Evaluation of the evidence to support current recommendations to meet the needs of premature infants: the role of human milk. Am J Clin Nutr 2007, 85(2):625S-628S.
10. Bier J.A., Oliver T., Ferguson A.E., et al. Human milk improves cognitive and motor development of premature infants during infancy. J Hum Lact 2002, 18(4):361-367.
11. Blaymore Bier J.A., Oliver T., Ferguson A., et al. Human milk reduces outpatient upper respiratory symptoms in premature infants during their first year of life. J Perinatol 2002, 22:354-359.
12. Lucas A., Morley R., Cole T.J. Randomised trial of early diet in preterm babies and later intelligence quotient. BMJ 1998, 317(7171):1481-1487.
13. Morales Y., Schanler R.J. Human milk and clinical outcomes in VLBW infants: how compelling is the evidence of benefit?. Semin Perinatol 2007, 31(2):83-88.
14. Meinzen-Derr J., Poindexter B., Wrage L., et al. Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death. J Perinatol 2009, 29(1):57-62.
15. Narayanan I., Prakash K., Murthy N.S., et al. Randomised controlled trial of effect of raw and holder pasteurised human milk and of formula supplements on incidence of neonatal infection. Lancet 1984, 2(8412):1111-1113.
16. Lemons J.A., Moye L., Hall D., et al. Differences in the composition of preterm and term human milk during early lactation. Pediatr Res 1982, 16(2):113-117.
17. Michaelsen K.F., Skafte L., Badsberg J.H., et al. Variation in macronutrients in human bank milk: influencing factors and implications for human milk banking. J Pediatr Gastroenterol Nutr 1990, 11(2):229-239.
18. Wojcik K.Y., Rechtman D.J., Lee M.L., et al. Macronutrient analysis of a nationwide sample of donor breast milk. J Am Diet Assoc 2009, 109:137-140.
19. Ziegler E.E. Breast-milk fortification. Acta Paediatr 2001, 90(7):720-723.
20. Allen J.C., Keller R.P., Archer P., et al. Studies in human lactation: milk composition and daily secretion rates of macronutrients in the first year of lactation. Am J Clin Nutr 1991, 54(1):69-80.
21. Daly S.E., Di Rosso A., Owens R.A., et al. Degree of breast emptying explains changes in the fat content, but not fatty acid composition, of human milk. Exp Physiol 1993, 78(6):741-755.
22. Mitoulas L.R., Kent J.C., Cox D.B., et al. Variation in fat, lactose and protein in human milk over 24 h and throughout the first year of lactation. Br J Nutr 2002, 88(1):29-37.
23. Bhatia J. Human milk and the premature infant. J Perinatol 2007, 27:S71-S74.
24. Polberger S. New approaches to optimizing early diets. Nestle Nutr Workshop Ser Pediatr Program 2009, 63:195-204. [discussion: 204-8, 259-68].
25. Weber A., Loui A., Jochum F., et al. Breast milk from mothers of very low birthweight infants: variability in fat and protein content. Acta Paediatr 2001, 90(7):772-775.
26. Bertino E., Coppa G.V., Giuliani F., et al. Effects of Holder pasteurization on human milk oligosaccharides. Int J Immunopathol Pharmacol 2008, 21(2):381-385.
27. Ewaschuk J.B., Unger S., O'Connor D.L., et al. Effect of pasteurization on selected immune components of donated human breast milk. J Perinatol 2011, 31(9):593-598.
28. McPherson R.J., Wagner C.L. The effect of pasteurization on transforming growth factor alpha and transforming growth factor beta 2 concentrations in human milk. Adv Exp Med Biol 2001, 501:559-566.
29. Untalan P.B., Keeney S.E., Palkowetz K.H., et al. Heat susceptibility of interleukin-10 and other cytokines in donor human milk. Breastfeed Med 2009, 4(3):137-144.
30. Silvestre D., Ruiz P., Martinez-Costa C., et al. Effect of pasteurization on the bactericidal capacity of human milk. J Hum Lact 2008, 24(4):371-376.
31. Vieira A.A., Soares F.V., Pimenta H.P., et al. Analysis of the influence of pasteurization, freezing/thawing, and offer processes on human milk's macronutrient concentrations. Early Hum Dev 2011, 87(8):577-580.
32. Ehrenkranz R.A., Dusick A.M., Vohr B.R., et al. Growth in the neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birth weight infants. Pediatrics 2006, 117(4):1253-1261.
33. Weisglas-Kuperus N., Hille E.T., Duivenvoorden H.J., et al. Intelligence of very preterm or very low birthweight infants in young adulthood. Arch Dis Child Fetal Neonatal Ed 2009, 94(3):F196-F200.
34. Carlson S.J., Ziegler E.E. Nutrient intakes and growth of very low birth weight infants. J Perinatol 1998, 18(4):252-258.
35. Embleton N.E., Pang N., Cooke R.J. Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants?. Pediatrics 2001, 107(2):270-273.
36. Latal-Hajnal B., von Siebenthal K., Kovari H., et al. Postnatal growth in VLBW infants: significant association with neurodevelopmental outcome. J Pediatr 2003, 143(2):163-170.
37. Kiechl-Kohlendorfer U., Fink F.M., Steichen-Gersdorf E. Transient symptomatic zinc deficiency in a breast-fed preterm infant. Pediatr Dermatol 2007, 24(5):536-540.
38. Obladen M., Loui A., Kampmann W., et al. Zinc deficiency in rapidly growing preterm infants. Acta Paediatr 1998, 87(6):685-691.
39. Arslanoglu S., Moro G.E., Ziegler E.E. Optimization of human milk fortification for preterm infants: new concepts and recommendations. J Perinat Med 2010, 38(3):233-238. The Wapm Working Group On Nutrition.
40. Rigo J. Protein, amino acid and other nitrogen compounds. Nutrition of the preterm infant: scientific basis and practical guidelines 2005, 45. Digital Educational Publishing, Inc, Cincinnati (OH). 2nd edition. R.C. Tsang, R. Uauy, B. Koletzko (Eds.).
41. Arslanoglu S., Moro G.E., Ziegler E.E. Preterm infants fed fortified human milk receive less protein than they need. J Perinatol 2009, 29(7):489-492.
42. de Halleux V., Rigo J. Variability in human milk composition: benefit of individualized fortification in very low birth weight infants. Am J Clin Nutr 2013, 98(2):529S-535S.
43. Senterre T., Rigo J. Optimizing early nutritional support based on recent recommendations in VLBW infants and postnatal growth restriction. J Pediatr Gastroenterol Nutr 2011, 53(5):536-542.
44. Baker R.D. Infant formula safety. Pediatrics 2002, 110(4):833-835.
45. Steele C., Kinzler S. Microbiology and infection control. Infant feedings: guidelines for preparation of human milk and formula in health care facilities 2011, 108-121. Diana Faulhaber, Chicago. 2nd edition. S.T. Robbins, R. Meyers (Eds.).
46. Moya F., Sisk P.M., Walsh K.R., et al. A new liquid human milk fortifier and linear growth in preterm infants. Pediatrics 2012, 130(4):e928-e935.
47. Erickson T., Gill G., Chan G.M. The effects of acidification on human milk's cellular and nutritional content. J Perinatol 2013, 33(5):371-373.
48. Lonnerdal B. Personalizing nutrient intakes of formula-fed infants: breast milk as a model. Nestle Nutr Workshop Ser Pediatr Program 2008, 62:189-198. [discussion: 198-203].
49. Kuschel C.A., Harding J.E. Multicomponent fortified human milk for promoting growth in preterm infants. Cochrane Database Syst Rev 2004, (1). CD000343.
50. Olsen I.E., Richardson D.K., Schmid C.H., et al. Intersite differences in weight growth velocity of extremely premature infants. Pediatrics 2002, 110(6):1125-1132.
51. Pieltain C., De Curtis M., Gerard P., et al. Weight gain composition in preterm infants with dual energy X-ray absorptiometry. Pediatr Res 2001, 49(1):120-124.
52. Henriksen C., Westerberg A.C., Ronnestad A., et al. Growth and nutrient intake among very-low-birth-weight infants fed fortified human milk during hospitalisation. Br J Nutr 2009, 102(8):1179-1186.
53. Radmacher P.G., Lewis S.L., Adamkin D. Individualizing fortification of human milk using real time human milk analysis. J Neonatal Perinatal Med 2013, 6:319-323.
54. Arslanoglu S., Moro G.E., Ziegler E.E. Adjustable fortification of human milk fed to preterm infants: does it make a difference?. J Perinatol 2006, 26(10):614-621.
55. Hay W.W. Optimizing protein intake in preterm infants. J Perinatol 2009, 29(7):465-466.
56. Radmacher P.G., Sparks B., Lewis S.L., et al. Real time human milk analysis contributes to more comprehensive nutritional management. J Investig Med 2013, 61(2):208A.
57. Rochow N., Fusch G., Choi A., et al. Target fortification of breast milk with fat, protein and carbohydrates for preterm infants. J Pediatr 2013, 163:1001-1007.
58. Polberger S., Raiha N.C., Juvonen P., et al. Individualized protein fortification of human milk for preterm infants: comparison of ultrafiltrated human milk protein and a bovine whey fortifier. J Pediatr Gastroenterol Nutr 1999, 29(3):332-338.
59. O'Neill E.F., Radmacher P.G., Sparks B., et al. Creamatocrit analysis of human milk overestimates fat and energy content when compared to a human milk analyzer using mid-infrared spectroscopy. J Pediatr Gastroenterol Nutr 2013, 56(5):569-573.
60. Sauer C.W., Kim J.H. Human milk macronutrient analysis using point-of-care near-infrared spectrophotometry. J Perinatol 2011, 31(5):339-343.
61. Agostoni C., Buonocore G., Carnielli V.P., et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010, 50(1):85-91.
62. AOAC Official method 972.16. Fat, lactose, protein, and solids in milk. Mid-infrared spectroscopic method. Official methods of analysis 2003, vol. 2. AOAC International, Gaithersburg (MD). 17th edition.
63. Biggs D.A., Johnsson G., Sjaunja L.O. Analysis of fat, protein, lactose and total solids by infra-red absorption 1987, 21-30. Monograph on Rapid Indirect Methods for Measurement of the Major Conponents of Milk. Bulletin of the International Dairy Federation 208, International Dairy Federation, Brussels (Belgium).
64. Biggs D.A., McKenna D. Alternative methods for infrared analysis of fat in milk: interlaboratory study. J Assoc Off Anal Chem 1989, 72:724-734.
65. Casadio Y.S., Williams T.M., Lai C.T., et al. Evaluation of a mid-infrared analyzer for the determination of the macronutrient composition of human milk. J Hum Lact 2010, 26(4):376-383.
66. Sjaunja L.-O. Studies on milk analysis of individual cow milk samples. I. Infrared spectrophotometry for analysis of fat, protein and lactose in milk. Acta Agric Scand 1984, 34(3):249-259.
67. Corvaglia L., Battistini B., Paoletti V., et al. Near-infrared reflectance analysis to evaluate the nitrogen and fat content of human milk in neonatal intensive care units. Arch Dis Child Fetal Neonatal Ed 2008, 93:F372-F375.
68. Lin P.W., Stoll B.J. Necrotising enterocolitis. Lancet 2006, 368(9543):1271-1283.
69. Stoll B.J. Epidemiology of necrotizing enterocolitis. Clin Perinatol 1994, 21(2):205-218.
70. Horbar J.D., Badger G.J., Carpenter J.H., et al. Trends in mortality and morbidity for very low birth weight infants, 1991-1999. Pediatrics 2002, 110(1 Pt 1):143-151.
71. Lemons J.A., Bauer C.R., Oh W., et al. Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network. Pediatrics 2001, 107(1):E1.
72. Peter C.S., Feuerhahn M., Bohnhorst B., et al. Necrotising enterocolitis: is there a relationship to specific pathogens?. Eur J Pediatr 1999, 158(1):67-70.
73. Lucas A., Cole T.J. Breast milk and neonatal necrotising enterocolitis. Lancet 1990, 336(8730):1519-1523.
74. Cristofalo E.A., Schanler R., Blanco C., et al. Randomized trial of exclusive human milk versus preterm formula diets in extremely premature infants. J Pediatr 2013, 163(6):1592-1595.
75. Embleton N.D., King C., Jarvis C., et al. Effectiveness of human milk-based fortifiers for preventing NEC in preterm infants: case not proven. Breastfeed Med 2013, 8(4):421.