Probiotics, prebiotics and the gastrointestinal tract in health and disease

Inflammopharmacology

Volumn 22, Issue 3, 2014, Pages 135-154

  Vitetta, Luis ^a,b   Briskey, David ^b   Alford, Hollie ^a   Hall, Sean ^a   Coulson, Samantha ^b  

^a Medlab   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Bifidobacteria; Clinical trials; Gastrointestinal tract; Inflammation; Internal environment; Lactobacillus; Microbiome; Nutrition; Prebiotics; Probiotics; Reactive oxygen species

Indexed keywords

ANTIBIOTIC AGENT; FRUCTOSE OLIGOSACCHARIDE; MESALAZINE; PLACEBO; PREBIOTIC AGENT; PROBIOTIC AGENT; REACTIVE OXYGEN METABOLITE; VANCOMYCIN;

ANTIINFLAMMATORY ACTIVITY; BACILLUS CLAUSII; BIFIDOBACTERIUM; BIFIDOBACTERIUM ANIMALIS; BIFIDOBACTERIUM BIFIDUM; BIFIDOBACTERIUM BREVE; BIFIDOBACTERIUM LONGUM INFANTIS; CLINICAL STUDY; CLOSTRIDIUM BUTYRICUM; CLOSTRIDIUM DIFFICILE; CONSTIPATION; CROHN DISEASE; DIARRHEA; DIGESTIVE SYSTEM INFLAMMATION; DRUG INDUCED DISEASE; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ESCHERICHIA; ESCHERICHIA COLI; GASTROENTERITIS; GASTROINTESTINAL DISEASE; GASTROINTESTINAL TRACT; HOMEOSTASIS; HUMAN; ILEITIS; INFECTIOUS DIARRHEA; INFLAMMATORY BOWEL DISEASE; IRRITABLE COLON; LACTOBACILLUS; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS BULGARICUS; LACTOBACILLUS CASEI; LACTOBACILLUS DELBRUECKII; LACTOBACILLUS GASSERI; LACTOBACILLUS JOHNSONII; LACTOBACILLUS PARACASEI; LACTOBACILLUS PLANTARUM; LACTOBACILLUS REUTERI; LACTOBACILLUS RHAMNOSUS; LACTOCOCCUS LACTIS; METABOLIC REGULATION; MICROBIOME; MUCUS SECRETION; NECROTIZING ENTEROCOLITIS; NONHUMAN; PRIORITY JOURNAL; PROPIONIBACTERIUM FREUDENDREICHII; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; RISK REDUCTION; SACCHAROMYCES BOULARDII; SIGNAL TRANSDUCTION; STREPTOCOCCUS; STREPTOCOCCUS THERMOPHILUS; SYSTEMATIC REVIEW; TH1 TH2 BALANCE; TRAVELLER DIARRHEA; TREATMENT OUTCOME; ULCERATIVE COLITIS; ANIMAL; DIET THERAPY; DRUG EFFECTS; GASTROINTESTINAL DISEASES; HEALTH STATUS; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY;

ANIMALS; GASTROINTESTINAL DISEASES; GASTROINTESTINAL TRACT; HEALTH STATUS; HUMANS; MICROBIOTA; PREBIOTICS; PROBIOTICS;

EID: 84901625811     PISSN: 09254692     EISSN: 15685608     Source Type: Journal    
DOI: 10.1007/s10787-014-0201-4     Document Type: Review

References (128)

1. Abdullah M, Syam AF, Simadibrata M, Gunawan J, Makmun D, Rani AA (2013) New insights on the pathomechanisms of inflammatory bowel disease. J Dig Dis 14(9):455-462
2. Adlerberth I (2008) Factors influencing the establishment of the intestinal microbiota in infancy. Nestle Nutr Workshop Ser Pediatr Progr 62:13-29
3. Amalaradjou MA, Bhunia AK (2012) Modern approaches in probiotics research to control foodborne pathogens. Adv Food Nutr Res 67:185-239
4. Andriulli A, Neri M, Loguercio C, Terreni N, Merla A, Cardarella MP, Federico A et al (2008) Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: a multicenter, randomized study. J Clin Gastroenterol 42(Suppl 3 Pt 2):S218-S223
5. Armuzzi A, Cremonini F, Ojetti V, Bartolozzi F, Canducci F, Candelli M, Santarelli L, Cammarota G, De Lorenzo A, Pola P, Gasbarrini G, Gasbarrini A (2001) Effect of Lactobacillus GG supplementation on antibiotic-associated gastrointestinal side effects during Helicobacter pylori eradication therapy: a pilot study. Digestion 63(1):1-7 (Pubitemid 32098452)
6. Arumugam M, Raes J, Pelletier E et al (2011) Enterotypes of the human gut microbiome. Nature 473(7346):174-180
7. Banaszkiewicz A, Szajewska H (2005) Ineffectiveness of Lactobacillus GG as an adjunct to lactulose for the treatment of constipation in children: a double-blind, placebo-controlled randomized trial. J Pediatr 146(3):364-369 (Pubitemid 40341747)
8. Beniwal RS, Arena VC, Thomas L, Narla S, Imperiale TF, Chaudhry RA, Ahmad UA (2003) A randomized trial of yogurt for prevention of antibiotic-associated diarrhea. Dig Dis Sci 48(10):2077-2082 (Pubitemid 37410101)
9. Bermudez-Brito M, Plaza-Diaz J, Munoz-Quezada S, Gomez-Llorente C, Gil A (2012) Probiotic mechanisms of action. Ann Nutr Metab 6:160-174
10. Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudensky B, Caplan M, Hammerman C (2005) Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr 147(2):192-196 (Pubitemid 41207832)
11. Bu LN, Chang MH, Ni YH, Chen HL, Cheng CC (2007) Lactobacillus casei rhamnosus cr35 in children with chronic constipation. Pediatr Int 49(4):485-490
12. Burcelin R, Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R (2008) Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57(6):1470-1481
13. Cappello C, Tremolaterra F, Pascariello A, Ciacci C, Iovino P (2013) A randomised clinical trial (RCT) of a symbiotic mixture in patients with irritable bowel syndrome (IBS): effects on symptoms, colonic transit and quality of life. Int J Colorectal Dis 28(3):349-358
14. Chiang SS, Pan TM (2013) Beneficial effects of phytoestrogens and their metabolites produced their by intestinal microflora on bone health. Appl Microbiol Biotechnol 97(4):1489-1500
15. Chouraqui JP, Van Egroo LD, Fichot MC (2004) Acidified milk formula supplemented with bifidobacterium lactis: impact on infant diarrhea in residential care settings. J Pediatr Gastroenterol Nutr 38(3):288-292
16. Cimperman L, Bayless G, Best K et al (2011) A randomized, double-blind, placebo-controlled pilot study of Lactobacillus reuteri ATCC 55730 for the prevention of antibiotic-associated diarrhea in hospitalized adults. J Clin Gastroenterol 45(9):785-789
17. Collier-Hyams LS, Sloane V, Batten BC, Neish AS (2006) Cutting edge: bacterial modulation of epithelial signaling via changes in neddylation of cullin-1. J Immunol 175:4194-4198 (Pubitemid 41361952)
18. Corrêa NB, Péret Filho LA, Penna FJ, Lima FM, Nicoli JR (2005) A randomized formula controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antibiotic-associated diarrhea in infants. J Clin Gastroenterol 39(5):385-389 (Pubitemid 40548075)
19. Costalos C, Skouteri V, Gounaris A, Sevastiadou S, Triandafilidou A, Ekonomidou C et al (2003) Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum Dev 74(2):89-96 (Pubitemid 37315841)
20. Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, Santarelli L, Nista EC, Cammarota G, Gasbarrini G, Gasbarrini A (2002) Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol 97(11):2744-2749 (Pubitemid 35265423)
21. Cui S, Hu Y (2012) Multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Int J Clin Exp Med 5(3):238-244
22. Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF (2002) Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study. Biol Neonate 82(2):103-108
23. Dapoigny M, Piche T, Ducrotte P, Lunaud B, Cardot JM, Bernalier-Donadille A (2012) Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome: a randomized, double-blind study. World J Gastroenterol 18(17):2067-2075
24. David L, Maurice C, Carmody R et al (2013) Diet rapidly and reproducibly alters the human gut microbiome. Nature. (Epub ahead of print)
25. Ding S, Lund PK (2011) Role of intestinal inflammation as an early event in obesity and insulin resistance. Curr Opin Clin Nutr 14:328-333
26. Drouault-Holowacz S, Bieuvelet S, Burckel A et al (2008) A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome. Gastroenterol Clin Biol 32(2):147-152 (Pubitemid 351637577)
27. Ducrotté P, Sawant P, Jayanthi V (2012) Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 18(30):4012-4018
28. Eckmann L (2006) Sensor molecules in intestinal innate immunity against bacterial infections. Curr Opin Gastroenterol 22(2):95-101
29. Enck P, Zimmermann K, Menke G et al (2008) A mixture of Escherichia coli (DSM 17252) and Enterococcus faecalis (DSM 16440) for treatment of the irritable bowel syndrome - a randomized controlled trial with primary care physicians. Neurogastroenterol Motil 20(10):1103-1109
30. Enss ML, Schmidt-Wittig U, Honer K et al (1994) Mechanical challenge causes alterations of rat colonic mucosa and released mucins. Alterations of mucosa and mucins. J Exp Anim Sci 36:128-140
31. Fernández-Carrocera LA, Solis-Herrera A, Cabanillas-Ayón M, Gallardo-Sarmiento RB, García-Pérez CS, Montaño- Rodríguez R, Echániz-Aviles MO (2013) Double-blind, randomised clinical assay to evaluate the efficacy of probiotics in preterm newborns weighing less than 1500 g in the prevention of necrotising enterocolitis. Arch Dis Child Fetal Neonatal Ed 98(1):F5-F9
32. Frohmader TJ, Chaboyer WP, Robertson IK, Gowardman J (2010) Decrease in frequency of liquid stool in enterally fed critically ill patients given the multispecies probiotic VSL#3: a pilot trial. Am J Crit Care 19(3):e1-e11
33. Fuller R (1989) Probiotics in man and animals. J Appl Bacteriol 66(5):365-378
34. Gawrońska A, Dziechciarz P, Horvath A, Szajewska H (2007) A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children. Aliment Pharmacol Ther 25(2):177-184 (Pubitemid 46046374)
35. Gionchetti P, Rizzello F, Venturi A et al (2000) Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double blind, placebo controlled trial. Gastroenterology 119:305-309 (Pubitemid 30621980)
36. Gionchetti P, Rizzello F, Helwig U et al (2003) Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo controlled trial. Gastroenterology 124:1202-1209 (Pubitemid 36531796)
37. Goto Y, Ivanov I (2013) Intestinal epithelial cells as mediators of the commensal-host immune cross talk. Immunol Cell Biol 91:204-214
38. Grossi E, Buresta R, Abbiati R, Cerutti R (2010) Pro-DIA study group. Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with acute diarrhea: a multicenter, randomized study in primary care. J Clin Gastroenterol 44(Suppl 1):S35-S41
39. Guandalini S, Pensabene L, Zikri MA, Dias JA, Casali LG, Hoekstra H et al (2000) Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial. J Pediatr Gastroenterol Nutr 30(1):54-60 (Pubitemid 30349946)
40. Guandalini S, Magazzu G, Chiaro A et al (2010) VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo-controlled, double-blind, crossover study. J Pediatr Gastroenterol Nutr 51(1):24-30
41. Guslandi M, Mezzi G, Sorghi M, Testoni PA (2000) Saccharomyces boulardii in maintenance treatment of Crohn's disease. Dig Dis Sci 45(7):1462-1464 (Pubitemid 30636526)
42. Guyonnet D, Chassany O, Ducrotte P, Picard C, Mouret M, Mercier CH, Matuchansky C (2007) Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial. Aliment Pharmacol Ther 26(3):475-486 (Pubitemid 47063138)
43. Hong KS, Kang HW, Im JP, Ji GE, Kim SG, Jung HC, Song IS, Kim JS (2009) Effect of probiotics on symptoms in Korean adults with irritable bowel syndrome. Gut Liver 3(2):101-107
44. Hooper LV (2004) Bacterial contributions to mammalian gut development. Trends Microbiol 12:129-134
45. Howarth GS, Wang H (2013) Role of endogenous microbiota, probiotics and their biological products in human health. Nutrients 5(1):58-81
46. Hvas CL, Kelsen J, Agnholt J et al (2007) Crohn's disease intestinal CD4 +T cells have impaired interleukin-10 production which is not restored by probiotic bacteria. Scand J Gastroenterol 42(5):592-601 (Pubitemid 46633815)
47. Ishikawa H, Akedo I, Umesaki Y, Tanaka R, Imaoka A, Otani T (2003) Randomized controlled trial of the effect of bifidobacteria-fermented milk on ulcerative colitis. J Am Coll Nutr 22(1):56-63 (Pubitemid 36164458)
48. Jiménez E, Marín ML, Martín R et al (2008) Is meconium from healthy newborns actually sterile? Res Microbiol 159(3):187-193
49. Jirapinyo P, Densupsoontorn N, Thamonsiri N, Wongarn R (2002) Prevention of antibiotic-associated diarrhea in infants by probiotics. J Med Assoc Thai 85(S2):S739-S742 (Pubitemid 35345830)
50. Kajander K, Hatakka K, Poussa T, Färkkilä M, Korpela R (2005) A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. Aliment Pharmacol Ther 22(5):387-394 (Pubitemid 41248105)
51. Kato K, Mizuno S, Umesaki Y, Ishii Y, Sugitani M, Imaoka A, Otsuka M et al (2004) Randomized placebo-controlled trial assessing the effect of bifidobacteria-fermented milk on active ulcerative colitis. Aliment Pharmacol Ther 20(10):1133-1141 (Pubitemid 39657947)
52. Ki Cha B, Mun Jung S, Hwan Choi C et al (2012) The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Gastroenterol 46(3):220-227
53. Kim HJ, Camilleri M, McKinzie S et al (2003) A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea- predominant irritable bowel syndrome. Aliment Pharmacol Ther 17(7):895-904 (Pubitemid 36459602)
54. Kim HJ, Vazquez Roque MI, Camilleri M et al (2005) A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil 17(5):687-696 (Pubitemid 41400717)
55. Kim MS, Hwang SS, Park EJ et al (2013) Strict vegetarian diet improves the risk factors associated with metabolic diseases by modulating gut microbiota and reducing intestinal inflammation. Environ Microbiol Rep 5(5):765-775
56. Koch S, Nusrat A (2012) The life and death of epithelia during inflammation: lessons learned from the gut. Annu Rev Pathol 7:35-60
57. Koebnick C, Wagner I, Leitzmann P, Stern U, Zunft HJ (2003) Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Can J Gastroenterol 17(11):655-659 (Pubitemid 37536846)
58. Kotowska M, Albrecht P, Szajewska H (2005) Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial. Aliment Pharmacol Ther 21(5):583-590 (Pubitemid 40381510)
59. Kruis W, Fric P, Pokrotnieks J, Lukás M, Fixa B, Kascák M, Kamm MA, Weismueller J et al (2004) Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53(11):1617-1623 (Pubitemid 39434105)
60. Kruis W, Chrubasik S, Boehm S, Stange C, Schulze J (2012) A double-blind placebo-controlled trial to study therapeutic effects of probiotic Escherichia coli Nissle 1917 in subgroups of patients with irritable bowel syndrome. Int J Colorectal Dis 27(4):467-474
61. La Rosa M, Bottaro G, Gulino N, Gambuzza F, Di Forti F, Inì G, Tornambè E (2003) Prevention of antibiotic-associated diarrhea with Lactobacillus sporogens and fructo-oligosaccharides in children. A multicentric double-blind vs placebo study. Minerva Pediatr 55(5):447-452 (Pubitemid 37474680)
62. Lawrence SJ, Korzenik JR, Mundy LM (2005) Probiotics for recurrent Clostridium difficile disease. J Med Microbiol 54(Pt 9):905-906 (Pubitemid 41216291)
63. Lee WJ (2008) Bacterial-modulated signaling pathways in gut homeostasis. Sci Signal 1:pe24
64. Li F, Hullar MA, Schwarz Y et al (2009) Human gut bacterial communities are altered by addition of cruciferous vegetables to a controlled fruit- and vegetable-free diet. J Nutr 139(9):1685-1691
65. Lin HC, Su BH, Chen AC, Lin TW, Tsai CH, Yeh TF, Oh W (2005) Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics 115(1):1-4 (Pubitemid 43046273)
66. Lin HC, Hsu CH, Chen HL, Chung MY, Hsu JF, Lien RI et al (2008) Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics 122(4):693-700
67. Lin PW, Myers LE, Ray L, Song SC, Nasr TR, Berardinelli AJ et al (2009) Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Radic Biol Med 47:1205-1211
68. Linnane AW, Kios M, Vitetta L (2007) Healthy aging: regulation of the metabolome by cellular redox modulation and prooxidant signaling systems: The essential roles of superoxide anion and hydrogen peroxide. Biogerontology 8:445-467 (Pubitemid 47365335)
69. Manzoni P, Mostert M, Leonessa ML, Priolo C, Farina D, Monetti C et al (2006) Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study. Clin Infect Dis 42(12):1735-1742 (Pubitemid 43839439)
70. Marcobal A, Sonnenburg JL (2012) Human milk oligosaccharide consumption by intestinal microbiota. Clin Microbiol Infect 18(Suppl. 4):12-15
71. Margreiter M, Ludl K, Phleps W, Kaehler ST (2006) Therapeutic value of a Lactobacillus gasseri and Bifidobacterium longum fixed bacterium combination in acute diarrhea: a randomized, double-blind, controlled clinical trial. Int J Clin Pharmacol Ther 44(5):207-215 (Pubitemid 43676439)
72. Marteau P, Lémann M, Seksik P, Laharie D, Colombel JF, Bouhnik Y, Cadiot G et al (2006) Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial. Gut 55(6):842-847 (Pubitemid 43764556)
73. Martin HM, Campbell BJ, Hart CA et al (2004) Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer. Gastroenterology 127:80-93 (Pubitemid 38962277)
74. Matthes H, Krummenerl T, Giensch M, Wolff C, Schulze J (2010) Clinical trial: probiotic treatment of acute distal ulcerative colitis with rectally administered Escherichia coli Nissle 1917 (EcN). BMC Complement Altern Med 15(10):13
75. Mazlyn MM, Nagarajah LH, Fatimah A, Norimah AK, Goh KL (2013) Effects of a probiotic fermented milk on functional constipation: a randomized, double-blind, placebo-controlled study. J Gastroenterol Hepatol 28(7):1141-1147
76. Mimura T, Rizzello F, Helwig U et al (2004) Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut 53:108-114 (Pubitemid 38083018)
77. Miyake K, Tanaka T, McNeil PL (2006) Disruption induced mucus secretion: repair and protection. PLoS Biol 4(9):e276
78. Mohan R, Koebnick C, Schildt J, Schmidt S, Mueller M, Possner M et al (2006) Effects of Bifidobacterium lactis Bb12 supplementation on intestinal microbiota of preterm infants: a double-blind, placebo-controlled, randomized study. J Clin Microbiol 44(11):4025-4031 (Pubitemid 44737246)
79. Montero Vega MT, de Andrés Martín A (2008) Toll-like receptors: a family of innate sensors of danger that alert and drive immunity. Allergol Immunopathol (Madr) 36(6):347-357
80. Mylonaki M, Rayment NB, Rampton DS et al (2005) Molecular characterization of rectal mucosa-associated bacterial flora in inflammatory bowel disease. Inflamm Bowel Dis 11(5):481-487 (Pubitemid 40704083)
81. Nagata S, Asahara T, Ohta T et al (2011) Effect of the continuous intake of probiotic-fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the faecal microflora in a health service facility for the aged. Br J Nutr 106(4):549-556
82. Nakamura Y, Omaye S (2012) Metabolic diseases and pro- and prebiotics: mechanistic insights. Nutr Metab 9:60
83. Neish AS (2013) Redox signaling mediated by the gut microbiota. Free Radic Res. doi:10.3109/10715762.2013.833331
84. Neish AS, Gewirtz AT, Zeng H, Young AN, Hobert ME, Karmali V et al (2000) Prokaryotic regulation of epithelial responses by inhibition of I kappa B-alpha ubiquitination. Science 289:1560-1563
85. Neuman MG, Nanau RM (2012) Inflammatory bowel disease: role of diet, microbiota, life style. Transl Res 160(1):29-44
86. Niedzielin K, Kordecki H, Birkenfeld B (2001) A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299 V in patients with irritable bowel syndrome. Eur J Gastroenterol Hepatol 13(10):1143-1147 (Pubitemid 33015878)
87. Nista EC, Candelli M, Cremonini F, Cazzato IA, Zocco MA, Franceschi F, Cammarota G, Gasbarrini G, Gasbarrini A (2004) Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo controlled trial. Aliment Pharmacol Ther 20(10):1181-1188 (Pubitemid 39657952)
88. Nobaek S, Johansson ML, Molin G, Ahrné S, Jeppsson B (2000) Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. Am J Gastroenterol 95(5):1231-1238 (Pubitemid 30263518)
89. O'Neill LA, Golenbock D, Bowie AG (2013) The history of toll-like receptors - redefining innate immunity. Nat Rev Immunol 13(6):453-460
90. Pereg D, Kimhi O, Tirosh A, Orr N, Kayouf R, Lishner M (2005) The effect of fermented yogurt on the prevention of diarrhea in a healthy adult population. Am J Infect Control 33(2):122-125 (Pubitemid 40283475)
91. Plummer S, Weaver MA, Harris JC, Dee P, Hunter J (2004) Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea. Int Microbiol 7(1):59-62 (Pubitemid 38901146)
92. Prantera C, Scribano ML, Falasco G, Andreoli A, Luzi C (2002) Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG. Gut 51(3):405-409
93. Ritchie ML, Romanuk TN (2012) A meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS One 7(4):e34938
94. Roberfroid MB (2007) Inulin-type fructans: functional food ingredients. J Nutr 137(11 Suppl):2493Se502S
95. Roberts LM, McCahon D, Holder R, Wilson S, Hobbs FD (2013) A randomised controlled trial of a probiotic 'functional food' in the management of irritable bowel syndrome. BMC Gastroenterol 7(13):45
96. Rougé C, Piloquet H, Butel MJ, Berger B, Rochat F, Ferraris L (2009) Oral supplementation with probiotics in very-low-birth-weight preterm infants: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 89(6):1828-1835
97. Salazar-Lindo E, Miranda-Langschwager P, Campos-Sanchez M, Chea-Woo E, Sack RB (2004) Lactobacillus casei strain GG in the treatment of infants with acute watery diarrhea: a randomized, double-blind, placebo controlled clinical trial [ISRCTN67363048]. BMC Pediatr 4:18
98. Samanta M, Sarkar M, Ghosh P, Ghosh JK, Sinha MK, Chatterjee S (2009) Prophylactic probiotics for prevention of necrotizing enterocolitis in very low birth weight newborns. J Trop Pediatr 55(2):128-131
99. Schmidt-Wittig U, Enss ML, Coenen M et al (1996) Response of rat colonic mucosa to a high fiber diet. Ann Nutr Metab 40:343-350 (Pubitemid 27119704)
100. Schultz M, Timmer A, Herfarth HH, Sartor RB, Vanderhoof JA, Rath HC (2004) Lactobacillus GG in inducing and maintaining remission of Crohn's disease. BMC Gastroenterol 4:5
101. Scoditti E, Calabriso N, Massaro M et al (2012) Mediterranean diet polyphenols reduce inflammatory angiogénesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch Biochem Biophys 527(2):81-89
102. Seki H, Shiohara M, Matsumura T, Miyagawa N, Tanaka M, Komiyama A, Kurata S (2003) Prevention of antibiotic-associated diarrhea in children by Clostridium butyricum MIYAIRI. Pediatr Int 45(1):86-90 (Pubitemid 36523566)
103. Serino M, Luche E, Gres S et al (2012) Metabolic adaptation to a high fat diet is associated with a change in the gut microbiota. Gut 61(4):543-553
104. Simrén M, Ohman L, Olsson J, Svensson U, Ohlson K, Posserud I, Strid H (2010) Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study. Aliment Pharmacol Ther 31(2):218-227
105. Song HJ, Kim JY, Jung SA, Kim SE, Park HS, Jeong Y, Hong SP et al (2010) Effect of probiotic Lactobacillus (Lacidofil® cap) for the prevention of antibiotic-associated diarrhea: a prospective, randomized, double-blind, multicenter study. J Korean Med Sci 25(12):1784-1791
106. Sood A, Midha V, Makharia GK, Ahuja V, Singal D, Goswami P, Tandon RK (2009) The probiotic preparation, VSL#3 induces remission in patients with mild-to-moderately active ulcerative colitis. Clin Gastroenterol Hepatol 7(11):1202-1209
107. Surawicz CM, McFarland LV, Greenberg RN, Rubin M, Fekety R, Mulligan ME, Garcia RJ, Brandmarker S, Bowen K, Borjal D, Elmer GW (2000) The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin Infect Dis 31(4):1012-1017 (Pubitemid 32299362)
108. Swidsinski A, Ladhoff A, Pernthaler A et al (2002) Mucosal flora in inflammatory bowel disease. Gastroenterology 122(1):44-54 (Pubitemid 34049193)
109. Szajewska H, Kotowska M, Mrukowicz JZ, Armańska M, Mikołajczyk W (2001) Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr 138(3):361-365 (Pubitemid 32207138)
110. Tabbers MM, Chmielewska A, Roseboom MG, Crastes N, Perrin C, Reitsma JB, Norbruis O, Szajewska H, Benninga MA (2011) Fermented milk containing Bifidobacterium lactis DN-173 010 in childhood constipation: a randomized, double-blind, controlled trial. Pediatrics 127(6):e1392-e1399
111. Thomas MR, Litin SC, Osmon DR, Corr AP, Weaver AL, Lohse CM (2001) Lack of effect of Lactobacillus GG on antibiotic-associated diarrhea: a randomized, placebo-controlled trial. Mayo Clin Proc 76(9):883-889 (Pubitemid 32825909)
112. Tien MS, Girardin SE, Regnault B et al (2006) Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. Immunol 176:1228-1237 (Pubitemid 43099727)
113. Tremaroli V, Bäckhed F (2012) Functional interactions between the gut microbiota and host metabolism. Nature 489(7415):242-249
114. Tursi A, Brandimarte G, Papa A, Giglio A, Elisei W, Giorgetti GM, Forti G et al (2010) Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study. Am J Gastroenterol 105(10):2218-2227
115. Van de Merwe JP, Schroder AM, Wensinck F et al (1988) The obligate anaerobic faecal flora of patients with Crohn's disease and their first-degree relatives. Scand J Gastroenterol 23(9):1125-1131
116. Van Gossum A, Dewit O, Louis E, de Hertogh G, Baert F, Fontaine F et al (2007) Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after lleo-caecal resection. Inflamm Bowel Dis 13(2):135-142 (Pubitemid 46806221)
117. Virk A, Mandrekar J, Berbari EF, Boyce TG, Fischer PR et al (2013) A randomized, double blind, placebo-controlled trial of an oral synbiotic (AKSB) for prevention of travelers' diarrhea. J Travel Med 20(2):88-94
118. Vitetta L, Sali A (2008) Probiotics, prebiotics and gastrointestinal health. Med Today 9:65-70
119. Vitetta L, Briskey D, Hayes E et al (2012) A review of the pharmacobiotic regulation of gastrointestinal inflammation by probiotics, commensal bacteria and prebiotics. Inflammopharmacology 20(5):251-266
120. Vitetta L, Linnane AW, Gobe GC (2013) From the gastrointestinal tract (GIT) to the kidneys: live bacterial cultures (probiotics) mediating reductions of uremic toxin levels via free radical signaling. Toxins (Basel) 5(11):2042-2057
121. Weizman Z, Asli G, Alsheikh A (2005) Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics 115(1):5-9 (Pubitemid 43046274)
122. Wenus C, Goll R, Loken EB, Biong AS, Halvorsen DS, Florholmen J (2008) Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink. Eur J Clin Nutr 62(2):299-301 (Pubitemid 351234268)
123. Whorwell PJ, Altringer L, Morel J et al (2006) Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. Am J Gastroenterol 101(7):1581-1590 (Pubitemid 43980633)
124. Wu GD, Chen J, Hoffmann C et al (2011) Linking long-term dietary patterns with gut microbial enterotypes. Science 334(6052):105-108
125. Wullt M, Hagslätt ML, Odenholt I (2003) Lactobacillus plantarum 299v for the treatment of recurrent Clostridium difficile-associated diarrhoea: a double-blind, placebo-controlled trial. Scand J Infect Dis 35(6-7):365-367 (Pubitemid 37038627)
126. Yan F, Cao H, Cover TL, Whitehead R, Washington MK, Polk DB (2007) Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 132:562-575 (Pubitemid 46274659)
127. Yang YX, He M, Hu G, Wei J, Pages P, Yang XH, Bourdu-Naturel S (2008) Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women. World J Gastroenterol 14(40):6237-6243
128. Yoon JS, Sohn W, Lee OY, Lee SP, Lee KN, Jun DW et al (2014) Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Gastroenterol Hepatol 29(1):52-59