Role of intestinal inflammation as an early event in obesity and insulin resistance

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 14, Issue 4, 2011, Pages 328-333

  Ding, Shengli ^a   Lund, Pauline K ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

cytokines; diet induced obesity; high fat diet; insulin resistance; intestinal inflammation

Indexed keywords

BIOLOGICAL MARKER; BUTYRIC ACID; C REACTIVE PROTEIN; CHOLECYSTOKININ; CHYLOMICRON; GAMMA INTERFERON; I KAPPA B; IMMUNOGLOBULIN A; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; NITRIC OXIDE; SATURATED FATTY ACID; SEROTONIN; SHORT CHAIN FATTY ACID; SUPPRESSOR OF CYTOKINE SIGNALING; TOLL LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; CARBOHYDRATE DIET; CELL DAMAGE; CHRONIC DISEASE; CROHN DISEASE; DIETARY INTAKE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ENTERITIS; ENTEROCHROMAFFIN CELL; ENTEROENDOCRINE CELL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HEALTH HAZARD; HUMAN; INSULIN RESISTANCE; LIPID DIET; MACROPHAGE MIGRATION; MICROFLORA; NONHUMAN; OBESITY; PH; PHOSPHORYLATION; REVIEW; SATIETY; SENSORY NERVE; SIGNAL TRANSDUCTION; SMALL INTESTINE; STOMACH PROTECTION; ULCERATIVE COLITIS; UPREGULATION; WEIGHT GAIN; WEIGHT REDUCTION;

ADIPOSE TISSUE; ANIMALS; BIOLOGICAL MARKERS; COLITIS; CYTOKINES; DIET; DIETARY FATS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; INTESTINES; LIPOPOLYSACCHARIDES; MODELS, ANIMAL; OBESITY; TOLL-LIKE RECEPTOR 5;

EID: 79959271480     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3283478727     Document Type: Review

References (44)

1. Kelly T, Yang W, Chen CS, et al. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 2008; 32:1431-1437.
2. Das UN. Obesity: genes, brain, gut, and environment. Nutrition 2010; 26: 459-473.
3. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011; 11:98-107.
4. Shoelson SE, Goldfine AB. Getting away from glucose: fanning the flames of obesity-induced inflammation. Nat Med 2009; 15:373-374.
5. Tanti JF, Jager J. Cellular mechanisms of insulin resistance: role of stressregulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr Opin Pharmacol 2009; 9:753-762.
6. Kant P, Hull MA. Excess body weight and obesity-the link with gastrointestinal and hepatobiliary cancer. Nat Rev Hepatol 2011; 8:224-238.
7. Maury E, Brichard SM. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 2010; 314:1-16.
8. Lebrun P, Van Obberghen E. SOCS proteins causing trouble in insulin action. Acta Physiol (Oxf) 2008; 192:29-36. (Pubitemid 350265362)
9. Ding S, Chi MM, Scull BP, et al. High-fat diet: bacteria interactions promote intestinal inflammation, which precedes and correlates with obesity and insulin resistance in mouse. PLoS One 2010; 5:e12191.
10. Kim F, Pham M, Maloney E, et al. Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance. Arterioscler Thromb Vasc Biol 2008; 28:1982-1988.
11. de La Serre CB, Ellis CL, Lee J, et al. Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am J Physiol Gastrointest Liver Physiol 2010; 299:G440-G448.
12. de Wit NJ, Bosch-Vermeulen H, de Groot PJ, et al. The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice. BMC Med Genomics 2008; 1:14.
13. Spagnuolo MI, Cicalese MP, Caiazzo MA, et al. Relationship between severe obesity and gut inflammation in children: what's next? Ital J Pediatr 2010; 36:66.
14. Pendyala S, Natarajan V. Redox regulation of Nox proteins. Respir Physiol Neurobiol 2010; 174:265-271.
15. Pendyala S, Neff LM, Suarez-Farinas M, Holt PR. Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis. Am J Clin Nutr 2011; 93:234-242.
16. Brignardello J, Morales P, Diaz E, et al. Pilot study: alterations of intestinal microbiota in obese humans are not associated with colonic inflammation or disturbances of barrier function. Aliment Pharmacol Ther 2010; 32 (11-12):1307-1314.
17. Tiihonen K, Ouwehand AC, Rautonen N. Effect of overweight on gastrointestinal microbiology and immunology: correlation with blood biomarkers. Br J Nutr 2010; 103:1070-1078.
18. Musso G, Gambino R, Cassader M. Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes. Annu Rev Med 2011; 62:361-380.
19. Backhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci USA 2007; 104:979-984. (Pubitemid 46154722)
20. Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006; 444:1027-1031. (Pubitemid 46018515)
21. Malo MS, Alam SN, Mostafa G, et al. Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota. Gut 2010; 59:1476-1484.
22. Hildebrandt MA, Hoffmann C, Sherrill-Mix SA, et al. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 2009; 137:1716-1724.
23. Garrett WS, Gallini CA, Yatsunenko T, et al. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe 2010; 8:292-300.
24. Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007; 56:1761-1772. (Pubitemid 47025442)
25. Cani PD, Delzenne NM, Amar J, Burcelin R. Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding. Pathol Biol (Paris) 2008; 56:305-309.
26. Cani PD, Bibiloni R, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008; 57:1470-1481.
27. Amar J, Burcelin R, Ruidavets JB, et al. Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr 2008; 87:1219-1223. (Pubitemid 351679761)
28. Ghanim H, Abuaysheh S, Sia CL, et al. Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care 2009; 32:2281-2287.
29. Deopurkar R, Ghanim H, Friedman J, et al. Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care 2010; 33:991-997.
30. Membrez M, Blancher F, Jaquet M, et al. Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. FASEB J 2008; 22:2416-2426. (Pubitemid 351948659)
31. Ghoshal S, Witta J, Zhong J, et al. Chylomicrons promote intestinal absorption of lipopolysaccharides. J Lipid Res 2009; 50:90-97.
32. De Bandt J, Waligora-Dupriet A, Butel M. Intestinal microbiota in inflammation and insulin resistance: relevance to humans. Curr Opin Clin Nutr Metabol Care 2011.
33. Bol-Schoenmakers M, Fiechter D, Raaben W, et al. Intestinal alkaline phosphatase contributes to the reduction of severe intestinal epithelial damage. Eur J Pharmacol 2010; 633 (1-3):71-77.
34. Gao Z, Yin J, Zhang J, et al. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 2009; 58:1509-1517.
35. Vijay-Kumar M, Sanders CJ, Taylor RT, et al. Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest 2007; 117:3909-3921. (Pubitemid 350224100)
36. Vijay-Kumar M, Aitken JD, Carvalho FA, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010; 328:228-231.
37. de Lartigue G, de La Serre CB, Raybould HE. Vagal afferent neurons in high fat diet-induced obesity; intestinal microflora, gut inflammation and cholecystokinin. Physiol Behav 2011.
38. Bertrand RL, Senadheera S, Markus I, et al. A Western diet increases serotonin availability in rat small intestine. Endocrinology 2011; 152:36-47.
39. Zhou J, Martin RJ, Tulley RT, et al. Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents. Am J Physiol Endocrinol Metab 2008; 295:E1160-E1166.
40. Delzenne NM, Cani PD, Neyrinck AM. Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data. J Nutr 2007; 137 (11 Suppl):2547S-2551S. (Pubitemid 350058733)
41. Garrison AP, Dekaney CM, von Allmen DC, et al. Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion. Am J Physiol Gastrointest Liver Physiol 2009; 296:G643-G650.
42. Moore BA, Peffer N, Pirone A, et al. GLP-2 receptor agonism ameliorates inflammation and gastrointestinal stasis in murine postoperative ileus. J Pharmacol Exp Ther 2010; 333:574-583.
43. Cani PD, Possemiers S, Van de Wiele T, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009; 58:1091-1103.
44. Cani PD, Knauf C, Iglesias MA, et al. Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes 2006; 55:1484-1490. (Pubitemid 44195391)