Effects of Bifidobacterium lactis Bb12 supplementation on intestinal microbiota of preterm infants: A double-blind, placebo-controlled, randomized study

Journal of Clinical Microbiology

Volumn 44, Issue 11, 2006, Pages 4025-4031

  Mohan, Ruchika ^a   Koebnick, Corinna ^a   Schildt, Janko ^b   Schmidt, Sabine ^a   Mueller, Manfred ^b   Possner, Mike ^c   Radke, Michael ^b   Blaut, Michael ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b KLINIKUM ERNST VON BERGMANN   (Germany)

^c Nestlé Nutrition ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; CEFOTAXIME; IMIPENEM; PENICILLIN G; PIPERACILLIN; PLACEBO; PROBIOTIC AGENT; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM CULTURE; BIFIDOBACTERIUM ANIMALIS; BIFIDOBACTERIUM LACTIS BB12; CLINICAL TRIAL; CLOSTRIDIUM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ENTEROBACTERIACEAE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; INFANT; INFANT FEEDING; MALE; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

BIFIDOBACTERIUM; CLOSTRIDIUM; COLONY COUNT, MICROBIAL; CULTURE MEDIA; DOUBLE-BLIND METHOD; DRUG RESISTANCE, BACTERIAL; ENTEROBACTERIACEAE; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT, NEWBORN; INFANT, PREMATURE; INTESTINES; MALE; PROBIOTICS;

BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS; CLOSTRIDIA; CLOSTRIDIUM; ENTEROBACTERIACEAE;

EID: 33750939835     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.00767-06     Document Type: Article

References (37)

1. Agarwal, R., N. Sharma, R. Chaudhry, A. Deorari, V. K. Paul, I. H. Gewolb, and P. Panigrahi. 2003. Effects of oral Lactobacillus GG on enteric microflora in low-birth-weight neonates. J. Pediatr. Gastroenterol. Nutr. 36:397-402.
2. Alm, E. W., D. B. Oerther, N. Larsen, D. A. Stahl, and L. Raskin. 1996. The oligonucleotide probe database. Appl. Environ. Microbiol. 62:3557-3559.
3. Amann, R. I., L. Krumholz, and D. A. Stahl. 1990. Fluorescent- oligonucleotide probing of whole cells for determinative, phylogenetic, and environmental studies in microbiology. J. Bacteriol. 172:762-770.
4. Baley, J. E., R. M. Kliegman, B. Boxerbaum, and A. A. Fanaroff. 1986. Fungal colonization in the very low birth weight infant. Pediatrics 78:225-232.
5. Blakey, J. L., L. Lubitz, G. L. Barnes, R. F. Bishop, N. T. Campbell, and G. L. Gillam. 1982. Development of gut colonisation in pre-term neonates. J. Med. Microbiol. 15:519-529.
6. Costalos, C., V. Skouteri, A. Gounaris, S. Sevastiadou, A. Triandafilidou, C. Ekonomidou, F. Kontaxaki, and V. Petrochilou. 2003. Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum. Dev. 74:89-96.
7. de la Cochetiere, M. F., H. Piloquet, C. des Robert, D. Darmaun, J. P. Galmiche, and J. C. Roze. 2004. Early intestinal bacterial colonization and necrotizing enterocolitis in premature infants: the putative role of Clostridium. Pediatr. Res. 56:366-370.
8. Deutsches Institut Fur Normung. 2000. DIN 58940-3 Bbl 1. Medical microbiology. Susceptibility testing of pathogens to antimicrobial agents. Part 3: agar diffusion test. Data for the interpretation of inhibition zone diameters, p. 175-184. Deutsches Institut Fur Normung. Berlin, Germany.
9. Franks, A. H., H. J. Harmsen, G. C. Raangs, G. J. Jansen, F. Schut, and G. W. Welling. 1998. Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Appl. Environ. Microbiol. 64:3336-3345.
10. Giovannoni, S. J., E. F. DeLong, G. J. Olsen, and N. R. Pace. 1988. Phylogenetic group-specific oligodeoxynucleotide probes for identification of single microbial cells. J. Bacteriol. 170:720-726.
11. Harmsen, H. J., G. C. Raangs, T. He, J. E. Degener, and G. W. Welling. 2002. Extensive set of 16S rRNA-based probes for detection of bacteria in human feces. Appl. Environ. Microbiol. 68:2982-2990.
12. Harmsen, H. J., P. Elfferich, F. Schut, and G. W. Welling. 1999. A 16S rRNA-targeted probe for detection of lactobacilli and enterococci in fecal samples bv fluorescent in situ hybridization. Microb. Ecol. Health Dis. 11:3-12.
13. Harmsen, H. J., A. C. Wildeboer-Veloo, G. C. Raangs, A. A. Wagendorp, N. Klijn, J. G. Bindels, and G. W. Welling. 2000. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection method. J. Pediatr. Gastroenterol. Nutr. 30:61-67.
14. He, F., A. C. Ouwehand, E. Isolauri, H. Hashimoto, Y. Benno, and S. Salminen. 2001. Comparison of mucosal adhesion and species identification of bifidobacteria isolated from healthy and allergic infants. FEMS Immunol. Med. Microbiol. 30:43-47.
15. He, F., A. C. Ouwehand, E. Isolauri, M. Hosoda, Y. Benno, and S. Salminen. 2001. Differences in composition and mucosal adhesion of bifidobacteria isolated from healthy adults and healthy seniors. Curr. Microbiol. 43:351-354.
16. Juntunen, M., P. V. Kirjavainen, A. C. Ouwehand, S. J. Salminen, and E. Isolauri. 2001. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin. Diagn. Lab. Immunol. 8:293-296.
17. Langendijk, P. S., F. Schut, G. J. Jansen, G. C. Raangs, G. R. Kamphuis, M. H. Wilkinson, and G. W. Welling. 1995. Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in fecal samples. Appl. Environ. Microbiol. 61:3069-3075.
18. Leclercq, R., and E. Derlot. 1988. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N. Engl. J. Med. 21:157-161.
19. Lee, S. H., and C. Malone. 1993. Use of multiple 16S rRNA-targeted fluorescent probes to increase signal strength and measure cellular RNA from natural planktonic bacteria. Mar. Ecol. Prog. Ser. 101:193-201.
20. Li, Y., T. Shimizu, A. Hosaka, N. Kaneko, Y. Ohtsuka, and Y. Yamashiro. 2004. Effects of Bifidobacterium breve supplementation on intestinal flora of low birth weight infants. Pediatr. Int. 46:509-515.
21. Mackie, R. I., A. Sghir, and H. R. Gaskins. 1999. Developmental microbial ecology of the neonatal gastrointestinal tract. Am. J. Clin. Nutr. 69(Suppl):1035S-1045S.
22. Manz, W., R. Amann, W. Ludwig, M. Vancanneyt, and K. H. Schleifer. 1996. Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment. Microbiology 142(Pt 5):1097-1106.
23. Matsuki, S., E. Ozaki, M. Shozu, M. Inoue, S. Shimizu, N. Yamaguchi, T. Karasawa, T. Yamagishi, and S. Nakamura. 2005. Colonization by Clostridium difficile of neonates in a hospital, and infants and children in three day-care facilities of Kanazawa, Japan. Int. Microbiol. 8:43-48.
24. Mikkelsen, L. L., C. Bendixen, M. Jakobsen, and B. B. Jensen. 2003. Enumeration of bifidobacteria in gastrointestinal samples from piglets. Appl. Environ Microbiol. 69:654-658.
25. Millar, M. R., C. J. Linton, A. Cade, D. Glancy, M. Hall, and H. Jalal. 1996. Application of 16S rRNA gene PCR to study bowel flora of preterm infants with and without necrotizing enterocolitis. J. Clin. Microbiol. 34:2506-2510.
26. Moubareck, C., F. Gavini, L. Vaugien, M. J. Butel, and F. Doucet-Populaire. 2005. Antimicrobial susceptibility of bifidobacteria. J. Antimicrob. Chemother. 55:38-44.
27. Poulsen, L. K., F. Lan, C. S. Kristensen, P. Hobolth, S. Molin, and K. A. Krogfelt. 1994. Spatial distribution of Escherichia coli in the mouse large intestine inferred from rRNA in situ hybridization. Infect. Immun. 62:5191-5194.
28. Reef, S. E., B. A. Lasker, D. S. Butcher, M. M. McNeil, R. Pruitt, H. Keyserling, and W. R. Jarvis. 1998. Nonperinatal nosocomial transmission of Candida albicans in a neonatal intensive care unit: prospective study. J. Clin. Microbiol. 36:1255-1259.
29. Rotimi, V. O., S. A. Olowe, and I. Ahmed. 1985. The development of bacterial flora of premature neonates. J. Hyg. (London) 94:309-318.
30. Sakata, H., H. Yoshioka, and J. Fujita. 1985. Development of the intestinal flora in very low birth weight infants compared to normal full term newborns. Eur. J. Pediatr. 144:186-190.
31. Schwiertz, A., B. Gruhl, M. Löbnitz, P. Michel, M. Radke, and M. Blaut. 2003. Development of the intestinal bacterial composition in hospitalized preterm infants in comparison with breast-fed, full term infants. Pediatr. Res. 54:393-399.
32. Suau, A., R. Bonnet, M. Sutren, J. J. Godon, G. R. Gibson, M. D. Collins, and J. Dore. 1999. Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. Appl. Environ. Microbiol. 65:4799-4807.
33. Thiel, R., and M. Blaut. 2005. An improved method for the automated enumeration of fluorescently labelled bacteria in human feces. J. Microbiol. Methods 61:369-379.
34. Trebesius, K., L. Leitritz, K. Adler, S. Schubert, I. B. Autenrieth, and J. Heesemann. 2000. Culture independent and rapid identification of bacterial pathogens in necrotising fasciitis and streptococcal toxic shock syndrome by fluorescence in situ hybridisation. Med. Microbiol. Immunol. (Berlin) 188:169-175.
35. Yoshioka, H., K. Iseki, and K. Fujita. 1983. Development and differences of intestinal flora in the neonatal period in breast-fed and bottle-fed infants. Pediatrics 72:317-321.
36. Yu, J. L., S. X. Wu, and H. Q. Jia. 2001. Study on antimicrobial susceptibility of bacteria causing neonatal infections: a 12 year study (1987-1998). Singapore Med. J. 42:107-110.
37. Zhou, J. S., C. J. Pillidge, P. K. Gopal, and H. S. Gill. 2005. Antibiotic susceptibility profiles of new probiotic Lactobacillus and Bifidobacterium strains. Int. J. Food Microbiol. 98:211-217.