메뉴 건너뛰기




Volumn 221, Issue 3, 2014, Pages 381-390

Inactivation of the adrenergic receptor β2 disrupts glucose homeostasis in mice

Author keywords

Adaptive thermogenesis; Brown adipose tissue (BAT); Obesity; adrenergic receptors

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CHOLESTEROL; DOBUTAMINE; GLUCOSE; MESSENGER RNA; NORADRENALIN; OXYGEN; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1;

EID: 84901594770     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-13-0526     Document Type: Article
Times cited : (29)

References (44)
  • 1
    • 0030061334 scopus 로고    scopus 로고
    • Vascular smooth muscle relaxation by a-adrenoceptor blocking action of dobutamine in isolated rabbit aorta
    • doi:10.1097/00005344-199601000-00006
    • Aikawa J, Fukazawa M, Ishikawa M, Moroi M, Namiki A & Yamaguchi T 1996 Vascular smooth muscle relaxation by a-adrenoceptor blocking action of dobutamine in isolated rabbit aorta. Journal of Cardiovascular Pharmacology 27 33-36. (doi:10.1097/00005344-199601000-00006)
    • (1996) Journal of Cardiovascular Pharmacology , vol.27 , pp. 33-36
    • Aikawa, J.1    Fukazawa, M.2    Ishikawa, M.3    Moroi, M.4    Namiki, A.5    Yamaguchi, T.6
  • 2
    • 0031252806 scopus 로고    scopus 로고
    • Role of b1-and b3-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes
    • Atgie C, D'Allaire F & Bukowiecki LJ 1997 Role of b1-and b3-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes. American Journal of Physiology 273 C1136-C1142.
    • (1997) American Journal of Physiology , vol.273
    • Atgie, C.1    D'Allaire, F.2    Bukowiecki, L.J.3
  • 3
    • 0037008157 scopus 로고    scopus 로고
    • AR signaling required for diet-induced thermogenesis and obesity resistance
    • doi:10.1126/science. 1073160
    • Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK & Lowell BB 2002 bAR signaling required for diet-induced thermogenesis and obesity resistance. Science 297 843-845. (doi:10.1126/science. 1073160)
    • (2002) Science , vol.297 , pp. 843-845
    • Bachman, E.S.1    Dhillon, H.2    Zhang, C.Y.3    Cinti, S.4    Bianco, A.C.5    Kobilka, B.K.6    Lowell, B.B.7
  • 4
    • 59349116234 scopus 로고    scopus 로고
    • Comparison of carvedilol and metoprolol on serum lipid concentration in diabetic hypertensive patients
    • doi:10.1111/j.1463-1326.2008.00927.x
    • Bell DS, Bakris GL & McGill JB 2009 Comparison of carvedilol and metoprolol on serum lipid concentration in diabetic hypertensive patients. Diabetes, Obesity & Metabolism 11 234-238. (doi:10.1111/j.1463-1326.2008.00927.x)
    • (2009) Diabetes, Obesity & Metabolism , vol.11 , pp. 234-238
    • Bell, D.S.1    Bakris, G.L.2    McGill, J.B.3
  • 6
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • doi:10.1152/physrev.00015.2003
    • Cannon B & Nedergaard J 2004 Brown adipose tissue: function and physiological significance. Physiological Reviews 84 277-359. (doi:10.1152/physrev.00015.2003)
    • (2004) Physiological Reviews , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 7
    • 79953108468 scopus 로고    scopus 로고
    • Role of b-adrenoceptors in glucose uptake in astrocytes using b-adrenoceptor knockout mice
    • doi:10.1111/j.1476-5381.2010.01153.x
    • Catus SL, Gibbs ME, Sato M, Summers RJ & Hutchinson DS 2011 Role of b-adrenoceptors in glucose uptake in astrocytes using b-adrenoceptor knockout mice. British Journal of Pharmacology 162 1700-1715. (doi:10.1111/j.1476-5381.2010.01153.x)
    • (2011) British Journal of Pharmacology , vol.162 , pp. 1700-1715
    • Catus, S.L.1    Gibbs, M.E.2    Sato, M.3    Summers, R.J.4    Hutchinson, D.S.5
  • 8
    • 1142299747 scopus 로고    scopus 로고
    • Norepinephrine increases glucose transport in brown adipocytes via b3-adrenoceptors through a cAMP, PKA, and PI3-kinase-dependent pathway stimulating conventional and novel PKCs
    • doi:10.1210/en.2003-0857
    • Chernogubova E, Cannon B & Bengtsson T 2004 Norepinephrine increases glucose transport in brown adipocytes via b3-adrenoceptors through a cAMP, PKA, and PI3-kinase-dependent pathway stimulating conventional and novel PKCs. Endocrinology 145 269-280. (doi:10.1210/en.2003-0857)
    • (2004) Endocrinology , vol.145 , pp. 269-280
    • Chernogubova, E.1    Cannon, B.2    Bengtsson, T.3
  • 9
    • 10744221610 scopus 로고    scopus 로고
    • Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis
    • doi:10.2337/diabetes.53.3.577
    • Christoffolete MA, Linardi CC, de Jesus L, Ebina KN, Carvalho SD, Ribeiro MO, Rabelo R, Curcio C, Martins L, Kimura ET et al. 2004 Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Diabetes 53 577-584. (doi:10.2337/diabetes.53.3.577)
    • (2004) Diabetes , vol.53 , pp. 577-584
    • Christoffolete, M.A.1    Linardi, C.C.2    de Jesus, L.3    Ebina, K.N.4    Carvalho, S.D.5    Ribeiro, M.O.6    Rabelo, R.7    Curcio, C.8    Martins, L.9    Kimura, E.T.10
  • 11
    • 0035787319 scopus 로고    scopus 로고
    • The b-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis
    • doi:10.1210/rp.56.1.309
    • Collins S & Surwit RS 2001 The b-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Progress in Hormone Research 56 309-328. (doi:10.1210/rp.56.1.309)
    • (2001) Recent Progress in Hormone Research , vol.56 , pp. 309-328
    • Collins, S.1    Surwit, R.S.2
  • 13
    • 0031685380 scopus 로고    scopus 로고
    • Gln27Glu variant of the human β2-adrenoreceptor gene is not associated with early-onset obesity in Danish men
    • doi:10.2337/diabetes.47.10.1657
    • Echwald SM, Sorensen TI, Tybjaerg-Hansen A, Andersen T & Pedersen O 1998 Gln27Glu variant of the human β2-adrenoreceptor gene is not associated with early-onset obesity in Danish men. Diabetes 47 1657-1658. (doi:10.2337/diabetes.47.10.1657)
    • (1998) Diabetes , vol.47 , pp. 1657-1658
    • Echwald, S.M.1    Sorensen, T.I.2    Tybjaerg-Hansen, A.3    Andersen, T.4    Pedersen, O.5
  • 15
    • 41549147564 scopus 로고    scopus 로고
    • Greenspan's Basic and Clinical Endocrinology
    • 8th edn. New York: McGraw-Hill Companies, Incorporated
    • Gardner D & Shoback D 2007 Greenspan's Basic and Clinical Endocrinology, 8th edn. New York: McGraw-Hill Companies, Incorporated.
    • (2007)
    • Gardner, D.1    Shoback, D.2
  • 16
    • 77956048486 scopus 로고    scopus 로고
    • Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis
    • doi:10.1210/en.2010-0511
    • Hall JA, Ribich S, Christoffolete MA, Simovic G, Correa-MedinaM, Patti ME & Bianco AC 2010 Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology 151 4573-4582. (doi:10.1210/en.2010-0511)
    • (2010) Endocrinology , vol.151 , pp. 4573-4582
    • Hall, J.A.1    Ribich, S.2    Christoffolete, M.A.3    Simovic, G.4    Correa-Medina, M.5    Patti, M.E.6    Bianco, A.C.7
  • 18
    • 15144343818 scopus 로고    scopus 로고
    • Role of endothelium and KC channels in dobutamine-induced relaxation in rat mesenteric artery
    • doi:10.1111/j.1440-1681.1998.tb02223.x
    • Huang Y, Kwok KH, Chan NW, Lau CW & Chen ZY 1998 Role of endothelium and KC channels in dobutamine-induced relaxation in rat mesenteric artery. Clinical and Experimental Pharmacology & Physiology 25 405-411. (doi:10.1111/j.1440-1681.1998.tb02223.x)
    • (1998) Clinical and Experimental Pharmacology & Physiology , vol.25 , pp. 405-411
    • Huang, Y.1    Kwok, K.H.2    Chan, N.W.3    Lau, C.W.4    Chen, Z.Y.5
  • 21
    • 18644381610 scopus 로고    scopus 로고
    • β1/β2/β3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting
    • doi:10.1016/S0014-5793(02)03387-2
    • Jimenez M, Leger B, Canola K, Lehr L, Arboit P, Seydoux J, Russell AP, Giacobino JP, Muzzin P & Preitner F 2002 β1/β2/β3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Letters 530 37-40. (doi:10.1016/S0014-5793(02)03387-2)
    • (2002) FEBS Letters , vol.530 , pp. 37-40
    • Jimenez, M.1    Leger, B.2    Canola, K.3    Lehr, L.4    Arboit, P.5    Seydoux, J.6    Russell, A.P.7    Giacobino, J.P.8    Muzzin, P.9    Preitner, F.10
  • 22
    • 34247519217 scopus 로고    scopus 로고
    • Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation
    • doi:10.1038/sj.ijo.0803499
    • Jocken JW, Blaak EE, Schiffelers S, Arner P, van Baak MA & Saris WH 2007 Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation. International Journal of Obesity 31 813-819. (doi:10.1038/sj.ijo.0803499)
    • (2007) International Journal of Obesity , vol.31 , pp. 813-819
    • Jocken, J.W.1    Blaak, E.E.2    Schiffelers, S.3    Arner, P.4    van Baak, M.A.5    Saris, W.H.6
  • 25
    • 0031436966 scopus 로고    scopus 로고
    • Human Beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte Beta-2 adrenoceptor function
    • doi:10.1172/JCI119854
    • Large V, Hellstrom L, Reynisdottir S, Lonnqvist F, Eriksson P, Lannfelt L & Arner P 1997 Human Beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte Beta-2 adrenoceptor function. Journal of Clinical Investigation 100 3005-3013. (doi:10.1172/JCI119854)
    • (1997) Journal of Clinical Investigation , vol.100 , pp. 3005-3013
    • Large, V.1    Hellstrom, L.2    Reynisdottir, S.3    Lonnqvist, F.4    Eriksson, P.5    Lannfelt, L.6    Arner, P.7
  • 27
    • 77950237717 scopus 로고    scopus 로고
    • The changed metabolic world with human brown adipose tissue: therapeutic visions
    • doi:10.1016/j.cmet.2010.03.007
    • Nedergaard J & Cannon B 2010 The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metabolism 11 268-272. (doi:10.1016/j.cmet.2010.03.007)
    • (2010) Cell Metabolism , vol.11 , pp. 268-272
    • Nedergaard, J.1    Cannon, B.2
  • 28
    • 33644501159 scopus 로고    scopus 로고
    • Multiple signalling pathways involved in β2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells
    • doi:10.1038/sj.bjp.0706626
    • Nevzorova J, Evans BA, Bengtsson T & Summers RJ 2006 Multiple signalling pathways involved in β2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells. British Journal of Pharmacology 147 446-454. (doi:10.1038/sj.bjp.0706626)
    • (2006) British Journal of Pharmacology , vol.147 , pp. 446-454
    • Nevzorova, J.1    Evans, B.A.2    Bengtsson, T.3    Summers, R.J.4
  • 29
    • 0029671269 scopus 로고    scopus 로고
    • Expression of β3-adrenoceptor and stimulation of glucose transport by b3-agonists in brown adipocyte primary culture
    • doi:10.1093/oxfordjournals. jbchem.a021196
    • Nikami H, Shimizu Y, Sumida M, Minokoshi Y, Yoshida T, Saito M & Shimazu T 1996 Expression of β3-adrenoceptor and stimulation of glucose transport by b3-agonists in brown adipocyte primary culture. Journal of Biochemistry 119 120-125. (doi:10.1093/oxfordjournals. jbchem.a021196)
    • (1996) Journal of Biochemistry , vol.119 , pp. 120-125
    • Nikami, H.1    Shimizu, Y.2    Sumida, M.3    Minokoshi, Y.4    Yoshida, T.5    Saito, M.6    Shimazu, T.7
  • 32
    • 62749092628 scopus 로고    scopus 로고
    • Demographic analyses of the effects of carvedilol vs metoprolol on glycemic control and insulin sensitivity in patients with type 2 diabetes and hypertension in the Glycemic Effects in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) study
    • doi:10.1111/j.1559-4572.2008.00017.x
    • Phillips RA, Fonseca V, Katholi RE, McGill JB, Messerli FH, Bell DS, Raskin P, Wright JT Jr, Iyengar M, Anderson KM et al. 2008 Demographic analyses of the effects of carvedilol vs metoprolol on glycemic control and insulin sensitivity in patients with type 2 diabetes and hypertension in the Glycemic Effects in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) study. Journal of the Cardiometabolic Syndrome 3 211-217. (doi:10.1111/j.1559-4572.2008.00017.x)
    • (2008) Journal of the Cardiometabolic Syndrome , vol.3 , pp. 211-217
    • Phillips, R.A.1    Fonseca, V.2    Katholi, R.E.3    McGill, J.B.4    Messerli, F.H.5    Bell, D.S.6    Raskin, P.7    Wright Jr., J.T.8    Iyengar, M.9    Anderson, K.M.10
  • 33
    • 79551492289 scopus 로고    scopus 로고
    • ADRB2 haplotype is associated with glucose tolerance and insulin sensitivity in obese postmenopausal women
    • doi:10.1038/oby.2010.197
    • Prior SJ, Goldberg AP & Ryan AS 2011 ADRB2 haplotype is associated with glucose tolerance and insulin sensitivity in obese postmenopausal women. Obesity 19 396-401. (doi:10.1038/oby.2010.197)
    • (2011) Obesity , vol.19 , pp. 396-401
    • Prior, S.J.1    Goldberg, A.P.2    Ryan, A.S.3
  • 35
    • 0033546313 scopus 로고    scopus 로고
    • Cardiovascular and metabolic alterations in mice lacking both b1-and β2-adrenergic receptors
    • doi:10.1074/jbc.274.24.16701
    • Rohrer DK, Chruscinski A, Schauble EH, Bernstein D & Kobilka BK 1999 Cardiovascular and metabolic alterations in mice lacking both b1-and β2-adrenergic receptors. Journal of Biological Chemistry 274 16701-16708. (doi:10.1074/jbc.274.24.16701)
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 16701-16708
    • Rohrer, D.K.1    Chruscinski, A.2    Schauble, E.H.3    Bernstein, D.4    Kobilka, B.K.5
  • 36
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in dietinduced thermogenesis
    • doi:10.1038/281031a0
    • Rothwell NJ & Stock MJ 1979 A role for brown adipose tissue in dietinduced thermogenesis. Nature 281 31-35. (doi:10.1038/281031a0)
    • (1979) Nature , vol.281 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 37
    • 33745946543 scopus 로고    scopus 로고
    • Do the metabolic effects of b blockers make them leading or supporting antihypertensive agents in the treatment of hypertension?
    • quiz 357-358. (doi:10.1111/j.1524-6175.2005.04679.x)
    • Sarafidis PA & Bakris GL 2006 Do the metabolic effects of b blockers make them leading or supporting antihypertensive agents in the treatment of hypertension? Journal of Clinical Hypertension 8 351-356 quiz 357-358. (doi:10.1111/j.1524-6175.2005.04679.x)
    • (2006) Journal of Clinical Hypertension , vol.8 , pp. 351-356
    • Sarafidis, P.A.1    Bakris, G.L.2
  • 40
    • 84866627441 scopus 로고    scopus 로고
    • Human-specific SNP in obesity genes, adrenergic receptor beta 2 (ADRB2), beta 3 (ADRB3), and PPARg2 (PPARG), during primate evolution
    • doi:10.1371/journal.pone. 0043461
    • Takenaka A, Nakamura S, Mitsunaga F, Inoue-Murayama M, Udono T & Suryobroto B 2012 Human-specific SNP in obesity genes, adrenergic receptor beta 2 (ADRB2), beta 3 (ADRB3), and PPARg2 (PPARG), during primate evolution. PLoS ONE 7 e43461. (doi:10.1371/journal.pone. 0043461)
    • (2012) PLoS ONE , vol.7
    • Takenaka, A.1    Nakamura, S.2    Mitsunaga, F.3    Inoue-Murayama, M.4    Udono, T.5    Suryobroto, B.6
  • 43
    • 0035051032 scopus 로고    scopus 로고
    • Clustering of metabolic abnormalities in obese individuals: the role of genetic factors
    • doi:10.3109/07853890109002062
    • Ukkola O & Bouchard C 2001 Clustering of metabolic abnormalities in obese individuals: the role of genetic factors. Annals of Medicine 33 79-90. (doi:10.3109/07853890109002062)
    • (2001) Annals of Medicine , vol.33 , pp. 79-90
    • Ukkola, O.1    Bouchard, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.