메뉴 건너뛰기




Volumn 31, Issue 5, 2007, Pages 813-819

Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation

Author keywords

ADRB2 gene; Fat oxidation; GNB3 gene; Lipolysis; Single nucleotide polymorphism

Indexed keywords

ARGININE; BETA 2 ADRENERGIC RECEPTOR; FATTY ACID; GLYCEROL; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; ISOPRENALINE;

EID: 34247519217     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0803499     Document Type: Article
Times cited : (33)

References (48)
  • 1
    • 0028485780 scopus 로고
    • Beta-adrenergic stimulation of skeletal muscle metabolism in relation to weight reduction in obese men
    • Blaak EE, Van Baak MA, Kemerink GJ, Pakbiers MT, Heidendal GA, Saris WH. Beta-adrenergic stimulation of skeletal muscle metabolism in relation to weight reduction in obese men. Am J Physiol 1994; 267 (2 Part 1): E316-E322.
    • (1994) Am J Physiol , vol.267 , Issue.2 PART 1
    • Blaak, E.E.1    Van Baak, M.A.2    Kemerink, G.J.3    Pakbiers, M.T.4    Heidendal, G.A.5    Saris, W.H.6
  • 2
    • 0032964606 scopus 로고    scopus 로고
    • Substrate utilization and thermogenic responses to beta-adrenergic stimulation in obese subjects with NIDDM
    • Blaak EE, Saris WH, Wolffenbuttel BH. Substrate utilization and thermogenic responses to beta-adrenergic stimulation in obese subjects with NIDDM. Int J Obes Relat Metab Disord 1999; 23: 411-418.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 411-418
    • Blaak, E.E.1    Saris, W.H.2    Wolffenbuttel, B.H.3
  • 3
    • 0033645223 scopus 로고    scopus 로고
    • Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise
    • Blaak EE, van Aggel-Leijssen DP, Wagenmakers AJ, Saris WH, van Baak MA. Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise. Diabetes 2000; 49: 2102-2107.
    • (2000) Diabetes , vol.49 , pp. 2102-2107
    • Blaak, E.E.1    van Aggel-Leijssen, D.P.2    Wagenmakers, A.J.3    Saris, W.H.4    van Baak, M.A.5
  • 4
    • 0028128529 scopus 로고
    • Beta-adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men
    • Blaak EE, Van Baak MA, Kemerink GJ, Pakbiers MT, Heidendal GA, Saris WH. Beta-adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men. Am J Physiol 1994; 267 (2 Part 1): E306-E315.
    • (1994) Am J Physiol , vol.267 , Issue.2 PART 1
    • Blaak, E.E.1    Van Baak, M.A.2    Kemerink, G.J.3    Pakbiers, M.T.4    Heidendal, G.A.5    Saris, W.H.6
  • 6
    • 0028347238 scopus 로고
    • Catecholamine resistance in fat cells of women with upper body obesity due to decreased expression of beta 2-adrenoceptors
    • Reynisdottir S, Wahrenberg H, Carlstrom K, Rossner S, Arner P. Catecholamine resistance in fat cells of women with upper body obesity due to decreased expression of beta 2-adrenoceptors. Diabetologia 1994; 37: 428-435.
    • (1994) Diabetologia , vol.37 , pp. 428-435
    • Reynisdottir, S.1    Wahrenberg, H.2    Carlstrom, K.3    Rossner, S.4    Arner, P.5
  • 7
    • 17344390843 scopus 로고
    • Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes
    • Kobilka BK, MacGregor C, Daniel K, Kobilka TS, Caron MG, Lefkowitz RJ. Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes. J Biol Chem 1987; 262: 15796-15802.
    • (1987) J Biol Chem , vol.262 , pp. 15796-15802
    • Kobilka, B.K.1    MacGregor, C.2    Daniel, K.3    Kobilka, T.S.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 8
    • 0023194433 scopus 로고
    • Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions
    • Kobilka BK, Frielle T, Dohlman HG, Bolanowski MA, Dixon RA, Keller P et al. Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. J Biol Chem 1987; 262: 7321-7327.
    • (1987) J Biol Chem , vol.262 , pp. 7321-7327
    • Kobilka, B.K.1    Frielle, T.2    Dohlman, H.G.3    Bolanowski, M.A.4    Dixon, R.A.5    Keller, P.6
  • 9
    • 0033832449 scopus 로고    scopus 로고
    • Pharmacogenetics of beta-1- and beta-2-adrenergic receptors
    • Liggett SB. Pharmacogenetics of beta-1- and beta-2-adrenergic receptors. Pharmacology 2000; 61: 167-173.
    • (2000) Pharmacology , vol.61 , pp. 167-173
    • Liggett, S.B.1
  • 10
    • 1642544641 scopus 로고    scopus 로고
    • Beta2-adrenoceptor polymorphisms: Relation between in vitro and in vivo phenotypes
    • Leineweber K, Brodde OE. Beta2-adrenoceptor polymorphisms: relation between in vitro and in vivo phenotypes. Life Sci 2004; 74: 2803-2814.
    • (2004) Life Sci , vol.74 , pp. 2803-2814
    • Leineweber, K.1    Brodde, O.E.2
  • 11
    • 0028068550 scopus 로고
    • Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties
    • Green SA, Turki J, Innis M, Liggett SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994; 33: 9414-9419.
    • (1994) Biochemistry , vol.33 , pp. 9414-9419
    • Green, S.A.1    Turki, J.2    Innis, M.3    Liggett, S.B.4
  • 12
    • 0035717657 scopus 로고    scopus 로고
    • Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes
    • Bengtsson K, Orho-Melander M, Melander O, Lindblad U, Ranstam J, Rastam L et al. Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes. Hypertension 2001; 37: 1303-1308.
    • (2001) Hypertension , vol.37 , pp. 1303-1308
    • Bengtsson, K.1    Orho-Melander, M.2    Melander, O.3    Lindblad, U.4    Ranstam, J.5    Rastam, L.6
  • 13
    • 0036634633 scopus 로고    scopus 로고
    • Significance of beta2-adrenergic receptor gene polymorphism in obesity and type 2 diabetes mellitus in Korean subjects
    • Kim SH, Kim DJ, Seo IA, Min YK, Lee MS, Kim KW et al. Significance of beta2-adrenergic receptor gene polymorphism in obesity and type 2 diabetes mellitus in Korean subjects. Metabolism 2002; 51: 833-837.
    • (2002) Metabolism , vol.51 , pp. 833-837
    • Kim, S.H.1    Kim, D.J.2    Seo, I.A.3    Min, Y.K.4    Lee, M.S.5    Kim, K.W.6
  • 14
    • 0035170038 scopus 로고    scopus 로고
    • Gln27Glu beta2-adrenergic receptor variant is associated with hypertriglyceridemia and the development of fatty liver
    • Iwamoto N, Ogawa Y, Kajihara S, Hisatomi A, Yasutake T, Yoshimura T et al. Gln27Glu beta2-adrenergic receptor variant is associated with hypertriglyceridemia and the development of fatty liver. Clin Chim Acta 2001; 314: 85-91.
    • (2001) Clin Chim Acta , vol.314 , pp. 85-91
    • Iwamoto, N.1    Ogawa, Y.2    Kajihara, S.3    Hisatomi, A.4    Yasutake, T.5    Yoshimura, T.6
  • 15
    • 0034243110 scopus 로고    scopus 로고
    • Interactions among the alpha2-, beta2-, and beta3-adrenergic receptor genes and obesity-related phenotypes in the Quebec family study
    • Ukkola O, Rankinen T, Weisnagel SJ, Sun G, Perusse L, Chagnon YC et al. Interactions among the alpha2-, beta2-, and beta3-adrenergic receptor genes and obesity-related phenotypes in the Quebec family study. Metabolism 2000; 49: 1063-1070.
    • (2000) Metabolism , vol.49 , pp. 1063-1070
    • Ukkola, O.1    Rankinen, T.2    Weisnagel, S.J.3    Sun, G.4    Perusse, L.5    Chagnon, Y.C.6
  • 16
    • 0031436966 scopus 로고    scopus 로고
    • Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function
    • Large V, Hellstrom L, Reynisdottir S, Lonnqvist F, Eriksson P, Lannfelt L et al. Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. J Clin Invest 1997; 100: 3005-3013.
    • (1997) J Clin Invest , vol.100 , pp. 3005-3013
    • Large, V.1    Hellstrom, L.2    Reynisdottir, S.3    Lonnqvist, F.4    Eriksson, P.5    Lannfelt, L.6
  • 17
    • 0032998134 scopus 로고    scopus 로고
    • The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females
    • Hellstrom L, Large V, Reynisdottir S, Wahrenberg H, Arner P. The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females. J Intern Med 1999; 245: 253-259.
    • (1999) J Intern Med , vol.245 , pp. 253-259
    • Hellstrom, L.1    Large, V.2    Reynisdottir, S.3    Wahrenberg, H.4    Arner, P.5
  • 18
    • 0034055290 scopus 로고    scopus 로고
    • Impact of polymorphisms of the human beta2-adrenoceptor gene on obesity in a French population
    • Meirhaeghe A, Helbecque N, Cottel D, Amouyel P. Impact of polymorphisms of the human beta2-adrenoceptor gene on obesity in a French population. Int J Obes Relat Metab Disord 2000; 24: 382-387.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 382-387
    • Meirhaeghe, A.1    Helbecque, N.2    Cottel, D.3    Amouyel, P.4
  • 19
    • 0033550795 scopus 로고    scopus 로고
    • Beta2-adrenoceptor gene polymorphism, body weight, and physical activity
    • Meirhaeghe A, Helbecque N, Cottel D, Amouyel P. Beta2-adrenoceptor gene polymorphism, body weight, and physical activity. Lancet 1999; 353: 896.
    • (1999) Lancet , vol.353 , pp. 896
    • Meirhaeghe, A.1    Helbecque, N.2    Cottel, D.3    Amouyel, P.4
  • 20
    • 0033614302 scopus 로고    scopus 로고
    • The Gln27Glu beta2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men
    • Mori Y, Kim-Motoyama H, Ito Y, Katakura T, Yasuda K, Ishiyama-Shigemoto S et al. The Gln27Glu beta2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men. Biochem Biophys Res Commun 1999; 258: 138-140.
    • (1999) Biochem Biophys Res Commun , vol.258 , pp. 138-140
    • Mori, Y.1    Kim-Motoyama, H.2    Ito, Y.3    Katakura, T.4    Yasuda, K.5    Ishiyama-Shigemoto, S.6
  • 21
    • 0032587498 scopus 로고    scopus 로고
    • Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus
    • Ishiyama-Shigemoto S, Yamada K, Yuan X, Ichikawa F, Nonaka K. Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus. Diabetologia 1999; 42: 98-101.
    • (1999) Diabetologia , vol.42 , pp. 98-101
    • Ishiyama-Shigemoto, S.1    Yamada, K.2    Yuan, X.3    Ichikawa, F.4    Nonaka, K.5
  • 23
    • 0027519404 scopus 로고
    • A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor
    • Green SA, Cole G, Jacinto M, Innis M, Liggett SB. A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem 1993; 268: 23116-23121.
    • (1993) J Biol Chem , vol.268 , pp. 23116-23121
    • Green, S.A.1    Cole, G.2    Jacinto, M.3    Innis, M.4    Liggett, S.B.5
  • 24
    • 0035876397 scopus 로고    scopus 로고
    • The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s)
    • Green SA, Rathz DA, Schuster AJ, Liggett SB. The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). Eur J Pharmacol 2001; 421: 141-147.
    • (2001) Eur J Pharmacol , vol.421 , pp. 141-147
    • Green, S.A.1    Rathz, D.A.2    Schuster, A.J.3    Liggett, S.B.4
  • 25
    • 0034945474 scopus 로고    scopus 로고
    • The effect of the beta(2) adrenoceptor gene Thr164Ile polymorphism on human adipose tissue lipolytic function
    • Hoffstedt J, Iliadou A, Pedersen NL, Schalling M, Arner P. The effect of the beta(2) adrenoceptor gene Thr164Ile polymorphism on human adipose tissue lipolytic function. Br J Pharmacol 2001; 133: 708-712.
    • (2001) Br J Pharmacol , vol.133 , pp. 708-712
    • Hoffstedt, J.1    Iliadou, A.2    Pedersen, N.L.3    Schalling, M.4    Arner, P.5
  • 26
    • 17344366286 scopus 로고    scopus 로고
    • Association of a human G-protein beta3 subunit variant with hypertension
    • Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 1998; 18: 45-48.
    • (1998) Nat Genet , vol.18 , pp. 45-48
    • Siffert, W.1    Rosskopf, D.2    Siffert, G.3    Busch, S.4    Moritz, A.5    Erbel, R.6
  • 27
    • 0025323257 scopus 로고
    • Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy
    • Patten JL, Johns DR, Valle D, Eil C, Gruppuso PA, Steele G et al. Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy. N Engl J Med 1990; 322: 1412-1419.
    • (1990) N Engl J Med , vol.322 , pp. 1412-1419
    • Patten, J.L.1    Johns, D.R.2    Valle, D.3    Eil, C.4    Gruppuso, P.A.5    Steele, G.6
  • 29
    • 0031713784 scopus 로고    scopus 로고
    • Association between a polymorphism in the G protein beta3 subunit gene and lower renin and elevated diastolic blood pressure levels
    • Schunkert H, Hense HW, Doring A, Riegger GA, Siffert W. Association between a polymorphism in the G protein beta3 subunit gene and lower renin and elevated diastolic blood pressure levels. Hypertension 1998; 32: 510-513.
    • (1998) Hypertension , vol.32 , pp. 510-513
    • Schunkert, H.1    Hense, H.W.2    Doring, A.3    Riegger, G.A.4    Siffert, W.5
  • 31
    • 0032794634 scopus 로고    scopus 로고
    • Worldwide ethnic distribution of the G protein beta3 subunit 825 T allele and its association with obesity in Caucasian, Chinese, and Black African individuals
    • Siffert W, Forster P, Jockel KH, Mvere DA, Brinkmann B, Naber C et al. Worldwide ethnic distribution of the G protein beta3 subunit 825 T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 1999; 10: 1921-1930.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1921-1930
    • Siffert, W.1    Forster, P.2    Jockel, K.H.3    Mvere, D.A.4    Brinkmann, B.5    Naber, C.6
  • 32
    • 3242754160 scopus 로고    scopus 로고
    • Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: A study of female dizygotic twins
    • Dong Y, Zhu H, Wang X, Dalageorgou C, Carter N, Spector TD et al. Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: a study of female dizygotic twins. Pharmacogenetics 2004; 14: 419-427.
    • (2004) Pharmacogenetics , vol.14 , pp. 419-427
    • Dong, Y.1    Zhu, H.2    Wang, X.3    Dalageorgou, C.4    Carter, N.5    Spector, T.D.6
  • 33
    • 0041881989 scopus 로고    scopus 로고
    • Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism
    • Hauner H, Meier M, Jockel KH, Frey UH, Siffert W. Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism. Pharmacogenetics 2003; 13: 453-459.
    • (2003) Pharmacogenetics , vol.13 , pp. 453-459
    • Hauner, H.1    Meier, M.2    Jockel, K.H.3    Frey, U.H.4    Siffert, W.5
  • 34
    • 0032589474 scopus 로고    scopus 로고
    • G-protein beta3 subunit gene splice variant and body fat distribution in Nunavut Inuit
    • Hegele RA, Anderson C, Young TK, Connelly PW. G-protein beta3 subunit gene splice variant and body fat distribution in Nunavut Inuit. Genome Res 1999; 9: 972-977.
    • (1999) Genome Res , vol.9 , pp. 972-977
    • Hegele, R.A.1    Anderson, C.2    Young, T.K.3    Connelly, P.W.4
  • 35
    • 0036020753 scopus 로고    scopus 로고
    • Effect of the (C825T) Gbeta(3) polymorphism on adrenoceptor-mediated lipolysis in human fat cells
    • Ryden M, Faulds G, Hoffstedt J, Wennlund A, Arner P. Effect of the (C825T) Gbeta(3) polymorphism on adrenoceptor-mediated lipolysis in human fat cells. Diabetes 2002; 51: 1601-1608.
    • (2002) Diabetes , vol.51 , pp. 1601-1608
    • Ryden, M.1    Faulds, G.2    Hoffstedt, J.3    Wennlund, A.4    Arner, P.5
  • 36
    • 77049310862 scopus 로고
    • The gross composition of the body
    • Siri WE. The gross composition of the body. Adv Biol Med Phys 1956; 4: 239-280.
    • (1956) Adv Biol Med Phys , vol.4 , pp. 239-280
    • Siri, W.E.1
  • 37
    • 0029150074 scopus 로고
    • A comparison of linkage disequilibrium measures for fine-scale mapping
    • Devlin B, Risch N. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 1995; 29: 311-322.
    • (1995) Genomics , vol.29 , pp. 311-322
    • Devlin, B.1    Risch, N.2
  • 39
    • 0034641736 scopus 로고    scopus 로고
    • Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness
    • Drysdale CM, McGraw DW, Stack CB, Stephens JC, Judson RS, Nandabalan K et al. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA 2000; 97: 10483-10488.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10483-10488
    • Drysdale, C.M.1    McGraw, D.W.2    Stack, C.B.3    Stephens, J.C.4    Judson, R.S.5    Nandabalan, K.6
  • 40
    • 0033561181 scopus 로고    scopus 로고
    • Biased tests of association: Comparisons of allele frequencies when departing from Hardy-Weinberg proportions
    • Schaid DJ, Jacobsen SJ. Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions. Am J Epidemiol 1999; 149: 706-711.
    • (1999) Am J Epidemiol , vol.149 , pp. 706-711
    • Schaid, D.J.1    Jacobsen, S.J.2
  • 41
    • 0033305407 scopus 로고    scopus 로고
    • Beta-adrenergically stimulated fat oxidation is diminished in middle-aged compared to young subjects
    • Blaak EE, van Baak MA, Saris WH. Beta-adrenergically stimulated fat oxidation is diminished in middle-aged compared to young subjects. J Clin Endocrinol Metab 1999; 84: 3764-3769.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3764-3769
    • Blaak, E.E.1    van Baak, M.A.2    Saris, W.H.3
  • 42
    • 0027213748 scopus 로고
    • Fatty acid kinetic responses to exercise. Effects of obesity, body fat distribution, and energyrestricted diet
    • Kanaley JA, Cryer PE, Jensen MD. Fatty acid kinetic responses to exercise. Effects of obesity, body fat distribution, and energyrestricted diet. J Clin Invest 1993; 92: 255-261.
    • (1993) J Clin Invest , vol.92 , pp. 255-261
    • Kanaley, J.A.1    Cryer, P.E.2    Jensen, M.D.3
  • 43
    • 0035744752 scopus 로고    scopus 로고
    • Gender differences in fat metabolism
    • Blaak E. Gender differences in fat metabolism. Curr Opin Clin Nutr Metab Care 2001; 4: 499-502.
    • (2001) Curr Opin Clin Nutr Metab Care , vol.4 , pp. 499-502
    • Blaak, E.1
  • 44
    • 0032990467 scopus 로고    scopus 로고
    • Catecholamine-induced lipolysis in obesity
    • Arner P. Catecholamine-induced lipolysis in obesity. Int J Obes Relat Metab Disord 1999; 23 (Suppl 1): 10-13.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , Issue.SUPPL. 1 , pp. 10-13
    • Arner, P.1
  • 45
    • 4544324948 scopus 로고    scopus 로고
    • Impaired beta-adrenergically mediated lipolysis in skeletal muscle of obese subjects
    • Blaak EE, Schiffelers SL, Saris WH, Mensink M, Kooi ME. Impaired beta-adrenergically mediated lipolysis in skeletal muscle of obese subjects. Diabetologia 2004; 47: 1462-1468.
    • (2004) Diabetologia , vol.47 , pp. 1462-1468
    • Blaak, E.E.1    Schiffelers, S.L.2    Saris, W.H.3    Mensink, M.4    Kooi, M.E.5
  • 46
    • 0242269451 scopus 로고    scopus 로고
    • The Gly16- > Arg16 and Gln27- > Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men
    • Dallongeville J, Helbecque N, Cottel D, Amouyel P, Meirhaeghe A. The Gly16- > Arg16 and Gln27- > Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men. J Clin Endocrinol Metab 2003; 88: 4862-4866.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4862-4866
    • Dallongeville, J.1    Helbecque, N.2    Cottel, D.3    Amouyel, P.4    Meirhaeghe, A.5
  • 47
    • 0030847462 scopus 로고    scopus 로고
    • A circadian rhythm in lipid mobilization which is altered in IDDM
    • Hagstrom-Toft E, Bolinder J, Ungerstedt U, Arner P. A circadian rhythm in lipid mobilization which is altered in IDDM. Diabetologia 1997; 40: 1070-1078.
    • (1997) Diabetologia , vol.40 , pp. 1070-1078
    • Hagstrom-Toft, E.1    Bolinder, J.2    Ungerstedt, U.3    Arner, P.4
  • 48
    • 0037330909 scopus 로고    scopus 로고
    • The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo
    • Bruck H, Leineweber K, Buscher R, Ulrich A, Radke J, Insel PA et al. The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo. Pharmacogenetics 2003; 13: 59-66.
    • (2003) Pharmacogenetics , vol.13 , pp. 59-66
    • Bruck, H.1    Leineweber, K.2    Buscher, R.3    Ulrich, A.4    Radke, J.5    Insel, P.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.