TGF-β2 induces senescence-associated changes in human trabecular meshwork cells

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 11, 2010, Pages 5718-5723

  Yu, Alice L ^a   Birke, Kerstin ^b   Moriniere, Jerome ^a   Welge Lüssen, Ulrich ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CLUSTERIN; OSTEONECTIN; PROTEIN P16; PROTEIN P21; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN; TRANSFORMING GROWTH FACTOR BETA2; TRANSGELIN;

APOLIPOPROTEIN J GENE; ARTICLE; CELL AGING; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; P16 GENE; P21 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RB GENE; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SM22 GENE; SPARC GENE; TRABECULAR MESHWORK; WESTERN BLOTTING;

ADULT; BETA-GALACTOSIDASE; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL AGING; CELLS, CULTURED; CLUSTERIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; LIPID PEROXIDATION; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; NEOPLASM PROTEINS; OSTEONECTIN; RETINOBLASTOMA PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRABECULAR MESHWORK; TRANSFORMING GROWTH FACTOR BETA2;

EID: 79955996025     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5679     Document Type: Article

References (48)

1. Lütjen-Drecoll E, Shimizu T, Rohrbach M, Rohen JW. Quantitative analysis of "plaque material" in the inner and outer wall of Schlemm's canal in normal and glaucomatous eyes. Exp Eye Res. 1986;42:443-455.
2. Rohen JW, Lütjen-Drecoll E, Flügel C, Meyer M, Grierson I. Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma (POAG). Exp Eye Res. 1993;56:683-692.
3. Tektas OY, Lütjen-Drecoll E. Structural changes of the trabecular meshwork in different kinds of glaucoma. Exp Eye Res. 2009;88: 769-775.
4. Liton PB, Challa P, Stinnett S, Luna C, Epstein DL, Gonzalez P. Cellular senescence in the glaucomatous outflow pathway. Exp Gerontol. 2005;40:745-748.
5. Dumont P, Chainiaux F, Eliaers F, et al. Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide. Cell Stress Chaperones. 2002;7:23-35.
6. Toussaint O, Medrano EE, von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol. 2000;35: 927-945.
7. Nair RR, Solway J, Boyd DD. Expression cloning identifies transgelin (SM22) as a novel repressor of 92-kDa type IV collagenase (MMP-9) expression. J Biol Chem. 2006;281:26424-26436.
8. Chen W, Kang J, Xia J, et al. P53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts. Int J Mol Med. 2008;21:645-653.
9. Rhee DJ, Fariss RN, Brekken R, Sage EH, Russell P. The matricellular protein SPARC is expressed in human trabecular meshwork. Exp Eye Res. 2003;77:601-607.
10. Luna C, Li G, Qiu J, Epstein DL, Gonzalez P. Role of miR-29b on the regulation of the extracellular matrix in human trabecular meshwork cells under chronic oxidative stress. Mol Vis. 2009;15:2488-2497.
11. Ben-Porath I, Weinberg RA. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol. 2005;37:961-976.
12. Chen J, Goligorsky MS. Premature senescence of endothelial cells: Methuselah's dilemma. Am J Physiol Heart Circ Physiol. 2006;290: H1729-H1739.
13. Dumont P, Burton M, Chen QM, et al. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Radic Biol Med. 2000;28:361-373.
14. Frippiat C, Chen QM, Zdanov S, Magalhaes JP, Remacle J, Toussaint O. Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem. 2001;276:2531-2537.
15. Frippiat C, Dewelle J, Remacle J, Toussaint O. Signal transduction in H2O2-induced senescence-like phenotype in human diploid fibroblasts. Free Radic Biol Med. 2002;33:1334-1346.
16. Izzotti A, Bagnis A, Sacca SC. The role of oxidative stress in glaucoma. Mutat Res. 2006;612:105-114.
17. Proell V, Carmona-Cuenca I, Murillo MM, Huber H, Fabregat I, Mikulits W. TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells. Comp Hepatol. 2007;6:1.
18. Picht G, Welge-Luessen U, Grehn F, Lütjen-Drecoll E. Transforming growth factor-beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development. Graefes Arch Clin Exp Ophthalmol. 2001;239:199-207.
19. Tripathi RC, Li J, Chan WF, Tripathi BJ. Aqueous humor in glaucomatous eyes contains an increased level of TGF-β2. Exp Eye Res. 1994;59:723-727.
20. Siegner A, May CA, Welge-Lüssen U, Bloemendal H, Lütjen-Drecoll E. AlphaB-crystallin in the primate ciliary muscle and trabecular meshwork. Eur J Cell Biol. 1996;71:165-169.
21. Welge-Lussen U, Eichhorn M, Bleomendal H, Lütjen-Drecoll E. Classification of human scleral spur cells in monolayer culture. Eur J Cell Biol. 1998;75:78-84.
22. Welge-Lussen U, May CA, Eichhorn M, Bloemendal H, Lütjen- Drecoll E. AlphaB-crystallin in the trabecular meshwork is inducible by transforming growth factor-beta. Invest Ophthalmol Vis Sci. 1999;40:2235-2241.
23. Welge-Lussen U, May CA, Lütjen-Drecoll E. Induction of tissue transglutaminase in the trabecular meshwork by TGF-beta1 and TGF-beta2. Invest Ophthalmol Vis Sci. 2000;41:2229-2238.
24. Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 1995;92:9363-9367.
25. Hodges NJ, Green RM, Chipman JK, Graham M. Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression. Mutagenesis. 2007;22:189-194.
26. Carini M, Aldini G, Piccone M, Facino RM. Fluorescent probes as markers of oxidative stress in keratinocyte cell lines following UVB exposure. Farmaco. 2000;55:526-534.
27. Caballero M, Liton PB, Challa P, Epstein DL, Gonzalez P. Effects of donor age on proteasome activity and senescence in trabecular meshwork cells. Biochem Biophys Res Commun. 2004;323:1048-1054.
28. Gabelt BT, Kaufman PL. Changes in aqueous humor dynamics with age and glaucoma. Prog Retin Eye Res. 2005;24:612-637.
29. Liton PB, Gonzalez P. Stress response of the trabecular meshwork. J Glaucoma. 2008;17:378-385.
30. Lütjen-Drecoll E. Morphological changes in glaucomatous eyes and the role of TGF-beta2 for the pathogenesis of the disease. Exp Eye Res. 2005;81:1-4.
31. Yu AL, Fuchshofer R, Kampik A, Welge-Lüssen U. Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues. Invest Ophthalmol Vis Sci. 2008;49:4872-4880.
32. Debacq-Chainiaux F, Borlon C, Pascal T, et al. Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway. J Cell Sci. 2005;118:743-758.
33. Reed MJ, Vernon RB, Abrass IB, Sage EH. TGF-beta1 induces the expression of type I collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors. J Cell Physiol. 1994;158:169-179.
34. Qiu P, Ritchie RP, Gong XQ, Hamamori Y, Li L. Dynamic changes in chromatin acetylation and the expression of histone acetyltransferases and histone deacetylases regulate the SM22alpha transcription in response to Smad3-mediated TGF-beta1 signaling. Biochem Biophys Res Commun. 2006;348:351-358.
35. Shiba H, Fujita T, Doi N, et al. Differential effects of various growth factors and cytokines on the synthesis of DNA, type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic rich in cysteine (SPARC), and alkaline phosphatase by human pulp cells in culture. J Cell Physiol. 1998;174:194-205.
36. Fuchshofer R, Yu AH, Welge-Lussen U, Tamm ER. Bone morphogenetic protein-7 is an antagonist of transforming growth factorbeta2 in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2007;48:715-726.
37. Fleenor DL, Shepard AR, Hellberg PE, Jacobson N, Pang IH, Clark AF. TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure. Invest Ophthalmol Vis Sci. 2006;47:226-234.
38. Gottanka J, Chan D, Eichhorn M, Lütjen-Drecoll E, Ethier CR. Effects of TGF-beta2 in perfused human eyes. Invest Ophthalmol Vis Sci. 2004;45:153-158.
39. Ding G, Franki N, Kapasi AA, Reddy K, Gibbons N, Singhal PC. Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats. Exp Mol Pathol. 2001;70:43-53.
40. Kim HS, Song MC, Kwak IH, Park TJ, Lim IK. Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. J Biol Chem. 2003;278:37497-37510.
41. Robert L, Labat-Robert J. Aging of connective tissues: from genetic to epigenetic mechanisms. Biogerontology. 2000;1:123-131.
42. Ksiazek K, Korybalska K, Jorres A, Witowski J. Accelerated senescence of human peritoneal mesothelial cells exposed to high glucose: the role of TGF-beta1. Lab Invest. 2007;87:345-356.
43. Yaswen P, Stampfer MR. Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells. Int J Biochem Cell Biol. 2002;34:1382-1394.
44. Rheinwald JG, Hahn WC, Ramsey MR, et al. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol. 2002;22:5157-5172.
45. Vaziri H, Benchimol S. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging. Exp Gerontol. 1996;31:295-301.
46. Iwasa H, Han J, Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells. 2003;8:131-144.
47. Naka K, Tachibana A, Ikeda K, Motoyama N. Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. J Biol Chem. 2003;279:2030-2037.
48. Spector A, Ma W, Wang RR. The aqueous humor is capable of generating and degrading H2O2. Invest Ophthalmol Vis Sci. 1998; 39:1188-1197.