LOX-1 in the maintenance of cytoskeleton and proliferation in senescent cardiac fibroblasts

Journal of Molecular and Cellular Cardiology

Volumn 60, Issue 1, 2013, Pages 184-190

  Wang, Xianwei ^a,b   Khaidakov, Magomed ^a   Ding, Zufeng ^a   Dai, Yao ^a,c   Mercanti, Federico ^a   Mehta, Jawahar L ^a  

^a CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^b XINXIANG MEDICAL UNIVERSITY   (China)

^c ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Cardiac fibroblast; Cell proliferation; LOX 1; Senescence

Indexed keywords

4 HYDROXYNONENAL; BETA CATENIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTEIN CDC42; PROTEIN KINASE B; PROTEIN MDM2; S6 KINASE;

AKT GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIAC FIBROBLAST; CELL ACTIVITY; CELL AGING; CELL ISOLATION; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOSKELETON; FIBROBLAST; GENETIC TRANSFECTION; MDM2 GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION;

AGING; ANIMALS; BIOLOGICAL MARKERS; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CYTOSKELETON; FIBROBLASTS; MICE; MUSCLE PROTEINS; MYOCARDIUM; SCAVENGER RECEPTORS, CLASS E;

MUS; PHOS;

EID: 84877842553     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.04.024     Document Type: Article

References (22)

1. Biernacka A., Frangogiannis N.G. Aging and cardiac fibrosis. Aging Dis 2011, 2:158-173.
2. Chen J., Han Y., Zhu W., Ma R., Han B., Cong X., et al. Specific receptor subtype mediation of LPA-induced dual effects in cardiac fibroblasts. FEBS Lett 2006, 580:4737-4745.
3. Chen M., Masaki T., Sawamura T. LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther 2002, 95:89-100.
4. Lu J., Wang X., Wang W., Muniyappa H., Hu C., Mitra S., et al. LOX-1 abrogation reduces cardiac hypertrophy and collagen accumulation following chronic ischemia in the mouse. Gene Ther 2012, 19:522-531.
5. Hu C., Dandapat A., Sun L., Marwali M.R., Inoue N., Sugawara F., et al. Modulation of angiotensin II-mediated hypertension and cardiac remodeling by lectin-like oxidized low-density lipoprotein receptor-1 deletion. Hypertension 2008, 52:556-562.
6. Wang X., Khaidakov M., Ding Z., Mitra S., Lu J., Dai Y., et al. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and cardiac fibroblast growth. Hypertension 2012, 60:1437-1442.
7. Khaidakov M., Wang X., Mehta J.L. Potential involvement of LOX-1 in functional consequence of endothelial senescence. PLoS One 2011, 6:e20964.
8. Wang X., Lu J., Khaidakov M., Mitra S., Ding Z., Raina S., et al. Aspirin suppresses cardiac fibroblast proliferation and collagen formation through downregulation of angiotensin type 1 receptor transcription. Toxicol Appl Pharmacol 2012, 259:346-354.
9. Souders C.A., Browers S.L., Baudino T.A. Cardiac fibroblast: the renaissance cell. Circ Res 2009, 105:1164-1176.
10. Wilson M.A., Shukitt-Hale B., Kalt W., Ingram D.K., Joseph J.A., Wolkow C.A. Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 2006, 5:59-68.
11. Ikeda S., Cunningham L.A., Boggess D., Hawes N., Hobson C.D., Sundberg J.P., et al. Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor). Hum Mol Genet 2003, 12:1029-1037.
12. Nobes C.D., Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995, 81:53-62.
13. Ip C.K., Cheung A.N., Ngan H.Y., Wong A.S. p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells. Oncogene 2011, 30:2420-2432.
14. Chouinard J.A., Grenier G., Khalil A., Vermette P. Oxidized-LDL induce morphological changes and increase stiffness of endothelial cells. Exp Cell Res 2008, 314:3007-3016.
15. Byfield F.J., Tikku S., Rothblat G.H., Gooch K.J., Levitan I. OxLDL increases endothelial stiffness, force generation, and network formation. J Lipid Res 2006, 47:715-723.
16. Essler M., Retzer M., Bauer M., Heemskerk J.W., Aepfelbacher M., Siess W. Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosphatase. J Biol Chem 1999, 274:30361-30364.
17. Miller Y.I., Worrall D.S., Funk C.D., Feramisco J.R., Witztum J.L. Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 1/15-lipoxygenase and phosphoinositide 3-kinase. Mol Biol Cell 2003, 14:4196-4206.
18. Mattaliano M.D., Wooters J., Shih H.H., Paulsen J.E. ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production. Am J Physiol Cell Physiol 2010, 298:C1180-C1187.
19. Jaffe A.B., Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005, 21:247-269.
20. Olson M.F., Ashworth A., Hall A. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 1995, 269:12701272.
21. Yasuda S., Taniguchi H., Oceguera-Yanez F., Ando Y., Watanabe S., Monypenny J., et al. An essential role of Cdc42-like GTPases in mitosis of HeLa cells. FEBS Lett 2006, 580:3375-3380.
22. Dai Y., Su W., Ding Z., Wang X., Mercanti F., Chen M., et al. Regulation of MSR-1 and CD36 in macrophages by LOX-1 mediated through PPAR-γ. Biochem Biophys Res Commun 2013, 431:496-500.