Differential effect of buffering agents on the crystallization of gemcitabine hydrochloride in frozen solutions

International Journal of Pharmaceutics

Volumn 471, Issue 1-2, 2014, Pages 56-64

  Patel, Mehulkumar ^a   Munjal, Bhushan ^a   Bansal, Arvind K ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Calorimetry (DSC); Crystallization tendency; Low temperature XRD; Lyophilization; Supersaturation; Unfrozen water

Indexed keywords

CITRIC ACID; GEMCITABINE; MALIC ACID; SUCCINIC ACID; TARTARIC ACID; BUFFER; DEOXYCYTIDINE; EXCIPIENT; MALIC ACID DERIVATIVE; SOLUTION AND SOLUBILITY; TARTARIC ACID DERIVATIVE;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; HEATING; LOW TEMPERATURE; PRIORITY JOURNAL; WATER CONTENT; X RAY DIFFRACTION; ANALOGS AND DERIVATIVES; CHEMISTRY; FREEZING; SOLUTION AND SOLUBILITY; TRANSITION TEMPERATURE;

BUFFERS; CALORIMETRY, DIFFERENTIAL SCANNING; CITRIC ACID; CRYSTALLIZATION; DEOXYCYTIDINE; EXCIPIENTS; FREEZE DRYING; FREEZING; MALATES; SOLUTIONS; SUCCINIC ACID; TARTRATES; TRANSITION TEMPERATURE; X-RAY DIFFRACTION;

EID: 84901456920     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.05.008     Document Type: Article

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