Influence of crystallizing and non-crystallizing cosolutes on trehalose crystallization during freeze-drying

Pharmaceutical Research

Volumn 27, Issue 11, 2010, Pages 2384-2393

  Sundaramurthi, Prakash ^a,b   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Teva Parenteral Medicines Inc   (United States)

Author keywords

dehydration; DSC; mannitol hemihydrate; processing; protein; trehalose dihydrate; XRD

Indexed keywords

CATALASE; LACTOSE DEHYDROGENASE; LYSOZYME; MANNITOL; OXIDOREDUCTASE; SUCROSE; TREHALOSE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CARBOHYDRATE ANALYSIS; CONTROLLED STUDY; COOLING; CRYSTALLIZATION; DEHYDRATION; FREEZE DRYING; MELTING POINT; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STABILITY; SOLUTE; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; FREEZE DRYING; TREHALOSE; X-RAY DIFFRACTION;

EID: 78549239500     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0221-8     Document Type: Article

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