The effect of crystallizing and non-crystallizing cosolutes on succinate buffer crystallization and the consequent pH shift in frozen solutions

Pharmaceutical Research

Volumn 28, Issue 2, 2011, Pages 374-385

  Sundaramurthi, Prakash ^a,b   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Teva Parenteral Medicines Inc   (United States)

Author keywords

buffer crystallization; cosolute; frozen solution; pH shift

Indexed keywords

BUFFER; GLYCINE; MANNITOL; SUCCINIC ACID; SUCROSE; TREHALOSE;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; COOLING; CRYSTALLIZATION; DECOMPOSITION; DEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; FREEZING; LOW TEMPERATURE; PH; PRIORITY JOURNAL; ROOM TEMPERATURE; SYNCHROTRON RADIATION; X RAY DIFFRACTION;

BUFFERS; CALORIMETRY, DIFFERENTIAL SCANNING; COLD TEMPERATURE; CRYSTALLIZATION; FREEZE DRYING; FREEZING; GLUCOSE; GLYCINE; HYDROGEN-ION CONCENTRATION; MANNITOL; SOLUTIONS; SUCCINATES; SUCCINIC ACID; SUCROSE; SYNCHROTRONS; TREHALOSE; WATER; X-RAY DIFFRACTION;

EID: 79952488362     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0282-8     Document Type: Article

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