Predicting the crystallization propensity of carboxylic acid buffers in frozen systems-relevance to freeze-drying

Journal of Pharmaceutical Sciences

Volumn 100, Issue 4, 2011, Pages 1288-1293

  Sundaramurthi, Prakash ^a,b   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Teva Parenteral Medicines Inc   (United States)

Author keywords

Buffer crystallization; Crystallization; Freeze drying; Freeze concentrate; Frozen solution; Injectables; Material science; PH change; Physical characterization; Solubility

Indexed keywords

BUFFER; CARBOXYLIC ACID; CITRIC ACID; MALIC ACID; SUCCINIC ACID; SOLUTION AND SOLUBILITY;

AQUEOUS SOLUTION; ARTICLE; COOLING; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; ENVIRONMENTAL TEMPERATURE; FREEZE DRYING; FREEZE THAWING; PH; PHYSICAL CHEMISTRY; SOLUBILITY; TEMPERATURE SENSITIVITY; X RAY DIFFRACTION; CHEMISTRY; FREEZING; SOLUTION AND SOLUBILITY;

BUFFERS; CALORIMETRY, DIFFERENTIAL SCANNING; CARBOXYLIC ACIDS; CRYSTALLIZATION; FREEZE DRYING; FREEZING; HYDROGEN-ION CONCENTRATION; PHARMACEUTICAL SOLUTIONS; SOLUBILITY;

EID: 79951916297     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22374     Document Type: Article

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