메뉴 건너뛰기




Volumn 19, Issue 5, 2014, Pages 5538-5549

Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats

Author keywords

Excretion; Flavonoids; LC MS MS; Scutellaria baicalensis Georgi; Wogonin

Indexed keywords

FLAVANONE DERIVATIVE; PLASMA PROTEIN; PROTEIN BINDING; WOGONIN;

EID: 84901410500     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19055538     Document Type: Article
Times cited : (53)

References (34)
  • 1
    • 24644435394 scopus 로고    scopus 로고
    • Therapeutic potential of wogonin: A naturally occurring flavonoid
    • Tai, M.C.; Tsang, S.Y.; Chang, L.Y.; Xue, H. Therapeutic potential of wogonin: A naturally occurring flavonoid. CNS Drug Rev. 2005, 11, 141-150.
    • (2005) CNS Drug Rev. , vol.11 , pp. 141-150
    • Tai, M.C.1    Tsang, S.Y.2    Chang, L.Y.3    Xue, H.4
  • 2
    • 0032750323 scopus 로고    scopus 로고
    • Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of scutellaria baicalensis georgi biochim
    • Gao, Z.; Huang, K.; Yang, X.; Xu, H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi Biochim. Biophys. Acta 1999, 1472, 643-650.
    • (1999) Biophys. Acta , vol.1472 , pp. 643-650
    • Gao, Z.1    Huang, K.2    Yang, X.3    Xu, H.4
  • 3
    • 0033071142 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants
    • You, K.M.; Jong, H.G.; Kim, H.P. Inhibition of cyclooxygenase/ lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants. Arch. Pharm. Res. 1999, 22, 18-24.
    • (1999) Arch. Pharm. Res. , vol.22 , pp. 18-24
    • You, K.M.1    Jong, H.G.2    Kim, H.P.3
  • 4
    • 0035839226 scopus 로고    scopus 로고
    • Inhibition of tpa-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from scutellaria radix
    • Park, B.K.; Heo, M.Y.; Park, H.; Kim, H.P. Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. Eur. J. Pharmacol. 2001, 425, 153-157.
    • (2001) Eur. J. Pharmacol. , vol.425 , pp. 153-157
    • Park, B.K.1    Heo, M.Y.2    Park, H.3    Kim, H.P.4
  • 5
    • 0034876980 scopus 로고    scopus 로고
    • Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells
    • Chang, Y.L.; Shen, J.J.; Wung, B.S.; Cheng, J.J.; Wang, D.L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Mol. Pharmacol. 2001, 60, 507-513.
    • (2001) Mol. Pharmacol. , vol.60 , pp. 507-513
    • Chang, Y.L.1    Shen, J.J.2    Wung, B.S.3    Cheng, J.J.4    Wang, D.L.5
  • 7
    • 33845642523 scopus 로고    scopus 로고
    • Difference of growth-inhibitory effect of scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell
    • Himeji, M.; Ohtsuki, T.; Fukazawa, H.; Tanaka, M.; Yazaki, S.; Ui, S.; Nishio, K.; Yamamoto, H.; Tasaka, K.; Mimura, A. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Cancer Lett. 2007, 245, 269-274.
    • (2007) Cancer Lett. , vol.245 , pp. 269-274
    • Himeji, M.1    Ohtsuki, T.2    Fukazawa, H.3    Tanaka, M.4    Yazaki, S.5    Ui, S.6    Nishio, K.7    Yamamoto, H.8    Tasaka, K.9    Mimura, A.10
  • 10
    • 67449135860 scopus 로고    scopus 로고
    • Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in beagle dogs
    • Peng, J.; Qi, Q.; You, Q.; Hu, R.; Liu, W.; Feng, F.; Wang, G.; Guo, Q.L. Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs. J. Ethnopharmacol. 2009, 124, 257-262.
    • (2009) J. Ethnopharmacol. , vol.124 , pp. 257-262
    • Peng, J.1    Qi, Q.2    You, Q.3    Hu, R.4    Liu, W.5    Feng, F.6    Wang, G.7    Guo, Q.L.8
  • 12
    • 79955554423 scopus 로고    scopus 로고
    • Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects
    • Enomoto, R.; Koshiba, C.; Suzuki, C.; Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Cancer Chemother. Pharmacol. 2011, 67, 1063-1072.
    • (2011) Cancer Chemother. Pharmacol. , vol.67 , pp. 1063-1072
    • Enomoto, R.1    Koshiba, C.2    Suzuki, C.3    Lee, E.4
  • 13
    • 0036016874 scopus 로고    scopus 로고
    • Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells sk-hep-1
    • Chen, Y.C.; Shen, S.C.; Lee, W.R.; Lin, H.Y.; Ko, C.H.; Shih C.M.; Yang, L.L. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. Arch. Toxicol. 2002, 76, 351-359.
    • (2002) Arch. Toxicol. , vol.76 , pp. 351-359
    • Chen, Y.C.1    Shen, S.C.2    Lee, W.R.3    Lin, H.Y.4    Ko, C.H.5    Shih, C.M.6    Yang, L.L.7
  • 14
    • 84865639410 scopus 로고    scopus 로고
    • Wogonin induces apoptosis by activating the ampk and p53 signaling pathways in human glioblastoma cells
    • Lee, D.H.; Lee, T.H.; Jung, C.H.; Kim, Y.H. Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. Cell. Signal. 2013, 24, 2216-2225.
    • (2013) Cell. Signal. , vol.24 , pp. 2216-2225
    • Lee, D.H.1    Lee, T.H.2    Jung, C.H.3    Kim, Y.H.4
  • 15
    • 84882744881 scopus 로고    scopus 로고
    • Wogonin induced g1 cell cycle arrest by regulating wnt/β-catenin signaling pathway and inactivating cdk8 in human colorectal cancer carcinoma cells
    • He, L.; Lu, N.; Dai, Q.S.; Zhao, Y.; Zhao, L.; Wang, H.; Li, Z.Y.; You, Q.D.; Guo, Q.L. Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. Toxicology 2013, 312, 36-47.
    • (2013) Toxicology , vol.312 , pp. 36-47
    • He, L.1    Lu, N.2    Dai, Q.S.3    Zhao, Y.4    Zhao, L.5    Wang, H.6    Li, Z.Y.7    You, Q.D.8    Guo, Q.L.9
  • 16
    • 80054765267 scopus 로고    scopus 로고
    • Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting gsk-3â and Änp63
    • Chow, S.E.; Chang, Y.L.; Chuang, S.F.; Wang, J.S. Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3â and ÄNp63. Cancer Chemother. Pharmacol. 2011, 68, 835-845.
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , pp. 835-845
    • Chow, S.E.1    Chang, Y.L.2    Chuang, S.F.3    Wang, J.S.4
  • 18
    • 84904047703 scopus 로고    scopus 로고
    • Inhibitory effects of wogonin on invasion by human oral cancer cells by decreasing the activity of matrix metalloproteinases and urokinase-plasminogen activator
    • Available online: accessed on 11 April 2013
    • Ho, Y.C.; Lee, S.S.; Yang, F.S.; Yu, C.C.; Chang, Y.C. Inhibitory effects of wogonin on invasion by human oral cancer cells by decreasing the activity of matrix metalloproteinases and urokinase-plasminogen activator. J. Dent. Sci. 2013, Available online: http://dx.doi.org/10.1016/j.jds.2013.02.024 (accessed on 11 April 2013).
    • (2013) J. Dent. Sci.
    • Ho, Y.C.1    Lee, S.S.2    Yang, F.S.3    Yu, C.C.4    Chang, Y.C.5
  • 19
    • 38349057321 scopus 로고    scopus 로고
    • Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts
    • Chung, H.; Jung, Y.M.; Shin, D.H.; Lee, J.Y.; Oh, M.Y.; Kim, H.J. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. Int. J. Cancer 2008, 122, 816-822.
    • (2008) Int. J. Cancer , vol.122 , pp. 816-822
    • Chung, H.1    Jung, Y.M.2    Shin, D.H.3    Lee, J.Y.4    Oh, M.Y.5    Kim, H.J.6
  • 20
    • 84856735270 scopus 로고    scopus 로고
    • Wogonin induces apoptosis and down-regulates survivin in human breast cancer mcf-7 cells by modulating pi3k-Akt pathway
    • Huang, K.F.; Zhang, G.D.; Huang, Y.Q.; Diao, Y. Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. Int. Immunopharmacol. 2012, 12, 334-341.
    • (2012) Int. Immunopharmacol. , vol.12 , pp. 334-341
    • Huang, K.F.1    Zhang, G.D.2    Huang, Y.Q.3    Diao, Y.4
  • 21
    • 33748175976 scopus 로고    scopus 로고
    • Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line smmc-7721
    • Wang, W.; Guo, Q.; You, Q.; Zhang, K.; Yang, Y.; Yu, J. Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. Anticancer Drugs 2006, 17, 797-805.
    • (2006) Anticancer Drugs , vol.17 , pp. 797-805
    • Wang, W.1    Guo, Q.2    You, Q.3    Zhang, K.4    Yang, Y.5    Yu, J.6
  • 22
    • 84898809667 scopus 로고    scopus 로고
    • Insights into drug discovery from natural medicines using reverse pharmacokinetics
    • Hao, H.P.; Zheng, X.; Wang, G.J. Insights into drug discovery from natural medicines using reverse pharmacokinetics. Trends Pharmacol. Sci. 2014, 35, 168-177.
    • (2014) Trends Pharmacol. Sci. , vol.35 , pp. 168-177
    • Hao, H.P.1    Zheng, X.2    Wang, G.J.3
  • 23
    • 84882385828 scopus 로고    scopus 로고
    • Lc-ms quantification and pharmacokinetics of the multi-constituents of huangqin tang in rat plasma after different single oral doses
    • Li, T.; Wang, Y.W.; Wang, Y.L.; Liang, R.X.; Zhang, D.; Zhang, H.H.; Chen, L.; Zhou, Z.M.; Yang, W.P. LC-MS quantification and pharmacokinetics of the multi-constituents of Huangqin Tang in rat plasma after different single oral doses. Yao Xue Xue Bao 2013, 48, 917-924.
    • (2013) Yao Xue Xue Bao , vol.48 , pp. 917-924
    • Li, T.1    Wang, Y.W.2    Wang, Y.L.3    Liang, R.X.4    Zhang, D.5    Zhang, H.H.6    Chen, L.7    Zhou, Z.M.8    Yang, W.P.9
  • 24
    • 84889598759 scopus 로고    scopus 로고
    • Differences in pharmacokinetics and anti-inflammatory effects between decoction and maceration of sanhuang xiexin tang in rats and mice
    • Zhang, Q.; Ma, Y.M.; Wang, Z.T.; Wang, C.H. Differences in pharmacokinetics and anti-inflammatory effects between decoction and maceration of Sanhuang Xiexin Tang in rats and mice. Planta Med. 2013, 79, 1666-1673.
    • (2013) Planta Med. , vol.79 , pp. 1666-1673
    • Zhang, Q.1    Ma, Y.M.2    Wang, Z.T.3    Wang, C.H.4
  • 25
    • 84883802588 scopus 로고    scopus 로고
    • Comparative pharmacokinetics of baicalin, wogonoside, baicalein and wogonin in plasma after oral administration of pure baicalin, radix scutellariae and scutellariae-paeoniae couple extracts in normal and ulcerative colitis rats
    • Zhang, Z.Q.; Liu, W.; Zhuang, L.; Wang, J.; Zhang, S. Comparative pharmacokinetics of baicalin, wogonoside, baicalein and wogonin in plasma after oral administration of pure baicalin, radix scutellariae and scutellariae-paeoniae couple extracts in normal and ulcerative colitis rats. Iran. J. Pharm. Res. 2013, 12, 399-409.
    • (2013) Iran. J. Pharm. Res. , vol.12 , pp. 399-409
    • Zhang, Z.Q.1    Liu, W.2    Zhuang, L.3    Wang, J.4    Zhang, S.5
  • 26
    • 84855884254 scopus 로고    scopus 로고
    • Impact of recovery on fraction unbound using equilibrium dialysis
    • Di, L.; Umland, J.P.; Trapa, P.E.; Maurer, T.S. Impact of recovery on fraction unbound using equilibrium dialysis. J. Pharm. Sci. 2012, 101, 1327-1335.
    • (2012) J. Pharm. Sci. , vol.101 , pp. 1327-1335
    • Di, L.1    Umland, J.P.2    Trapa, P.E.3    Maurer, T.S.4
  • 27
    • 59349120231 scopus 로고    scopus 로고
    • Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets
    • Aggarwal, B.B.; Sung, B. Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets. Trends Pharmacol. Sci. 2009, 30, 85-88.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 85-88
    • Aggarwal, B.B.1    Sung, B.2
  • 29
    • 33845424456 scopus 로고    scopus 로고
    • Involvement of udp-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein
    • Zhang, L.; Lin, G.; Zuo, Z. Involvement of UDP-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein. Pharm. Res. 2007, 24, 81-89.
    • (2007) Pharm. Res. , vol.24 , pp. 81-89
    • Zhang, L.1    Lin, G.2    Zuo, Z.3
  • 30
    • 0037025836 scopus 로고    scopus 로고
    • Quantification of the flavonoid wogonin and its major metabolite wogonin 7β-d-gluduronide in rat plasma by liquid chromatoghraphy-Tandem mass spectrometry
    • Chen, X.Y.; Wang, H.Y.; Du, Y.; Zhong, D.F. Quantification of the flavonoid wogonin and its major metabolite wogonin 7β-d-gluduronide in rat plasma by liquid chromatoghraphy-Tandem mass spectrometry. J. Chromatogr. B 2002, 775, 169-178.
    • (2002) J. Chromatogr. B , vol.775 , pp. 169-178
    • Chen, X.Y.1    Wang, H.Y.2    Du, Y.3    Zhong, D.F.4
  • 31
    • 84865370023 scopus 로고    scopus 로고
    • Study on plasma concentration and bioavailability of wogoninin beagle's dogs
    • Li, J.C.; Chen, F.H.; Dong, H.J.; Gao, S. Study on Plasma Concentration and Bioavailability of Wogoninin Beagle's Dogs. Chin. Herb. Med. 2011, 3, 144-149.
    • (2011) Chin. Herb. Med. , vol.3 , pp. 144-149
    • Li, J.C.1    Chen, F.H.2    Dong, H.J.3    Gao, S.4
  • 32
    • 84857637435 scopus 로고    scopus 로고
    • Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in radix scutellariae
    • Li, C.; Zhang, L.; Zhou, L.; Wo, S.K.; Lin, G.; Zuo, Z. Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. AAPS J. 2012, 14, 23-34.
    • (2012) AAPS J. , vol.14 , pp. 23-34
    • Li, C.1    Zhang, L.2    Zhou, L.3    Wo, S.K.4    Lin, G.5    Zuo, Z.6
  • 34
    • 1642523230 scopus 로고    scopus 로고
    • Simultaneous determination of glipizide and rosiglitazone unbound drug concentrations in plasma by equilibrium dialysis and liquid chromatography- Tandem mass spectrometry
    • Lin, Z.J.; Desai-Krieger, D.; Shum, L. Simultaneous determination of glipizide and rosiglitazone unbound drug concentrations in plasma by equilibrium dialysis and liquid chromatography-Tandem mass spectrometry. J. Chromatogr. B 2004, 801, 265-272.
    • (2004) J. Chromatogr. B , vol.801 , pp. 265-272
    • Lin, Z.J.1    Desai-Krieger, D.2    Shum, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.