메뉴 건너뛰기




Volumn 48, Issue 6, 2013, Pages 917-924

LC-MS quantification and pharmacokinetics of the multi-constituents of huangqin tang in rat plasma after different single oral doses

Author keywords

Flavonoids; Huangqin Tang; Pharmacokinetics; Terpenoids

Indexed keywords

BAICALEIN; BAICALIN; CHINESE DRUG; FLAVONOID; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; HUANGQIN TANG; HYDROCHLORIC ACID; OROXYLIN A; TERPENOID; UNCLASSIFIED DRUG; WOGONIN; WOGONOSIDE; 5,7-DIHYDROXY-6-METHOXY-2-PHENYLCHROMEN-4-ONE; FLAVANONE DERIVATIVE; GLUCOSIDE; HERBACEOUS AGENT; HUANGQIN-TANG; PAEONIFLORIN; PENTACYCLIC TRITERPENE; TERPENE;

EID: 84882385828     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (32)
  • 1
    • 84882313477 scopus 로고
    • A preliminary study on the pharmacology of the compound prescription Huangqin Tang and its component drugs [J]
    • Huang L, Ye WH, Cai BW, et al. A preliminary study on the pharmacology of the compound prescription Huangqin Tang and its component drugs [J], China J Chin Mater Med, 1990, 15:51-53.
    • (1990) China J Chin Mater Med , vol.15 , pp. 51-53
    • Huang, L.1    Ye, W.H.2    Cai, B.W.3
  • 2
    • 57249108666 scopus 로고    scopus 로고
    • Modem pharmacodynamics research and clinic application of Huangqintang [J]
    • Zhang B, Liang X, Liu Q. Modem pharmacodynamics research and clinic application of Huangqintang [J]. China J Chin Mater Med, 2008, 33:2587-2590.
    • (2008) China J Chin Mater Med , vol.33 , pp. 2587-2590
    • Zhang, B.1    Liang, X.2    Liu, Q.3
  • 3
    • 84862777420 scopus 로고    scopus 로고
    • Old formula, new Rx: The journey of PHY906 as cancer adjuvant therapy [J]
    • Liu SH, Cheng YC. Old formula, new Rx: the journey of PHY906 as cancer adjuvant therapy [J], J Ethnopharmacol, 2012, 140:614-623.
    • (2012) J Ethnopharmacol , vol.140 , pp. 614-623
    • Liu, S.H.1    Cheng, Y.C.2
  • 4
    • 80054884803 scopus 로고    scopus 로고
    • Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones [J]
    • Li C, Lin G, Zuo Z. Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones [J]. Biopharm Drug Dispos, 2011, 32:427-445.
    • (2011) Biopharm Drug Dispos , vol.32 , pp. 427-445
    • Li, C.1    Lin, G.2    Zuo, Z.3
  • 5
    • 58749114381 scopus 로고    scopus 로고
    • New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents wogonin, baicalein and baicalin [J]
    • Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents wogonin, baicalein and baicalin [J]. Cancer Treat Rev, 2009, 35:57-68.
    • (2009) Cancer Treat Rev , vol.35 , pp. 57-68
    • Li-Weber, M.1
  • 6
    • 46849110600 scopus 로고    scopus 로고
    • Review of pharmacological effects of Glycyrrhiza sp and its bioactive compounds [J]
    • Asl MN, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds [J], Phytother Res, 2008, 22:709-724.
    • (2008) Phytother Res , vol.22 , pp. 709-724
    • Asl, M.N.1    Hosseinzadeh, H.2
  • 7
    • 75449094617 scopus 로고    scopus 로고
    • Chemical constituents and bioactivities of plants from the Genus Paeonia [J]
    • Wu SH, Wu DG, Chen YW. Chemical constituents and bioactivities of plants from the Genus Paeonia [J], Chem Biodivers, 2010, 7:90-104.
    • (2010) Chem Biodivers , vol.7 , pp. 90-104
    • Wu, S.H.1    Wu, D.G.2    Chen, Y.W.3
  • 9
    • 34247890673 scopus 로고    scopus 로고
    • Study on stability of baicalein [J]
    • Yao YH, Zhang LW. Study on stability of baicalein [J], Chin J Spectrosc Lab, 2006, 23:346-348.
    • (2006) Chin J Spectrosc Lab , vol.23 , pp. 346-348
    • Yao, Y.H.1    Zhang, L.W.2
  • 10
    • 1542497833 scopus 로고    scopus 로고
    • Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats [J]
    • Zuo F, Zhou ZM, Zhang Q, et al. Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats [J], Biol Pharm Bull, 2003, 26:911-919.
    • (2003) Biol Pharm Bull , vol.26 , pp. 911-919
    • Zuo, F.1    Zhou, Z.M.2    Zhang, Q.3
  • 11
    • 34548435160 scopus 로고    scopus 로고
    • Pharmacokinetics of flavonoids from Xiexin decoction in rats [J]
    • Yan JC, Liu ZM, Wang TM, et al. Pharmacokinetics of flavonoids from Xiexin decoction in rats [J]. Acta Pharm Sin, 2007, 42:722-729.
    • (2007) Acta Pharm Sin , vol.42 , pp. 722-729
    • Yan, J.C.1    Liu, Z.M.2    Wang, T.M.3
  • 12
    • 84878273166 scopus 로고    scopus 로고
    • HPLC-MS and HPLC-MS/MS analysis of seven active constituents of Xiao-Xu-Ming decoction and application to a pharmacokinetic study after oral administration to rat [J]
    • Wang Y, Ding C, Wu C, et al. HPLC-MS and HPLC-MS/MS analysis of seven active constituents of Xiao-Xu-Ming decoction and application to a pharmacokinetic study after oral administration to rat [J], Acta Pharm Sin B, 2012, 2:188-197.
    • (2012) Acta Pharm Sin B , vol.2 , pp. 188-197
    • Wang, Y.1    Ding, C.2    Wu, C.3
  • 13
    • 52749095314 scopus 로고    scopus 로고
    • Comparison of pharmacokinetics of baicalein and baicalin in rats [J]
    • Guo XY, Yang L, Chen Y, et al. Comparison of pharmacokinetics of baicalein and baicalin in rats [J]. Chin Pharm J, 2008, 43:524-526.
    • (2008) Chin Pharm J , vol.43 , pp. 524-526
    • Guo, X.Y.1    Yang, L.2    Chen, Y.3
  • 14
    • 33847790184 scopus 로고    scopus 로고
    • Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix Scutellariae extract and Huang-Lian-Jie-Du-Tang to rats [J]
    • Lu T, Song J, Huang F, et al. Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix Scutellariae extract and Huang-Lian-Jie-Du-Tang to rats [J], J Ethnopharmacol, 2007, 110:412-418.
    • (2007) J Ethnopharmacol , vol.110 , pp. 412-418
    • Lu, T.1    Song, J.2    Huang, F.3
  • 15
    • 27644442245 scopus 로고    scopus 로고
    • Absorption and enterohepatic circulation of baicalin in rats [J]
    • Xing J, Chen X, Zhong D. Absorption and enterohepatic circulation of baicalin in rats [J]. Life Sci, 2005, 78:140-146.
    • (2005) Life Sci , vol.78 , pp. 140-146
    • Xing, J.1    Chen, X.2    Zhong, D.3
  • 16
    • 0029856413 scopus 로고    scopus 로고
    • Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats; relevance to the intestinal bacterial hydrolysis [J]
    • Takeda S, Ishihara K, Wakui Y, et al. Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats; relevance to the intestinal bacterial hydrolysis [J], J Pharm Pharmacol, 1996, 48:902-905.
    • (1996) J Pharm Pharmacol , vol.48 , pp. 902-905
    • Takeda, S.1    Ishihara, K.2    Wakui, Y.3
  • 17
    • 0034141439 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling [J]
    • Ploeger BA, Meulenbelt J, DeJongh J. Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling [J]. Toxicol Appl Pharmacol, 2000, 162:177-188.
    • (2000) Toxicol Appl Pharmacol , vol.162 , pp. 177-188
    • Ploeger, B.A.1    Meulenbelt, J.2    DeJongh, J.3
  • 18
    • 0034949640 scopus 로고    scopus 로고
    • Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography [J]
    • Zuo F, Zhou ZM, Liu ML. Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography [J], Biol Pharm Bull, 2001, 24:693-697.
    • (2001) Biol Pharm Bull , vol.24 , pp. 693-697
    • Zuo, F.1    Zhou, Z.M.2    Liu, M.L.3
  • 19
    • 44249126748 scopus 로고    scopus 로고
    • The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats [J]
    • Zhang X, Li Z, Leung W, et al. The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats [J]. J Pain, 2008, 9:497-505.
    • (2008) J Pain , vol.9 , pp. 497-505
    • Zhang, X.1    Li, Z.2    Leung, W.3
  • 20
    • 80051714633 scopus 로고    scopus 로고
    • Comparison of pharmacokinetics between different doses of baicalein in rats [J]
    • Che QM, Yang L, Chen Y, et al. Comparison of pharmacokinetics between different doses of baicalein in rats [J], Chin J New Drugs, 2007, 16:604-606.
    • (2007) Chin J New Drugs , vol.16 , pp. 604-606
    • Che, Q.M.1    Yang, L.2    Chen, Y.3
  • 21
    • 33748433372 scopus 로고    scopus 로고
    • Pharmacokinetic comparisons of Shuang-Huang-Lian with the different combinations of its constitutional herbs [J]
    • Di B, Feng N, Liu W. Pharmacokinetic comparisons of Shuang-Huang-Lian with the different combinations of its constitutional herbs [J]. J Ethnopharmacol, 2006, 107:401-405.
    • (2006) J Ethnopharmacol , vol.107 , pp. 401-405
    • Di, B.1    Feng, N.2    Liu, W.3
  • 22
    • 84882388357 scopus 로고    scopus 로고
    • Effects of different Dahuang Huanglian Xiexin decoction formulations on the pharmacokinetics of baicalin and wogonoside in rats [J]
    • Huang P, JW G, Zou J, et al. Effects of different Dahuang Huanglian Xiexin decoction formulations on the pharmacokinetics of baicalin and wogonoside in rats [J], World Sci Technol Mod Tradit Chin Med Mater Med, 2012, 14:1445-1450.
    • (2012) World Sci Technol Mod Tradit Chin Med Mater Med , vol.14 , pp. 1445-1450
    • Huang, P.1    Jw, G.2    Zou, J.3
  • 23
    • 84871032395 scopus 로고    scopus 로고
    • Pharmacokinetic interactions among major bioactive components in Radix Scutellariae via metabolic competition [J]
    • Li CR, Zhang L, Wo SK, et al. Pharmacokinetic interactions among major bioactive components in Radix Scutellariae via metabolic competition [J]. Biopharm Drug Dispos, 2012, 33:487-500.
    • (2012) Biopharm Drug Dispos , vol.33 , pp. 487-500
    • Li, C.R.1    Zhang, L.2    Wo, S.K.3
  • 24
    • 24944525305 scopus 로고    scopus 로고
    • Comparison of the metabolism of baicalin in rats orally administered with Radix Scutellariae extract and Shuang-Huang-Lian extract [J]
    • Feng NP, Di B, Liu WY. Comparison of the metabolism of baicalin in rats orally administered with Radix Scutellariae extract and Shuang-Huang-Lian extract [J], Chem Pharm Bull, 2005, 53:978-983.
    • (2005) Chem Pharm Bull , vol.53 , pp. 978-983
    • Feng, N.P.1    Di, B.2    Liu, W.Y.3
  • 25
    • 33746641680 scopus 로고    scopus 로고
    • The uptake characteristics of flavonoids in Caco-2 model system [J]
    • Chen BL, Li SL, Li P, et al. The uptake characteristics of flavonoids in Caco-2 model system [J]. Chin J Nat Med, 2006, 4:299-302.
    • (2006) Chin J Nat Med , vol.4 , pp. 299-302
    • Chen, B.L.1    Li, S.L.2    Li, P.3
  • 26
    • 58249119578 scopus 로고    scopus 로고
    • Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model [J]
    • Tian XJ, Yang XW, Yang X, et al. Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model [J], Int J Pharm, 2009, 367:58-64.
    • (2009) Int J Pharm , vol.367 , pp. 58-64
    • Tian, X.J.1    Yang, X.W.2    Yang, X.3
  • 27
    • 51349086819 scopus 로고    scopus 로고
    • Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayersl [J]
    • Dai J, Yang J, Li C. Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayersl [J]. Acta Pharmacol Sin, 2008, 29:1086-1093.
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 1086-1093
    • Dai, J.1    Yang, J.2    Li, C.3
  • 28
    • 34249297623 scopus 로고    scopus 로고
    • Mechanistic study on the intestinal absorption and disposition of baicalein [J]
    • Zhang L, Lin G, Kovács B, et al. Mechanistic study on the intestinal absorption and disposition of baicalein [J]. Eur J Pharm Sci, 2007, 31:221-231.
    • (2007) Eur J Pharm Sci , vol.31 , pp. 221-231
    • Zhang, L.1    Lin, G.2    Kovács, B.3
  • 29
    • 84857637435 scopus 로고    scopus 로고
    • Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae [J]
    • Li C, Zhang L, Zhou L, et al. Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae [J], AAPS J, 2012, 14:23-33.
    • (2012) AAPS J , vol.14 , pp. 23-33
    • Li, C.1    Zhang, L.2    Zhou, L.3
  • 30
    • 47949093788 scopus 로고    scopus 로고
    • Plasma and urinary tanshinol from Salvia milliorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine [J]
    • Lu T, Yang J, Gao X, et al. Plasma and urinary tanshinol from Salvia milliorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine [J]. DrugMetab Dispos, 2008, 36:1578-1586.
    • (2008) DrugMetab Dispos , vol.36 , pp. 1578-1586
    • Lu, T.1    Yang, J.2    Gao, X.3
  • 31
    • 71049183577 scopus 로고    scopus 로고
    • Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats [J]
    • Liu H, Yang J, Du F, et al. Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats [J]. Drug Metab Dispos, 2009, 37:2290-2298.
    • (2009) Drug Metab Dispos , vol.37 , pp. 2290-2298
    • Liu, H.1    Yang, J.2    Du, F.3
  • 32
    • 84872927084 scopus 로고    scopus 로고
    • Development of an SPE-HPLC-MS method for simultaneous determination and pharmacokinetic study of bioactive constituents of Yu Ping Feng San in rat plasma after oral administration [J]
    • Li T, Wang YW, Wang YL, et al. Development of an SPE-HPLC-MS method for simultaneous determination and pharmacokinetic study of bioactive constituents of Yu Ping Feng San in rat plasma after oral administration [J]. J Ethnopharmacol, 2013, 145:784-792.
    • (2013) J Ethnopharmacol , vol.145 , pp. 784-792
    • Li, T.1    Wang, Y.W.2    Wang, Y.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.