Regular and moderate exercise initiated in middle age prevents age-related amyloidogenesis and preserves synaptic and neuroprotective signaling in mouse brain cortex

Experimental Gerontology

Volumn 57, Issue , 2014, Pages 57-65

  Di Loreto, Silvia ^a   Falone, Stefano ^b   D'Alessandro, Antonella ^b   Santini, Silvano ^b   Sebastiani, Pierluigi ^a   Cacchio, Marisa ^c   Amicarelli, Fernanda ^a,b  

^a INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

Author keywords

Amyloid beta; Brain cortex; Exercise; Middle age; Neuroprotection; Sirtuins

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN RECEPTOR P75; SIRTUIN 3; SORTILIN; SYNAPSIN; SYNAPSIN 1A; UNCLASSIFIED DRUG; NERVE GROWTH FACTOR; SIRT3 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN MITOCHONDRION; CELL FUNCTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EXERCISE INTENSITY; FEMALE; MIDDLE AGED; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVE STIMULATION; NERVE TRACT; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RUNNING; SYNAPTIC TRANSMISSION; TREADMILL EXERCISE; AGING; ANIMAL; METABOLISM; RANDOMIZATION;

AGING; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL CORTEX; FEMALE; MICE; NERVE GROWTH FACTOR; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; SIRTUIN 3; SYNAPSINS; SYNAPTIC TRANSMISSION;

EID: 84901375130     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.05.006     Document Type: Article

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