Effect of a neuroprotective exercise protocol on oxidative state and BDNF levels in the rat hippocampus

Brain Research

Volumn 1188, Issue 1, 2008, Pages 182-188

  Cechetti, Fernanda ^a   Fochesatto, Cíntia ^a   Scopel, Denise ^a   Nardin, Patrícia ^a   Gonçalves, Carlos Alberto ^a   Netto, Carlos Alexandre ^a   Siqueira, Ionara Rodrigues ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

BDNF; Brain; Hippocampus; Moderate exercise; Oxidative stress; Treadmill

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; FREE RADICAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; HIPPOCAMPUS; MACROMOLECULE; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TREADMILL EXERCISE;

ANIMALS; ANTIOXIDANTS; BRAIN; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CYTOPROTECTION; EXERCISE TEST; EXERCISE THERAPY; FREE RADICALS; HIPPOCAMPUS; MALE; ORGAN CULTURE TECHNIQUES; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; TREATMENT OUTCOME;

RATTUS; RATTUS NORVEGICUS;

EID: 37449018547     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.10.012     Document Type: Article

References (64)

1. Acikgoz O., Aksu I., Topcu A., and Kayatekin B.M. Acute exhaustive exercise does not alter lipid peroxidation levels and antioxidant enzyme activities in rat hippocampus, prefrontal cortex and striatum. Neurosci. Lett. 406 (2006) 148-151
2. Almli L.M., Hamrick S.E., Koshy A.A., Tauber M.G., and Ferriero D.M. Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons. Dev. Brain Res. 132 (2001) 121-129
3. Beck T., Lindholm D., Castron E., and Wree A. Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus. J. Cereb. Blood Flow Metab. 14 (1994) 689-692
4. Berchtold N.C., Chinn G., Chou M., Kesslak J.P., and Cotman C.W. Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus. Neuroscience 13 (2005) 853-861
5. Blaha G.R., Raghupathi R., Saatman K.E., and McIntosh T.K. Brain-derived neurotrophic factor administration after traumatic brain injury in the rat does not protect against behavioral or histological deficits. Neuroscience 99 (2000) 483-493
6. Blum R., Kafitz K.W., and Konnerth A. Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9. Nature 419 (2002) 687-693
7. Bondy S.C. Evaluation of free radical-initiated oxidant events within the nervous system. Methods Neurosci. 30 (1996) 243-259
8. Brooks G.A., and White T.P. Determination of metabolic and heart rate responses of rats to treadmill exercise. J. Appl. Physiol. 45 (1978) 1009-1015
9. Bromont C., Marie C., and Bralet J. Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats. Stroke 20 (1989) 918-924
10. Candelario-Jalil E., Mhadu N.H., Al-Dalain S.M., Martinez G., and Leon O.S. Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neurosci. Res. 41 (2001) 233-241
11. Cechetti F., Rhod A., Simão F., Santin K., Salbego C., Netto C.A., and Siqueira I.R. Effect of treadmill exercise on cell damage in rat hippocampal slices submitted to oxygen and glucose deprivation. Brain Res. 1157 (2007) 121-125
12. Ding Q., Vaynman S., Souda P., Whitelegge J.P., and Gomez-Pinilla F. Exercise affects energy metabolism and neural plasticity-related proteins in the hippocampus as revealed by proteomic analysis. Eur. J. Neurosci. 24 (2006) 1265-1276
13. Driver A.S., Kodavanti P.R.S., and Mundy W.R. Age-related in reactive oxygen species production in rat brain homogenates. Neurotoxicol. Teratol. 22 (2000) 175-181
14. Ellekjær E.F., Wyller T.B., Sverre J.M., and Holmen J. Lifestyle factors and risk of cerebral infarction. Stroke 23 (1992) 829-834
15. Evelson P., Travacio M., Repetto M., Escobar J., Llesuy S., and Lissi E.A. Evaluation of total reactive antioxidant potential (TRAP) of tissue homogenates and their cytosols. Arch. Biochem. Biophys. 388 (2001) 261-266
16. Flaim S.F., Minteer W.J., Clark D.P., and Zelis R. Cardiovascular response to acute aquatic and treadmill exercise in the untrained rat. J. Appl. Physiol. 46 (1979) 302-308
17. Gobbo O.L., and O'Mara S.M. Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic factor. Behav. Brain Res. 159 (2005) 21-26
18. Gomez-Pinilla F., Ying Z., Roy R., Molteni R., and Edgerton V. Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J. Neurophysiol. 88 (2002) 2187-2195
19. Gusow K., Szabelski M., Rzeska A., Karolczak J., Sulowska H., and Wiczk W. Photophysical properties of tyrosine at low pH range. Chem. Phys. Lett. 362 (2002) 519-526
20. Håheim L.L., Holme I., Hjermann I., and Leren P. Risk factors of stroke incidence and mortality: a 12-year follow-up of the Oslo Study. Stroke 24 (1993) 1484-1489
21. Harmsen P., Rosengren A., Tsipogianni A., and Wilhelmsen L. Risk factors for stroke in middle-aged men in Goteborg, Sweden. Stroke 21 (1990) 223-229
22. Johnson R., Rhodes J., Jeffrey S., Garland Jr. T., and Mitchell G. Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel running. Neuroscience 121 (2003) 1-7
23. Koh J.Y., Gwag B.J., Lobner D., and Choi D.W. Potentiated necrosis of cultured cortical neurons by neurotrophins. Science 268 (1995) 573-575
24. Kokaia Z., Metsis M., Kokaia M., Bengzon J., Elmer E., Smith M.L., Timmusk T., Siesjo B.K., Persson H., and Lindvall O. Brain insults in rats induce increased expression of the BDNF gene through differential use of multiple promoters. Eur. J. Neurosci. 6 (1994) 587-596
25. Kramer A.F., Hahn S., Cohen N.J., Banich M.T., McAuley E., Harrison C.R., Chason J., Vakil E., Bardell L., Boileau R.A., and Colcombe A. Ageing, fitness and neurocognitive function. Nature 400 (1999) 418-419
26. Lebel C.P., Ali S.F., McKee M., and Bondy S.C. Organometal induced increases in oxygen reactive species: the potential of 20,70-dichloro-fluorescein diacetate as an index of neurotoxic damage. Toxicol. Appl. Pharmacol. 104 (1990) 17-24
27. Lee I.M., and Paffenbarger Jr. R.S. Physical activity and stroke incidence: the Harvard Alumni Health Study. Stroke 29 (1998) 2049-2054
28. Leeuweenburgh C., Hollander J., Leichtweis S., Griffiths M., Gore M., and Ji L.L. Adaptation of glutathione antioxidant system to endurance training are tissue and muscle fiber specific. Am. J. Physiol. 272 (1997) 363-369
29. Lissi E., Pascual C., and del Castillo M.D. Luminol luminescence induced by 2,20-azo-bis(2-amidinopropane) thermolysis. Free Radic. Res. Commun. 17 (1992) 299-311
30. Lissi E., Salim-Hanna M., Pascual C., and del Castillo M.D. Evaluation of total antioxidant potential (TRAP) and total antioxidant reactivity from luminol-enhanced chemiluminescence measurements. Free Radic. Biol. Med. 18 (1995) 153-158
31. Liu J., Yeo H.C., Overvik-Douki E., Hagen T., Doniger S.J., Chyu D.W., Brooks G.A., and Ames B.N. Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants. J. Appl. Physiol. 89 (2000) 21-28
32. Mattson M.P. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Res. 886 (2000) 47-53
33. Molteni I.R., Ying Z., and Gomez-Pinilla F. Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray. Eur. J. Neurosci. 16 (2002) 1107-1116
34. Neeper S., Gomez-Pinilla F., Choi J., and Cotman C. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 726 (1996) 49-56
35. Ogonovszky H., Berkes I., Kumagai S., Kaneko T., Tahara S., Goto S., and Radák Z. The effects of moderate-, strenuos- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain. Neurochem. Int. 46 (2005) 635-640
36. Oliff H., Berchtold N., Isackson P., and Cotman C. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Mol. Cell Res. 61 (1998) 147-153
37. Poo M.-M. Neurotrophins as a synaptic modulators. Nat. Rev., Neurosci. 2 (2001) 24-32
38. Powers S.K., Criswell D., Lawler J., Ji L.L., Martin D., Herb R.A., and Dudley G. Influence of exercise and fiber type on antioxidant enzyme activity in rat skeletal muscle. Am. J. Physiol. 266 (1994) 376-380
39. Prehn J.H. Marked diversity in the action of growth factors on N-methyl-d-aspartate-induced neuronal degeneration. Eur. J. Pharmacol. 306 (1996) 81-88
40. Pringle A.K., Sundstrom L.E., Wilde G.J., Williams L.R., and Iannotti F. Brain-derived neurotrophic factor, but not neurotrophin-3, prevents ischaemia-induced neuronal cell death in organotypic rat hippocampal slice cultures. Neurosci. Lett. 211 (1996) 203-206
41. Radák Z., Asano K., Inoue M., Kizaki T., Oh-Ishi S., Suzuki K., Taniguchi N., and Ohno H. Superoxide dismutase derivative reduces oxidative damage in skeletal muscle of rats during exhaustive exercise. J. Appl. Physiol. 79 (1995) 129-135
42. Radák Z., Kaneco T., Tahara S., Nakato H., Pucsok J., Sasvári M., Nyakas C., and Goto S. Regular exercise improves cognitive function and decreases oxidative damage in rat brain. Neurochem. Int. 38 (2001) 17-23
43. Radák Z., Toldy A., Szabo Z., Siamilis S., Nyakas C., Silye G., Jakus J., and Goto S. The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem. Int. 49 (2006) 387-392
44. Ramsden M., Berchtold N.C., Patrick Kesslak J., Cotman C.W., and Pike C.J. Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Res. 971 (2003) 239-244
45. Risedal A., Zeng J., and Johansson B.B. Early training may exacerbate brain damage after focal brain ischemia in the rat. J. Cereb. Blood Flow Metab. 19 (1999) 997-1003
46. Rose C.R., Blum R., Pichler B., Lepier A., Kafitz K., and Konnerth A. Truncated TrkB-T1 mediates neurotrophin evoked calcium signaling in glial cells. Nature 426 (2003) 74-78
47. Sacco R.L., Gan R., Boden-Albala B., Lin I.F., Kargman D.E., Hauser A., Shea S., and Paik M.C. Leisure-time physical activity and ischemic stroke risk: the Northern Manhattan Stroke Study. Stroke 29 (1998) 380-387
48. Salonen J., Puska P., and Tuomilehto J. Physical activity and risk of myocardial infarction, cerebral stroke and death. Am. J. Epidemiol. 115 (1982) 526-537
49. Schabitz W.R., Schwab S., Spranger M., and Hacke W. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 17 (1997) 500-506
50. Scopel D., Fochesatto C., Cimarosti H., Rabbo M., Belló-Klein A., Salbego C., Netto C.A., and Siqueira I.R. Exercise intensity influences cell injury in rat hippocampal slices exposed to oxygen and glucose deprivation. Brain Res. Bull. 71 (2006) 155-159
51. 2 release by subsarcolemmal, and intermyofibrillar mitochondria. Free Radic. Biol. Med. 35 (2003) 24-32
52. Shimohama S., Tamura Y., Akaike A., Tsukahara T., Ohara O., Watanabe S., and Kimura J. Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons. Neurosci. Lett. 164 (1993) 55-58
53. Somani S.M., and Husain K. Exercise training alters kinetics of antioxidant enzymes in rat tissues. Biochem. Mol. Biol. Int. 38 (1996) 587-595
54. Somani S.M., Husain K., and Schlorff E.C. Response of antioxidant system to physical and chemical stress. In: Baskin S.I., and Salem H. (Eds). Oxidants, Antioxidants and Radicals (1994), Taylor and Francis, Washington 125-143
55. Somani S.M., Ravi R., and Rybak L.P. Effect of exercise training on antioxidant system in brain regions of rat. Pharmacol. Biochem. Behav. 50 (1995) 635-639
56. Sriram K., Pai K.S., Boyd M.R., and Ravindranath V. Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice. Brain Res. 749 (1997) 44-52
57. Stummer W., Weber K., Tranmer B., Baethmann A., and Kempski O. Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia. Stroke 25 (1994) 1862-1869
58. Suzuki M., Katamine S., and Tatsumi S. Exercise-induced enhancement of lipid peroxid metabolism in tissues and their transference into brain in rat. J. Nutr. Sci. Vitaminol. 29 (1983) 141-151
59. Toldy A., Stadler K., Sasvari M., Jakus J., Jung K.J., Chung H.Y., Berkes I., Nyakas C., and Radák Z. The effect of exercise and nettle supplementation on oxidative stress markers in the rat brain. Brain Res. Bull. 65 (2005) 487-493
60. Van Praag H., Kempermann G., and Gage F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2 (1999) 266-270
61. Vaynman S., Ying Z., and Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur. J. Neurosci. 20 (2004) 2580-2590
62. Vaynman S., Ying Z., Yin D., and Gomez-Pinilla F. Exercise differentially regulates synaptic proteins associated to the function of BDNF. Brain Res. 1070 (2006) 124-130
63. Wang R.Y., Yang Y.R., and Yu S.M. Protective effects of treadmill training on infarction in rats. Brain Res. 922 (2001) 140-143
64. White B.C., Sullivan J.M., DeGracia D.J., O'Neil B.J., Neumar R.W., Grossman L.I., Rafols J.A., and Krause G.S. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J. Neurol. Sci. 179 (2000) 1-33