Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Sun, Ning ^a   Chan, Fung Yi ^a,c   Lu, Yu Jing ^a,b   Neves, Marco A C ^c   Lui, Hok Kiu ^a   Wang, Yong ^a   Chow, Ka Yan ^a   Chan, Kin Fai ^a   Yan, Siu Cheong ^a   Leung, Yun Chung ^a   Abagyan, Ruben ^c,d   Chan, Tak Hang ^a   Wong, Kwok Yin ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b GUANGDONG UNIVERSITY OF TECHNOLOGY   (China)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d Molsoft LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 PHENOXYALKYLBERBERINE DERIVATIVE; ANTIINFECTIVE AGENT; BERBERINE; BERBERINE DERIVATIVE; FTSZ PROTEIN; FTSZ PROTEIN INHIBITOR; GUANOSINE TRIPHOSPHATASE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CYTOSKELETON PROTEIN; FTSZ PROTEIN, BACTERIA;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG POTENCY; ENTEROCOCCUS FAECIUM; ENZYME ACTIVITY; ESCHERICHIA COLI; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERIZATION; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT ENTEROCOCCUS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GRAM POSITIVE BACTERIUM; METABOLISM; MICROBIAL SENSITIVITY TEST; PROTEIN CONFORMATION; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BERBERINE; CYTOSKELETAL PROTEINS; ESCHERICHIA COLI; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION;

EID: 84901336638     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097514     Document Type: Article

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