Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ

Journal of the American Chemical Society

Volumn 132, Issue 26, 2010, Pages 9069-9077

  Plaza, Alberto ^a   Keffer, Jessica L ^a   Bifulco, Giuseppe ^b   Lloyd, John R ^a   Bewley, Carole A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BACTERIOLOGY; CELL PROLIFERATION; COMPUTER SIMULATION; ETHERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

BACTERIAL CELL DIVISION; BACTERIAL CYTOSKELETAL PROTEIN FTSZ; BINDING EPITOPES; CHRYSOPHYTE ALGAE; ENZYME ASSAYS; ETHER BOND; GRAM-POSITIVE BACTERIUM; GTP BINDING; GTPASE ACTIVITY; IN-VITRO; LOW ENERGIES; MACROCYCLES; MACROCYCLICS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR DOCKING SIMULATIONS; NATURAL PRODUCTS; PROTOFILAMENTS; S. AUREUS; SATURATION-TRANSFER DIFFERENCES; STRUCTURAL CLASS; VANCOMYCIN-RESISTANT ENTEROCOCCI;

BINDING ENERGY;

ANTIINFECTIVE AGENT; CHRYSOPHAENTIN A; CHRYSOPHAENTIN B; CHRYSOPHAENTIN C; CHRYSOPHAENTIN D; CHRYSOPHAENTIN E; CHRYSOPHAENTIN F; CHRYSOPHAENTIN G; CHRYSOPHAENTIN H; FTSZ PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CYTOSKELETON PROTEIN; FTSZ PROTEIN, BACTERIA; MACROCYCLIC COMPOUND; METHANOL;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENTEROCOCCUS FAECIUM; ENZYME INHIBITION; GROWTH INHIBITION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; IC 50; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TRANSMISSION ELECTRON MICROSCOPY; VANCOMYCIN RESISTANT ENTEROCOCCUS; ANTAGONISTS AND INHIBITORS; ANTIBIOTIC RESISTANCE; BACTERIA; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; EUKARYOTE; ISOLATION AND PURIFICATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE;

ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL PROTEINS; CYTOSKELETAL PROTEINS; DRUG RESISTANCE, BACTERIAL; EUKARYOTA; GTP PHOSPHOHYDROLASES; MACROCYCLIC COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; METHANOL; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954247268     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja102100h     Document Type: Article

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