메뉴 건너뛰기




Volumn 2014, Issue 3, 2014, Pages

Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIGENIC VARIATION; ARTICLE; ATTENUATION; BLOODSTREAM INFECTION; CELL CYCLE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GROWTH RETARDATION; HISTONE METHYLATION; IMMUNOFLUORESCENCE; KINETICS; KINETOPLAST; MICROSCOPY; NONHUMAN; PROTEIN ANALYSIS; TRYPANOSOMA BRUCEI; ALLELE; CELL DIFFERENTIATION; GENE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; TRYPANOSOMA BRUCEI BRUCEI;

EID: 84901322899     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.02324     Document Type: Article
Times cited : (68)

References (42)
  • 1
    • 1642483811 scopus 로고    scopus 로고
    • Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream
    • doi: 10.1111/j.1365-2958.2003.03937.x
    • Amiguet-Vercher A., Pérez-Morga D, Pays A, Poelvoorde P, Xong H, Tebabi P, Vanhamme L, Pays E. 2004. Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream. Molecular Microbiology 51:1577-1588. doi: 10.1111/j.1365-2958.2003.03937.x.
    • (2004) Molecular Microbiology , vol.51 , pp. 1577-1588
    • Amiguet-Vercher, A.1    Pérez-Morga, D.2    Pays, A.3    Poelvoorde, P.4    Xong, H.5    Tebabi, P.6    Vanhamme, L.7    Pays, E.8
  • 3
    • 0032576751 scopus 로고    scopus 로고
    • The role of transferrin-receptor variation in the host range of Trypanosoma brucei
    • doi: 10.1038/35166
    • Bitter W., Gerrits H, Kieft R, Borst P. 1998. The role of transferrin-receptor variation in the host range of Trypanosoma brucei. Nature 391:499-502. doi: 10.1038/35166.
    • (1998) Nature , vol.391 , pp. 499-502
    • Bitter, W.1    Gerrits, H.2    Kieft, R.3    Borst, P.4
  • 4
    • 0037023543 scopus 로고    scopus 로고
    • Antigenic variation and allelic exclusion
    • Borst P. 2002. Antigenic variation and allelic exclusion. Cell 109:5-8.
    • (2002) Cell , vol.109 , pp. 5-8
    • Borst, P.1
  • 5
    • 0025825726 scopus 로고
    • A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
    • doi: 10.1016/0092-8674(91)90418-X
    • Buck L., Axel R. 1991. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65:175-187. doi: 10.1016/0092-8674(91)90418-X.
    • (1991) Cell , vol.65 , pp. 175-187
    • Buck, L.1    Axel, R.2
  • 6
    • 0030592441 scopus 로고    scopus 로고
    • Targeted disruption of expression site-associated gene-1 in bloodstream-form Trypanosoma brucei
    • doi: 10.1016/0166-6851(96)02672-2
    • Carruthers V. B, Navarro M, Cross GA. 1996. Targeted disruption of expression site-associated gene-1 in bloodstream-form Trypanosoma brucei. Molecular and Biochemical Parasitology 81:65-79. doi: 10.1016/0166-6851(96)02672-2.
    • (1996) Molecular and Biochemical Parasitology , vol.81 , pp. 65-79
    • Carruthers, V.B.1    Navarro, M.2    Cross, G.A.3
  • 7
    • 0033199568 scopus 로고    scopus 로고
    • Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei
    • doi: 10.1093/emboj/18.17.4846
    • Chaves I., Rudenko G, Dirks-Mulder A, Cross M, Borst P. 1999. Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei. The EMBO Journal 18:4846-4855. doi: 10.1093/emboj/18.17.4846.
    • (1999) The EMBO Journal , vol.18 , pp. 4846-4855
    • Chaves, I.1    Rudenko, G.2    Dirks-Mulder, A.3    Cross, M.4    Borst, P.5
  • 8
    • 0016809286 scopus 로고
    • Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei
    • doi: 10.1017/S003118200004717X
    • Cross G. A 1975. Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei. Parasitology 71:393-417. doi: 10.1017/S003118200004717X.
    • (1975) Parasitology , vol.71 , pp. 393-417
    • Cross, G.A.1
  • 9
    • 66149089452 scopus 로고    scopus 로고
    • A surface transporter family conveys the trypanosome differentiation signal
    • doi: 10.1038/nature07997
    • Dean S., Marchetti R, Kirk K, Matthews KR. 2009. A surface transporter family conveys the trypanosome differentiation signal. Nature 459:213-217. doi: 10.1038/nature07997.
    • (2009) Nature , vol.459 , pp. 213-217
    • Dean, S.1    Marchetti, R.2    Kirk, K.3    Matthews, K.R.4
  • 11
    • 8644219648 scopus 로고    scopus 로고
    • Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei
    • doi: 10.1101/gad.323404
    • Engstler M., Boshart M. 2004. Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei. Genes & Development 18:2798-2811. doi: 10.1101/gad.323404.
    • (2004) Genes & Development , vol.18 , pp. 2798-2811
    • Engstler, M.1    Boshart, M.2
  • 12
    • 35548966701 scopus 로고    scopus 로고
    • Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes
    • doi: 10.1016/j.cell.2007.08.046
    • Engstler M., Pfohl T, Herminghaus S, Boshart M, Wiegertjes G, Heddergott N, Overath P. 2007. Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes. Cell 131:505-515. doi: 10.1016/j.cell.2007.08.046.
    • (2007) Cell , vol.131 , pp. 505-515
    • Engstler, M.1    Pfohl, T.2    Herminghaus, S.3    Boshart, M.4    Wiegertjes, G.5    Heddergott, N.6    Overath, P.7
  • 13
    • 48349107004 scopus 로고    scopus 로고
    • A histone methyltransferase modulates antigenic variation in African trypanosomes
    • doi: 10.1371/journal.pbio.0060161
    • Figueiredo L. M, Janzen CJ, Cross GAM. 2008. A histone methyltransferase modulates antigenic variation in African trypanosomes. PLOS Biology 6:e161. doi: 10.1371/journal.pbio.0060161.
    • (2008) PLOS Biology , vol.6
    • Figueiredo, L.M.1    Janzen, C.J.2    Cross, G.A.M.3
  • 14
    • 84876342100 scopus 로고    scopus 로고
    • Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum
    • doi: 10.1111/cmi.12115
    • Guizetti J., Scherf A. 2013. Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum. Cellular Microbiology 15:718-726. doi: 10.1111/cmi.12115.
    • (2013) Cellular Microbiology , vol.15 , pp. 718-726
    • Guizetti, J.1    Scherf, A.2
  • 16
    • 0018831573 scopus 로고
    • Novel expression-linked copies of the genes for variant surface antigens in trypanosomes
    • doi: 10.1038/284078a0
    • Hoeijmakers J. H, Frasch AC, Bernards A, Borst P, Cross GA. 1980. Novel expression-linked copies of the genes for variant surface antigens in trypanosomes. Nature 284:78-80. doi: 10.1038/284078a0.
    • (1980) Nature , vol.284 , pp. 78-80
    • Hoeijmakers, J.H.1    Frasch, A.C.2    Bernards, A.3    Borst, P.4    Cross, G.A.5
  • 17
    • 0034472569 scopus 로고    scopus 로고
    • Expression-site-associated gene 8 (ESAG8) of Trypanosoma brucei is apparently essential and accumulates in the nucleolus
    • Hoek M., Engstler M, Cross GA. 2000. Expression-site-associated gene 8 (ESAG8) of Trypanosoma brucei is apparently essential and accumulates in the nucleolus. Journal of Cell Science 113:3959-3968.
    • (2000) Journal of Cell Science , vol.113 , pp. 3959-3968
    • Hoek, M.1    Engstler, M.2    Cross, G.A.3
  • 18
    • 0034793842 scopus 로고    scopus 로고
    • Expression-site-associated-gene-8 (ESAG8) is not required for regulation of the VSG expression site in Trypanosoma brucei
    • doi: 10.1016/S0166-6851(01)00341-3
    • Hoek M., Cross GA. 2001. Expression-site-associated-gene-8 (ESAG8) is not required for regulation of the VSG expression site in Trypanosoma brucei. Molecular and Biochemical Parasitology 117:211-215. doi: 10.1016/S0166-6851(01)00341-3.
    • (2001) Molecular and Biochemical Parasitology , vol.117 , pp. 211-215
    • Hoek, M.1    Cross, G.A.2
  • 19
    • 0037046097 scopus 로고    scopus 로고
    • Trypanosoma brucei expression-site-associated-gene-8 protein interacts with a Pumilio family protein
    • Hoek M., Zanders T, Cross GAM. 2002. Trypanosoma brucei expression-site-associated-gene-8 protein interacts with a Pumilio family protein. Molecular and Biochemical Parasitology 120:269-283.
    • (2002) Molecular and Biochemical Parasitology , vol.120 , pp. 269-283
    • Hoek, M.1    Zanders, T.2    Cross, G.A.M.3
  • 20
    • 78649657053 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the control of antigenic variation in African trypanosomes
    • doi: 10.1016/j.mib.2010.08.009
    • Horn D., McCulloch R. 2010. Molecular mechanisms underlying the control of antigenic variation in African trypanosomes. Current Opinion in Microbiology 13:700-705. doi: 10.1016/j.mib.2010.08.009.
    • (2010) Current Opinion in Microbiology , vol.13 , pp. 700-705
    • Horn, D.1    McCulloch, R.2
  • 21
    • 33747003677 scopus 로고    scopus 로고
    • Selective di-or trimethylation of histone H3 lysine 76 by two DOT1 homologs is important for cell cycle regulation in Trypanosoma brucei
    • doi: 10.1016/j.molcel.2006.06.027
    • Janzen C. J, Hake SB, Lowell JE, Cross GAM. 2006. Selective di-or trimethylation of histone H3 lysine 76 by two DOT1 homologs is important for cell cycle regulation in Trypanosoma brucei. Molecular Cell 23:497-507. doi: 10.1016/j.molcel.2006.06.027.
    • (2006) Molecular Cell , vol.23 , pp. 497-507
    • Janzen, C.J.1    Hake, S.B.2    Lowell, J.E.3    Cross, G.A.M.4
  • 22
    • 84880525997 scopus 로고    scopus 로고
    • An epigenetic trap stabilizes singular olfactory receptor expression
    • doi: 10.1016/j.cell.2013.06.039
    • Lyons D. B, Allen WE, Goh T, Tsai L, Barnea G, Lomvardas S. 2013. An epigenetic trap stabilizes singular olfactory receptor expression. Cell 154:325-336. doi: 10.1016/j.cell.2013.06.039.
    • (2013) Cell , vol.154 , pp. 325-336
    • Lyons, D.B.1    Allen, W.E.2    Goh, T.3    Tsai, L.4    Barnea, G.5    Lomvardas, S.6
  • 23
    • 79955066245 scopus 로고    scopus 로고
    • Transmission stages dominate trypanosome within-host dynamics during chronic infections
    • doi: 10.1016/j.chom.2011.03.013
    • MacGregor P., Savill NJ, Hall D, Matthews KR. 2011. Transmission stages dominate trypanosome within-host dynamics during chronic infections. Cell Host & Microbe 9:310-318. doi: 10.1016/j.chom.2011.03.013.
    • (2011) Cell Host & Microbe , vol.9 , pp. 310-318
    • McGregor, P.1    Savill, N.J.2    Hall, D.3    Matthews, K.R.4
  • 24
    • 84861200974 scopus 로고    scopus 로고
    • Trypanosomal immune evasion, chronicity and transmission: An elegant balancing act
    • doi: 10.1038/nrmicro2779
    • MacGregor P., Szöo{double acute}r B, Savill NJ, Matthews KR. 2012. Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act. Nature Reviews Microbiology 10:431-438. doi: 10.1038/nrmicro2779.
    • (2012) Nature Reviews Microbiology , vol.10 , pp. 431-438
    • McGregor, P.1    Szöor, B.2    Savill, N.J.3    Matthews, K.R.4
  • 25
    • 84870566620 scopus 로고    scopus 로고
    • Identification of the regulatory elements controlling the transmission stage-specific gene expression of PAD1 in Trypanosoma brucei
    • doi: 10.1093/nar/gks533
    • MacGregor P., Matthews KR. 2012. Identification of the regulatory elements controlling the transmission stage-specific gene expression of PAD1 in Trypanosoma brucei. Nucleic Acids Research 40:7705-7717. doi: 10.1093/nar/gks533.
    • (2012) Nucleic Acids Research , vol.40 , pp. 7705-7717
    • McGregor, P.1    Matthews, K.R.2
  • 27
    • 0030037305 scopus 로고    scopus 로고
    • Stable expression of mosaic coats of variant surface glycoproteins in Trypanosoma brucei
    • doi: 10.1126/science.272.5269.1795
    • Muñoz-Jordán JL, Davies KP, Cross GA. 1996. Stable expression of mosaic coats of variant surface glycoproteins in Trypanosoma brucei. Science 272:1795-1797. doi: 10.1126/science.272.5269.1795.
    • (1996) Science , vol.272 , pp. 1795-1797
    • Muñoz-Jordán, J.L.1    Davies, K.P.2    Cross, G.A.3
  • 28
    • 36349016790 scopus 로고    scopus 로고
    • Prominent roles for odorant receptor coding sequences in allelic exclusion
    • doi: 10.1016/j.cell.2007.10.050
    • Nguyen M. Q, Zhou Z, Marks CA, Ryba NJP, Belluscio L. 2007. Prominent roles for odorant receptor coding sequences in allelic exclusion. Cell 131:1009-1017. doi: 10.1016/j.cell.2007.10.050.
    • (2007) Cell , vol.131 , pp. 1009-1017
    • Nguyen, M.Q.1    Zhou, Z.2    Marks, C.A.3    Ryba, N.J.P.4    Belluscio, L.5
  • 29
    • 0033592539 scopus 로고    scopus 로고
    • N-linked glycans containing linear poly-N-acetyllactosamine as sorting signals in endocytosis in Trypanosoma brucei
    • 1169-11S1, doi: 10.1016/S0960-9822(00)80018-4
    • Nolan D. P, Geuskens M, Pays E. 1999. N-linked glycans containing linear poly-N-acetyllactosamine as sorting signals in endocytosis in Trypanosoma brucei. Current Biology 9:1169-11S1. doi: 10.1016/S0960-9822(00)80018-4.
    • (1999) Current Biology , vol.9
    • Nolan, D.P.1    Geuskens, M.2    Pays, E.3
  • 30
    • 0023025407 scopus 로고
    • The effect of citrate/cis-aconitate on oxidative metabolism during transformation of Trypanosoma brucei
    • doi: 10.1111/j.1432-1033.1986.tb09955.x
    • Overath P., Czichos J, Haas C. 1986. The effect of citrate/cis-aconitate on oxidative metabolism during transformation of Trypanosoma brucei. European Journal of Biochemistry 160:175-182. doi: 10.1111/j.1432-1033.1986.tb09955.x.
    • (1986) European Journal of Biochemistry , vol.160 , pp. 175-182
    • Overath, P.1    Czichos, J.2    Haas, C.3
  • 31
    • 0035946414 scopus 로고    scopus 로고
    • The VSG expression sites of Trypanosoma brucei: Multipurpose tools for the adaptation of the parasite to mammalian hosts
    • doi: 10.1016/S0166-6851(01)00242-0
    • Pays E., Lips S, Nolan D, Vanhamme L, Pérez-Morga D. 2001. The VSG expression sites of Trypanosoma brucei: multipurpose tools for the adaptation of the parasite to mammalian hosts. Molecular and Biochemical Parasitology 114:1-16. doi: 10.1016/S0166-6851(01)00242-0.
    • (2001) Molecular and Biochemical Parasitology , vol.114 , pp. 1-16
    • Pays, E.1    Lips, S.2    Nolan, D.3    Vanhamme, L.4    Pérez-Morga, D.5
  • 32
    • 0031438790 scopus 로고    scopus 로고
    • Cell density triggers slender to stumpy differentiation of Trypanosoma brucei bloodstream forms in culture
    • doi: 10.1016/S0166-6851(97)00160-6
    • Reuner B., Vassella E, Yutzy B, Boshart M. 1997. Cell density triggers slender to stumpy differentiation of Trypanosoma brucei bloodstream forms in culture. Molecular and Biochemical Parasitology 90:269-280. doi: 10.1016/S0166-6851(97)00160-6.
    • (1997) Molecular and Biochemical Parasitology , vol.90 , pp. 269-280
    • Reuner, B.1    Vassella, E.2    Yutzy, B.3    Boshart, M.4
  • 33
    • 78650307411 scopus 로고    scopus 로고
    • The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes
    • doi: 10.1016/j.molbiopara.2010.11.004
    • Schwede A., Jones N, Engstler M, Carrington M. 2011. The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes. Molecular and Biochemical Parasitology 175:201-204. doi: 10.1016/j.molbiopara.2010.11.004.
    • (2011) Molecular and Biochemical Parasitology , vol.175 , pp. 201-204
    • Schwede, A.1    Jones, N.2    Engstler, M.3    Carrington, M.4
  • 34
    • 0346362447 scopus 로고    scopus 로고
    • Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse
    • doi: 10.1126/science.1089122
    • Serizawa S., Miyamichi K, Nakatani H, Suzuki M, Saito M, Yoshihara Y, Sakano H. 2003. Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science 302:2088-2094. doi: 10.1126/science.1089122.
    • (2003) Science , vol.302 , pp. 2088-2094
    • Serizawa, S.1    Miyamichi, K.2    Nakatani, H.3    Suzuki, M.4    Saito, M.5    Yoshihara, Y.6    Sakano, H.7
  • 36
    • 0033928734 scopus 로고    scopus 로고
    • Genetic interference in Trypanosoma brucei by heritable and inducible double-stranded RNA
    • doi: 10.1017/S1355838200000297
    • Shi H., Djikeng A, Mark T, Wirtz E, Tschudi C, Ullu E. 2000. Genetic interference in Trypanosoma brucei by heritable and inducible double-stranded RNA. RNA 6:1069-1076. doi: 10.1017/S1355838200000297.
    • (2000) RNA , vol.6 , pp. 1069-1076
    • Shi, H.1    Djikeng, A.2    Mark, T.3    Wirtz, E.4    Tschudi, C.5    Ullu, E.6
  • 37
    • 70449584523 scopus 로고    scopus 로고
    • Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation
    • doi: 10.1371/journal.pone.0007532
    • Smith T. K, Vasileva N, Gluenz E, Terry S, Portman N, Kramer S, Carrington M, Michaeli S, Gull K, Rudenko G. 2009. Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation. PLoS ONE 4:e7532. doi: 10.1371/journal.pone.0007532.
    • (2009) PLoS ONE , vol.4
    • Smith, T.K.1    Vasileva, N.2    Gluenz, E.3    Terry, S.4    Portman, N.5    Kramer, S.6    Carrington, M.7    Michaeli, S.8    Gull, K.9    Rudenko, G.10
  • 39
    • 0030696101 scopus 로고    scopus 로고
    • Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway
    • Vassella E., Reuner B, Yutzy B, Boshart M. 1997. Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway. Journal of Cell Science 110:2661-2671.
    • (1997) Journal of Cell Science , vol.110 , pp. 2661-2671
    • Vassella, E.1    Reuner, B.2    Yutzy, B.3    Boshart, M.4
  • 40
    • 0027969338 scopus 로고
    • Gene expression mediated by bacteriophage T3 and T7 RNA polymerases in transgenic trypanosomes
    • doi: 10.1093/nar/22.19.3887
    • Wirtz E., Hartmann C, Clayton C. 1994. Gene expression mediated by bacteriophage T3 and T7 RNA polymerases in transgenic trypanosomes. Nucleic Acids Research 22:3887-3894. doi: 10.1093/nar/22.19.3887.
    • (1994) Nucleic Acids Research , vol.22 , pp. 3887-3894
    • Wirtz, E.1    Hartmann, C.2    Clayton, C.3
  • 41
    • 0033525524 scopus 로고    scopus 로고
    • A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei
    • doi: 10.1016/S0166-6851(99)00002-X
    • Wirtz E., Leal S, Ochatt C, Cross GA. 1999. A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Molecular and Biochemical Parasitology 99:89-101. doi: 10.1016/S0166-6851(99)00002-X.
    • (1999) Molecular and Biochemical Parasitology , vol.99 , pp. 89-101
    • Wirtz, E.1    Leal, S.2    Ochatt, C.3    Cross, G.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.