Identification of the regulatory elements controlling the transmission stage-specific gene expression of PAD1 in Trypanosoma brucei

Nucleic Acids Research

Volumn 40, Issue 16, 2012, Pages 7705-7717

  MacGregor, Paula ^a   Matthews, Keith R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; MESSENGER RNA;

3' UNTRANSLATED REGION; AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAT GENE; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GENE MAPPING; GENE REPRESSION; GENE SILENCING; GENETIC IDENTIFICATION; MOUSE; NONHUMAN; PAD1 GENE; PARASITE DEVELOPMENT; PARASITE TRANSMISSION; PARASITE VECTOR; PRIORITY JOURNAL; REGULATORY SEQUENCE; TRANSGENIC ORGANISM; TRYPANOSOMA BRUCEI;

3' UNTRANSLATED REGIONS; ANIMALS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE SILENCING; MEMBRANE TRANSPORT PROTEINS; MICE; POLYADENYLATION; PROTOZOAN PROTEINS; REGULATORY SEQUENCES, RIBONUCLEIC ACID; TRYPANOSOMA BRUCEI BRUCEI;

EUKARYOTA; GLOSSINA (GENUS); MAMMALIA; TRYPANOSOMA BRUCEI; TRYPANOSOMATIDAE;

EID: 84870566620     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks533     Document Type: Article

References (41)

1. Duester, G. (2008) Retinoic acid synthesis and signaling during early organogenesis. Cell, 134, 921-931.
2. Marsh, L., Neiman, A.M. and Herskowitz, I. (1991) Signal transduction during pheromone response in yeast. Annu. Rev. Cell. Biol., 7, 699-728.
3. Kay, R.R. and Jermyn, K.A. (1983) A possible morphogen controlling differentiation in Dictyostelium. Nature, 303, 242-244.
4. Pan, J. and Snell, W.J. (2000) Signal transduction during fertilization in the unicellular green alga, Chlamydomonas. Curr. Opin. Microbiol., 3, 596-602.
5. Madhani, H.D. and Fink, G.R. (1998) The control of filamentous differentiation and virulence in fungi. Trends Cell Biol., 8, 348-353.
6. Sogin, M.L., Elwood, H.J. and Gunderson, J.H. (1986) Evolutionary diversity of eukaryotic small-subunit rRNA genes. Proc. Natl. Acad. Sci. USA, 83, 1383-1387.
7. Berriman, M., Ghedin, E., Hertz-Fowler, C., Blandin, G., Renauld, H., Bartholomeu, D.C., Lennard, N.J., Caler, E., Hamlin, N.E., Haas, B. et al. (2005) The genome of the African trypanosome Trypanosoma brucei. Science, 309, 416-422.
8. LeBowitz, J.H., Smith, H.Q., Rusche, L. and Beverley, S.M. (1993) Coupling of poly (A) site selection and trans-splicing in Leishmania. Genes Dev., 7, 996-1007.
9. Matthews, K.R., Tschudi, C. and Ullu, E. (1994) A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes. Genes Dev., 8, 491-501.
10. Clayton, C. and Shapira, M. (2007) Post-transcriptional regulation of gene expression in trypanosomes and leishmanias. Mol. Biochem. Parasitol., 156, 93-101.
11. Matthews, K.R. Controlling and coordinating development in vector-transmitted parasites. Science, 331, 1149-1153.
12. Fenn, K. and Matthews, K.R. (2007) The cell biology of Trypanosoma brucei differentiation. Curr. Opin. Microbiol., 10, 539-546.
13. Zilberstein, D. and Shapira, M. (1994) The Role Of Ph and Temperature In the Development Of Leishmania Parasites. Annu. Rev. Microbiol., 48, 449-470.
14. Engstler, M. and Boshart, M. (2004) Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei. Genes Dev., 18, 2798-2811.
15. Garcia, E.S., Genta, F.A., de Azambuja, P. and Schaub, G.A. Interactions between intestinal compounds of triatomines and Trypanosoma cruzi. Trends Parasitol., 26, 499-505.
16. Roditi, I. and Lehane, M.J. (2008) Interactions between trypanosomes and tsetse flies. Curr. Opin. Microbiol., 11, 345-351.
17. Roditi, I. and Liniger, M. (2002) Dressed for success: the surface coats of insect-borne protozoan parasites. Trends Microbiol., 10, 128-134.
18. Vassella, E., VandenAbbeele, J., Butikofer, P., Renggli, C.K., Furger, A., Brun, R. and Roditi, I. (2000) A major surface glycoprotein of Trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia. Genes Dev., 14, 615-626.
19. Siegel, T.N., Gunasekera, K., Cross, G.A. and Ochsenreiter, T. (2011) Gene expression in Trypanosoma brucei: lessons from high-throughput RNA sequencing. Trends Parasitol, 27, 434-441.
20. Nolan, D.P., Rolin, S., Rodriguez, J.R., Van Den Abbeele, J. and Pays, E. (2000) Slender and stumpy bloodstream forms of Trypanosoma brucei display a differential response to extracellular acidic and proteolytic stress. Eur. J. Biochem., 267, 18-27.
21. Czichos, J., Nonnengaesser, C. and Overath, P. (1986) Trypanosoma brucei: cis-aconitate and temperature reduction as triggers of synchronous transformation of bloodstream to procyclic trypomastigotes in vitro. Exp. Parasitol., 62, 283-291.
22. Dean, S.D., Marchetti, R., Kirk, K. and Matthews, K. (2009) A surface transporter family conveys the trypanosome differentiation signal. Nature, 459, 213-217.
23. Reuner, B., Vassella, E., Yutzy, B. and Boshart, M. (1997) Cell density triggers slender to stumpy differentiation of Trypanosoma brucei bloodstream forms in culture. Mol Biochem. Parasitol., 90, 269-280.
24. Vassella, E., Reuner, B., Yutzy, B. and Boshart, M. (1997) Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway. J. Cell Sci., 110 (Pt 21), 2661-2671.
25. MacGregor, P. and Matthews, K.R. (2010) New discoveries in the transmission biology of sleeping sickness parasites: applying the basics. J. Mol. Med., 88, 865-871.
26. Macgregor, P., Savill, N.J., Hall, D. and Matthews, K.R. (2011) Transmission Stages dominate trypanosome within-host dynamics during chronic infections. Cell Host Microbe, 9, 310-318.
27. Vickerman, K. (1965) Polymorphism and mitochondrial activity in sleeping sickness trypanosomes. Nature, 208, 762-766.
28. Vickerman, K. (1985) Developmental cycles and biology of pathogenic trypanosomes. Brit. Med. Bull., 41, 105-114.
29. Hirumi, H. and Hirumi, K. (1989) Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J. Parasitol., 75, 985-989.
30. Lanham, S.M. (1968) Separation of trypanosomes from the blood of infected rats and mice by anion-exchangers. Nature, 218, 1273-1274.
31. Mayho, M., Fenn, K., Craddy, P., Crosthwaite, S. and Matthews, K. (2006) Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei: evidence for genome-wide conservation of life-cycle stage-specific regulatory elements. Nucleic Acids Res., 34, 5312-5324.
32. Biebinger, S., Wirtz, L.E., Lorenz, P. and Clayton, C. (1997) Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei. Mol. Biochem. Parasitol., 85, 99-112.
33. Siegel, T.N., Hekstra, D.R., Wang, X., Dewell, S. and Cross, G.A. (2010) Genome-wide analysis of mRNA abundance in two lifecycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. Nucleic Acids Res., 38, 4946-4957.
34. Kabani, S., Fenn, K., Ross, A., Ivens, A., Smith, T.K., Ghazal, P. and Matthews, K. (2009) Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei. BMC Genomics, 10, 427.
35. Laxman, S., Riechers, A., Sadilek, M., Schwede, F. and Beavo, J.A. (2006) Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpylike forms. Proc. Natl. Acad. Sci. USA, 103, 19194-19199.
36. Denninger, V., Figarella, K., Schonfeld, C., Brems, S., Busold, C., Lang, F., Hoheisel, J. and Duszenko, M. (2007) Troglitazone induces differentiation in Trypanosoma brucei. Exp Cell Res, 313, 1805-1819.
37. Brecht, M. and Parsons, M. (1998) Changes in polysome profiles accompany trypanosome development. Mol. Biochem. Parasitol., 97, 189-198.
38. Clayton, C.E. (2002) NEW EMBO MEMBER'S REVIEW Life without transcriptional control? From fly to man and back again. EMBO J., 21, 1881-1888.
39. Ding, Y., Chan, C.Y. and Lawrence, C.E. (2004) Sfold web server for statistical folding and rational design of nucleic acids. Nucleic Acids Res., 32, W135-W141.
40. Ding, Y., Chan, C.Y. and Lawrence, C.E. (2005) RNA secondary structure prediction by centroids in a Boltzmann weighted ensemble. RNA, 11, 1157-1166.
41. Ding, Y. and Lawrence, C.E. (2003) A statistical sampling algorithm for RNA secondary structure prediction. Nucleic Acids Res., 31, 7280-7301.