메뉴 건너뛰기




Volumn 97, Issue 1, 2014, Pages 37-43

Lipidomic analysis of the liver from high-fat diet induced obese mice identifies changes in multiple lipid classes

Author keywords

Fatty acids; Lipidomic profiling; Obesity; Phospholipids

Indexed keywords

ABC TRANSPORTER A1; CERAMIDE; CHOLESTEROL; INTERLEUKIN 8; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PLASMALOGEN; SPHINGOMYELIN; TRIACYLGLYCEROL;

EID: 84901320675     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2014.05.002     Document Type: Article
Times cited : (66)

References (55)
  • 1
    • 37849028864 scopus 로고    scopus 로고
    • Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study
    • Allard J.P., et al. Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study. J. Hepatol. 2008, 48:300-307.
    • (2008) J. Hepatol. , vol.48 , pp. 300-307
    • Allard, J.P.1
  • 2
    • 84881153162 scopus 로고    scopus 로고
    • High-fat diet induces dynamic metabolic alterations in multiple biological matrices of rats
    • An Y., et al. High-fat diet induces dynamic metabolic alterations in multiple biological matrices of rats. J. Proteome Res. 2013, 12:3755-3768.
    • (2013) J. Proteome Res. , vol.12 , pp. 3755-3768
    • An, Y.1
  • 3
    • 84979851098 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine
    • Arendt B.M., et al. Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine. Appl. Physiol. Nutr. Metab. 2013, 38:334-340.
    • (2013) Appl. Physiol. Nutr. Metab. , vol.38 , pp. 334-340
    • Arendt, B.M.1
  • 4
    • 84864365428 scopus 로고    scopus 로고
    • Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes
    • Barber M.N., et al. Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes. PLoS ONE 2012, 7:e41456.
    • (2012) PLoS ONE , vol.7
    • Barber, M.N.1
  • 5
    • 68049099023 scopus 로고    scopus 로고
    • Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis
    • Basciano H., et al. Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis. Am. J. Physiol. Endocrinol. Metab. 2009, 297:E462-E473.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297
    • Basciano, H.1
  • 6
    • 73449095236 scopus 로고    scopus 로고
    • Lipidomic dissection of nonalcoholic steatohepatitis: moving beyond foie gras to fat traffic
    • Bass N.M. Lipidomic dissection of nonalcoholic steatohepatitis: moving beyond foie gras to fat traffic. Hepatology 2010, 51:4-7.
    • (2010) Hepatology , vol.51 , pp. 4-7
    • Bass, N.M.1
  • 7
    • 78149284997 scopus 로고    scopus 로고
    • Role of hepatic desaturases in obesity-related metabolic disorders
    • Bjermo H., Riserus U. Role of hepatic desaturases in obesity-related metabolic disorders. Curr. Opin. Clin. Nutr. Metab. Care 2010, 13:703-708.
    • (2010) Curr. Opin. Clin. Nutr. Metab. Care , vol.13 , pp. 703-708
    • Bjermo, H.1    Riserus, U.2
  • 8
    • 84864046701 scopus 로고    scopus 로고
    • Functions of plasmalogen lipids in health and disease
    • Braverman N.E., Moser A.B. Functions of plasmalogen lipids in health and disease. Biochim. Biophys. Acta 2012, 1822:1442-1452.
    • (2012) Biochim. Biophys. Acta , vol.1822 , pp. 1442-1452
    • Braverman, N.E.1    Moser, A.B.2
  • 9
    • 84856493679 scopus 로고    scopus 로고
    • ATP binding cassette transporter A1 (ABCA1) associated proteins: potential drug targets in the metabolic syndrome and atherosclerotic disease?
    • Buechler C., Bauer S. ATP binding cassette transporter A1 (ABCA1) associated proteins: potential drug targets in the metabolic syndrome and atherosclerotic disease?. Curr. Pharm. Biotechnol. 2012, 13:319-330.
    • (2012) Curr. Pharm. Biotechnol. , vol.13 , pp. 319-330
    • Buechler, C.1    Bauer, S.2
  • 10
    • 79959672175 scopus 로고    scopus 로고
    • Adiponectin, a key adipokine in obesity related liver diseases
    • Buechler C., et al. Adiponectin, a key adipokine in obesity related liver diseases. World J. Gastroenterol. 2011, 17:2801-2811.
    • (2011) World J. Gastroenterol. , vol.17 , pp. 2801-2811
    • Buechler, C.1
  • 11
    • 84866391624 scopus 로고    scopus 로고
    • Reversion of hepatic steatosis by exercise training in obese mice: the role of sterol regulatory element-binding protein-1c
    • Cintra D.E., et al. Reversion of hepatic steatosis by exercise training in obese mice: the role of sterol regulatory element-binding protein-1c. Life Sci. 2012, 91:395-401.
    • (2012) Life Sci. , vol.91 , pp. 395-401
    • Cintra, D.E.1
  • 12
    • 33747469042 scopus 로고    scopus 로고
    • How different is the dietary pattern in non-alcoholic steatohepatitis patients?
    • Cortez-Pinto H., et al. How different is the dietary pattern in non-alcoholic steatohepatitis patients?. Clin. Nutr. 2006, 25:816-823.
    • (2006) Clin. Nutr. , vol.25 , pp. 816-823
    • Cortez-Pinto, H.1
  • 13
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly K.L., et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 2005, 115:1343-1351.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1
  • 14
    • 84860589540 scopus 로고    scopus 로고
    • A rapid GC-MS method for quantification of positional and geometric isomers of fatty acid methyl esters
    • Ecker J., et al. A rapid GC-MS method for quantification of positional and geometric isomers of fatty acid methyl esters. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2012, 897:98-104.
    • (2012) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.897 , pp. 98-104
    • Ecker, J.1
  • 15
    • 84894282174 scopus 로고    scopus 로고
    • Lipidomic analysis of serum from high fat diet induced obese mice
    • Eisinger K., et al. Lipidomic analysis of serum from high fat diet induced obese mice. Int. J. Mol. Sci. 2014, 15:2991-3002.
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 2991-3002
    • Eisinger, K.1
  • 16
    • 84884733951 scopus 로고    scopus 로고
    • Fatty liver is associated with transcriptional downregulation of stearoyl-CoA desaturase and impaired protein dimerization
    • Fernandez Gianotti T., et al. Fatty liver is associated with transcriptional downregulation of stearoyl-CoA desaturase and impaired protein dimerization. PLoS ONE 2013, 8:e76912.
    • (2013) PLoS ONE , vol.8
    • Fernandez Gianotti, T.1
  • 17
    • 80054084310 scopus 로고    scopus 로고
    • Short-term inhibition of SREBP-1c expression reverses diet-induced non-alcoholic fatty liver disease in mice
    • Frederico M.J., et al. Short-term inhibition of SREBP-1c expression reverses diet-induced non-alcoholic fatty liver disease in mice. Scand. J. Gastroenterol. 2011, 46:1381-1388.
    • (2011) Scand. J. Gastroenterol. , vol.46 , pp. 1381-1388
    • Frederico, M.J.1
  • 18
    • 79961211515 scopus 로고    scopus 로고
    • Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model
    • Gorden D.L., et al. Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model. PLoS ONE 2011, 6:e22775.
    • (2011) PLoS ONE , vol.6
    • Gorden, D.L.1
  • 19
    • 84888019126 scopus 로고    scopus 로고
    • A diet high in alpha-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats
    • Hanke D., et al. A diet high in alpha-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. Prostaglandins Leukot. Essent. Fat. Acids 2013, 89:391-401.
    • (2013) Prostaglandins Leukot. Essent. Fat. Acids , vol.89 , pp. 391-401
    • Hanke, D.1
  • 20
    • 44249098959 scopus 로고    scopus 로고
    • Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases
    • Hardwick J.P. Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. Biochem. Pharmacol. 2008, 75:2263-2275.
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 2263-2275
    • Hardwick, J.P.1
  • 21
    • 34347248400 scopus 로고    scopus 로고
    • Effect of dietary cholesterol and high fat on ceramide concentration in rat tissues
    • Ichi I., et al. Effect of dietary cholesterol and high fat on ceramide concentration in rat tissues. Nutrition 2007, 23:570-574.
    • (2007) Nutrition , vol.23 , pp. 570-574
    • Ichi, I.1
  • 22
    • 77951433803 scopus 로고    scopus 로고
    • Hepatic glycosphingolipid deficiency and liver function in mice
    • Jennemann R., et al. Hepatic glycosphingolipid deficiency and liver function in mice. Hepatology 2010, 51:1799-1809.
    • (2010) Hepatology , vol.51 , pp. 1799-1809
    • Jennemann, R.1
  • 23
    • 79955433960 scopus 로고    scopus 로고
    • Metabolomic analysis of livers and serum from high-fat diet induced obese mice
    • Kim H.J., et al. Metabolomic analysis of livers and serum from high-fat diet induced obese mice. J. Proteome Res. 2011, 10:722-731.
    • (2011) J. Proteome Res. , vol.10 , pp. 722-731
    • Kim, H.J.1
  • 24
    • 84904473506 scopus 로고    scopus 로고
    • Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease
    • (in press)
    • Kurek K., et al. Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease. Liver Int. 2013, (in press).
    • (2013) Liver Int.
    • Kurek, K.1
  • 25
    • 8844257213 scopus 로고    scopus 로고
    • Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential
    • Lee R.G., et al. Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential. Circ. Res. 2004, 95:998-1004.
    • (2004) Circ. Res. , vol.95 , pp. 998-1004
    • Lee, R.G.1
  • 26
    • 43249110882 scopus 로고    scopus 로고
    • Phosphatidylcholine and choline homeostasis
    • Li Z., Vance D.E. Phosphatidylcholine and choline homeostasis. J. Lipid Res. 2008, 49:1187-1194.
    • (2008) J. Lipid Res. , vol.49 , pp. 1187-1194
    • Li, Z.1    Vance, D.E.2
  • 27
    • 65549136260 scopus 로고    scopus 로고
    • Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase
    • Li Z.Z., et al. Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J. Biol. Chem. 2009, 284:5637-5644.
    • (2009) J. Biol. Chem. , vol.284 , pp. 5637-5644
    • Li, Z.Z.1
  • 28
    • 0032805993 scopus 로고    scopus 로고
    • Quantitative measurement of different ceramide species from crude cellular extracts by electrospray ionization tandem mass spectrometry (ESI-MS/MS)
    • Liebisch G., et al. Quantitative measurement of different ceramide species from crude cellular extracts by electrospray ionization tandem mass spectrometry (ESI-MS/MS). J. Lipid Res. 1999, 40:1539-1546.
    • (1999) J. Lipid Res. , vol.40 , pp. 1539-1546
    • Liebisch, G.1
  • 29
    • 7444270716 scopus 로고    scopus 로고
    • High-throughput quantification of phosphatidylcholine and sphingomyelin by electrospray ionization tandem mass spectrometry coupled with isotope correction algorithm
    • Liebisch G., et al. High-throughput quantification of phosphatidylcholine and sphingomyelin by electrospray ionization tandem mass spectrometry coupled with isotope correction algorithm. Biochim. Biophys. Acta 2004, 1686:108-117.
    • (2004) Biochim. Biophys. Acta , vol.1686 , pp. 108-117
    • Liebisch, G.1
  • 30
    • 33646048311 scopus 로고    scopus 로고
    • High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS)
    • Liebisch G., et al. High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS). Biochim. Biophys. Acta 2006, 1761:121-128.
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 121-128
    • Liebisch, G.1
  • 31
    • 84877106380 scopus 로고    scopus 로고
    • Shorthand notation for lipid structures derived from mass spectrometry
    • Liebisch G., et al. Shorthand notation for lipid structures derived from mass spectrometry. J. Lipid Res. 2013, 54:1523-1530.
    • (2013) J. Lipid Res. , vol.54 , pp. 1523-1530
    • Liebisch, G.1
  • 32
    • 84858859318 scopus 로고    scopus 로고
    • High fat diet induced hepatic steatosis and insulin resistance: role of dysregulated ceramide metabolism
    • Longato L., et al. High fat diet induced hepatic steatosis and insulin resistance: role of dysregulated ceramide metabolism. Hepatol. Res. 2012, 42:412-427.
    • (2012) Hepatol. Res. , vol.42 , pp. 412-427
    • Longato, L.1
  • 33
    • 84860225393 scopus 로고    scopus 로고
    • Cytochrome P450s in the synthesis of cholesterol and bile acids-from mouse models to human diseases
    • Lorbek G., et al. Cytochrome P450s in the synthesis of cholesterol and bile acids-from mouse models to human diseases. FEBS J. 2012, 279:1516-1533.
    • (2012) FEBS J. , vol.279 , pp. 1516-1533
    • Lorbek, G.1
  • 34
    • 50049102248 scopus 로고    scopus 로고
    • Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics
    • Matyash V., et al. Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. J. Lipid Res. 2008, 49:1137-1146.
    • (2008) J. Lipid Res. , vol.49 , pp. 1137-1146
    • Matyash, V.1
  • 35
    • 84878839327 scopus 로고    scopus 로고
    • Oils rich in alpha-linolenic acid independently protect against characteristics of fatty liver disease in the delta6-desaturase null mouse
    • Monteiro J., et al. Oils rich in alpha-linolenic acid independently protect against characteristics of fatty liver disease in the delta6-desaturase null mouse. Can. J. Physiol. Pharmacol. 2013, 91:469-479.
    • (2013) Can. J. Physiol. Pharmacol. , vol.91 , pp. 469-479
    • Monteiro, J.1
  • 36
    • 77649274673 scopus 로고    scopus 로고
    • Medium-chain fatty acids: functional lipids for the prevention and treatment of the metabolic syndrome
    • Nagao K., Yanagita T. Medium-chain fatty acids: functional lipids for the prevention and treatment of the metabolic syndrome. Pharmacol. Res. 2010, 61:208-212.
    • (2010) Pharmacol. Res. , vol.61 , pp. 208-212
    • Nagao, K.1    Yanagita, T.2
  • 37
    • 84890116926 scopus 로고    scopus 로고
    • Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids
    • Oresic M., et al. Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids. Diabetologia 2013, 56:2266-2274.
    • (2013) Diabetologia , vol.56 , pp. 2266-2274
    • Oresic, M.1
  • 38
    • 38749132313 scopus 로고    scopus 로고
    • Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet
    • Osabe M., et al. Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet. Drug Metab. Dispos. 2008, 36:294-302.
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 294-302
    • Osabe, M.1
  • 39
    • 36349024819 scopus 로고    scopus 로고
    • A lipidomic analysis of nonalcoholic fatty liver disease
    • Puri P., et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007, 46:1081-1090.
    • (2007) Hepatology , vol.46 , pp. 1081-1090
    • Puri, P.1
  • 40
    • 73149094543 scopus 로고    scopus 로고
    • The plasma lipidomic signature of nonalcoholic steatohepatitis
    • Puri P., et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology 2009, 50:1827-1838.
    • (2009) Hepatology , vol.50 , pp. 1827-1838
    • Puri, P.1
  • 41
    • 84877661047 scopus 로고    scopus 로고
    • Medium chain triglycerides dose-dependently prevent liver pathology in a rat model of non-alcoholic fatty liver disease
    • Ronis M.J., et al. Medium chain triglycerides dose-dependently prevent liver pathology in a rat model of non-alcoholic fatty liver disease. Exp. Biol. Med. (Maywood) 2013, 238:151-162.
    • (2013) Exp. Biol. Med. (Maywood) , vol.238 , pp. 151-162
    • Ronis, M.J.1
  • 42
    • 60749121730 scopus 로고    scopus 로고
    • Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention
    • Russo G.L. Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochem. Pharmacol. 2009, 77:937-946.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 937-946
    • Russo, G.L.1
  • 43
    • 73449097463 scopus 로고    scopus 로고
    • Metabolism and atherogenic disease association of lysophosphatidylcholine
    • Schmitz G., Ruebsaamen K. Metabolism and atherogenic disease association of lysophosphatidylcholine. Atherosclerosis 2010, 208:10-18.
    • (2010) Atherosclerosis , vol.208 , pp. 10-18
    • Schmitz, G.1    Ruebsaamen, K.2
  • 44
    • 84863205849 scopus 로고    scopus 로고
    • NIH image to ImageJ: 25years of image analysis
    • Schneider C.A., et al. NIH image to ImageJ: 25years of image analysis. Nat. Methods 2012, 9:671-675.
    • (2012) Nat. Methods , vol.9 , pp. 671-675
    • Schneider, C.A.1
  • 45
    • 84858799393 scopus 로고    scopus 로고
    • Comparison of native and capric acid-enriched mustard oil effects on oxidative stress and antioxidant protection in rats
    • Sengupta A., Ghosh M. Comparison of native and capric acid-enriched mustard oil effects on oxidative stress and antioxidant protection in rats. Br. J. Nutr. 2012, 107:845-849.
    • (2012) Br. J. Nutr. , vol.107 , pp. 845-849
    • Sengupta, A.1    Ghosh, M.2
  • 46
    • 33644878716 scopus 로고    scopus 로고
    • Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism
    • Song H., et al. Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism. Am. J. Physiol. Endocrinol. Metab. 2006, 290:E17-E25.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290
    • Song, H.1
  • 47
    • 84863502669 scopus 로고    scopus 로고
    • Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
    • Tanaka N., et al. Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology 2012, 56:118-129.
    • (2012) Hepatology , vol.56 , pp. 118-129
    • Tanaka, N.1
  • 48
    • 84873165069 scopus 로고    scopus 로고
    • Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
    • Vance J.E., Tasseva G. Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. Biochim. Biophys. Acta 2013, 1831:543-554.
    • (2013) Biochim. Biophys. Acta , vol.1831 , pp. 543-554
    • Vance, J.E.1    Tasseva, G.2
  • 49
    • 85028111693 scopus 로고    scopus 로고
    • Lipidomic analysis of the liver identifies changes of major and minor lipid species in adiponectin deficient mice
    • Wanninger J., et al. Lipidomic analysis of the liver identifies changes of major and minor lipid species in adiponectin deficient mice. Exp. Mol. Pathol. 2013, 94:412-417.
    • (2013) Exp. Mol. Pathol. , vol.94 , pp. 412-417
    • Wanninger, J.1
  • 50
    • 84874786444 scopus 로고    scopus 로고
    • Differential intrahepatic phospholipid zonation in simple steatosis and nonalcoholic steatohepatitis
    • Wattacheril J., et al. Differential intrahepatic phospholipid zonation in simple steatosis and nonalcoholic steatohepatitis. PLoS ONE 2013, 8:e57165.
    • (2013) PLoS ONE , vol.8
    • Wattacheril, J.1
  • 51
    • 84869238321 scopus 로고    scopus 로고
    • Alleviative effects of resveratrol on nonalcoholic fatty liver disease are associated with up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expressions in rats
    • Xin P., et al. Alleviative effects of resveratrol on nonalcoholic fatty liver disease are associated with up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expressions in rats. Food Chem. Toxicol. 2013, 52:12-18.
    • (2013) Food Chem. Toxicol. , vol.52 , pp. 12-18
    • Xin, P.1
  • 52
    • 77954659321 scopus 로고    scopus 로고
    • Suppression of ABCA1 by unsaturated fatty acids leads to lipid accumulation in HepG2 cells
    • Yang Y., et al. Suppression of ABCA1 by unsaturated fatty acids leads to lipid accumulation in HepG2 cells. Biochimie 2010, 92:958-963.
    • (2010) Biochimie , vol.92 , pp. 958-963
    • Yang, Y.1
  • 53
    • 67651165606 scopus 로고    scopus 로고
    • Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice
    • Zhao H., et al. Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice. Hepatology 2009, 50:85-93.
    • (2009) Hepatology , vol.50 , pp. 85-93
    • Zhao, H.1
  • 54
    • 58249116770 scopus 로고    scopus 로고
    • Beta-glycosphingolipids improve glucose intolerance and hepatic steatosis of the Cohen diabetic rat
    • Zigmond E., et al. Beta-glycosphingolipids improve glucose intolerance and hepatic steatosis of the Cohen diabetic rat. Am. J. Physiol. Endocrinol. Metab. 2009, 296:E72-E78.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296
    • Zigmond, E.1
  • 55
    • 59949098866 scopus 로고    scopus 로고
    • Effects of high dietary fat and cholesterol on expression of PPAR alpha, LXR alpha, and their responsive genes in the liver of apoE and LDLR double deficient mice
    • Zou Y., et al. Effects of high dietary fat and cholesterol on expression of PPAR alpha, LXR alpha, and their responsive genes in the liver of apoE and LDLR double deficient mice. Mol. Cell. Biochem. 2009, 323:195-205.
    • (2009) Mol. Cell. Biochem. , vol.323 , pp. 195-205
    • Zou, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.