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Volumn 91, Issue 6, 2013, Pages 469-479

Oils rich in Δ-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse1

Author keywords

Alpha linolenic acid; Delta 6 d saturase; Knock out mouse; Liver; Phospholipid; Polyunsaturated fatty acid; Steatosis

Indexed keywords

CANOLA OIL; LARD; LINOLENIC ACID; LINOLEOYL COENZYME A DESATURASE; LINSEED OIL; MENHADEN OIL; FISH OIL; MONOUNSATURATED FATTY ACID; PHOSPHOLIPID;

EID: 84878839327     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2012-0308     Document Type: Article
Times cited : (34)

References (46)
  • 1
    • 20044376106 scopus 로고    scopus 로고
    • Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease
    • doi:10.1203/01.PDR.0000153672.43030.75. PMID:15659701
    • Alwayn, I.P., Gura, K., Nose, V., Zausche, B., Javid, P., Garza, J., et al. 2005. Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease. Pediatr. Res. 57(3): 445-452. doi:10.1203/01.PDR.0000153672.43030.75. PMID:15659701.
    • (2005) Pediatr. Res , vol.57 , Issue.3 , pp. 445-452
    • Alwayn, I.P.1    Gura, K.2    Nose, V.3    Zausche, B.4    Javid, P.5    Garza, J.6
  • 2
    • 69549138351 scopus 로고    scopus 로고
    • Are all n-3 polyunsaturated fatty acids created equal?
    • doi:10.1186/1476-511X-8-33. PMID:19664246
    • Anderson, B.M., and Ma, D.W. 2009. Are all n-3 polyunsaturated fatty acids created equal? Lipids Health Dis. 8: 33. doi:10.1186/1476-511X-8-33. PMID:19664246.
    • (2009) Lipids Health Dis , vol.8 , pp. 33
    • Anderson, B.M.1    Ma, D.W.2
  • 3
    • 0034509843 scopus 로고    scopus 로고
    • Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease
    • doi:10.1038/sj.ejcn.1601102. PMID:11114683
    • Bemelmans, W.J., Muskiet, F.A., Feskens, E.J., de,Vries, J.H., Broer, J., May, J.F., et al. 2000. Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease. Eur. J. Clin. Nutr. 54(12): 865-871. doi:10.1038/sj.ejcn.1601102. PMID:11114683.
    • (2000) Eur. J. Clin. Nutr , vol.54 , Issue.12 , pp. 865-871
    • Bemelmans, W.J.1    Muskiet, F.A.2    Feskens, E.J.3    de Vries, J.H.4    Broer, J.5    May, J.F.6
  • 4
    • 36649015221 scopus 로고    scopus 로고
    • Immunomodulation by omega-3 fatty acids
    • doi:10.1016/j.plefa.2007.10.015.PMID:18032006
    • Calder, P.C. 2007. Immunomodulation by omega-3 fatty acids. Prostaglandins Leukot. Essent. Fatty Acids, 77(5-6): 327-335. doi:10.1016/j.plefa.2007.10.015.PMID:18032006.
    • (2007) Prostaglandins Leukot. Essent. Fatty Acids , vol.77 , Issue.5-6 , pp. 327-335
    • Calder, P.C.1
  • 5
    • 49149113521 scopus 로고    scopus 로고
    • Alpha-linolenic acid and risk of nonfatal acute myocardial infarction
    • doi:10.1161/?CIRCULATIONAHA.107.762419. PMID:18606916
    • Campos, H., Baylin, A., and Willett, W.C. 2008. Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. Circulation, 118(4): 339-345. doi:10.1161/?CIRCULATIONAHA.107.762419. PMID:18606916.
    • (2008) Circulation , vol.118 , Issue.4 , pp. 339-345
    • Campos, H.1    Baylin, A.2    Willett, W.C.3
  • 6
    • 33646882162 scopus 로고    scopus 로고
    • Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: A pilot study
    • doi:10.1111/j.1365-2036.2006.02885.x. PMID:16611275
    • Capanni, M., Calella, F., Biagini, M.R., Genise, S., Raimondi, L., Bedogni, G., et al. 2006. Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment. Pharmacol. Ther. 23(8): 1143-1151. doi:10.1111/j.1365-2036.2006.02885.x. PMID:16611275.
    • (2006) Aliment. Pharmacol. Ther , vol.23 , Issue.8 , pp. 1143-1151
    • Capanni, M.1    Calella, F.2    Biagini, M.R.3    Genise, S.4    Raimondi, L.5    Bedogni, G.6
  • 7
    • 51649092992 scopus 로고    scopus 로고
    • C-reactive protein and coronary heart disease: A critical review
    • doi:10.1111/j.1365-2796.2008.02015.x. PMID:18823504
    • Casas, J.P., Shah, T., Hingorani, A.D., Danesh, J., and Pepys, M.B. 2008. C-reactive protein and coronary heart disease: a critical review. J. Intern. Med. 264(4): 295-314. doi:10.1111/j.1365-2796.2008.02015.x. PMID:18823504.
    • (2008) J. Intern. Med , vol.264 , Issue.4 , pp. 295-314
    • Casas, J.P.1    Shah, T.2    Hingorani, A.D.3    Danesh, J.4    Pepys, M.B.5
  • 8
    • 0030038986 scopus 로고    scopus 로고
    • The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil
    • PMID:8604658
    • Caughey, G.E., Mantzioris, E., Gibson, R.A., Cleland, L.G., and James, M.J. 1996. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am. J. Clin. Nutr. 63(1): 116-122. PMID:8604658.
    • (1996) Am. J. Clin. Nutr , vol.63 , Issue.1 , pp. 116-122
    • Caughey, G.E.1    Mantzioris, E.2    Gibson, R.A.3    Cleland, L.G.4    James, M.J.5
  • 9
    • 57349171883 scopus 로고    scopus 로고
    • Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats
    • doi:10.1017/S000711450899053X.PMID:18492301
    • Chicco, A.G., D'Alessandro, M.E., Hein, G.J., Oliva, M.E., and Lombardo, Y.B. 2009. Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats. Br. J. Nutr. 101(1): 41-50. doi:10.1017/S000711450899053X.PMID:18492301.
    • (2009) Br. J. Nutr , vol.101 , Issue.1 , pp. 41-50
    • Chicco, A.G.1    D'Alessandro, M.E.2    Hein, G.J.3    Oliva, M.E.4    Lombardo, Y.B.5
  • 11
    • 10144234128 scopus 로고    scopus 로고
    • Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene
    • doi:10.1074/jbc.271.40.24698. PMID:8798738
    • Fan, C.Y., Pan, J., Chu, R., Lee, D., Kluckman, K.D., Usuda, N., et al. 1996. Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J. Biol. Chem. 271(40): 24698-24710. doi:10.1074/jbc.271.40.24698. PMID:8798738.
    • (1996) J. Biol. Chem , vol.271 , Issue.40 , pp. 24698-24710
    • Fan, C.Y.1    Pan, J.2    Chu, R.3    Lee, D.4    Kluckman, K.D.5    Usuda, N.6
  • 12
    • 70449158340 scopus 로고
    • A simple method for the isolation nd purification of total lipides from animal tissues
    • PMID:13428781
    • Folch, J., Lees, M., and SloaneStanley, G.H. 1957. A simple method for the isolation nd purification of total lipides from animal tissues. J. Biol. Chem. 226(1): 497-509. PMID:13428781.
    • (1957) J. Biol. Chem , vol.226 , Issue.1 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloanestanley, G.H.3
  • 13
    • 67449127220 scopus 로고    scopus 로고
    • Whole-body synthesis-secretion rates of long-chain n-3 PUFAs from circulating unesterified alpha-linolenic acid in unanesthetized rats
    • doi:10.1194/jlr.M900223-JLR200. PMID:19074373
    • Gao, F., Kiesewetter, D., Chang, L., Ma, K., Bell, J.M., Rapoport, S.I., et al. 2009. Whole-body synthesis-secretion rates of long-chain n-3 PUFAs from circulating unesterified alpha-linolenic acid in unanesthetized rats. J. Lipid Res. 50(4): 749-758. doi:10.1194/jlr.M900223-JLR200. PMID:19074373.
    • (2009) J. Lipid Res , vol.50 , Issue.4 , pp. 749-758
    • Gao, F.1    Kiesewetter, D.2    Chang, L.3    Ma, K.4    Bell, J.M.5    Rapoport, S.I.6
  • 14
    • 78650055830 scopus 로고    scopus 로고
    • Lipodystrophy: Metabolic insights from a rare disorder
    • doi:10.1677/JOE-10-0272. PMID:20870709
    • Huang-Doran, I., Sleigh, A., Rochford, J.J., O'Rahilly, S., and Savage, D.B. 2010. Lipodystrophy: metabolic insights from a rare disorder. J. Endocrinol. 207(3): 245-255. doi:10.1677/JOE-10-0272. PMID:20870709.
    • (2010) J. Endocrinol , vol.207 , Issue.3 , pp. 245-255
    • Huang-Doran, I.1    Sleigh, A.2    Rochford, J.J.3    O'Rahilly, S.4    Savage, D.B.5
  • 15
    • 13944270939 scopus 로고    scopus 로고
    • Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men
    • doi:10.1194/jlr.M400225-JLR200. PMID:15576848
    • Hussein, N., Ah-Sing, E., Wilkinson, P., Leach, C., Griffin, B.A., and Millward, D.J. 2005. Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. J. Lipid Res. 46(2): 269-280. doi:10.1194/jlr.M400225-JLR200. PMID:15576848.
    • (2005) J. Lipid Res , vol.46 , Issue.2 , pp. 269-280
    • Hussein, N.1    Ah-Sing, E.2    Wilkinson, P.3    Leach, C.4    Griffin, B.A.5    Millward, D.J.6
  • 16
    • 43249114663 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acid regulation of hepatic gene transcription
    • doi:10.1097/MOL.0b013e3282ffaf6a. PMID:18460914
    • Jump, D.B. 2008. N-3 polyunsaturated fatty acid regulation of hepatic gene transcription. Curr. Opin. Lipidol. 19(3): 242-247. doi:10.1097/MOL.0b013e3282ffaf6a. PMID:18460914.
    • (2008) Curr. Opin. Lipidol , vol.19 , Issue.3 , pp. 242-247
    • Jump, D.B.1
  • 17
    • 43049181895 scopus 로고    scopus 로고
    • Docosahexaenoic acid (DHA) and hepatic gene transcription
    • doi:10.1016/j.chemphyslip.2008.02.007. PMID:18343222
    • Jump, D.B., Botolin, D., Wang, Y., Xu, J., Demeure, O., and Christian, B. 2008. Docosahexaenoic acid (DHA) and hepatic gene transcription. Chem. Phys. Lipids. 153(1): 3-13. doi:10.1016/j.chemphyslip.2008.02.007. PMID:18343222.
    • (2008) Chem. Phys. Lipids , vol.153 , Issue.1 , pp. 3-13
    • Jump, D.B.1    Botolin, D.2    Wang, Y.3    Xu, J.4    Demeure, O.5    Christian, B.6
  • 18
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: Getting both pathology and metabolic context right
    • doi:10.1111/j.1440-1746.2008.05543.x. PMID:18752564
    • Larter, C.Z., and Yeh, M.M. 2008. Animal models of NASH: getting both pathology and metabolic context right. J. Gastroenterol. Hepatol. 23(11): 1635-1648. doi:10.1111/j.1440-1746.2008.05543.x. PMID:18752564.
    • (2008) J. Gastroenterol. Hepatol , vol.23 , Issue.11 , pp. 1635-1648
    • Larter, C.Z.1    Yeh, M.M.2
  • 19
    • 39149132072 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation
    • doi:10.1111/j.1440-1746.2007.05157.x. PMID:17868330
    • Larter, C.Z., Yeh, M.M., Cheng, J., Williams, J., Brown, S., dela, P.A., et al. 2008. Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. J. Gastroenterol. Hepatol. 23(2): 267-275. doi:10.1111/j.1440-1746.2007.05157.x. PMID:17868330.
    • (2008) J. Gastroenterol. Hepatol , vol.23 , Issue.2 , pp. 267-275
    • Larter, C.Z.1    Yeh, M.M.2    Cheng, J.3    Williams, J.4    Brown, S.5    Dela, P.A.6
  • 20
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    • doi:10.1172/JCI8814. PMID:10772651
    • Leclercq, I.A., Farrell, G.C., Field, J., Bell, D.R., Gonzalez, F.J., and Robertson, G.R. 2000. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J. Clin. Invest. 105(8): 1067-1075. doi:10.1172/JCI8814. PMID:10772651.
    • (2000) J. Clin. Invest , vol.105 , Issue.8 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 21
    • 33747474408 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and metabolic syndrome
    • doi:10.1097/01.mco.0000241677.40170.17. PMID:16912563
    • Machado, M., and Cortez-Pinto, H. 2006. Non-alcoholic steatohepatitis and metabolic syndrome. Curr. Opin. Clin. Nutr. Metab Care, 9(5): 637-642. doi:10.1097/01.mco.0000241677.40170.17. PMID:16912563.
    • (2006) Curr. Opin. Clin. Nutr. Metab Care , vol.9 , Issue.5 , pp. 637-642
    • Machado, M.1    Cortez-Pinto, H.2
  • 22
    • 78649447062 scopus 로고    scopus 로고
    • Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: Relationship with central serotonin turnover
    • doi:10.1016/j.plefa.2010.08.004. PMID:20817496
    • McNamara, R.K., Jandacek, R., Rider, T., Tso, P., Cole-Strauss, A., and Lipton, J.W. 2010. Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover. Prostaglandins Leukot. Essent. Fatty Acids, 83(4-6): 185-191. doi:10.1016/j.plefa.2010.08.004. PMID:20817496.
    • (2010) Prostaglandins Leukot. Essent. Fatty Acids , vol.83 , Issue.4-6 , pp. 185-191
    • McNamara, R.K.1    Jandacek, R.2    Rider, T.3    Tso, P.4    Cole-Strauss, A.5    Lipton, J.W.6
  • 23
    • 84861472018 scopus 로고    scopus 로고
    • Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel [increment]-6-desaturase null mouse
    • doi:10.1186/1476-511X-11-60. PMID:22642787
    • Monteiro, J., Li, F.J., Maclennan, M., Rabalski, A., Moghadasian, M.H., Nakamura, M.T., et al. 2012. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel [increment]-6-desaturase null mouse. Lipids Health Dis. 11(1): 60. doi:10.1186/1476-511X-11-60. PMID:22642787.
    • (2012) Lipids Health Dis , vol.11 , Issue.1 , pp. 60
    • Monteiro, J.1    Li, F.J.2    Maclennan, M.3    Rabalski, A.4    Moghadasian, M.H.5    Nakamura, M.T.6
  • 24
    • 0033777508 scopus 로고    scopus 로고
    • Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration
    • doi:10.1046/j.1471-4159.2000.0752563.x. PMID: 11080210
    • Moriguchi, T., Greiner, R.S., and Salem, N., Jr. 2000. Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. J. Neurochem. 75(6): 2563-2573. doi:10.1046/j.1471-4159.2000.0752563.x. PMID: 11080210.
    • (2000) J. Neurochem , vol.75 , Issue.6 , pp. 2563-2573
    • Moriguchi, T.1    Greiner, R.S.2    Salem Jr., N.3
  • 25
    • 0035062627 scopus 로고    scopus 로고
    • Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum
    • PMID:11254754
    • Moriguchi, T., Loewke, J., Garrison, M., Catalan, J.N., and Salem, N., Jr. 2001. Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. J. Lipid Res. 42(3): 419-427. PMID:11254754.
    • (2001) J. Lipid Res , vol.42 , Issue.3 , pp. 419-427
    • Moriguchi, T.1    Loewke, J.2    Garrison, M.3    Catalan, J.N.4    Salem Jr., N.5
  • 26
    • 0037382071 scopus 로고    scopus 로고
    • Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
    • doi: 10.1053/jhep.2003.50132. PMID:12668986
    • Musso, G., Gambino, R., De, M.F., Cassader, M., Rizzetto, M., Durazzo, M., et al. 2003. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology, 37(4): 909-916. doi: 10.1053/jhep.2003.50132. PMID:12668986.
    • (2003) Hepatology , vol.37 , Issue.4 , pp. 909-916
    • Musso, G.1    Gambino, R.2    De, M.F.3    Cassader, M.4    Rizzetto, M.5    Durazzo, M.6
  • 27
    • 0037321682 scopus 로고    scopus 로고
    • Essential fatty acid synthesis and its regulation in mammals
    • doi:10.1016/S0952-3278(02)00264-8. PMID:12538078
    • Nakamura, M.T., and Nara, T.Y. 2003. Essential fatty acid synthesis and its regulation in mammals. Prostaglandins Leukot. Essent. Fatty Acids, 68(2): 145-150. doi:10.1016/S0952-3278(02)00264-8. PMID:12538078.
    • (2003) Prostaglandins Leukot. Essent. Fatty Acids , vol.68 , Issue.2 , pp. 145-150
    • Nakamura, M.T.1    Nara, T.Y.2
  • 28
    • 34249668818 scopus 로고    scopus 로고
    • Epidemiology and natural history of NAFLD and NASH
    • doi:10.1016/j.cld.2007.02.009. PMID: 17544968
    • Ong, J.P., and Younossi, Z.M. 2007. Epidemiology and natural history of NAFLD and NASH. Clin. Liver Dis. 11(1): 1-16, vii. doi:10.1016/j.cld.2007.02.009. PMID: 17544968.
    • (2007) Clin. Liver Dis , vol.11 , Issue.1
    • Ong, J.P.1    Younossi, Z.M.2
  • 29
    • 58149253146 scopus 로고    scopus 로고
    • Hepatic steatosis in n-3 fatty acid depleted mice: Focus on metabolic alterations related to tissue fatty acid composition
    • doi:10.1186/1472-6793-8-21. PMID:1904641
    • Pachikian, B.D., Neyrinck, A.M., Cani, P.D., Portois, L., Deldicque, L., DeBacker, F.C., et al. 2008. Hepatic steatosis in n-3 fatty acid depleted mice: focus on metabolic alterations related to tissue fatty acid composition. BMC Physiol. 8: 21. doi:10.1186/1472-6793-8-21. PMID:19046413.
    • (2008) BMC Physiol , vol.8 , pp. 21
    • Pachikian, B.D.1    Neyrinck, A.M.2    Cani, P.D.3    Portois, L.4    Deldicque, L.5    Debacker, F.C.6
  • 30
    • 36349024819 scopus 로고    scopus 로고
    • A lipidomic analysis of nonalcoholic fatty liver disease
    • doi:10.1002/hep.21763. PMID:17654743
    • Puri, P., Baillie, R.A., Wiest, M.M., Mirshahi, F., Choudhury, J., Cheung, O., et al. 2007. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology, 46(4): 1081-1090. doi:10.1002/hep.21763. PMID:17654743.
    • (2007) Hepatology , vol.46 , Issue.4 , pp. 1081-1090
    • Puri, P.1    Baillie, R.A.2    Wiest, M.M.3    Mirshahi, F.4    Choudhury, J.5    Cheung, O.6
  • 31
    • 18244385206 scopus 로고    scopus 로고
    • A new transgenic rat model of hepatic steatosis and the metabolic syndrome
    • doi:10.1161/01.HYP.0000161995.64192.2b. PMID: 15809359
    • Qi, N.R., Wang, J., Zidek, V., Landa, V., Mlejnek, P., Kazdova, L., et al. 2005. A new transgenic rat model of hepatic steatosis and the metabolic syndrome. Hypertension, 45(5): 1004-1011. doi:10.1161/01.HYP.0000161995.64192.2b. PMID: 15809359.
    • (2005) Hypertension , vol.45 , Issue.5 , pp. 1004-1011
    • Qi, N.R.1    Wang, J.2    Zidek, V.3    Landa, V.4    Mlejnek, P.5    Kazdova, L.6
  • 32
    • 70349574856 scopus 로고    scopus 로고
    • Designer oils' low in n-6:N-3 fatty acid ratio beneficially modifies cardiovascular risks in mice
    • doi:10.1007/s00394-009-0015-0. PMID:19333643
    • Riediger, N.D., Azordegan, N., Harris-Janz, S., Ma, D.W., Suh, M., and Moghadasian, M.H. 2009. 'Designer oils' low in n-6:n-3 fatty acid ratio beneficially modifies cardiovascular risks in mice. Eur. J. Nutr. 48(5): 307-314. doi:10.1007/s00394-009-0015-0. PMID:19333643.
    • (2009) Eur. J. Nutr , vol.48 , Issue.5 , pp. 307-314
    • Riediger, N.D.1    Azordegan, N.2    Harris-Janz, S.3    Ma, D.W.4    Suh, M.5    Moghadasian, M.H.6
  • 33
    • 33845574569 scopus 로고    scopus 로고
    • Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1
    • doi:10.1194/jlr.M600198-JLR200. PMID:16829692
    • Rizki, G., Arnaboldi, L., Gabrielli, B., Yan, J., Lee, G.S., Ng, R.K., et al. 2006. Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1. J. Lipid Res. 47(10): 2280-2290. doi:10.1194/jlr.M600198-JLR200. PMID:16829692.
    • (2006) J. Lipid Res , vol.47 , Issue.10 , pp. 2280-2290
    • Rizki, G.1    Arnaboldi, L.2    Gabrielli, B.3    Yan, J.4    Lee, G.S.5    Ng, R.K.6
  • 34
    • 78649315164 scopus 로고    scopus 로고
    • The cardiovascular effects of flaxseed and its omega-3 fatty acid, alphalinolenic acid
    • doi:10.1016/S0828-282X(10) 70455-4. PMID:21076723
    • Rodriguez-Leyva, D., Dupasquier, C.M., McCullough, R., and Pierce, G.N. 2010. The cardiovascular effects of flaxseed and its omega-3 fatty acid, alphalinolenic acid. Can. J. Cardiol. 26(9): 489-496. doi:10.1016/S0828-282X(10) 70455-4. PMID:21076723.
    • (2010) Can. J. Cardiol , vol.26 , Issue.9 , pp. 489-496
    • Rodriguez-Leyva, D.1    Dupasquier, C.M.2    McCullough, R.3    Pierce, G.N.4
  • 35
    • 77949535934 scopus 로고    scopus 로고
    • Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice
    • doi:10.1194/jlr.M001180. PMID:19690334
    • Roqueta-Rivera, M., Stroud, C.K., Haschek, W.M., Akare, S.J., Segre, M., Brush, R.S., et al. 2010. Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice. J. Lipid Res. 51(2): 360-367. doi:10.1194/jlr.M001180. PMID:19690334.
    • (2010) J. Lipid Res , vol.51 , Issue.2 , pp. 360-367
    • Roqueta-Rivera, M.1    Stroud, C.K.2    Haschek, W.M.3    Akare, S.J.4    Segre, M.5    Brush, R.S.6
  • 36
    • 80955139524 scopus 로고    scopus 로고
    • Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice
    • doi:10.1095/biolreprod.110.089524. PMID:21653892
    • Roqueta-Rivera, M., Abbott, T.L., Sivaguru, M., Hess, R.A., and Nakamura, M.T. 2011. Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice. Biol. Reprod. doi:10.1095/biolreprod.110.089524. PMID:21653892.
    • (2011) Biol. Reprod
    • Roqueta-Rivera, M.1    Abbott, T.L.2    Sivaguru, M.3    Hess, R.A.4    Nakamura, M.T.5
  • 37
    • 77953228973 scopus 로고    scopus 로고
    • Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in delta6-desaturase knockout (6-DS KO) mice: Beneficial effects of arachidonic acid
    • doi:10.1016/j.atherosclerosis.2009.11.044. PMID:20042190
    • Rosenblat, M., Volkova, N., Roqueta-Rivera, M., Nakamura, M.T., and Aviram, M. 2010. Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid. Atherosclerosis, 210(2): 414-421. doi:10.1016/j.atherosclerosis.2009.11.044. PMID:20042190.
    • (2010) Atherosclerosis , vol.210 , Issue.2 , pp. 414-421
    • Rosenblat, M.1    Volkova, N.2    Roqueta-Rivera, M.3    Nakamura, M.T.4    Aviram, M.5
  • 38
    • 70350346689 scopus 로고    scopus 로고
    • Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration
    • doi:10.1194/jlr.M900039-JLR200. PMID:19351970
    • Stroud, C.K., Nara, T.Y., Roqueta-Rivera, M., Radlowski, E.C., Lawrence, P., Zhang, Y., et al. 2009. Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration. J. Lipid Res. 50(9): 1870-1880. doi:10.1194/jlr.M900039-JLR200. PMID:19351970.
    • (2009) J. Lipid Res , vol.50 , Issue.9 , pp. 1870-1880
    • Stroud, C.K.1    Nara, T.Y.2    Roqueta-Rivera, M.3    Radlowski, E.C.4    Lawrence, P.5    Zhang, Y.6
  • 39
    • 77449103003 scopus 로고    scopus 로고
    • Chronic intake of a highcholesterol diet resulted in hepatic steatosis, focal nodular hyperplasia and fibrosis in non-obese mice
    • doi:10.1017/ S0007114509991772. PMID:19818196
    • Sumiyoshi, M., Sakanaka, M., and Kimura, Y. 2010. Chronic intake of a highcholesterol diet resulted in hepatic steatosis, focal nodular hyperplasia and fibrosis in non-obese mice. Br. J. Nutr. 103(3): 378-385. doi:10.1017/ S0007114509991772. PMID:19818196.
    • (2010) Br. J. Nutr , vol.103 , Issue.3 , pp. 378-385
    • Sumiyoshi, M.1    Sakanaka, M.2    Kimura, Y.3
  • 40
    • 41349102802 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
    • doi:10.1097/MCG. 0b013e31815591aa. PMID:18277895
    • Tanaka, N., Sano, K., Horiuchi, A., Tanaka, E., Kiyosawa, K., and Aoyama, T. 2008. Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis. J. Clin. Gastroenterol. 42(4): 413-418. doi:10.1097/MCG. 0b013e31815591aa. PMID:18277895.
    • (2008) J. Clin. Gastroenterol , vol.42 , Issue.4 , pp. 413-418
    • Tanaka, N.1    Sano, K.2    Horiuchi, A.3    Tanaka, E.4    Kiyosawa, K.5    Aoyama, T.6
  • 41
    • 33947108446 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and increased risk of cardiovascular disease
    • doi:10.1016/j. atherosclerosis.2006.08.021. PMID:16970951
    • Targher, G., and Arcaro, G. 2007. Non-alcoholic fatty liver disease and increased risk of cardiovascular disease. Atherosclerosis, 191(2): 235-240. doi:10.1016/j. atherosclerosis.2006.08.021. PMID:16970951.
    • (2007) Atherosclerosis , vol.191 , Issue.2 , pp. 235-240
    • Targher, G.1    Arcaro, G.2
  • 43
    • 36049022781 scopus 로고    scopus 로고
    • Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardio- vascular risk factors in type 2 diabetes: Results of a randomized controlled trial
    • doi:10.2337/dc07-1144. PMID:17686832
    • Vuksan, V., Whitham, D., Sievenpiper, J.L., Jenkins, A.L., Rogovik, A.L., Bazinet, R.P., et al. 2007. Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardio- vascular risk factors in type 2 diabetes: results of a randomized controlled trial. Diabetes Care, 30(11): 2804-2810. doi:10.2337/dc07-1144. PMID:17686832.
    • (2007) Diabetes Care , vol.30 , Issue.11 , pp. 2804-2810
    • Vuksan, V.1    Whitham, D.2    Sievenpiper, J.L.3    Jenkins, A.L.4    Rogovik, A.L.5    Bazinet, R.P.6
  • 44
    • 23044447185 scopus 로고    scopus 로고
    • Alpha-linolenic acid but not conjugated linolenic acid is hypocholesterolaemic in hamsters
    • doi:10.1079/BJN20041365. PMID: 15946404
    • Yang, L., Leung, K.Y., Cao, Y., Huang, Y., Ratnayake, W.M., and Chen, Z.Y. 2005. Alpha-linolenic acid but not conjugated linolenic acid is hypocholesterolaemic in hamsters. Br. J. Nutr. 93(4): 433-438. doi:10.1079/BJN20041365. PMID: 15946404.
    • (2005) Br. J. Nutr , vol.93 , Issue.4 , pp. 433-438
    • Yang, L.1    Leung, K.Y.2    Cao, Y.3    Huang, Y.4    Ratnayake, W.M.5    Chen, Z.Y.6
  • 45
    • 7944228499 scopus 로고    scopus 로고
    • Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women
    • PMID:15514264
    • Zhao, G., Etherton, T.D., Martin, K.R., West, S.G., Gillies, P.J., and Kris-Etherton, P.M. 2004. Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J. Nutr. 134(11): 2991-2997. PMID:15514264.
    • (2004) J. Nutr , vol.134 , Issue.11 , pp. 2991-2997
    • Zhao, G.1    Etherton, T.D.2    Martin, K.R.3    West, S.G.4    Gillies, P.J.5    Kris-Etherton, P.M.6
  • 46
    • 63449137594 scopus 로고    scopus 로고
    • Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia
    • doi:10.3748/wjg.14.6395. PMID:19009658
    • Zhu, F.S., Liu, S., Chen, X.M., Huang, Z.G., and Zhang, D.W. 2008. Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia. World J. Gastroenterol. 14(41): 6395-6400. doi:10.3748/wjg.14.6395. PMID:19009658.
    • (2008) World J. Gastroenterol , vol.14 , Issue.41 , pp. 6395-6400
    • Zhu, F.S.1    Liu, S.2    Chen, X.M.3    Huang, Z.G.4    Zhang, D.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.