메뉴 건너뛰기




Volumn 56, Issue 10, 2013, Pages 2266-2274

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

(21)  Orešič, Matej a   Hyötyläinen, Tuulia a   Kotronen, Anna b   Gopalacharyulu, Peddinti a   Nygren, Heli a   Arola, Johanna b   Castillo, Sandra a   Mattila, Ismo a   Hakkarainen, Antti b   Borra, Ronald J H c,d   Honka, Miikka Juhani c   Verrijken, An e   Francque, Sven e   Iozzo, Patricia c,f   Leivonen, Marja g   Jaser, Nabil g   Juuti, Anne g   Sørensen, Thorkild I A h   Nuutila, Pirjo c   Van Gaal, Luc d   more..


Author keywords

Lipidomics; Mass spectrometry; Non alcoholic fatty liver disease

Indexed keywords

BIOLOGICAL MARKER; LIPID; LYSOPHOSPHATIDYLCHOLINE; PHOSPHOLIPID; TRIACYLGLYCEROL;

EID: 84890116926     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2981-2     Document Type: Article
Times cited : (131)

References (46)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • 11961152 10.1056/NEJMra011775 1:CAS:528:DC%2BD38XivVOmsrY%3D
    • Angulo P (2002) Nonalcoholic fatty liver disease. N Engl J Med 346:1221-1231
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 33845460005 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease as a determinant of cardiovascular disease
    • 16828776 10.1016/j.atherosclerosis.2006.06.004 1:CAS:528: DC%2BD28XhtlartLnP author reply 20-11
    • Targher G (2007) Non-alcoholic fatty liver disease as a determinant of cardiovascular disease. Atherosclerosis 190:18-19, author reply 20-11
    • (2007) Atherosclerosis , vol.190 , pp. 18-19
    • Targher, G.1
  • 3
    • 65449156905 scopus 로고    scopus 로고
    • NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An eleven-year follow-up study
    • 19293782 10.1038/ajg.2009.67
    • Adams LA, Waters OR, Knuiman MW, Elliott RR, Olynyk JK (2009) NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. Am J Gastroenterol 104:861-867
    • (2009) Am J Gastroenterol , vol.104 , pp. 861-867
    • Adams, L.A.1    Waters, O.R.2    Knuiman, M.W.3    Elliott, R.R.4    Olynyk, J.K.5
  • 4
    • 37549047145 scopus 로고    scopus 로고
    • Fatty liver: A novel component of the metabolic syndrome
    • 17690317 10.1161/ATVBAHA.107.147538 1:CAS:528:DC%2BD2sXhsVeiu7nI
    • Kotronen A, Yki-Jarvinen H (2008) Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol 28:27-38
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 27-38
    • Kotronen, A.1    Yki-Jarvinen, H.2
  • 5
    • 33845914986 scopus 로고    scopus 로고
    • Mechanisms linking obesity with cardiovascular disease
    • 17167476 10.1038/nature05487
    • Van Gaal LF, Mertens IL, de Block CE (2006) Mechanisms linking obesity with cardiovascular disease. Nature 444:875-880
    • (2006) Nature , vol.444 , pp. 875-880
    • Van Gaal, L.F.1    Mertens, I.L.2    De Block, C.E.3
  • 6
    • 84866552629 scopus 로고    scopus 로고
    • Liver transplantation for nonalcoholic steatohepatitis: The new epidemic
    • 22964732 10.1097/SLA.0b013e31826b4b7e
    • Agopian VG, Kaldas FM, Hong JC et al (2012) Liver transplantation for nonalcoholic steatohepatitis: the new epidemic. Ann Surg 256:624-633
    • (2012) Ann Surg , vol.256 , pp. 624-633
    • Agopian, V.G.1    Kaldas, F.M.2    Hong, J.C.3
  • 7
    • 0035083988 scopus 로고    scopus 로고
    • Imaging of hepatic steatosis
    • 11296698 10.1055/s-2001-12930 1:STN:280:DC%2BD3MrgsVGrtQ%3D%3D
    • Siegelman ES, Rosen MA (2001) Imaging of hepatic steatosis. Semin Liver Dis 21:71-80
    • (2001) Semin Liver Dis , vol.21 , pp. 71-80
    • Siegelman, E.S.1    Rosen, M.A.2
  • 8
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • 15565570 10.1002/hep.20466
    • Browning JD, Szczepaniak LS, Dobbins R et al (2004) Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40:1387-1395
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 9
    • 84876293750 scopus 로고    scopus 로고
    • Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal
    • 23183525 10.1016/j.jhep.2012.11.021
    • Machado MV, Cortez-Pinto H (2013) Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal. J Hepatol 58:1007-1019
    • (2013) J Hepatol , vol.58 , pp. 1007-1019
    • Machado, M.V.1    Cortez-Pinto, H.2
  • 10
    • 69249087403 scopus 로고    scopus 로고
    • Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors
    • 19524579 10.1053/j.gastro.2009.06.005 1:CAS:528:DC%2BD1MXhtF2isrbK
    • Kotronen A, Peltonen M, Hakkarainen A et al (2009) Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology 137:865-872
    • (2009) Gastroenterology , vol.137 , pp. 865-872
    • Kotronen, A.1    Peltonen, M.2    Hakkarainen, A.3
  • 11
    • 63249121641 scopus 로고    scopus 로고
    • Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver
    • 18952834 10.2337/db08-1074 1:CAS:528:DC%2BD1MXptVCnsg%3D%3D
    • Kotronen A, Seppanen-Laakso T, Westerbacka J et al (2009) Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes 58:203-208
    • (2009) Diabetes , vol.58 , pp. 203-208
    • Kotronen, A.1    Seppanen-Laakso, T.2    Westerbacka, J.3
  • 12
    • 78649695476 scopus 로고    scopus 로고
    • Splanchnic balance of free fatty acids, endocannabinoids and lipids in subjects with NAFLD
    • 20600015 10.1053/j.gastro.2010.06.064 1:CAS:528:DC%2BC3cXhsFaktrbP
    • Westerbacka J, Kotronen A, Fielding BA et al (2010) Splanchnic balance of free fatty acids, endocannabinoids and lipids in subjects with NAFLD. Gastroenterology 139:1961-1971
    • (2010) Gastroenterology , vol.139 , pp. 1961-1971
    • Westerbacka, J.1    Kotronen, A.2    Fielding, B.A.3
  • 13
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • 15864352 1:CAS:528:DC%2BD2MXktFSktLk%3D
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115:1343-1351
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 14
    • 0031839599 scopus 로고    scopus 로고
    • Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men
    • 9643360 1:CAS:528:DyaK1cXjslCkurc%3D
    • Aarsland A, Wolfe RR (1998) Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men. J Lipid Res 39:1280-1286
    • (1998) J Lipid Res , vol.39 , pp. 1280-1286
    • Aarsland, A.1    Wolfe, R.R.2
  • 15
    • 79953754873 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues
    • 21207295 10.1007/978-1-61737-985-7-15 1:CAS:528:DC%2BC3MXmsVSgtbo%3D
    • Nygren H, Seppanen-Laakso T, Castillo S, Hyotylainen T, Oresic M (2011) Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods Mol Biol 708:247-257
    • (2011) Methods Mol Biol , vol.708 , pp. 247-257
    • Nygren, H.1    Seppanen-Laakso, T.2    Castillo, S.3    Hyotylainen, T.4    Oresic, M.5
  • 16
    • 79951676665 scopus 로고    scopus 로고
    • Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension
    • 10.1038/ijo.2010.134 1:STN:280:DC%2BC3M7ptVCnsA%3D%3D
    • Francque S, Verrijken A, Mertens I et al (2011) Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension. Int J Obes (Lond) 35:270-278
    • (2011) Int J Obes (Lond) , vol.35 , pp. 270-278
    • Francque, S.1    Verrijken, A.2    Mertens, I.3
  • 18
    • 0342314436 scopus 로고    scopus 로고
    • Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients
    • 10905483 10.2337/diabetes.49.5.749 1:CAS:528:DC%2BD3cXjsF2ms74%3D
    • Ryysy L, Hakkinen AM, Goto T et al (2000) Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49:749-758
    • (2000) Diabetes , vol.49 , pp. 749-758
    • Ryysy, L.1    Hakkinen, A.M.2    Goto, T.3
  • 19
    • 33645786275 scopus 로고    scopus 로고
    • Hepatic lipid accumulation in healthy subjects: A comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy
    • 16506186 10.1002/mrm.20825 1:CAS:528:DC%2BD28XjslGmtbY%3D
    • Machann J, Thamer C, Schnoedt B et al (2006) Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy. Magn Reson Med 55:913-917
    • (2006) Magn Reson Med , vol.55 , pp. 913-917
    • Machann, J.1    Thamer, C.2    Schnoedt, B.3
  • 20
    • 0037045055 scopus 로고    scopus 로고
    • Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy
    • 12409740 10.1097/00002030-200211080-00011 1:CAS:528:DC%2BD38XosFegtbk%3D
    • Sutinen J, Hakkinen AM, Westerbacka J et al (2002) Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy. AIDS 16:2183-2193
    • (2002) AIDS , vol.16 , pp. 2183-2193
    • Sutinen, J.1    Hakkinen, A.M.2    Westerbacka, J.3
  • 21
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: Prevalence of hepatic steatosis in the general population
    • 15339742 10.1152/ajpendo.00064.2004 1:CAS:528:DC%2BD2MXhsVCktLg%3D
    • Szczepaniak LS, Nurenberg P, Leonard D et al (2005) Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 288:E462-E468
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Szczepaniak, L.S.1    Nurenberg, P.2    Leonard, D.3
  • 22
    • 77954772536 scopus 로고    scopus 로고
    • MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data
    • 10.1186/1471-2105-11-395
    • Pluskal T, Castillo S, Villar-Briones A, Oresic M (2010) MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinforma 11:395
    • (2010) BMC Bioinforma , vol.11 , pp. 395
    • Pluskal, T.1    Castillo, S.2    Villar-Briones, A.3    Oresic, M.4
  • 23
    • 33846820527 scopus 로고    scopus 로고
    • Model-based methods of classification: Using the mclust software in chemometrics
    • 10.1360/jos180001
    • Fraley C, Raftery AE (2007) Model-based methods of classification: using the mclust software in chemometrics. J Stat Soft 18:1-13
    • (2007) J Stat Soft , vol.18 , pp. 1-13
    • Fraley, C.1    Raftery, A.E.2
  • 24
    • 0000778956 scopus 로고
    • Genetic algorithms and artificial life
    • 10.1162/artl.1994.1.3.267
    • Mitchell M, Forrest S (1994) Genetic algorithms and artificial life. Artificial Life 1:267-289
    • (1994) Artificial Life , vol.1 , pp. 267-289
    • Mitchell, M.1    Forrest, S.2
  • 25
    • 0002909179 scopus 로고
    • Modeling adaptive autonomous agents
    • 10.1162/artl.1993.1.1-2.135
    • Maes P (1993) Modeling adaptive autonomous agents. Artificial Life 1:135-162
    • (1993) Artificial Life , vol.1 , pp. 135-162
    • Maes, P.1
  • 27
    • 84942484786 scopus 로고
    • Ridge regression: Biased estimation for nonorthogonal problems
    • 10.1080/00401706.1970.10488634
    • Hoerl AE, Kennard RW (1970) Ridge regression: biased estimation for nonorthogonal problems. Technometrics 12:55-67
    • (1970) Technometrics , vol.12 , pp. 55-67
    • Hoerl, A.E.1    Kennard, R.W.2
  • 28
    • 0023710206 scopus 로고
    • Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach
    • 3203132 10.2307/2531595 1:STN:280:DyaL1M%2Fns12ksQ%3D%3D
    • DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837-845
    • (1988) Biometrics , vol.44 , pp. 837-845
    • Delong, E.R.1    Delong, D.M.2    Clarke-Pearson, D.L.3
  • 29
    • 79952709519 scopus 로고    scopus 로고
    • PROC: An open-source package for R and S+ to analyze and compare ROC curves
    • 10.1186/1471-2105-12-77
    • Robin X, Turck N, Hainard A et al (2011) pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinforma 12:77
    • (2011) BMC Bioinforma , vol.12 , pp. 77
    • Robin, X.1    Turck, N.2    Hainard, A.3
  • 30
    • 39549118158 scopus 로고    scopus 로고
    • Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers
    • 18038452 10.1002/hep.21984
    • Guha IN, Parkes J, Roderick P et al (2008) Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European Liver Fibrosis Panel and exploring simple markers. Hepatology 47:455-460
    • (2008) Hepatology , vol.47 , pp. 455-460
    • Guha, I.N.1    Parkes, J.2    Roderick, P.3
  • 31
    • 61449266414 scopus 로고    scopus 로고
    • Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations
    • 19214471 10.1007/s00125-009-1282-2 1:CAS:528:DC%2BD1MXisFSjur0%3D
    • Kotronen A, Velagapudi VR, Yetukuri L et al (2009) Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations. Diabetologia 52:684-690
    • (2009) Diabetologia , vol.52 , pp. 684-690
    • Kotronen, A.1    Velagapudi, V.R.2    Yetukuri, L.3
  • 32
    • 64349124701 scopus 로고    scopus 로고
    • Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry
    • 18832345 10.1194/jlr.D800028-JLR200 1:CAS:528:DC%2BD1MXitlCqtbg%3D
    • Wiesner P, Leidl K, Boettcher A, Schmitz G, Liebisch G (2009) Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry. J Lipid Res 50:574-585
    • (2009) J Lipid Res , vol.50 , pp. 574-585
    • Wiesner, P.1    Leidl, K.2    Boettcher, A.3    Schmitz, G.4    Liebisch, G.5
  • 33
    • 77956815968 scopus 로고    scopus 로고
    • Composition and lipid spatial distribution of HDL particles in subjects with low and high HDL-cholesterol
    • 20431113 10.1194/jlr.M006494 1:CAS:528:DC%2BC3cXpvVOks74%3D
    • Yetukuri L, Söderlund S, Koivuniemi A et al (2010) Composition and lipid spatial distribution of HDL particles in subjects with low and high HDL-cholesterol. J Lipid Res 51:2341-2351
    • (2010) J Lipid Res , vol.51 , pp. 2341-2351
    • Yetukuri, L.1    Söderlund, S.2    Koivuniemi, A.3
  • 34
    • 84877579741 scopus 로고    scopus 로고
    • CB(1) blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans
    • 10.1038/ijo.2012.1116
    • Bergholm R, Sevastianova K, Santos A et al (2012) CB(1) blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans. Int J Obes (Lond). doi: 10.1038/ijo.2012.1116
    • (2012) Int J Obes (Lond)
    • Bergholm, R.1    Sevastianova, K.2    Santos, A.3
  • 35
    • 38649111018 scopus 로고    scopus 로고
    • Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
    • 18242210 10.1053/j.gastro.2007.11.038 1:CAS:528:DC%2BD1cXivFKqurg%3D
    • Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S (2008) Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 134:424-431
    • (2008) Gastroenterology , vol.134 , pp. 424-431
    • Fabbrini, E.1    Mohammed, B.S.2    Magkos, F.3    Korenblat, K.M.4    Patterson, B.W.5    Klein, S.6
  • 36
    • 34848891301 scopus 로고    scopus 로고
    • Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance
    • 17849096 10.1007/s00125-007-0790-1 1:CAS:528:DC%2BD2sXhtFSlsL%2FN
    • Adiels M, Westerbacka J, Soro-Paavonen A et al (2007) Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia 50:2356-2365
    • (2007) Diabetologia , vol.50 , pp. 2356-2365
    • Adiels, M.1    Westerbacka, J.2    Soro-Paavonen, A.3
  • 37
    • 84866621997 scopus 로고    scopus 로고
    • Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans
    • 22952180 10.3945/ajcn.112.038695 1:CAS:528:DC%2BC38XhsVCku7%2FF
    • Sevastianova K, Santos A, Kotronen A et al (2012) Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr 96:727-734
    • (2012) Am J Clin Nutr , vol.96 , pp. 727-734
    • Sevastianova, K.1    Santos, A.2    Kotronen, A.3
  • 38
    • 79953329970 scopus 로고    scopus 로고
    • Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
    • 21403394 10.1172/JCI44442 1:CAS:528:DC%2BC3MXksFahs78%3D
    • Rhee EP, Cheng S, Larson MG et al (2011) Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest 121:1402-1411
    • (2011) J Clin Invest , vol.121 , pp. 1402-1411
    • Rhee, E.P.1    Cheng, S.2    Larson, M.G.3
  • 39
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • 12107194 10.1210/jc.87.7.3023 1:CAS:528:DC%2BD38XlsVGjsbs%3D
    • Seppala-Lindroos A, Vehkavaara S, Hakkinen AM et al (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87:3023-3028
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3023-3028
    • Seppala-Lindroos, A.1    Vehkavaara, S.2    Hakkinen, A.M.3
  • 40
    • 33644827082 scopus 로고    scopus 로고
    • Overproduction of large VLDL particles is driven by increased liver fat content in man
    • 16463046 10.1007/s00125-005-0125-z 1:CAS:528:DC%2BD28XitF2jsbg%3D
    • Adiels M, Taskinen MR, Packard C et al (2006) Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia 49:755-765
    • (2006) Diabetologia , vol.49 , pp. 755-765
    • Adiels, M.1    Taskinen, M.R.2    Packard, C.3
  • 41
    • 30044437451 scopus 로고    scopus 로고
    • The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis
    • 16375767 10.1186/1476-5926-4-10
    • Poynard T, Ratziu V, Naveau S et al (2005) The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Comp Hepatol 4:10
    • (2005) Comp Hepatol , vol.4 , pp. 10
    • Poynard, T.1    Ratziu, V.2    Naveau, S.3
  • 42
    • 33751246499 scopus 로고    scopus 로고
    • The Fatty Liver Index: A simple and accurate predictor of hepatic steatosis in the general population
    • 17081293 10.1186/1471-230X-6-33
    • Bedogni G, Bellentani S, Miglioli L et al (2006) The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol 6:33
    • (2006) BMC Gastroenterol , vol.6 , pp. 33
    • Bedogni, G.1    Bellentani, S.2    Miglioli, L.3
  • 43
    • 84856274286 scopus 로고    scopus 로고
    • Standardized ultrasound hepatic/renal ratio and hepatic attenuation rate to quantify liver fat content: An improvement method
    • 10.1038/oby.2011.302 1:CAS:528:DC%2BC38XhsFCmsbg%3D
    • Xia MF, Yan HM, He WY et al (2012) Standardized ultrasound hepatic/renal ratio and hepatic attenuation rate to quantify liver fat content: an improvement method. Obesity (Silver Spring) 20:444-452
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 444-452
    • Xia, M.F.1    Yan, H.M.2    He, W.Y.3
  • 44
    • 79956011925 scopus 로고    scopus 로고
    • Progression from isolated steatosis to steatohepatitis and fibrosis in nonalcoholic fatty liver disease
    • 1:STN:280:DC%2BC3MrmvFWgsg%3D%3D
    • Pais R, Pascale A, Fedchuck L, Charlotte F, Poynard T, Ratziu V (2011) Progression from isolated steatosis to steatohepatitis and fibrosis in nonalcoholic fatty liver disease. Gastroenterol Clin Biol 35:23-28
    • (2011) Gastroenterol Clin Biol , vol.35 , pp. 23-28
    • Pais, R.1    Pascale, A.2    Fedchuck, L.3    Charlotte, F.4    Poynard, T.5    Ratziu, V.6
  • 45
    • 33244479164 scopus 로고    scopus 로고
    • Insulin glargine or NPH combined with metformin in type 2 diabetes: The LANMET study
    • 16456680 10.1007/s00125-005-0132-0 1:STN:280:DC%2BD287gtlantw%3D%3D
    • Yki-Jarvinen H, Kauppinen-Makelin R, Tiikkainen M et al (2006) Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study. Diabetologia 49:442-451
    • (2006) Diabetologia , vol.49 , pp. 442-451
    • Yki-Jarvinen, H.1    Kauppinen-Makelin, R.2    Tiikkainen, M.3
  • 46
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • 20427778 10.1056/NEJMoa0907929 1:CAS:528:DC%2BC3cXls1Oltr4%3D
    • Sanyal AJ, Chalasani N, Kowdley KV et al (2010) Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 362:1675-1685
    • (2010) N Engl J Med , vol.362 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.