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Advanced Synthesis and Catalysis
Volumn 356, Issue 8, 2014, Pages 1866-1872
Palladium on carbon-catalyzed one-pot N-arylindole synthesis: Intramolecular aromatic amination, aromatization, and intermolecular aromatic amination
Author keywords

amination; cross coupling; heterogeneous catalysis; indoles; palladium
Indexed keywords

EID: 84901308164     PISSN: 16154150     EISSN: 16154169     Source Type: Journal    
DOI: 10.1002/adsc.201301168     Document Type: Article
Times cited : (29)
References (114)
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    • The cyclization effectively proceeded using even 1.5 equiv. of NaO-t-Bu in the presence of 10% Pd/C (2 mol%) and DPPF (3 mol%) in mesitylene at 140°C. The low selectivity for the formation of indoline (1) or indole (2) was however achieved, and a mixture of 1 and 2 was obtained in 94% yield in the ratio of 48:52, respectively.
    • The cyclization effectively proceeded using even 1.5 equiv. of NaO-t-Bu in the presence of 10% Pd/C (2 mol%) and DPPF (3 mol%) in mesitylene at 140°C. The low selectivity for the formation of indoline (1) or indole (2) was however achieved, and a mixture of 1 and 2 was obtained in 94% yield in the ratio of 48:52, respectively.
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    • The amount of AcOH was determined to be 1.5 equiv., since 1 equiv. out of 2.5 equiv. of NaO-t-Bu should be theoretically consumed during the cyclization to quench the generated hydrogen bromide.
    • The amount of AcOH was determined to be 1.5 equiv., since 1 equiv. out of 2.5 equiv. of NaO-t-Bu should be theoretically consumed during the cyclization to quench the generated hydrogen bromide.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.