Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective α1 adrenoceptor antagonists

Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2003, Pages 265-283

  Balle, Thomas ^a,b   Perregaard, Jens ^a   Ramirez, Martha Teresa ^a   Larsen, Anna Kirstine ^a   Søby, Karina Krøjer ^a   Liljefors, Tommy ^b   Andersen, Kim ^a  

^a H LUNDBECK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 FLUOROPHENYL) 3 (4 PIPERIDINYL) 1H INDOLE DERIVATIVE; 1,4 DIHYDRO 2,6 DIMETHYL 4 (4 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLIC ACID [3 (4,4 DIPHENYL 1 PIPERIDINYL)PROPYL]AMIDE METHYL ESTER; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR; NITROGEN; PHENTOLAMINE; PIPERIDINE; PRAZOSIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN RECEPTOR; SERTINDOLE; TAMSULOSIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; NONHUMAN; PHARMACOPHORE; RECEPTOR AFFINITY; SYNTHESIS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTIPSYCHOTIC AGENTS; AZOLES; BRAIN; CELL LINE; CRICETINAE; HUMANS; IMIDAZOLES; INDOLES; PYRIDINES; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE; RECEPTORS, SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 0037448384     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020938y     Document Type: Article

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