Mangiferin Facilitates Islet Regeneration and β-Cell Proliferation through Upregulation of Cell Cycle and β-Cell Regeneration Regulators

International Journal of Molecular Sciences

Volumn 15, Issue 5, 2014, Pages 9016-9035

  Wang, Hai Lian ^a,b   Li, Chun Yang ^a   Zhang, Bin ^a   Liu, Yuan De ^c   Lu, Bang Min ^a   Shi, Zheng ^a   An, Na ^a   Zhao, Liang Kai ^a   Zhang, Jing Jing ^d   Bao, Jin Ku ^a   Wang, Yi ^b,e  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c Department of Pharmacy 91889 Military Hospital   (China)

^d GUANGDONG MEDICAL UNIVERSITY   (China)

^e NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

Cell cycle; Islet regeneration; Mangiferin; Partial pancreatectomy; cell

Indexed keywords

CYCLIN D1; CYCLIN D2; CYCLIN DEPENDENT KINASE 4; GLUCOKINASE; GLUCOSE TRANSPORTER 2; MANGIFERIN; NEUROGENIN 3; TRANSCRIPTION FACTOR PDX 1; GLUCOSE; INSULIN; XANTHONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL CYCLE; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; DRUG DOSE INCREASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; INTRAVENOUS GLUCOSE TOLERANCE TEST; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL HYPERPLASIA; PANCREAS RESECTION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PANCREAS ISLET; PHYSIOLOGY; REGENERATION; SURGERY; UPREGULATION;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN D1; CYCLIN D2; CYCLIN-DEPENDENT KINASE 4; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; REGENERATION; UP-REGULATION; XANTHONES;

EID: 84901301607     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15059016     Document Type: Article

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