Plasma metabolic profiling analysis of nephrotoxicity induced by acyclovir using metabonomics coupled with multivariate data analysis

Journal of Pharmaceutical and Biomedical Analysis

Volumn 97, Issue , 2014, Pages 151-156

  Zhang, Xiuxiu ^a   Li, Yubo ^a   Zhou, Huifang ^a   Fan, Simiao ^a   Zhang, Zhenzhu ^a   Wang, Lei ^a   Zhang, Yanjun ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Acyclovir; Metabonomics; Multivariate data analysis; Nephrotoxicity; RRLC Q TOF MS

Indexed keywords

ACICLOVIR; ARACHIDONIC ACID; ARGININE; BIOLOGICAL MARKER; CREATININE; DRUG METABOLITE; GLYCEROPHOSPHOLIPID; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE A2; PHYTOSPHINGOSINE; PROLINE; TRYPTOPHAN; ANTIVIRUS AGENT;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CREATININE BLOOD LEVEL; DRUG METABOLISM; GLOMERULUS; KIDNEY PARENCHYMA; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; KIDNEY; KIDNEY DISEASE; METABOLISM; METABOLOMICS; MULTIVARIATE ANALYSIS; PLASMA; PROCEDURES;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL MARKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; KIDNEY; KIDNEY DISEASES; MALE; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; MULTIVARIATE ANALYSIS; PLASMA; RATS;

EID: 84901299281     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.04.036     Document Type: Article

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