An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid

Journal of Pharmaceutical and Biomedical Analysis

Volumn 86, Issue , 2013, Pages 56-64

  Peng, Siyuan ^a   Yan, Lijuan ^b   Zhang, Jie ^a   Wang, Zhanlin ^a   Tian, Meiping ^a   Shen, Heqing ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b Xiamen Entry Exit Inspection and Quarantine Bureau   (China)

Author keywords

Biomarker; Hepatotoxicity; Metabonomics; Perfluorooctanoic acid; Transcriptomics

Indexed keywords

ACYLCARNITINE; AMINO ACID; BIOLOGICAL MARKER; CARNITINE; CHOLESTEROL; LIPID; PERFLUOROOCTANOIC ACID; TRICARBOXYLIC ACID;

AMINO ACID METABOLISM; ARTICLE; CELL VIABILITY; CHOLESTEROL SYNTHESIS; CITRIC ACID CYCLE; CYTOSOL; FATTY ACID OXIDATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPID METABOLISM; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MASS SPECTROMETRY; METABOLISM; METABOLOMICS; MICROARRAY ANALYSIS; MITOCHONDRION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTOMICS; UPREGULATION;

BIOMARKER; HEPATOTOXICITY; METABONOMICS; PERFLUOROOCTANOIC ACID; TRANSCRIPTOMICS;

CAPRYLATES; CELL LINE, TRANSFORMED; CELL SURVIVAL; FLUOROCARBONS; HUMANS; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; PILOT PROJECTS; TRANSCRIPTOME;

EID: 84882944032     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.07.014     Document Type: Article

References (30)

1. Wang T., Wang Y., Liao C., Cai Y., Jiang G. Perspectives on the inclusion of perfluorooctane sulfonate into the Stockholm Convention on Persistent Organic Pollutants. Environmental Science & Technology 2009, 43:5171-5175.
2. Lau C., Anitole K., Hodes C., Lai D., Pfahles-Hutchens A., Seed J. Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicological Sciences 2007, 99:366-394.
3. Vestergren R., Cousins I.T. Tracking the pathways of human exposure to perfluorocarboxylates. Environmental Science & Technology 2009, 43:5565-5575.
4. Calafat A.M., Wong L.Y., Kuklenyik Z., Reidy J.A., Needham L.L. Polyfluoroalkyl chemicals in the US population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000. Environmental Health Perspectives 2007, 115:1596-1602.
5. Bao J., Liu W., Liu L., Jin Y., Dai J., Ran X., Zhang Z., Tsuda S. Perfluorinated compounds in the environment and the blood of residents living near fluorochemical plants in Fuxin, China. Environmental Science & Technology 2010, 45:8075-8080.
6. Son H.Y., Kim S.H., Shin H.I., Bae H.I., Yang J.H. Perfluorooctanoic acid-induced hepatic toxicity following 21-day oral exposure in mice. Archives of Toxicology 2008, 82:239-246.
7. Adinehzadeh M., Nicholas V. Effects of peroxisome proliferators on rat liver phospholipids: sphingomyelin degradation may be involved in hepatotoxic mechanism of perfluorodecanoic acid. Chemical Research in Toxicology 1998, 11:428-440.
8. Kudo N., Mizuguchi H., Yamamoto A., Kawashima Y. Alterations by perfluorooctanoic acid of glycerolipid metabolism in rat liver. Chemico-Biological Interactions 1999, 118:69-83.
9. Kudo N., Bandai N., Suzuki E., Katakura M., Kawashima Y. Induction by perfluorinated fatty acids with different carbon chain length of peroxisomal β-oxidation in the liver of rats. Chemico-Biological Interactions 2000, 124:119-132.
10. Bjork J., Butenhoff J., Wallace K. Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes. Toxicology 2011, 288:8-17.
11. Guruge K.S., Yeung L.W., Yamanaka N., Miyazaki S., Lam P.K., Giesy J.P., Jones P.D., Yamashita N. Gene expression profiles in rat liver treated with perfluorooctanoic acid (PFOA). Toxicological Sciences 2006, 89:93-107.
12. Nilsen A.J., Landin M.A., Haug K.H., Fonnum F., Berger U., Osmundsen H. Comparative hepatic gene expression profiling of rats treated with 1H, 1H, 2H, 2H-heptadecafluorodecan-1-ol or with pentadecafluorooctanoic acid. Physiological Genomics 2008, 34:285-303.
13. Rosen M.B., Thibodeaux J.R., Wood C.R., Zehr R.D., Schmid J.E., Lau C. Gene expression profiling in the lung and liver of PFOA-exposed mouse fetuses. Toxicology 2007, 239:15-33.
14. Ding L., Hao F., Shi Z., Wang Y., Zhang H., Tang H., Dai J. Systems biological responses to chronic perfluorododecanoic acid exposure by integrated metabonomic and transcriptomic studies. Journal of Proteome Research 2009, 8:2882-2891.
15. Mendrick D.L., Schnackenberg L. Genomic and metabolomic advances in the identification of disease and adverse event biomarkers. Biomarkers 2009, 3:605-615.
16. Zhang H., Ding L., Fang X., Shi Z., Zhang Y., Chen H., Yan X., Dai J. Biological responses to perfluorododecanoic acid exposure in rat kidneys as determined by integrated proteomic and metabonomic studies. PLoS ONE 2011, 6:e20862.
17. Buhrke T., Kibellus A., Lampen A. In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths. Toxicology Letters 2013, 218:97-104.
18. Wang X.H., Tian Y., Guo Z.J., Fan Z.P., Qiu D.K., Zeng M.D. Cholesterol metabolism and expression of its relevant genes in cultured steatotic hepatocytes. Journal of Digestive Diseases 2009, 10:310-314.
19. Wang M., Zhao R., Wang W., Mao X., Yu J. Lipid regulation effects of Polygoni Multiflori Radix, its processed products and its major substances on steatosis human liver cell line L02. Journal of Ethnopharmacology 2012, 139:287-293.
20. Zheng L., Lv G.C., Sheng J., Yang Y.D. Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-a expression, a novel mechanism for the pathogenesis of NAFLD. Journal of Gastroenterology and Hepatology 2010, 25:156-163.
21. Ge L., Wang J., Qi W., Miao H.H., Cao J., Qu Y.X., Li B.L., Song B.L. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metabolism 2008, 7:508-519.
22. Bijlsma S., Bobeldijk I., Verheij E.R., Ramaker R., Kochhar S., Macdonald I.A., van Ommen B., Smilde A.K. Large-scale human metabolomics studies: a strategy for data (pre-)processing and validation. Analytical Chemistry 2006, 78:567-574.
23. Keun H.C., Ebbels T., Antti H., Bollard M.E., Beckonert O., Holmes E., Lindon J.C., Nicholson J.K. Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling. Analytica Chimica Acta 2003, 490:265-276.
24. Zhang J., Yan L., Chen W., Lin L., Song X., Yan X., Hang W., Huang B. Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system. Analytica Chimica Acta 2009, 650:16-22.
25. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative CT method. Nature Protocols 2008, 3:1101-1108.
26. Vaz F.M., Wanders R.J. Carnitine biosynthesis in mammals. Biochemical Journal 2002, 361:417-429.
27. Tian M., Peng S., Martin F.L., Zhang J., Liu L., Wang Z., Dong S., Shen H. Perfluorooctanoic acid induces gene promoter hypermethylation of glutathione-S-transferase Pi in human liver L02 cells. Toxicology 2012, 296:48-55.
28. Palmer C.N., Hsu M.-H., Griffin K.J., Raucy J.L., Johnson E.F. Peroxisome proliferator activated receptor-α expression in human liver. Molecular Pharmacology 1998, 53:14-22.
29. Bjork J.A., Wallace K.B. Structure-activity relationships and human relevance for perfluoroalkyl acid-induced transcriptional activation of peroxisome proliferation in liver cell cultures. Toxicological Sciences 2009, 111:89-99.
30. Steenland K., Fletcher T., Savitz D.A. Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA). Environmental Health Perspectives 2010, 118:1100-1108.