Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages

Free Radical Biology and Medicine

Volumn 51, Issue 9, 2011, Pages 1686-1696

  Shoeb, Mohammad ^a   Yadav, Umesh C S ^a   Srivastava, Satish K ^a   Ramana, Kota V ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Aldose reductase; Arachidonic acid; COX 2; Free radicals; Inflammation; LOX 5; LPS

Indexed keywords

ALDEHYDE REDUCTASE; ARACHIDONIC ACID; BACTERIUM LIPOPOLYSACCHARIDE; CALCIMYCIN; CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2; FIDARESTAT; LEUKOTRIENE B4; LIPOXYGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROSTACYCLIN; PROSTAGLANDIN E2; SMALL INTERFERING RNA; THROMBOXANE SYNTHASE; TRANSCRIPTION FACTOR EGR 1; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DENSITOMETRY; DRUG INHIBITION; HEART; IMMUNOREGULATION; INFLAMMATION; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ALDEHYDE REDUCTASE; ANIMALS; ARACHIDONIC ACID; CELLS, CULTURED; ENDOTOXINS; INDOMETHACIN; INFLAMMATION; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); MURINAE; MUS;

EID: 80053608290     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.07.024     Document Type: Article

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