Design and synthesis of novel furoquinoline based inhibitors of multiple targets in the PI3K/Akt-mTOR pathway

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 12, 2008, Pages 3603-3606

  Lohar, Manoj V ^a   Mundada, Ramswaroop ^a   Bhonde, Mandar ^a   Padgaonkar, Amol ^a   Deore, Vijaykumar ^a   Yewalkar, Nilambari ^a   Bhatia, Dimple ^a   Rathos, Maggie ^a   Joshi, Kalpana ^a   Vishwakarma, Ram A ^a   Kumar, Sanjay ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 7 METHOXY 4 (4 NITROPHENYLTHIO)FURO[2,3 B]QUINOLINE; FUROQUINOLINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; QUINOLINE DERIVATIVE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ASSAY; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BLOTTING, WESTERN; CELL LINE, TUMOR; DRUG DESIGN; ENZYME INHIBITORS; FURANS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MOLECULAR STRUCTURE; PHOSPHORYLATION; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLINES; SIGNAL TRANSDUCTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44649152229     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.078     Document Type: Article

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