Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells

Oncotarget

Volumn 5, Issue 9, 2014, Pages 2678-2687

  Choi, Young Eun ^a   Battelli, Chiara ^b   Watson, Jacqueline ^a   Liu, Joyce ^a   Curtis, Jennifer ^a   Morse, Alexander N ^c   Matulonis, Ursula A ^a   Chowdhury, Dipanjan ^a   Konstantinopoulos, Panagiotis A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Maine Center for Cancer Medicine and Blood Disorders   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

Epithelial ovarian cancer; Heat shock protein 90 inhibitors; Homologous recombination; PARP inhibitors; Platinum

Indexed keywords

BRCA1 PROTEIN; CARBOPLATIN; OLAPARIB; RAD51 PROTEIN; TANESPIMYCIN; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; ENZYME INHIBITOR; MACROCYCLIC LACTAM; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE;

ARTICLE; BREAST CANCER CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; OVARIAN CANCER CELL LINE; OVARY CARCINOMA; RAD51 GENE; RECOMBINATION REPAIR; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; DRUG EFFECTS; DRUG RESISTANCE; ENZYME IMMUNOASSAY; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; PATHOLOGY; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BENZOQUINONES; BLOTTING, WESTERN; BRCA1 PROTEIN; BREAST NEOPLASMS; CARBOPLATIN; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOENZYME TECHNIQUES; LACTAMS, MACROCYCLIC; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; PHTHALAZINES; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASES; RECOMBINATIONAL DNA REPAIR; TUMOR CELLS, CULTURED;

EID: 84901236439     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1929     Document Type: Article

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