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Volumn 83, Issue 6, 2014, Pages 741-752

CD44-targeted docetaxel conjugate for cancer cells and cancer stem-like cells: A novel hyaluronic acid-based drug delivery system

Author keywords

cancer stem cells; conjugation; macromolecular drug delivery; polysaccharides; prodrugs

Indexed keywords

DOCETAXEL; HERMES ANTIGEN; HYALURONIC ACID; TAXOID; WATER;

EID: 84901234041     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12288     Document Type: Article
Times cited : (63)

References (53)
  • 1
    • 78349310182 scopus 로고    scopus 로고
    • Prediction of outcome of patients with metastatic breast cancer: Evaluation with prognostic factors and Nottingham prognostic index
    • Liu M.T., Huang W.T., Wang A.Y., Huang C.C., Huang C.Y., Chang T.H., Pi C.P., Yang H.H,. (2010) Prediction of outcome of patients with metastatic breast cancer: evaluation with prognostic factors and Nottingham prognostic index. Support Care Cancer; 18: 1553-1564.
    • (2010) Support Care Cancer , vol.18 , pp. 1553-1564
    • Liu, M.T.1    Huang, W.T.2    Wang, A.Y.3    Huang, C.C.4    Huang, C.Y.5    Chang, T.H.6    Pi, C.P.7    Yang, H.H.8
  • 3
    • 77950605087 scopus 로고    scopus 로고
    • Management of prostate cancer recurrence after definitive radiation therapy
    • Boukaram C., Hannoun-Levi J.-M., (2010) Management of prostate cancer recurrence after definitive radiation therapy. Cancer Treat Rev; 36: 91-100.
    • (2010) Cancer Treat Rev , vol.36 , pp. 91-100
    • Boukaram, C.1    Hannoun-Levi, J.-M.2
  • 4
    • 43949138899 scopus 로고    scopus 로고
    • Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer
    • Coley H.M., (2008) Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer. Cancer Treat Rev; 34: 378-390.
    • (2008) Cancer Treat Rev , vol.34 , pp. 378-390
    • Coley, H.M.1
  • 5
    • 77957961187 scopus 로고    scopus 로고
    • The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches
    • Lacerda L., Pusztai L., Woodward W.A., (2010) The role of tumor initiating cells in drug resistance of breast cancer: implications for future therapeutic approaches. Drug Resist Updat; 13: 99-108.
    • (2010) Drug Resist Updat , vol.13 , pp. 99-108
    • Lacerda, L.1    Pusztai, L.2    Woodward, W.A.3
  • 6
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell P.C., (1976) The clonal evolution of tumor cell populations. Science; 194: 23.
    • (1976) Science , vol.194 , pp. 23
    • Nowell, P.C.1
  • 7
    • 63649119820 scopus 로고    scopus 로고
    • Cancer stem cell-directed therapies: Recent data from the laboratory and clinic
    • Park C.Y., Tseng D., Weissman I.L., (2008) Cancer stem cell-directed therapies: recent data from the laboratory and clinic. Mol Ther; 17: 219-230.
    • (2008) Mol Ther , vol.17 , pp. 219-230
    • Park, C.Y.1    Tseng, D.2    Weissman, I.L.3
  • 8
    • 80052479916 scopus 로고    scopus 로고
    • The role of breast cancer stem cells in metastasis and therapeutic implications
    • Velasco-Velázquez M.A., Popov V.M., Lisanti M.P., Pestell R.G., (2011) The role of breast cancer stem cells in metastasis and therapeutic implications. Am J Pathol; 179: 2-11.
    • (2011) Am J Pathol , vol.179 , pp. 2-11
    • Velasco-Velázquez, M.A.1    Popov, V.M.2    Lisanti, M.P.3    Pestell, R.G.4
  • 9
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta P.B., Onder T.T., Jiang G., Tao K., Kuperwasser C., Weinberg R.A., Lander E.S., (2009) Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell; 138: 645-659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7
  • 10
    • 84856066278 scopus 로고    scopus 로고
    • Salinomycin - A new cancer drug candidate
    • Huczynski A., (2012) Salinomycin-a new cancer drug candidate. Chem Biol Drug Des; 79: 235-238.
    • (2012) Chem Biol Drug des , vol.79 , pp. 235-238
    • Huczynski, A.1
  • 11
    • 44649133215 scopus 로고    scopus 로고
    • A potential target associated with both cancer and cancer stem cells: A combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes
    • Liu Y., Lu W.-L., Guo J., Du J., Li T., Wu J.-W., Wang G.-L., Wang J.-C., Zhang X., Zhang Q., (2008) A potential target associated with both cancer and cancer stem cells: a combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes. J Control Release; 129: 18-25.
    • (2008) J Control Release , vol.129 , pp. 18-25
    • Liu, Y.1    Lu, W.-L.2    Guo, J.3    Du, J.4    Li, T.5    Wu, J.-W.6    Wang, G.-L.7    Wang, J.-C.8    Zhang, X.9    Zhang, Q.10
  • 12
    • 80055112766 scopus 로고    scopus 로고
    • The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles
    • Zhang Y., Zhang H., Wang X., Wang J., Zhang X., Zhang Q., (2012) The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles. Biomaterials; 33: 679-691.
    • (2012) Biomaterials , vol.33 , pp. 679-691
    • Zhang, Y.1    Zhang, H.2    Wang, X.3    Wang, J.4    Zhang, X.5    Zhang, Q.6
  • 13
    • 84877925735 scopus 로고    scopus 로고
    • Docetaxel-loaded solid lipid nanoparticles: Preparation, characterization, in vitro, and in vivo evaluations
    • Mosallaei N., Jaafari M.R., Hanafi-Bojd M.Y., Golmohammadzadeh S., Malaekeh-Nikouei B., (2013) Docetaxel-loaded solid lipid nanoparticles: preparation, characterization, in vitro, and in vivo evaluations. J Pharm Sci; 102: 1994-2004.
    • (2013) J Pharm Sci , vol.102 , pp. 1994-2004
    • Mosallaei, N.1    Jaafari, M.R.2    Hanafi-Bojd, M.Y.3    Golmohammadzadeh, S.4    Malaekeh-Nikouei, B.5
  • 14
    • 84871362496 scopus 로고    scopus 로고
    • Antibody-drug conjugates for the treatment of cancer
    • Flygare J.A., Pillow T.H., Aristoff P., (2013) Antibody-drug conjugates for the treatment of cancer. Chem Biol Drug Des; 81: 113-121.
    • (2013) Chem Biol Drug des , vol.81 , pp. 113-121
    • Flygare, J.A.1    Pillow, T.H.2    Aristoff, P.3
  • 16
    • 84872491549 scopus 로고    scopus 로고
    • Developmental signaling pathways in cancer stem cells of solid tumors
    • Karamboulas C., Ailles L., (2013) Developmental signaling pathways in cancer stem cells of solid tumors. Biochim Biophys Acta; 1830: 2481-2495.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 2481-2495
    • Karamboulas, C.1    Ailles, L.2
  • 19
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore C.M., Kuperwasser C., (2008) Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res; 10: R25.
    • (2008) Breast Cancer Res , vol.10
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 20
    • 0034208501 scopus 로고    scopus 로고
    • A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells
    • Luo Y., Ziebell M.R., Prestwich G.D., (2000) A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells. Biomacromolecules; 1: 208-218.
    • (2000) Biomacromolecules , vol.1 , pp. 208-218
    • Luo, Y.1    Ziebell, M.R.2    Prestwich, G.D.3
  • 21
    • 3042697038 scopus 로고    scopus 로고
    • Hyaluronan: From extracellular glue to pericellular cue
    • Toole B.P., (2004) Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer; 4: 528-539.
    • (2004) Nat Rev Cancer , vol.4 , pp. 528-539
    • Toole, B.P.1
  • 22
    • 77950819301 scopus 로고    scopus 로고
    • New advances on critical implications of tumor-and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence
    • Mimeault M., Batra S., (2010) New advances on critical implications of tumor-and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence. Histol Histopathol; 25: 1057-1073.
    • (2010) Histol Histopathol , vol.25 , pp. 1057-1073
    • Mimeault, M.1    Batra, S.2
  • 23
    • 42449161959 scopus 로고    scopus 로고
    • Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies
    • Mimeault M., Hauke R., Batra S., (2007) Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies. Clin Pharmacol Ther; 83: 673-691.
    • (2007) Clin Pharmacol Ther , vol.83 , pp. 673-691
    • Mimeault, M.1    Hauke, R.2    Batra, S.3
  • 24
    • 0347355523 scopus 로고    scopus 로고
    • Cytokines regulate the affinity of soluble CD44 for hyaluronan
    • Cichy J., Puré E., (2004) Cytokines regulate the affinity of soluble CD44 for hyaluronan. FEBS Lett; 556: 69-74.
    • (2004) FEBS Lett , vol.556 , pp. 69-74
    • Cichy, J.1    Puré, E.2
  • 25
    • 0027956397 scopus 로고
    • Hyaluronate receptors: Key players in growth, differentiation, migration and tumor progression
    • Sherman L., Sleeman J., Herrlich P., Ponta H., (1994) Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression. Curr Opin Cell Biol; 6: 726-733.
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 726-733
    • Sherman, L.1    Sleeman, J.2    Herrlich, P.3    Ponta, H.4
  • 26
    • 56649100319 scopus 로고    scopus 로고
    • The structure of glycosaminoglycans and their interactions with proteins
    • Gandhi N.S., Mancera R.L., (2008) The structure of glycosaminoglycans and their interactions with proteins. Chem Biol Drug Des; 72: 455-482.
    • (2008) Chem Biol Drug des , vol.72 , pp. 455-482
    • Gandhi, N.S.1    Mancera, R.L.2
  • 28
    • 0037085254 scopus 로고    scopus 로고
    • Signaling properties of hyaluronan receptors
    • Turley E.A., Noble P.W., Bourguignon L.Y.W., (2002) Signaling properties of hyaluronan receptors. J Biol Chem; 277: 4589-4592.
    • (2002) J Biol Chem , vol.277 , pp. 4589-4592
    • Turley, E.A.1    Noble, P.W.2    Bourguignon, L.Y.W.3
  • 29
    • 33751270222 scopus 로고    scopus 로고
    • Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective
    • Götte M., Yip G.W., (2006) Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective. Cancer Res; 66: 10233-10237.
    • (2006) Cancer Res , vol.66 , pp. 10233-10237
    • Götte, M.1    Yip, G.W.2
  • 30
    • 84872007099 scopus 로고    scopus 로고
    • Targeting CD44 by hyaluronic acid-based nano drug delivery systems may eradicate cancer stem cells in human breast cancer
    • Goodarzi N., Ghahremani M.H., Dinarvand R., (2011) Targeting CD44 by hyaluronic acid-based nano drug delivery systems may eradicate cancer stem cells in human breast cancer. J Med Hypotheses Ideas; 5: 26-30.
    • (2011) J Med Hypotheses Ideas , vol.5 , pp. 26-30
    • Goodarzi, N.1    Ghahremani, M.H.2    Dinarvand, R.3
  • 31
    • 84865967844 scopus 로고    scopus 로고
    • Endocytosis and intracellular trafficking as gateways for nanomedicine delivery: Opportunities and challenges
    • Duncan R., Richardson S.C., (2012) Endocytosis and intracellular trafficking as gateways for nanomedicine delivery: opportunities and challenges. Mol Pharm; 9: 2380-2402.
    • (2012) Mol Pharm , vol.9 , pp. 2380-2402
    • Duncan, R.1    Richardson, S.C.2
  • 33
    • 84862804254 scopus 로고    scopus 로고
    • The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy
    • Burke A.R., Singh R.N., Carroll D.L., Wood J.C.S., D'Agostino R.B. Jr, Ajayan P.M., Torti F.M., Torti S.V., (2012) The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy. Biomaterials; 33: 2961-2970.
    • (2012) Biomaterials , vol.33 , pp. 2961-2970
    • Burke, A.R.1    Singh, R.N.2    Carroll, D.L.3    Wood, J.C.S.4    D'Agostino, Jr.R.B.5    Ajayan, P.M.6    Torti, F.M.7    Torti, S.V.8
  • 34
    • 84878151456 scopus 로고    scopus 로고
    • Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity
    • Stratford E.W., Bostad M., Castro R., Skarpen E., Berg K., Høgset A., Myklebost O., Selbo P.K., (2013) Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta; 1830: 4235-4243.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 4235-4243
    • Stratford, E.W.1    Bostad, M.2    Castro, R.3    Skarpen, E.4    Berg, K.5    Høgset, A.6    Myklebost, O.7    Selbo, P.K.8
  • 35
    • 0033200301 scopus 로고    scopus 로고
    • Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate
    • Luo Y., Prestwich G.D., (1999) Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate. Bioconjug Chem; 10: 755-763.
    • (1999) Bioconjug Chem , vol.10 , pp. 755-763
    • Luo, Y.1    Prestwich, G.D.2
  • 36
    • 48049091570 scopus 로고    scopus 로고
    • Doxorubicin conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS): Conjugation chemistry, characterization, in vitro and in vivo evaluation
    • Cao N., Feng S.-S., (2008) Doxorubicin conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS): conjugation chemistry, characterization, in vitro and in vivo evaluation. Biomaterials; 29: 3856-3865.
    • (2008) Biomaterials , vol.29 , pp. 3856-3865
    • Cao, N.1    Feng, S.-S.2
  • 37
    • 70849114663 scopus 로고    scopus 로고
    • Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives
    • Oh E.J., Park K., Kim K.S., Kim J., Yang J.-A., Kong J.-H., Lee M.Y., Hoffman A.S., Hahn S.K., (2010) Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives. J Control Release; 141: 2-12.
    • (2010) J Control Release , vol.141 , pp. 2-12
    • Oh, E.J.1    Park, K.2    Kim, K.S.3    Kim, J.4    Yang, J.-A.5    Kong, J.-H.6    Lee, M.Y.7    Hoffman, A.S.8    Hahn, S.K.9
  • 38
  • 39
    • 38349083479 scopus 로고    scopus 로고
    • Controlling coupling reaction of EDC and NHS for preparation of collagen gels using ethanol/water co-solvents
    • Nam K., Kimura T., Kishida A., (2008) Controlling coupling reaction of EDC and NHS for preparation of collagen gels using ethanol/water co-solvents. Macromol Biosci; 8: 32-37.
    • (2008) Macromol Biosci , vol.8 , pp. 32-37
    • Nam, K.1    Kimura, T.2    Kishida, A.3
  • 40
    • 79955673207 scopus 로고    scopus 로고
    • Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications
    • Schanté C.E., Zuber G., Herlin C., Vandamme T.F., (2011) Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications. Carbohydr Polym; 85: 469-489.
    • (2011) Carbohydr Polym , vol.85 , pp. 469-489
    • Schanté, C.E.1    Zuber, G.2    Herlin, C.3    Vandamme, T.F.4
  • 41
    • 33645516370 scopus 로고    scopus 로고
    • Controlled synthesis and inclusion ability of a hyaluronic acid derivative bearing beta-cyclodextrin molecules
    • Charlot A., Heyraud A., Guenot P., Rinaudo M., Auzely-Velty R., (2006) Controlled synthesis and inclusion ability of a hyaluronic acid derivative bearing beta-cyclodextrin molecules. Biomacromolecules; 7: 907-913.
    • (2006) Biomacromolecules , vol.7 , pp. 907-913
    • Charlot, A.1    Heyraud, A.2    Guenot, P.3    Rinaudo, M.4    Auzely-Velty, R.5
  • 43
    • 70350622459 scopus 로고    scopus 로고
    • In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration
    • Lee E., Kim H., Lee I.-H., Jon S., (2009) In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration. J Control Release; 140: 79-85.
    • (2009) J Control Release , vol.140 , pp. 79-85
    • Lee, E.1    Kim, H.2    Lee, I.-H.3    Jon, S.4
  • 44
    • 0034601831 scopus 로고    scopus 로고
    • Cross-linked hyaluronic acid hydrogel films: New biomaterials for drug delivery
    • Luo Y., Kirker K.R., Prestwich G.D., (2000) Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J Control Release; 69: 169-184.
    • (2000) J Control Release , vol.69 , pp. 169-184
    • Luo, Y.1    Kirker, K.R.2    Prestwich, G.D.3
  • 45
    • 27944463584 scopus 로고    scopus 로고
    • Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding
    • Tzircotis G., Thorne R.F., Isacke C.M., (2005) Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding. J Cell Sci; 118: 5119-5128.
    • (2005) J Cell Sci , vol.118 , pp. 5119-5128
    • Tzircotis, G.1    Thorne, R.F.2    Isacke, C.M.3
  • 47
    • 0035365162 scopus 로고    scopus 로고
    • Modulation of docetaxel-induced apoptosis and cell cycle arrest by all- trans retinoic acid in prostate cancer cells
    • Nehme A., Varadarajan P., Sellakumar G., Gerhold M., Niedner H., Zhang Q., Lin X., Christen R.D., (2001) Modulation of docetaxel-induced apoptosis and cell cycle arrest by all- trans retinoic acid in prostate cancer cells. Br J Cancer; 84: 1571-1576.
    • (2001) Br J Cancer , vol.84 , pp. 1571-1576
    • Nehme, A.1    Varadarajan, P.2    Sellakumar, G.3    Gerhold, M.4    Niedner, H.5    Zhang, Q.6    Lin, X.7    Christen, R.D.8
  • 48
    • 82555179201 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells
    • Chen J., Sun W.L., Wasylyk B., Wang Y.P., Zheng H., (2012) c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells. Anticancer Drugs; 23: 98-107.
    • (2012) Anticancer Drugs , vol.23 , pp. 98-107
    • Chen, J.1    Sun, W.L.2    Wasylyk, B.3    Wang, Y.P.4    Zheng, H.5
  • 49
    • 0032417169 scopus 로고    scopus 로고
    • 12 Heparin-induced thrombocytopenia: Diagnostic tests and biological mechanisms
    • Amiral J., Meyer D., (1998) 12 Heparin-induced thrombocytopenia: diagnostic tests and biological mechanisms. Baillieres Clin Haematol; 11: 447-460.
    • (1998) Baillieres Clin Haematol , vol.11 , pp. 447-460
    • Amiral, J.1    Meyer, D.2
  • 50
    • 0031938871 scopus 로고    scopus 로고
    • Increased serum levels of hyaluronic acid in pregnancies complicated by preeclampsia or hemolysis, elevated liver enzymes, and low platelets syndrome
    • Osmers R.G.W., Schütz E., Diedrich F., Wehry B., Krauβ T., Oellerich M., Kuhn W., (1998) Increased serum levels of hyaluronic acid in pregnancies complicated by preeclampsia or hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Obstet Gynecol; 178: 341-345.
    • (1998) Am J Obstet Gynecol , vol.178 , pp. 341-345
    • Osmers, R.G.W.1    Schütz, E.2    Diedrich, F.3    Wehry, B.4    Krau, T.5    Oellerich, M.6    Kuhn, W.7
  • 51
    • 84857060355 scopus 로고    scopus 로고
    • Hyaluronic acid influence on platelet-induced airway smooth muscle cell proliferation
    • Svensson Holm A.-C.B., Bengtsson T., Grenegård M., Lindström E.G., (2012) Hyaluronic acid influence on platelet-induced airway smooth muscle cell proliferation. Exp Cell Res; 318: 632-640.
    • (2012) Exp Cell Res , vol.318 , pp. 632-640
    • Svensson Holm, A.-C.B.1    Bengtsson, T.2    Grenegård, M.3    Lindström, E.G.4
  • 52
    • 0028337820 scopus 로고
    • CD44 can mediate the adhesion of platelets to hyaluronan
    • Koshiishi I., Shizari M., Underhill C.B., (1994) CD44 can mediate the adhesion of platelets to hyaluronan. Blood; 84: 390-396.
    • (1994) Blood , vol.84 , pp. 390-396
    • Koshiishi, I.1    Shizari, M.2    Underhill, C.B.3
  • 53
    • 51049098968 scopus 로고    scopus 로고
    • Anticancer therapeutics: Targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor
    • Platt V.M., Szoka F.C. Jr, (2008) Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor. Mol Pharm; 5: 474-486.
    • (2008) Mol Pharm , vol.5 , pp. 474-486
    • Platt, V.M.1    Szoka, Jr.F.C.2


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