C-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells

Anti-Cancer Drugs

Volumn 23, Issue 1, 2012, Pages 98-107

  Chen, Juan ^a   Sun, Wei Liang ^a   Wasylyk, Bohdan ^b   Wang, Yan Ping ^a   Zheng, Hong ^a  

^a SICHUAN UNIVERSITY   (China)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

breast cancer; G2 M arrest; JNK; microtubule depolymerization; microtubule binding agents

Indexed keywords

ANTINEOPLASTIC AGENT; COMBRETASTATIN A4; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PACLITAXEL; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; XRP 44X;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN MCF 7; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG MECHANISM; HUMAN; HUMAN CELL; MICROTUBULE; PRIORITY JOURNAL;

BREAST NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; FEMALE; FLAVONOIDS; G2 PHASE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICROTUBULES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PACLITAXEL; PHOSPHORYLATION; PIPERAZINES; PYRAZOLES; STILBENES;

EID: 82555179201     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0b013e32834bc978     Document Type: Article

References (38)

1. Jordan MA,Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 2004; 4:253-265. (Pubitemid 38525281)
2. Amos LA, Schlieper D. Microtubules and maps. Adv Protein Chem 2005; 71:257-298. (Pubitemid 41446931)
3. Cobb MH, Goldsmith EJ. How MAP kinases are regulated. J Biol Chem 1995; 270:14843-14846.
4. Sturgill TW, Ray LB. Muscle proteins related to microtubule associated protein-2 are substrates for an insulin-stimulatable kinase. Biochem Biophys Res Commun 1986; 134:565-571. (Pubitemid 16070535)
5. Ray LB, Sturgill TW. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. Proc Natl Acad Sci USA 1987; 84:1502-1506. (Pubitemid 17066717)
6. Bogoyevitch MA, Kobe B. Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev 2006; 70:1061-1095. (Pubitemid 44958264)
7. Hu JY, Chu ZG, Han J, Dang YM, Yan H, Zhang Q, et al. The p38/MAPK pathway regulates microtubule polymerization through phosphorylation of MAP4 and Op18 in hypoxic cells. Cell Mol Life Sci 2010; 67:321-333.
8. Stone AA, Chambers TC. Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human Kβ3 carcinoma cells. Exp Cell Res 2000; 254:110-119. (Pubitemid 30066737)
9. Shtil AA, Mandlekar S, Yu R, Walter RJ, Hagen K, Tan TH, et al. Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells. Oncogene 1999; 18:377-384. (Pubitemid 29060613)
10. Wasylyk C, Zheng H, Castell C, Debussche L, Multon MC, Wasylyk B. Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Res 2008; 68:1275-1283. (Pubitemid 351346833)
11. Nagaiah G, Remick SC. Combretastatin A4 phosphate: a novel vascular disrupting agent. Future Oncol 2010; 6:1219-1228.
12. Olmsted JB, Borisy GG. Microtubules. Annu Rev Biochem 1973; 42: 507-540.
13. Vistica DT, Skehan P, Scudiero D, Monks A, Pittman A, Boyd MR. Tetrazolium-based assays for cellular viability: a critical examination ofselected parameters affecting formazan production. Cancer Res 1991; 51:2515-2520.
14. Kanthou C, Tozer GM. The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells. Blood 2002; 99: 2060-2069. (Pubitemid 34525489)
15. Bershadsky AD, Gelfand VI, Svitkina TM, Tint IS. Microtubules in mouse embryo fibroblasts extracted with Triton X-100. Cell Biol Int Rep 1978; 2:425-432. (Pubitemid 9020115)
16. Lieuvin A, Labbe JC, Doree M, Job D. Intrinsic microtubule stability in interphase cells. J Cell Biol 1994; 124:985-996. (Pubitemid 24109400)
17. Bacus SS, Gudkov AV, Lowe M, Lyass L, Yung Y, Komarov AP, et al. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 2001; 20:147-155. (Pubitemid 32150260)
18. Ren Y, Jiang H, Yang F, Nakaso K, Feng J. Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation. J Biol Chem 2009; 284:4009-4017.
19. Wittmann T, Hyman A, Desai A. The spindle: a dynamic assembly of microtubules and motors. Nat Cell Biol 2001; 3:E28-E34. (Pubitemid 32114823)
20. Kaestner P, Bastians H. Mitotic drug targets. J Cell Biochem 2010; 111:258-265.
21. Woods CM, Zhu J, McQueney PA, Bollag D, Lazarides E. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol Med 1995; 1:506-526.
22. Jordan MA,Wendell K, Gardiner S, DerryWB, Copp H,Wilson L. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996; 56:816-825. (Pubitemid 26055472)
23. Ye K, Zhou J, Landen JW, Bradbury EM, Joshi HC. Sustained activation of p34(cdc2) is required for noscapine-induced apoptosis. J Biol Chem 2001; 276:46697-46700.
24. Rieder CL, Cole R. Microtubule disassembly delays the G2-M transition in vertebrates. Curr Biol 2000; 10:1067-1070.
25. Coffey ET, Hongisto V, Dickens M, Davis RJ, Courtney MJ. Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons. J Neurosci 2000; 20:7602-7613.
26. Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell 2003; 4:521-533. (Pubitemid 36437559)
27. Bjorkblom B, Ostman N, Hongisto V, Komarovski V, Filen JJ, Nyman TA, et al. Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J Neurosci 2005; 25:6350-6361. (Pubitemid 40962530)
28. Kawauchi T, Chihama K, Nabeshima Y, Hoshino M. The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration. EMBO J 2003; 22:4190-4201. (Pubitemid 37021747)
29. Daire V, Giustiniani J, Leroy-Gori I, Quesnoit M, Drevensek S, Dimitrov A, et al. Kinesin-1 regulates microtubule dynamics via a c-Jun N-terminal kinase-dependent mechanism. J Biol Chem 2009; 284:31992-32001.
30. Morfini G, Pigino G, Szebenyi G, You Y, Pollema S, Brady ST. JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport. Nat Neurosci 2006; 9:907-916. (Pubitemid 43980505)
31. Morfini GA, You YM, Pollema SL, Kaminska A, Liu K, Yoshioka K, et al. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat Neurosci 2009; 12:864-871.
32. Buee-Scherrer V, Goedert M. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells. FEBS Lett 2002; 515:151-154. (Pubitemid 34273915)
33. Liu F, Li B, Tung EJ, Grundke-Iqbal I, Iqbal K, Gong CX. Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation. Eur J Neurosci 2007; 26:3429-3436. (Pubitemid 350243526)
34. Tang SC. Predictive markers of tubulin-targeting agents in breast cancer. Clin Breast Cancer 2008; 8 (Suppl 2):S79-S84.
35. Teraishi F,Wu S, Sasaki J, Zhang L, Davis JJ, Guo W, et al. JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells. Cell Mol Life Sci 2005; 62:2382-2389. (Pubitemid 41500554)
36. Cuadrado A, Garcia-Fernandez LF, Gonzalez L, Suarez Y, Losada A, Alcaide V, et al. Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. J Biol Chem 2003; 278: 241-250. (Pubitemid 36043568)
37. Mandlekar S, Yu R, Tan TH, Kong AN. Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells. Cancer Res 2000; 60: 5995-6000.
38. Powers CJ, McLeskey SW, Wellstein A. Fibroblast growth factors, their receptors and signaling. Endocr Relat Cancer 2000; 7: 165-197.