Overview of the phytomedicine approaches against Helicobacter pylori

World Journal of Gastroenterology

Volumn 20, Issue 19, 2014, Pages 5594-5609

  Vale, Filipa F ^a   Oleastro, Mónica ^b  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b NATIONAL INSTITUTE OF HEALTH DR RICARDO JORGE   (Portugal)

Author keywords

Alternative treatment; Antibiotic resistance; Botanical therapy; Helicobacter pylori; Herb medicine; Herbal medicine; Phytomedicine; Phytotherapy; Probiotics

Indexed keywords

AGRIMONIA PILOSA EXTRACT; BACOPA MONNIERI EXTRACT; BETEL EXTRACT; BLACK PEPPER EXTRACT; CINNAMON EXTRACT; CLARITHROMYCIN; CURCUMIN; CYCLOOXYGENASE 1; DOXYCYCLINE; GARLIC OIL; GLYCYRRHIZA GLABRA EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; KAVA EXTRACT; LEVOFLOXACIN; LYCOPENE; MAGNOLIA OFFICINALIS EXTRACT; METRONIDAZOLE; NIGELLA SATIVA EXTRACT; NITAZOXANIDE; OMEPRAZOLE; PANTOPRAZOLE; PELARGONIUM SIDOIDES EXTRACT; PLANT EXTRACT; PROTON PUMP INHIBITOR; SALVIA OFFICINALIS EXTRACT; TUMOR NECROSIS FACTOR ALPHA; ANTIINFECTIVE AGENT; PLANT MEDICINAL PRODUCT; PROBIOTIC AGENT;

ANTIBIOTIC RESISTANCE; APITHERAPY; ARTICLE; CHINESE MEDICINE; CHRONIC GASTRITIS; CLINICAL TRIAL (TOPIC); DRUG TREATMENT FAILURE; EVIDENCE BASED MEDICINE; FOOD AND DRUG ADMINISTRATION; GASTROESOPHAGEAL REFLUX; HELICOBACTER INFECTION; HUMAN; IMMUNIZATION; MARGINAL ZONE LYMPHOMA; PEPTIC ULCER; PHOTODYNAMIC THERAPY; PHYTOTHERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); STOMACH CARCINOMA; SYSTEMATIC REVIEW (TOPIC); TREATMENT FAILURE; DRUG EFFECTS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; IMMUNE SYSTEM; INFLAMMATION; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; CLINICAL TRIALS AS TOPIC; DRUG RESISTANCE, BACTERIAL; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNE SYSTEM; INFLAMMATION; PHYTOCHEMICALS; PHYTOTHERAPY; PROBIOTICS; TREATMENT OUTCOME;

EID: 84901218213     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i19.5594     Document Type: Article

References (149)

1. Basso D, Plebani M, Kusters JG. Pathogenesis of Helicobacter pylori infection. Helicobacter 2010; 15 Suppl 1: 14-20 [PMID: 21054648 DOI: 10.1111/j.1523-5378.2010.00781.x]
2. Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T, El-Omar EM, Kuipers EJ. Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut 2012; 61: 646-664 [PMID: 22491499 DOI: 10.1136/gutjnl-2012-302084]
3. Salama NR, Hartung ML, Müller A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol 2013; 11: 385-399 [PMID: 23652324 DOI: 10.1038/nrmicro3016]
4. Müller A, Oertli M, Arnold IC. H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection. Cell Commun Signal 2011; 9: 25 [PMID: 22044597 DOI: 10.1186/1478-811X-9-25]
5. Israel DA, Salama N, Krishna U, Rieger UM, Atherton JC, Falkow S, Peek RM. Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc Natl Acad Sci USA 2001; 98: 14625-14630 [PMID: 11724955 DOI: 10.1073/pnas.251551698]
6. Salama NR, Gonzalez-Valencia G, Deatherage B, Aviles-Jimenez F, Atherton JC, Graham DY, Torres J. Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection. J Bacteriol 2007; 189: 3834-3845 [PMID: 17337568 DOI: 10.1128/JB.01696-06]
7. Dorer MS, Cohen IE, Sessler TH, Fero J, Salama NR. Natural competence promotes Helicobacter pylori chronic infection. Infect Immun 2013; 81: 209-215 [PMID: 23115044 DOI: 10.1128/IAI.01042-12]
8. Falush D, Kraft C, Taylor NS, Correa P, Fox JG, Achtman M, Suerbaum S. Recombination and mutation during longterm gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size, and minimal age. Proc Natl Acad Sci USA 2001; 98: 15056-15061 [PMID: 11742075 DOI: 10.1073/pnas.251396098]
9. Alm RA, Bina J, Andrews BM, Doig P, Hancock RE, Trust TJ. Comparative genomics of Helicobacter pylori: analysis of the outer membrane protein families. Infect Immun 2000; 68: 4155-4168 [PMID: 10858232 DOI: 10.1128/ IAI.68.7.4155-4168.2000]
10. Pride DT, Blaser MJ. Concerted evolution between duplicated genetic elements in Helicobacter pylori. J Mol Biol 2002; 316: 629-642 [PMID: 11866522 DOI: 10.1006/jmbi.2001.5311]
11. Solnick JV, Hansen LM, Salama NR, Boonjakuakul JK, Syvanen M. Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques. Proc Natl Acad Sci USA 2004; 101: 2106-2111 [PMID: 14762173 DOI: 10.1073/pnas.0308573100]
12. Mégraud F. Helicobacter pylori resistance to antibiotics: prevalence, mechanism, detection. What's new? Can J Gastroenterol 2003; 17 Suppl B: 49B-52B [PMID: 12845352]
13. Kraft C, Suerbaum S. Mutation and recombination in Helicobacter pylori: mechanisms and role in generating strain diversity. Int J Med Microbiol 2005; 295: 299-305 [PMID: 16173496 DOI: 10.1016/j.ijmm.2005.06.002]
14. Deng B, Li Y, Zhang Y, Bai L, Yang P. Helicobacter pylori infection and lung cancer: a review of an emerging hypothesis. Carcinogenesis 2013; 34: 1189-1195 [PMID: 23568955 DOI: 10.1093/carcin/bgt114]
15. Papagiannakis P, Michalopoulos C, Papalexi F, Dalampoura D, Diamantidis MD. The role of Helicobacter pylori infection in hematological disorders. Eur J Intern Med 2013; 24: 685-690 [PMID: 23523153 DOI: 10.1016/j.ejim.2013.02.011]
16. Roubaud Baudron C, Letenneur L, Langlais A, Buissonnière A, Mégraud F, Dartigues JF, Salles N. Does Helicobacter pylori infection increase incidence of dementia? The Personnes Agées QUID Study. J Am Geriatr Soc 2013; 61: 74-78 [PMID: 23252507 DOI: 10.1111/jgs.12065]
17. Figura N, Franceschi F, Santucci A, Bernardini G, Gasbarrini G, Gasbarrini A. Extragastric manifestations of Helicobacter pylori infection. Helicobacter 2010; 15 Suppl 1: 60-68 [PMID: 21054655 DOI: 10.1111/j.1523-5378.2010.00778.x]
18. Niccoli G, Franceschi F, Cosentino N, Giupponi B, De Marco G, Merra G, Conte M, Montone RA, Ferrante G, Bacà M, Gasbarrini A, Silveri NG, Crea F. Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori. Coron Artery Dis 2010; 21: 217-221 [PMID: 20389238 DOI: 10.1097/MCA.0b013e3283399f36]
19. De Bastiani R, Gabrielli M, Ubaldi E, Benedetto E, Sanna G, Cottone C, Candelli M, Zocco MA, Saulnier N, Santoliquido A, Papaleo P, Gasbarrini G, Gasbarrini A. High prevalence of Cag-A positive H. pylori strains in ischemic stroke: a primary care multicenter study. Helicobacter 2008; 13: 274-277 [PMID: 18665936 DOI: 10.1111/j.1523-5378.2008.00610.x]
20. Oertli M, Müller A. Helicobacter pylori targets dendritic cells to induce immune tolerance, promote persistence and confer protection against allergic asthma. Gut Microbes 2012; 3: 566-571 [PMID: 22895083 DOI: 10.4161/gmic.21750]
21. Banić M, Franceschi F, Babić Z, Gasbarrini A. Extragastric manifestations of Helicobacter pylori infection. Helicobacter 2012; 17 Suppl 1: 49-55 [PMID: 22958156 DOI: 10.1111/ j.1523-5378.2012.00983.x]
22. O'Connor A, O'Moráin C. Helicobacter pylori infection in Europe: current perspectives. Expert Rev Gastroenterol Hepatol 2013; 7: 541-548 [PMID: 23985003 DOI: 10.1586/17474124.201 3.824707]
23. Malfertheiner P, Sipponen P, Naumann M, Moayyedi P, Mégraud F, Xiao SD, Sugano K, Nyrén O. Helicobacter pylori eradication has the potential to prevent gastric cancer: a stateof-the-art critique. Am J Gastroenterol 2005; 100: 2100-2115 [PMID: 16128957 DOI: 10.1111/j.1572-0241.2005.41688.x]
24. Molina-Infante J, Perez-Gallardo B, Fernandez-Bermejo M, Hernandez-Alonso M, Vinagre G, Dueñas C, Mateos-Rodriguez JM, Gonzalez-Garcia G, Abadia EG, Gisbert JP. Clinical trial: clarithromycin vs. levofloxacin in first-line triple and sequential regimens for Helicobacter pylori eradication. Aliment Pharmacol Ther 2010; 31: 1077-1084 [PMID: 20180787 DOI: 10.1111/j.1365-2036.2010.04274.x]
25. Mégraud F. The challenge of Helicobacter pylori resistance to antibiotics: the comeback of bismuth-based quadruple therapy. Therap Adv Gastroenterol 2012; 5: 103-109 [PMID: 22423259 DOI: 10.1177/1756283X11432492]
26. Gisbert JP. Helicobacter pylori eradication: A new, singlecapsule bismuth-containing quadruple therapy. Nat Rev Gastroenterol Hepatol 2011; 8: 307-309 [PMID: 21643037 DOI: 10.1038/nrgastro.2011.84]
27. Basu PP, Rayapudi K, Pacana T, Shah NJ, Krishnaswamy N, Flynn M. A randomized study comparing levofloxacin, omeprazole, nitazoxanide, and doxycycline versus triple therapy for the eradication of Helicobacter pylori. Am J Gastroenterol 2011; 106: 1970-1975 [PMID: 21989146 DOI: 10.1038/ajg.2011.306]
28. Dubois A, Borén T. Helicobacter pylori is invasive and it may be a facultative intracellular organism. Cell Microbiol 2007; 9: 1108-1116 [PMID: 17388791 DOI: 10.1111/ j.1462-5822.2007.00921.x]
29. Mégraud F. H pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut 2004; 53: 1374-1384 [PMID: 15306603 DOI: 10.1136/gut.2003.022111]
30. Glupczynski Y, Mégraud F, Lopez-Brea M, Andersen LP. European multicentre survey of in vitro antimicrobial resistance in Helicobacter pylori. Eur J Clin Microbiol Infect Dis 2001; 20: 820-823 [PMID: 11783701 DOI: 10.1007/ s100960100611]
31. Megraud F, Coenen S, Versporten A, Kist M, Lopez-Brea M, Hirschl AM, Andersen LP, Goossens H, Glupczynski Y. Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption. Gut 2013; 62: 34-42 [PMID: 22580412 DOI: 10.1136/gutjnl-2012-302254]
32. Perna F, Zullo A, Ricci C, Hassan C, Morini S, Vaira D. Levofloxacin-based triple therapy for Helicobacter pylori retreatment: role of bacterial resistance. Dig Liver Dis 2007; 39: 1001-1005 [PMID: 17889627 DOI: 10.1016/j.dld.2007.06.016]
33. Kobayashi I, Murakami K, Kato M, Kato S, Azuma T, Takahashi S, Uemura N, Katsuyama T, Fukuda Y, Haruma K, Nasu M, Fujioka T. Changing antimicrobial susceptibility epidemiology of Helicobacter pylori strains in Japan between 2002 and 2005. J Clin Microbiol 2007; 45: 4006-4010 [PMID: 17942652 DOI: 10.1128/JCM.00740-07]
34. Lee JW, Kim N, Kim JM, Nam RH, Chang H, Kim JY, Shin CM, Park YS, Lee DH, Jung HC. Prevalence of primary and secondary antimicrobial resistance of Helicobacter pylori in Korea from 2003 through 2012. Helicobacter 2013; 18: 206-214 [PMID: 23241101 DOI: 10.1111/hel.12031]
35. Binh TT, Shiota S, Nguyen LT, Ho DD, Hoang HH, Ta L, Trinh DT, Fujioka T, Yamaoka Y. The incidence of primary antibiotic resistance of Helicobacter pylori in Vietnam. J Clin Gastroenterol 2013; 47: 233-238 [PMID: 23090037 DOI: 10.1097/MCG.0b013e3182676e2b]
36. Lu H, Zhang W, Graham DY. Bismuth-containing quadruple therapy for Helicobacter pylori: lessons from China. Eur J Gastroenterol Hepatol 2013; 25: 1134-1140 [PMID: 23778309 DOI: 10.1097/MEG.0b013e3283633b57]
37. Shokrzadeh L, Jafari F, Dabiri H, Baghaei K, Zojaji H, Alizadeh AH, Aslani MM, Zali MR. Antibiotic susceptibility profile of Helicobacter pylori isolated from the dyspepsia patients in Tehran, Iran. Saudi J Gastroenterol 2011; 17: 261-264 [PMID: 21727733 DOI: 10.4103/1319-3767.82581]
38. Ayala G, Galván-Portillo M, Chihu L, Fierros G, Sánchez A, Carrillo B, Román A, López-Carrillo L, Silva-Sánchez J. Resistance to antibiotics and characterization of Helicobacter pylori strains isolated from antrum and body from adults in Mexico. Microb Drug Resist 2011; 17: 149-155 [PMID: 21303219 DOI: 10.1089/mdr.2010.0154]
39. Eisig JN, Silva FM, Barbuti RC, Navarro-Rodriguez T, Moraes-Filho JP, Pedrazzoli Jr J. Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option. Arq Gastroenterol 2011; 48: 261-264 [PMID: 22147131 DOI: 10.1590/S0004-28032011000400008]
40. Fischbach L, Evans EL. Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori. Aliment Pharmacol Ther 2007; 26: 343-357 [PMID: 17635369 DOI: 10.1111/ j.1365-2036.2007.03386.x]
41. Czinn SJ, Blanchard T. Vaccinating against Helicobacter pylori infection. Nat Rev Gastroenterol Hepatol 2011; 8: 133-140 [PMID: 21304478 DOI: 10.1038/nrgastro.2011.1]
42. Food and Agriculture Organization, World Health Organi-zation. Guidelines for the evaluation of probiotics in food. Report of a joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food. London, Ontario, Canada: World Health Organization, 2000
43. Jonkers D, Stockbrügger R. Review article: Probiotics in gastrointestinal and liver diseases. Aliment Pharmacol Ther 2007; 26 Suppl 2: 133-148 [PMID: 18081657 DOI: 10.1111/ j.1365-2036.2007.03480.x]
44. Lesbros-Pantoflickova D, Corthésy-Theulaz I, Blum AL. Helicobacter pylori and probiotics. J Nutr 2007; 137: 812S-818S [PMID: 17311980]
45. Johnson-Henry KC, Mitchell DJ, Avitzur Y, Galindo-Mata E, Jones NL, Sherman PM. Probiotics reduce bacterial colonization and gastric inflammation in H. pylori-infected mice. Dig Dis Sci 2004; 49: 1095-1102 [PMID: 15387328 DOI: 10.1023/B: DDAS.0000037794.02040.c2]
46. Sgouras DN, Panayotopoulou EG, Martinez-Gonzalez B, Petraki K, Michopoulos S, Mentis A. Lactobacillus johnsonii La1 attenuates Helicobacter pylori-associated gastritis and reduces levels of proinflammatory chemokines in C57BL/6 mice. Clin Diagn Lab Immunol 2005; 12: 1378-1386 [PMID: 16339060]
47. Wang ZH, Gao QY, Fang JY. Meta-analysis of the efficacy and safety of Lactobacillus-containing and Bifidobacteriumcontaining probiotic compound preparation in Helicobacter pylori eradication therapy. J Clin Gastroenterol 2013; 47: 25-32 [PMID: 23090045 DOI: 10.1097/MCG.0b013e318266f6cf]
48. Szajewska H, Horvath A, Piwowarczyk A. Meta-analysis: the effects of Saccharomyces boulardii supplementation on Helicobacter pylori eradication rates and side effects during treatment. Aliment Pharmacol Ther 2010; 32: 1069-1079 [PMID: 21039671 DOI: 10.1111/j.1365-2036.2010.04457.x]
49. Wainwright M. Photodynamic antimicrobial chemotherapy (PACT). J Antimicrob Chemother 1998; 42: 13-28 [PMID: 9700525 DOI: 10.1093/jac/42.1.13]
50. Hamblin MR, Viveiros J, Yang C, Ahmadi A, Ganz RA, Tolkoff MJ. Helicobacter pylori accumulates photoactive porphyrins and is killed by visible light. Antimicrob Agents Chemother 2005; 49: 2822-2827 [PMID: 15980355 DOI: 10.1128/ AAC.49.7.2822-2827.2005]
51. Choi SS, Lee HK, Chae HS. In vitro photodynamic antimicrobial activity of methylene blue and endoscopic white light against Helicobacter pylori 26695. J Photochem Photobiol B 2010; 101: 206-209 [PMID: 20692848]
52. Choi S, Lee H, Chae H. Comparison of in vitro photodynamic antimicrobial activity of protoporphyrin IX between endoscopic white light and newly developed narrowband endoscopic light against Helicobacter pylori 26695. J Photochem Photobiol B 2012; 117: 55-60 [PMID: 23079538 DOI: 10.1016/j.jphotobiol.2012.08.015]
53. Hanlon GW. Bacteriophages: an appraisal of their role in the treatment of bacterial infections. Int J Antimicrob Agents 2007; 30: 118-128 [PMID: 17566713 DOI: 10.1016/j.ijantimicag.2007. 04.006]
54. Vale FF, Alves Matos AP, Carvalho P, Vitor JM. Helicobacter pylori phage screening. Microsc Microanal 2008; 14 suppl 3: 150-151 [DOI: 10.1017/S1431927608089721]
55. Lehours P, Vale FF, Bjursell MK, Melefors O, Advani R, Glavas S, Guegueniat J, Gontier E, Lacomme S, Alves Matos A, Menard A, Mégraud F, Engstrand L, Andersson AF. Genome sequencing reveals a phage in Helicobacter pylori. MBio 2011; 2: pii: e00239-11 [PMID: 22086490 DOI: 10.1128/ mBio.00239-11]
56. Luo CH, Chiou PY, Yang CY, Lin NT. Genome, integration, and transduction of a novel temperate phage of Helicobacter pylori. J Virol 2012; 86: 8781-8792 [PMID: 22696647 DOI: 10.1128/JVI.00446-12]
57. Uchiyama J, Takeuchi H, Kato S, Takemura-Uchiyama I, Ujihara T, Daibata M, Matsuzaki S. Complete genome sequences of two Helicobacter pylori bacteriophages isolated from Japanese patients. J Virol 2012; 86: 11400-11401 [PMID: 22997420 DOI: 10.1128/JVI.01767-12]
58. Thiberge JM, Boursaux-Eude C, Lehours P, Dillies MA, Creno S, Coppée JY, Rouy Z, Lajus A, Ma L, Burucoa C, Ruskoné-Foumestraux A, Courillon-Mallet A, De Reuse H, Boneca IG, Lamarque D, Mégraud F, Delchier JC, Médigue C, Bouchier C, Labigne A, Raymond J. From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma. BMC Genomics 2010; 11: 368 [PMID: 20537153 DOI: 10.1186/1471-2164-11-368]
59. Lukacik P, Barnard TJ, Keller PW, Chaturvedi KS, Seddiki N, Fairman JW, Noinaj N, Kirby TL, Henderson JP, Steven AC, Hinnebusch BJ, Buchanan SK. Structural engineering of a phage lysin that targets gram-negative pathogens. Proc Natl Acad Sci USA 2012; 109: 9857-9862 [PMID: 22679291 DOI: 10.1073/pnas.1203472109]
60. Vítor JM, Vale FF. Alternative therapies for Helicobacter pylori: probiotics and phytomedicine. FEMS Immunol Med Microbiol 2011; 63: 153-164 [PMID: 22077218 DOI: 10.1111/ j.1574-695X.2011.00865.x]
61. Bent S. Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center. J Gen Intern Med 2008; 23: 854-859 [PMID: 18415652 DOI: 10.1007/s11606-008-0632-y]
62. Ke F, Yadav PK, Ju LZ. Herbal medicine in the treatment of ulcerative colitis. Saudi J Gastroenterol 2012; 18: 3-10 [PMID: 22249085 DOI: 10.4103/1319-3767.91726]
63. Petrovska BB. Historical review of medicinal plants' usage. Pharmacogn Rev 2012; 6: 1-5 [PMID: 22654398 DOI: 10.4103/0973-7847.95849]
64. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983; 1: 1273-1275 [PMID: 6134060]
65. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; 1: 1311-1315 [PMID: 6145023 DOI: 10.1016/ S0140-6736(84)91816-6]
66. Chin EP, Chiang my, wang fy, wang kw. the effect of chianchung-tang, a chinese herb recipe, upon shay rat ulceration. Yaoxue Xuebao 1965; 12: 440-445 [PMID: 14342704]
67. Chakǔrski I, Matev M, Stefanov G, Koǐchev A, Angelova I. Treanntment of duodenal ulcers and gastroduodenitis with a herbal combination of Symphitum officinalis and Calendula officinalis with and without antacids. Vutr Boles 1981; 20: 44-47 [PMID: 7336704]
68. Stockbrügger RW. Antimuscarinic drugs. Methods Find Exp Clin Pharmacol 1989; 11 Suppl 1: 79-86 [PMID: 2657292]
69. Sodeman WA, Augur NA, Pollard HM. Physiology and pharmacology of belladonna therapy in acid-peptic disease. Med Clin North Am 1969; 53: 1379-1388 [PMID: 4900719]
70. Madureira MC, Paiva JM, Fernandes AF, Gonçalves A, Catalão C, Fernandes C. Estudo etnofarmacológico de plantas medicinais de S. Tomé e Príncipe. São Tomé: Ministerío de Saúde da RDSTP, 2008
71. Zaidi SF, Yamada K, Kadowaki M, Usmanghani K, Sugiyama T. Bactericidal activity of medicinal plants, employed for the treatment of gastrointestinal ailments, against Helicobacter pylori. J Ethnopharmacol 2009; 121: 286-291 [PMID: 19041711 DOI: 10.1016/j.jep.2008.11.001]
72. Wang YC, Huang TL. Screening of anti-Helicobacter pylori herbs deriving from Taiwanese folk medicinal plants. FEMS Immunol Med Microbiol 2005; 43: 295-300 [PMID: 15681161 DOI: 10.1016/j.femsim.2004.09.008]
73. Stamatis G, Kyriazopoulos P, Golegou S, Basayiannis A, Skaltsas S, Skaltsa H. In vitro anti-Helicobacter pylori activity of Greek herbal medicines. J Ethnopharmacol 2003; 88: 175-179 [PMID: 12963139 DOI: 10.1016/S0378-8741(03)00217-4]
74. Lai CH, Rao YK, Fang SH, Sing YT, Tzeng YM. Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. Bioorg Med Chem Lett 2010; 20: 5462-5465 [PMID: 20705463 DOI: 10.1016/j.bmcl.2010.07.094]
75. Lien HM, Wang CY, Chang HY, Huang CL, Peng MT, Sing YT, Chen CC, Lai CH. Bioevaluation of Anisomeles indica extracts and their inhibitory effects on Helicobacter pylorimediated inflammation. J Ethnopharmacol 2013; 145: 397-401 [PMID: 23178270 DOI: 10.1016/j.jep.2012.11.015]
76. Kundu P, De R, Pal I, Mukhopadhyay AK, Saha DR, Swarnakar S. Curcumin alleviates matrix metalloproteinase-3 and-9 activities during eradication of Helicobacter pylori infection in cultured cells and mice. PLoS One 2011; 6: e16306 [PMID: 21283694 DOI: 10.1371/journal.pone.0016306]
77. Lai CH, Wang HJ, Chang YC, Hsieh WC, Lin HJ, Tang CH, Sheu JJ, Lin CJ, Yang MS, Tseng SF, Wang WC. Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain. FEMS Microbiol Lett 2011; 323: 155-163 [PMID: 22092715 DOI: 10.1111/ j.1574-6968.2011.02372.x]
78. Pastene E, Speisky H, García A, Moreno J, Troncoso M, Figueroa G. In vitro and in vivo effects of apple peel polyphenols against Helicobacter pylori. J Agric Food Chem 2010; 58: 7172-7179 [PMID: 20486708 DOI: 10.1021/jf100274g]
79. Geethangili M, Fang SH, Lai CH, Rao YK, Lien HM, Tzeng YM. Inhibitory effect of Antrodia camphorata constituents on the Helicobacter pylori-associated gastric inflammation. Food Chem 2010; 119: 149-153 [DOI: 10.1016/ j.foodchem.2009.06.006]
80. Kataoka M, Hirata K, Kunikata T, Ushio S, Iwaki K, Ohashi K, Ikeda M, Kurimoto M. Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils. J Gastroenterol 2001; 36: 5-9 [PMID: 11211212 DOI: 10.1007/s005350170147]
81. Takabayashi F, Nakamura Y, Harada N. Effect of black tea aqueous non-dialysate onHelicobacter pylori infection in Mongolian gerbils. Environ Health Prev Med 2004; 9: 176-180 [PMID: 21432329 DOI: 10.1007/BF02898098]
82. Takabayashi F, Harada N, Yamada M, Murohisa B, Oguni I. Inhibitory effect of green tea catechins in combination with sucralfate on Helicobacter pylori infection in Mongolian gerbils. J Gastroenterol 2004; 39: 61-63 [PMID: 14767736 DOI: 10.1007/s00535-003-1246-0]
83. Matsubara S, Shibata H, Ishikawa F, Yokokura T, Takahashi M, Sugimura T, Wakabayashi K. Suppression of Helicobacter pylori-induced gastritis by green tea extract in Mongolian gerbils. Biochem Biophys Res Commun 2003; 310: 715-719 [PMID: 14550260 DOI: 10.1016/j.bbrc.2003.09.066]
84. Ruggiero P, Rossi G, Tombola F, Pancotto L, Lauretti L, Del Giudice G, Zoratti M. Red wine and green tea reduce H pylori-or VacA-induced gastritis in a mouse model. World J Gastroenterol 2007; 13: 349-354 [PMID: 17230601]
85. Ruggiero P, Tombola F, Rossi G, Pancotto L, Lauretti L, Del Giudice G, Zoratti M. Polyphenols reduce gastritis induced by Helicobacter pylori infection or VacA toxin administration in mice. Antimicrob Agents Chemother 2006; 50: 2550-2552 [PMID: 16801443 DOI: 10.1128/AAC.01042-05]
86. Souza Mdo C, Beserra AM, Martins DC, Real VV, Santos RA, Rao VS, Silva RM, Martins DT. In vitro and in vivo anti-Helicobacter pylori activity of Calophyllum brasiliense Camb. J Ethnopharmacol 2009; 123: 452-458 [PMID: 19501278 DOI: 10.1016/j.jep.2009.03.030]
87. Lemos LM, Martins TB, Tanajura GH, Gazoni VF, Bonaldo J, Strada CL, Silva MG, Dall'oglio EL, de Sousa Júnior PT, Martins DT. Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb. J Ethnopharmacol 2012; 141: 432-439 [PMID: 22425905 DOI: 10.1016/ j.jep.2012.03.006]
88. Puram S, Suh HC, Kim SU, Bethapudi B, Joseph JA, Agarwal A, Kudiganti V. Effect of GutGard in the Management of Helicobacter pylori: A Randomized Double Blind Placebo Controlled Study. Evid Based Complement Alternat Med 2013; 2013: 263805 [PMID: 23606875 DOI: 10.1155/2013/263805]
89. Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, Randhawa MA. Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia. Saudi J Gastroenterol 2010; 16: 207-214 [PMID: 20616418 DOI: 10.4103/1319-3767.65201]
90. Lin J, Huang WW. A systematic review of treating Helicobacter pylori infection with Traditional Chinese Medicine. World J Gastroenterol 2009; 15: 4715-4719 [PMID: 19787835 DOI: 10.3748/wjg.15.4715]
91. Xie JH, Chen YL, Wu QH, Wu J, Su JY, Cao HY, Li YC, Li YS, Liao JB, Lai XP, Huang P, Su ZR. Gastroprotective and anti-Helicobacter pylori potential of herbal formula HZJW: safety and efficacy assessment. BMC Complement Altern Med 2013; 13: 119 [PMID: 23721522 DOI: 10.1186/1472-6882-13-119]
92. Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000; 52: 673-751 [PMID: 11121513]
93. Lin YT, Kwon YI, Labbe RG, Shetty K. Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies. Appl Environ Microbiol 2005; 71: 8558-8564 [PMID: 16332847 DOI: 10.1128/AEM.71.12.855 8-8564.2005]
94. Hassani AR, Ordouzadeh N, Ghaemi A, Amirmozafari N, Hamdi K, Nazari R. In vitro inhibition of Helicobacter pylori urease with non and semi fermented Camellia sinensis. Indian J Med Microbiol 2009; 27: 30-34 [PMID: 19172056]
95. Pastene E, Troncoso M, Figueroa G, Alarcón J, Speisky H. Association between polymerization degree of apple peel polyphenols and inhibition of Helicobacter pylori urease. J Agric Food Chem 2009; 57: 416-424 [PMID: 19128009 DOI: 10.1021/jf8025698]
96. Lima ZP, Calvo TR, Silva EF, Pellizzon CH, Vilegas W, Brito AR, Bauab TM, Hiruma-Lima CA. Brazilian medicinal plant acts on prostaglandin level and Helicobacter pylori. J Med Food 2008; 11: 701-708 [PMID: 19053863 DOI: 10.1089/ jmf.2007.0676]
97. Lima ZP, dos Santos Rde C, Torres TU, Sannomiya M, Rodrigues CM, dos Santos LC, Pellizzon CH, Rocha LR, Vilegas W, Souza Brito AR, Cardoso CR, Varanda EA, de Moraes HP, Bauab TM, Carli C, Carlos IZ, Hiruma-Lima CA. Byrsonima fagifolia: an integrative study to validate the gastroprotective, healing, antidiarrheal, antimicrobial and mutagenic action. J Ethnopharmacol 2008; 120: 149-160 [PMID: 18761075 DOI: 10.1016/j.jep.2008.07.047]
98. Shin JE, Kim JM, Bae EA, Hyun YJ, Kim DH. In vitro inhibitory effect of flavonoids on growth, infection and vacuolation of Helicobacter pylori. Planta Med 2005; 71: 197-201 [PMID: 15770537 DOI: 10.1055/s-2005-837816]
99. Quílez A, Berenguer B, Gilardoni G, Souccar C, de Mendonça S, Oliveira LF, Martín-Calero MJ, Vidari G. Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & amp; Pav. J Ethnopharmacol 2010; 128: 583-589 [PMID: 20152892 DOI: 10.1016/j.jep.2010.01.060]
100. Asha MK, Debraj D, Prashanth D, Edwin JR, Srikanth HS, Muruganantham N, Dethe SM, Anirban B, Jaya B, Deepak M, Agarwal A. In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action. J Ethnopharmacol 2013; 145: 581-586 [PMID: 23220194 DOI: 10.1016/j.jep.2012.11.033]
101. Boquet P, Ricci V, Galmiche A, Gauthier NC. Gastric cell apoptosis and H. pylori: has the main function of VacA finally been identified? Trends Microbiol 2003; 11: 410-413 [PMID: 13678854 DOI: 10.1016/S0966-842X(03)00211-7]
102. Mahady GB, Pendland SL. Resveratrol inhibits the growth of Helicobacter pylori in vitro. Am J Gastroenterol 2000; 95: 1849 [PMID: 10926010]
103. Paulo L, Oleastro M, Gallardo E, Queiroz JA, Domigues F. Anti-Helicobacter pylori and urease inhibitory activities of resveratrol and red wine. Food Res Int 2011; 44: 964-969 [DOI: 10.1016/j.foodres.2011.02.017]
104. Martini S, Bonechi C, Rossi C, Figura N. Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. J Nat Prod 2011; 74: 2257-2260 [PMID: 21936484 DOI: 10.1021/np100761u]
105. Martini S, D'Addario C, Braconi D, Bernardini G, Salvini L, Bonechi C, Figura N, Santucci A, Rossi C. Antibacterial activity of grape extracts on cagA-positive and-negative Helicobacter pylori clinical isolates. J Chemother 2009; 21: 507-513 [PMID: 19933041]
106. Sintara K, Thong-Ngam D, Patumraj S, Klaikeaw N, Chatsuwan T. Curcumin suppresses gastric NF-kappaB activation and macromolecular leakage in Helicobacter pyloriinfected rats. World J Gastroenterol 2010; 16: 4039-4046 [PMID: 20731017 DOI: 10.3748/wjg.v16.i32.4039]
107. Cui K, Lu W, Zhu L, Shen X, Huang J. Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity. Biochem Biophys Res Commun 2013; 435: 289-294 [PMID: 23611786 DOI: 10.1016/j.bbrc.2013.04.026]
108. Coelho LG, Bastos EM, Resende CC, Paula e Silva CM, Sanches BS, de Castro FJ, Moretzsohn LD, Vieira WL, Trindade OR. Brazilian green propolis on Helicobacter pylori infection. a pilot clinical study. Helicobacter 2007; 12: 572-574 [PMID: 17760728 DOI: 10.1111/j.1523-5378.2007.00525.x]
109. Nir Y, Potasman I, Stermer E, Tabak M, Neeman I. Controlled trial of the effect of cinnamon extract on Helicobacter pylori. Helicobacter 2000; 5: 94-97 [PMID: 10849058 DOI: 10.1046/j.1523-5378.2000.00014.x]
110. Hu FL. [A multicenter study of Chinese patent medicine wenweishu/yangweishu in the treatment of Helicobacter pylori positive patients with chronic gastritis and peptic ulcer]. Zhonghua Yixue Zazhi 2010; 90: 75-78 [PMID: 20356485]
111. Aydin A, Ersöz G, Tekesin O, Akçiçek E, Tuncyürek M. Garlic oil and Helicobacter pylori infection. Am J Gastroenterol 2000; 95: 563-564 [PMID: 10685782]
112. Graham DY, Anderson SY, Lang T. Garlic or jalapeño peppers for treatment of Helicobacter pylori infection. Am J Gastroenterol 1999; 94: 1200-1202 [PMID: 10235193]
113. Shidfar F, Agah S, Ekhlasi G, Salehpour A, Ghourchian S. Lycopene an adjunctive therapy for Helicobacter pylori eradication: a quasi-control trial. J Complement Integr Med 2012; 9: Article 14 [PMID: 22850072 DOI: 10.1515/1553-3840.1588]
114. Beil W, Kilian P. EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells. Phytomedicine 2007; 14 Suppl 6: 5-8 [PMID: 17188478 DOI: 10.1016/j.phymed.2006.11.024]
115. Wittschier N, Faller G, Hensel A. An extract of Pelargonium sidoides (EPs 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach. Phytomedicine 2007; 14: 285-288 [PMID: 17350240 DOI: 10.1016/j.phymed.2006.12.008]
116. Burger O, Ofek I, Tabak M, Weiss EI, Sharon N, Neeman I. A high molecular mass constituent of cranberry juice inhibits helicobacter pylori adhesion to human gastric mucus. FEMS Immunol Med Microbiol 2000; 29: 295-301 [PMID: 11118911 DOI: 10.1111/j.1574-695X.2000.tb01537.x]
117. Shmuely H, Burger O, Neeman I, Yahav J, Samra Z, Niv Y, Sharon N, Weiss E, Athamna A, Tabak M, Ofek I. Susceptibility of Helicobacter pylori isolates to the antiadhesion activity of a high-molecular-weight constituent of cranberry. Diagn Microbiol Infect Dis 2004; 50: 231-235 [PMID: 15582295 DOI: 10.1016/j.diagmicrobio.2004.08.011]
118. Shi DH, Liu YW, Liu WW, Gu ZF. Inhibition of urease by extracts derived from 15 Chinese medicinal herbs. Pharm Biol 2011; 49: 752-755 [PMID: 21639688 DOI: 10.3109/13880209.20 10.547205]
119. Moleiro FC, Andreo MA, Santos Rde C, Moraes Tde M, Rodrigues CM, Carli CB, Lopes FC, Pellizzon CH, Carlos IZ, Bauab TM, Vilegas W, Hiruma-Lima CA. Mouririelliptica: validation of gastroprotective, healing and anti-Helicobacter pylori effects. J Ethnopharmacol 2009; 123: 359-368 [PMID: 19501267 DOI: 10.1016/j.jep.2009.03.040]
120. Moraes Tde M, Rodrigues CM, Kushima H, Bauab TM, Villegas W, Pellizzon CH, Brito AR, Hiruma-Lima CA. Hancornia speciosa: indications of gastroprotective, healing and anti-Helicobacter pylori actions. J Ethnopharmacol 2008; 120: 161-168 [PMID: 18761076 DOI: 10.1016/j.jep.2008.08.001]
121. Castillo-Juárez I, Rivero-Cruz F, Celis H, Romero I. Anti-Helicobacter pylori activity of anacardic acids from Amphipterygium adstringens. J Ethnopharmacol 2007; 114: 72-77 [PMID: 17768020 DOI: 10.1016/j.jep.2007.07.022]
122. Ishizone S, Maruta F, Suzuki K, Miyagawa S, Takeuchi M, Kanaya K, Oana K, Hayama M, Kawakami Y, Ota H. In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model. Int J Med Sci 2007; 4: 203-208 [PMID: 17717596 DOI: 10.7150/ijms.4.203]
123. Robles-Zepeda RE, Velázquez-Contreras CA, Garibay-Escobar A, Gálvez-Ruiz JC, Ruiz-Bustos E. Antimicrobial activity of Northwestern Mexican plants against Helicobacter pylori. J Med Food 2011; 14: 1280-1283 [PMID: 21663492 DOI: 10.1089/jmf.2010.0263]
124. Goel RK, Sairam K, Babu MD, Tavares IA, Raman A. In vitro evaluation of Bacopa monniera on anti-Helicobacter pylori activity and accumulation of prostaglandins. Phytomedicine 2003; 10: 523-527 [PMID: 13678238 DOI: 10.1078/09447110332 2331494]
125. Banskota AH, Tezuka Y, Adnyana IK, Ishii E, Midorikawa K, Matsushige K, Kadota S. Hepatoprotective and anti-Helicobacter pylori activities of constituents from Brazilian propolis. Phytomedicine 2001; 8: 16-23 [PMID: 11292234 DOI: 10.1078/0944-7113-00004]
126. Zhang BL, Fan CQ, Dong L, Wang FD, Yue JM. Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from
127. Bai CL, Osaki T, Yonezawa H, Hanawa T, Zaman C, Kurata S, Kamiya S, Tanaka H. In vitro and in vivo effects of the Mongolian drug Amu-ru 7 on Helicobacter pylori growth and viability. Microbiol Immunol 2010; 54: 508-515 [PMID: 20840149 DOI: 10.1111/j.1348-0421.2010.00246.x]
128. Cwikla C, Schmidt K, Matthias A, Bone KM, Lehmann R, Tiralongo E. Investigations into the antibacterial activities of phytotherapeutics against Helicobacter pylori and Campylobacter jejuni. Phytother Res 2010; 24: 649-656 [PMID: 19653313 DOI: 10.1002/ptr.2933]
129. De R, Kundu P, Swarnakar S, Ramamurthy T, Chowdhury A, Nair GB, Mukhopadhyay AK. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrob Agents Chemother 2009; 53: 1592-1597 [PMID: 19204190 DOI: 10.1128/ AAC.01242-08]
130. Adeniyi BA, Anyiam FM. In vitro anti-Helicobacter pylori potential of methanol extract of Allium ascalonicum Linn. (Liliaceae) leaf: susceptibility and effect on urease activity. Phytother Res 2004; 18: 358-361 [PMID: 15173992 DOI: 10.1002/ptr.1265]
131. Zhou Y, Taylor B, Smith TJ, Liu ZP, Clench M, Davies NW, Rainsford KD. A novel compound from celery seed with a bactericidal effect against Helicobacter pylori. J Pharm Pharmacol 2009; 61: 1067-1077 [PMID: 19703351 DOI: 10.1211/ jpp/61.08.0011]
132. Kushima H, Nishijima CM, Rodrigues CM, Rinaldo D, Sassá MF, Bauab TM, Stasi LC, Carlos IZ, Brito AR, Vilegas W, Hiruma-Lima CA. Davilla elliptica and Davilla nitida: gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action. J Ethnopharmacol 2009; 123: 430-438 [PMID: 19501275 DOI: 10.1016/j.jep.2009.03.031]
133. Daroch F, Hoeneisen M, González CL, Kawaguchi F, Salgado F, Solar H, García A. In vitro antibacterial activity of Chilean red wines against Helicobacter pylori. Microbios 2001; 104: 79-85 [PMID: 11297014]
134. Zaidi SF, Ahmed K, Yamamoto T, Kondo T, Usmanghani K, Kadowaki M, Sugiyama T. Effect of resveratrol on Helicobacter pylori-induced interleukin-8 secretion, reactive oxygen species generation and morphological changes in human gastric epithelial cells. Biol Pharm Bull 2009; 32: 1931-1935 [PMID: 19881312 DOI: 10.1248/bpb.32.1931]
135. Goswami SK, Das DK. Resveratrol and chemoprevention. Cancer Lett 2009; 284: 1-6 [PMID: 19261378 DOI: 10.1016/ j.canlet.2009.01.041]
136. Brown JC, Jiang X. Activities of muscadine grape skin and polyphenolic constituents against Helicobacter pylori. J Appl Microbiol 2013; 114: 982-991 [PMID: 23294280 DOI: 10.1111/ jam.12129]
137. Ustün O, Ozçelik B, Akyön Y, Abbasoglu U, Yesilada E. Flavonoids with anti-Helicobacter pylori activity from Cistus laurifolius leaves. J Ethnopharmacol 2006; 108: 457-461 [PMID: 16870372 DOI: 10.1016/j.jep.2006.06.001]
138. Njume C, Afolayan AJ, Green E, Ndip RN. Volatile compounds in the stem bark of Sclerocarya birrea (Anacardiaceae) possess antimicrobial activity against drug-resistant strains of Helicobacter pylori. Int J Antimicrob Agents 2011; 38: 319-324 [PMID: 21752604 DOI: 10.1016/j.ijantimicag.2011. 05.002]
139. Lai CH, Fang SH, Rao YK, Geethangili M, Tang CH, Lin YJ, Hung CH, Wang WC, Tzeng YM. Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts. J Ethnopharmacol 2008; 118: 522-526 [PMID: 18602230 DOI: 10.1016/ j.jep.2008.05.022]
140. Fang SH, Rao YK, Tzeng YM. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol 2008; 116: 333-340 [PMID: 18187278 DOI: 10.1016/j.jep.2007.11.040]
141. Vega AE, Wendel GH, Maria AO, Pelzer L. Antimicrobial activity of Artemisia douglasiana and dehydroleucodine against Helicobacter pylori. J Ethnopharmacol 2009; 124: 653-655 [PMID: 19422904 DOI: 10.1016/j.jep.2009.04.051]
142. Bork PM, Schmitz ML, Kuhnt M, Escher C, Heinrich M. Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB. FEBS Lett 1997; 402: 85-90 [PMID: 9013864 DOI: 10.1016/S0014-5793(96)01502-5]
143. Zhang XQ, Gu HM, Li XZ, Xu ZN, Chen YS, Li Y. Anti-Helicobacter pylori compounds from the ethanol extracts of Geranium wilfordii. J Ethnopharmacol 2013; 147: 204-207 [PMID: 23500884 DOI: 10.1016/j.jep.2013.02.032]
144. Sidahmed HM, Abdelwahab SI, Mohan S, Abdulla MA, Mohamed Elhassan Taha M, Hashim NM, Hadi AH, Vadivelu J, Loke Fai M, Rahmani M, Yahayu M. α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property: A Mechanistic Study. Evid Based Complement Alternat Med 2013; 2013: 450840 [PMID: 23634169 DOI: 10.1155/2013/450840]
145. Liu W, Liu Y, Zhang XZ, Li N, Cheng H. In vitro bactericidal activity of Jinghua Weikang Capsule and its individual herb Chenopodium ambrosioides L. against antibiotic-resistant Helicobacter pylori. Chin J Integr Med 2013; 19: 54-57 [PMID: 23275015 DOI: 10.1007/s11655-012-1248-y]
146. Jung K, Chin YW, Chung YH, Park YH, Yoo H, Min DS, Lee B, Kim J. Anti-gastritis and wound healing effects of Momordicae Semen extract and its active component. Immunopharmacol Immunotoxicol 2013; 35: 126-132 [PMID: 22889079 DOI: 10.3109/08923973.2012.712139]
147. Tran CD, Butler RN, Miller MJ. The role of Amazonian herbal medicine Sangre de Grado in Helicobacter pylori infection and its association with metallothionein expression. Helicobacter 2006; 11: 134-135 [PMID: 16579844 DOI: 10.1111/ j.1523-5378.2006.00388.x]
148. Sidahmed HM, Hashim NM, Amir J, Abdulla MA, Hadi AH, Abdelwahab SI, Taha MM, Hassandarvish P, Teh X, Loke MF, Vadivelu J, Rahmani M, Mohan S. Pyranocycloartobiloxanthone A, a novel gastroprotective compound from Artocarpus obtusus Jarret, against ethanol-induced acute gastric ulcer in vivo. Phytomedicine 2013; 20: 834-843 [PMID: 23570997 DOI: 10.1016/j.phymed.2013.03.002]
149. Hajimahmoodi M, Shams-Ardakani M, Saniee P, Siavoshi F, Mehrabani M, Hosseinzadeh H, Foroumadi P, Safavi M, Khanavi M, Akbarzadeh T, Shafiee A, Foroumadi A. In vitro antibacterial activity of some Iranian medicinal plant extracts against Helicobacter pylori. Nat Prod Res 2011; 25: 1059-1066 [PMID: 21726128 DOI: 10.1080/14786419.2010.501763]