In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action

Journal of Ethnopharmacology

Volumn 145, Issue 2, 2013, Pages 581-586

  Asha, Mannanthendil Kumaran ^a   Debraj, Debnath ^a   Prashanth, D'Souza ^a   Edwin, Jothie Richard ^a   Srikanth, H S ^a   Muruganantham, Nithyanantham ^a   Dethe, Shekhar Michael ^a   Anirban, Bhaskar ^a   Jaya, Balachandran ^a   Deepak, Mundkinajeddu ^a   Agarwal, Amit ^a  

^a Natural Remedies Pvt Ltd   (India)

Author keywords

Anti Adhesion; DNA gyrase; Glycyrrhiza glabra; GutGard ; Helicobacter pylori; Protein synthesis

Indexed keywords

ANTIINFECTIVE AGENT; DIHYDROFOLATE REDUCTASE; DNA TOPOISOMERASE (ATP HYDROLYSING); FLAVONOID; GLABRIDIN; GLYCYRRHIZA GLABRA EXTRACT; GLYCYRRHIZIC ACID; GUTGARD; UNCLASSIFIED DRUG;

AGAR DILUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM ADHERENCE; BROTH DILUTION; CONTROLLED STUDY; GLYCYRRHIZA GLABRA; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN SYNTHESIS; STOMACH MUCOSA;

ANTI-BACTERIAL AGENTS; DNA GYRASE; ENZYME INHIBITORS; FLAVONOIDS; FOLIC ACID ANTAGONISTS; GLYCYRRHIZA; HELICOBACTER PYLORI; PLANT EXTRACTS; PROTEIN BIOSYNTHESIS; TETRAHYDROFOLATE DEHYDROGENASE;

GLYCYRRHIZA GLABRA; HELICOBACTER PYLORI; HELICOBACTER PYLORI 26695;

EID: 84872123486     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.11.033     Document Type: Article

References (43)

1. A.M. Aly, L. Al-Alousi, and H.A. Salem Licorice: a possible anti-inflammatory and anti-ulcer drug AAPS PharmSciTech 6 2005 E74 82
2. P.K. Bardhan Epidemiological features of Helicobacter pylori infection in developing countries Clinical Infectious Diseases 25 1997 973 978
3. R.R. Berardi Peptic ulcer disease J.T. Dipiro, R.L. Talbert, G.C. Yee, G.R. Matzke, B.G. Wells, L.M. Posey, Pharmacotherapy: A Pathophysiology Approach fifth ed. 2002 McGraw-Hill New York 612
4. R.L. Blakley Eukaryotic dihydrofolate reductase F.F. Nord, A. Meister, Advances in Enzymology and Related Areas of Molecular Biology vol. 70 1995 John Wiley & Sons Inc. Hoboken, NJ 23 102
5. TM) on COX and LOX products Phytomedicine 18 2011 278 284
6. C.V. Chandrasekaran, K. Sundarajan, A. Gupta, H.S. Srikanth, J. Edwin, and A. Agarwal Evaluation of the genotoxic potential of standardized extract of Glycyrrhiza glabra (GutGard™) Regulatory Toxicology and Pharmacology 61 2011 373 380
7. Cheng, A.; Sheng, W.H.; Liou, J.M.; Wang, H.P.; Wu, M.S.; Lin, J.T.; Chang, S.C. Comparative in vitro antimicrobial susceptibility and synergistic activity of antimicrobial combinations against Helicobacter pylori isolates in Taiwan. Journal of Microbiology, Immunology and Infection, 〈http://dx.doi. org/10.1016/j.jmii.2012.08.021〉, in press.
8. J.W. Conn, D.R. Rovner, and E.L. Cohen Licorice-induced pseudoaldosteronism. Hypertension, hypokalemia, aldosteronopenia, and suppressed plasma renin activity Journal of the American Medical Association 205 1968 492 496
9. M.P. Costi, and S. Ferrari Update on antifolate drugs targets Current Drug Targets 2 2001 135 166
10. E.A. Davis, and D.J. Morris Medicinal uses of licorice through the millennia: the good and plenty of it Molecular and Cellular Endocrinology 78 1991 1 6
11. B. De, R.N. Maiti, V.K. Joshi, V.K. Agrawal, and R.K. Goel Effect of some Sitavirya drugs on gastric secretion and ulceration Indian Journal of Experimental Biology 35 1997 1084 1087
12. B.E. Dunn, H. Cohen, and M.J. Blaser Helicobacter pylori Clinical Microbiology Reviews 10 1997 720 741
13. L.L. Eftang, Y. Esbensen, T.M. Tannæs, I.R. Bukholm, and G. Bukholm Interleukin-8 is the single most up-regulated gene in whole genome profiling of Helicobacter pylori exposed gastric epithelial cells BMC Microbiology 12 2012 9
14. B.J. Egan, M. Katicic, H.J. O'Connor, and C.A. O'Morain Treatment of Helicobacter pylori Helicobacter 12 2007 31 37
15. M.J. Farthing Helicobacter pylori infection: an overview British Medical Bulletin 54 1998 1 6
16. T. Fukai, A. Marumo, K. Kaitou, T. Kanda, S. Terada, and T. Nomura Anti-Helicobacter pylori flavonoids from licorice extract Life Sciences 71 2002 1449 1463
17. J.E. Gready Dihydrofolate reductase: binding of substrates and inhibitors and catalytic mechanism Advances in Pharmacology and Chemotherapy 17 1980 37 102
18. S. Hayashi, T. Sugiyama, K. Amano, H. Isogai, E. Isogai, M. Aihara, M. Kikuchi, M. Asaka, K. Yokota, K. Oguma, N. Fujii, and Y. Hirai Effect of rebamipide, a novel antiulcer agent, on Helicobacter pylori adhesion to gastric epithelial cells Antimicrobial Agents and Chemotherapy 42 1998 1895 1899
19. M.T. Khayyal, M.A. el-Ghazaly, S.A. Kenawy, M. Seif-el-Nasr, L.G. Mahran, Y.A. Kafafi, and S.N. Okpanyi Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination Arzneimittel-Forschung 51 2001 545 553
20. D.H. Kim, S.W. Hong, B.T. Kim, E.A. Bae, H.Y. Park, and M.J. Han Biotransformation of glycyrrhizin by human intestinal bacteria and its relation to biological activities Archives of Pharmacal Research 23 2000 172 177
21. I. Kobayashi, H. Muraoka, T. Saika, M. Nishida, T. Fujioka, and M. Nasu Micro-broth dilution method with air-dried microplate for determining MICs of clarithromycin and amoxycillin for Helicobacter pylori isolates Journal of Medical Microbiology 53 2004 403 406
22. R. Krausse, J. Bielenberg, W. Blaschek, and U. Ullmann In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites Journal of Antimicrobial Chemotherapy 54 2004 243 246
23. P. Luber, E. Bartelt, E. Genschow, J. Wagner, and H. Hahn Comparison of broth microdilution, E test, and agar dilution methods for antibiotic susceptibility testing of Campylobacter jejuni and Campylobacter coli Journal of Clinical Microbiology 41 2003 1062 1068
24. P.F. McDermott, S.M. Bodeis, and R.D. Walker Abstracts. 11th international workshop on Campylobacter, Helicobacter and related organisms International Journal of Medical Microbiology 291 2001 109 110
25. D.J. McKenna, K. Jones, and K. Hughes Botanical Medicines: The Desk Reference for Major Herbal Supplements second ed. 2008 Viva Books New Delhi
26. G.L. Mendz, A.J. Shepley, S.L. Hazell, and M.A. Smith Purine metabolism and the microaerophily of Helicobacter pylori Archives of Microbiology 168 1997 448 456
27. L.A. Mitscher, R.P. Leu, M.S. Bathala, W.N. Wu, and J.L. Beal Antimicrobial agents from higher plants-I: introduction, rationale, and methodology Lloydia 35 1972 157 166
28. C. Monder, P.M. Stewart, V. Lakshmi, R. Valentino, D. Burt, and C.R. Edwards Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: in vivo and in vitro studies Endocrinology 125 1989 1046 1053
29. D.J. Morris, E. Davis, and S.A. Latif Licorice, tobacco chewing, and hypertension New England Journal of Medicine 322 1990 849 850
30. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 65 1983 55 63
31. M. Mukherjee, N. Bhaskaran, R. Srinath, H.N. Shivaprasad, J. Joshua Allan, D. Shekhar, and Amit Agarwal Anti-ulcer and antioxidant activity of GutGard™ Indian Journal of Experimental Biology 48 2010 269 274
32. H. Myllykallio, D. Leduc, J. Filee, and U. Liebl Life without dihydrofolate reductase FolA Trends in Microbiology 11 2003 220 223
33. A. Patrzykat, C.L. Friedrich, L. Zhang, V. Mendoza, and R.E. Hancock Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli Antimicrobial Agents and Chemotherapy 46 2002 605 614
34. K.R. Raveendra, V. Srinivasa, K.R. Sushma, J. Joshua Allan, K. Shankargouda Goudar, H.N. Shivaprasad, K. Venkateshwarlu, P. Geetharani, G. Sushma, and Amit Agarwal An extract of Glycyrrhiza glabra (GutGard) alleviates symptoms of functional dyspepsia: a randomized, double-blind, placebo-controlled study Evidence-Based Complementary and Alternative Medicine 2012 2012 216970 10.1155/2012/216970 Article ID: 216970
35. R. Reynolds, J. Shackcloth, D. Felmingham, and A. MacGowan Comparison of BSAC agar dilution and NCCLS broth microdilution MIC methods for in vitro susceptibility testing of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis: the BSAC respiratory resistance surveillance programme Journal of Antimicrobial Chemotherapy 52 2003 925 930
36. E. Rimbara, N. Noguchi, T. Kawai, and M. Sasatsu Fluoroquinolone resistance in Helicobacter pylori: role of mutations at position 87 and 91 of GyrA on the level of resistance and identification of a resistance conferring mutation in GyrB Helicobacter 17 2011 36 42
37. G.W. Souness, and D.J. Morris The antinatriuretic and kaliuretic effects of the glucocorticoids corticosterone and cortisol following pretreatment with carbenoxolone sodium (a liquorice derivative) in the adrenalectomized rat Endocrinology 124 1989 1588 1590
38. S.K. Tiwari, A.A. Khan, G. Manoj, S. Ahmed, Z. Abid, A. Habeeb, and C.M. Habibullah A simple multiplex PCR assay for diagnosing virulent Helicobacter pylori infection in human gastric biopsy specimens from subjects with gastric carcinoma and other gastro-duodenal diseases Journal of Applied Microbiology 103 2007 2353 2360
39. S.K. Tiwari, G. Manoj, G.V. Kumar, G. Sivaram, S.I. Hassan, B. Prabhakar, U. Devi, S. Jalaluddin, K. Kumar, S. Ahmed, Z. Abid, M.A. Habeeb, A.A. Khan, and C.M. Habibullah Prognostic significance of genotyping Helicobacter pylori infection in patients in younger age groups with gastric cancer Postgraduate Medical Journal 84 2008 193 197
40. T. Wadstrom, S. Hirmo, H. Novak, A. Guzman, M. Ringnér-Pantzar, M. Utt, and P. Aleljung Sulfatides inhibit binding of Helicobacter pylori to the gastric cancer Kato III cell line Current Microbiology 34 1997 267 272
41. K.B. Waites, T.A. Figarola, T. Schmid, D.M. Crabb, L.B. Duffy, and J.W. Simecka Comparison of agar versus broth dilution techniques for determining antibiotic susceptibilities of Ureaplasma urealyticum Diagnostic Microbiology and Infectious Diseases 14 1991 265 271
42. N. Wittschier, G. Faller, and A. Hensel Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa Journal of Ethnopharmacology 125 2009 218 223
43. Z.P. Xiao, Z.Y. Peng, M.J. Peng, W.B. Yan, Y.Z. Ouyang, and H.L. Zhu Flavonoids health benefits and their molecular mechanism Mini Reviews in Medicinal Chemistry 11 2011 169 177