The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle

Neuropharmacology

Volumn 82, Issue , 2014, Pages 132-142

  Ma, Kai Li ^a,b   Song, Lian Kun ^a   Yuan, Yu He ^a   Zhang, Ying ^b   Han, Ning ^a   Gao, Kai ^c   Chen, Nai Hong ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b INSTITUTE OF MEDICAL BIOLOGY   (China)

^c INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

Author keywords

Cell cycle; Importin ; Neurotoxicity; Nuclear accumulation; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; AMINO ACID; KARYOPHERIN ALPHA; GLUCOSE; HYBRID PROTEIN; ROTENONE; SNCA PROTEIN, HUMAN; SNCA PROTEIN, MOUSE; UNCOUPLING PROTEIN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NUCLEUS; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL CYCLE S PHASE; CELL VIABILITY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; HISTOPATHOLOGY; IN VITRO STUDY; MOUSE; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WESTERN BLOTTING; ACTIVE TRANSPORT; ANIMAL; C57BL MOUSE; CELL NUCLEUS; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PC12 CELL LINE; PHYSIOLOGY; RAT; SCINTISCANNING; SUBSTANTIA NIGRA; TOXICITY; TOXICITY AND INTOXICATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA KARYOPHERINS; ALPHA-SYNUCLEIN; ANIMALS; BEHAVIOR, ANIMAL; CELL CYCLE; CELL NUCLEUS; DOPAMINERGIC NEURONS; GLUCOSE; MICE, INBRED C57BL; NEUROTOXICITY SYNDROMES; PC12 CELLS; RATS; RECOMBINANT FUSION PROTEINS; ROTENONE; SUBSTANTIA NIGRA; TRANSFECTION; UNCOUPLING AGENTS;

EID: 84901188413     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.07.035     Document Type: Article

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