A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy

Neuropathology and Applied Neurobiology

Volumn 30, Issue 5, 2004, Pages 546-554

  Nishie, M ^a   Mori, F ^a   Yoshimoto, M ^b   Takahashi, H ^c   Wakabayashi, K ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b Medicinal Research Laboratories   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

Author keywords

synuclein; Morphometry; Multiple system atrophy; Neuronal cytoplasmic inclusions; Neuronal intranuclear inclusions

Indexed keywords

ALPHA SYNUCLEIN;

ADULT; AGED; ARTICLE; BRAIN NUCLEUS; CELL NUCLEUS INCLUSION BODY; CELL POPULATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE COURSE; HUMAN; IMMUNOHISTOCHEMISTRY; INCIDENCE; INFERIOR OLIVE; MALE; OLIGODENDROGLIA; PONS; PRIORITY JOURNAL; PROTEIN AGGREGATION; QUANTITATIVE ANALYSIS; SHY DRAGER SYNDROME;

AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; INTRANUCLEAR INCLUSION BODIES; MALE; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; MULTIPLE SYSTEM ATROPHY; NERVE TISSUE PROTEINS; NEURONS; OLIVARY NUCLEUS; PONS; SYNUCLEINS;

EID: 7044226609     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2004.00564.x     Document Type: Article

References (44)

1. Bannister R, Oppenheimer DR. Degenerative diseases of the nervous system associated with autonomic failure. Brain 1972; 95: 457-74
2. Quinn N. Multiple system atrophy - the nature of the beast. J Neurol Neurosurg Psychiatry 1989; (Suppl.): 78-89
3. Wenning GK, Tison F, Ben Shlomo Y, Daniel SE, Quinn NP. Multiple system atrophy: a review of 203 pathologically proven cases. Mov Disord 1997; 12: 133-47
4. Watanabe H, Saito Y, Terao S, Ando T, Kachi T, Mukai E, Aiba I, Abe Y, Tamakoshi A, Doyu M, Hirayama M, Sobue G. Progression and prognosis in multiple system atrophy. An analysis of 230 Japanese patients. Brain 2002; 125: 1070-83
5. Papp MI, Kahn JE, Lantos PL. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci 1989; 94: 79-100
6. Nakazato Y, Yamazaki H, Hirato J, Ishida Y, Yamaguchi H. Oligodendroglial microtubular tangles in olivopontocerebellar atrophy. J Neuropathol Exp Neurol 1990; 49: 521-30
7. Mochizuki A, Mizusawa H, Ohkoshi N, Yoshizawa K, Komatsuzaki Y, Inoue K, Kanazawa I. Argentophilic intracytoplasmic inclusions in multiple system atrophy. J Neurol 1992; 239: 311-6
8. Papp MI, Lantos PL. The distribution of oligodendroglial inclusions in multiple system atrophy and its relevance to clinical symptomatology. Brain 1994; 117: 235-43
9. Kato S, Nakamura H. Cytoplasmic argyrophilic inclusions in neurons of pontine nuclei in patients with olivopontocerebellar atrophy: immunohistochemical and ultrastructural studies. Acta Neuropathol 1990; 79: 584-94
10. Arima K, Murayama S, Mukoyama M, Inose T. Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy. 1. Neuronal cytoplasmic inclusions. Acta Neuropathol 1992; 83: 453-60
11. Papp MI, Lantos PL. Accumulation of tubular structures in oligodendroglial and neuronal cells as the basic alteration in multiple system atrophy. J Neurol Sci 1992; 107: 172-82
12. Arai N, Papp MI, Lantos PL. New observation on ubiquitinated neurons in the cerebral cortex of multiple system atrophy (MSA). Neurosci Lett 1994; 182: 197-200
13. Arima K, Uéda K, Sunohara N, Arakawa K, Hirai S, Nakamura M, Tonozuka-Uehara H, Kawai M. NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. Acta Neuropathol 1998; 96: 439-44
14. Gai WP, Power JHT, Blumbergs PC, Blessing WW. Multiple-system atrophy: a new α-synuclein disease? Lancet 1998; 352: 547-8
15. Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M. Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett 1998; 251: 205-8
16. Tu P-H, Calvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee VM-Y. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann Neurol 1998; 44: 415-22
17. Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H. α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 1998; 249: 180-2
18. Wakabayashi K, Hayashi S, Kakita A, Yamada M, Toyoshima Y, Yoshimoto M, Takahashi H. Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy. Acta Neuropathol 1998; 96: 445-52
19. Dickson DW, Liu W-K, Hardy J, Farrer M, Mehta N, Uitti R, Mark M, Zimmerman T, Golbe L, Sage J, Sima A, D'Amato C, Albin R, Gilman S, Yen S-H. Widespread alterations of α-synuclein in multiple system atrophy. Am J Pathol 1999; 155: 1241-51
20. Duda JE, Giasson BI, Gur TL, Montine TJ, Robertson D, Biaggioni I, Hurtig HI, Stern MB, Gollomp SM, Grossman M, Lee VM-Y, Trojanowski JQ. Immunohistochemical and biochemical studies demonstrate a distinct profile of α-synuclein permutations in multiple system atrophy. J Neuropathol Exp Neurol 2000; 59: 830-41
21. Wenning GK, Quinn N, Magalhaes M, Mathias C, Daniel SE. 'Minimal change' multiple system atrophy. Mov Disord 1994; 9: 161-6
22. Inoue M, Yagishita S, Ryo M, Hasegawa K, Amano N, Matsushita M. The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: a correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar systems. Acta Neuropathol 1997; 93: 585-91
23. Nakazato Y, Suzuki S. Oligodendroglial microtubular tangles in multiple system atrophy. Neuropathology 1996; 16: 145-50
24. Probst-Cousin S, Rickert CH, Schmid KW, Gullotta F. Cell death mechanisms in multiple system atrophy. J Neuropathol Exp Neurol 1998; 57: 814-21
25. Matsuo A, Akiguchi I, Lee GC, McGeer EG, McGeer PL, Kimura J. Myelin degeneration in multiple system atrophy detected by unique antibodies. Am J Pathol 1998; 153: 735-44
26. Braak H, Rüb U, Del Tredici K. Involvement of precerebellar nuclei in multiple system atrophy. Neuropathol Appl Neurobiol 2003; 29: 60-76
27. Gilman S, Low PA, Quinn N, Albanese A, Ben-Shlomo Y, Fowler CJ, Kaufmann H, Klockgether T, Lang AE, Lantos PL, Litvan I, Mathias CJ, Oliver E, Robertson D, Schatz I, Wenning GK. Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 1999; 163: 94-8
28. Piao Y-S, Mori F, Hayashi S, Tanji K, Yoshimoto M, Kakita A, Wakabayashi K, Takahashi H. α-Synuclein pathology affecting Bergmann glia of the cerebellum in patients with α-synucleinopathies. Acta Neuropathol 2003; 105: 403-9
29. Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec 1946; 94: 239-47
30. Yokoyama T, Kusunoki J, Hasegawa K, Sakai H, Yagishita S. Distribution and dynamic process of neuronal cytoplasmic inclusion (NCI) in MSA: correlation of the density of NCI and the degree of involvement of the pontine nuclei. Neuropathology 2001; 21: 145-54
31. Sakurai A, Okamoto K, Yaguchi M, Fujita Y, Mizuno Y, Nakazato Y, Gonatas NK. Pathology of the inferior olivary nucleus in patients with multiple system atrophy. Acta Neuropathol 2002; 103: 550-4
32. Giasson BI, Uryu K, Trojanowski JQ, Lee VM-Y. Mutant and wild type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro. J Biol Chem 1999; 274: 7619-22
33. 3 Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM-Y. Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein. Neuron 2002; 34: 521-33
34. Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L. Dopaminergic loss and inclusion body formation in α-synuclein mice: implications for neurodegenerative disorders. Science 2000; 287: 1265-9
35. Su M, Yoshida Y, Hirata Y, Watahiki Y, Nagata K. Primary involvement of the motor area in association with the nigrostriatal pathway in multiple system atrophy: neuropathological and morphometric evaluations. Acta Neuropathol 2001; 101: 57-64
36. Kahle PJ, Neumann M, Ozmen L, Müller V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C. Selective insolubility of α-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol 2001; 159: 2215-25
37. van der Putten H, Wiederhold K-H, Probst A, Barbieri S, Mistl C, Danner S, Kauffmann S, Hofele K, Spooren WPJM, Ruegg MA, Lin S, Caroni P, Sommer B, Tolnay M, Bilbe G. Neuropathology in mice expressing human α-synuclein. J Neurosci 2000; 20: 6021-9
38. Kahle PJ, Neumann M, Ozmen L, Müller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C. Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes. EMBO Rep 2002; 3: 583-8
39. Rockenstein E, Mallory M, Hashimoto M, Song D, Shults CW, Lang I, Masliah E. Differential neuropathological alterations in transgenic mice expressing α-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res 2002; 68: 568-78
40. Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM-Y. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 2003; 300: 636-40
41. Arima K, Hirai S, Sunohara N, Aoto K, Izumiyama Y, Uéda K, Ikeda K, Kawai M. Cellular co-localization of phosphorylated tau- and NACP/α-synuclein-epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies. Brain Res 1999; 843: 53-61
42. Ishizawa T, Mattila P, Davies P, Wang D, Dickson DW. Colocalization of tau and alpha-synuclein epitopes in Lewy bodies. J Neuropathol Exp Neurol 2003; 62: 389-97
43. Giasson BI, Mabon ME, Duda JE, Montine TJ, Robertson D, Hurtig HI, Lee VM-Y, Trojanowski JQ. Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy. Acta Neuropathol 2003: 106: 243-50
44. Piao Y-S, Hayashi S, Hasegawa M, Wakabayashi K, Yamada M, Yoshimoto M, Ishikawa A, Iwatsubo T, Takahashi H. Co-localization of α-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathol 2001; 101: 285-93