-
1
-
-
0344808098
-
Immunoelectron-microscopic demonstration of NACP/α-synuclein- epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies
-
DOI 10.1016/S0006-8993(98)00734-3, PII S0006899398007343
-
K. Arima, K. Uéda, N. Sunohara, S. Hirai, Y. Izumiyama, H. Tonozuka-Uehara, and M. Kawai Immunoelectron-microscopic demonstration of NACP/a-synucleinepitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies Brain Res 808 1998 93 100 (Pubitemid 29003204)
-
(1998)
Brain Research
, vol.808
, Issue.1
, pp. 93-100
-
-
Arima, K.1
Ueda, K.2
Sunohara, N.3
Hirai, S.4
Izumiyama, Y.5
Tonozuka-Uehara, H.6
Kawai, M.7
-
3
-
-
81955161848
-
Striatal inhibition of calpains prevents levodopa-induced neurochemical changes and abnormal involuntary movements in the hemiparkinsonian rat model
-
L. Chagniel, C. Robitaille, M. Lebel, and M. Cyr Striatal inhibition of calpains prevents levodopa-induced neurochemical changes and abnormal involuntary movements in the hemiparkinsonian rat model Neurobiol. Dis. 45 1 2012 645 655
-
(2012)
Neurobiol. Dis.
, vol.45
, Issue.1
, pp. 645-655
-
-
Chagniel, L.1
Robitaille, C.2
Lebel, M.3
Cyr, M.4
-
4
-
-
1642395294
-
Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- treated mice
-
DOI 10.1016/j.brainres.2004.01.065, PII S0006899304001726
-
B. Chera, K.E. Schaecher, A. Rocchini, S.Z. Imam, E.A. Sribnick, S.K. Ray, S.F. Ali, and N.L. Banik Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-treated mice Brain Res. 1006 2 2004 150 156 (Pubitemid 38393759)
-
(2004)
Brain Research
, vol.1006
, Issue.2
, pp. 150-156
-
-
Chera, B.1
Schaecher, K.E.2
Rocchini, A.3
Imam, S.Z.4
Sribnick, E.A.5
Ray, S.K.6
Ali, S.F.7
Banik, N.L.8
-
6
-
-
0026781572
-
A novel N18TG2x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin
-
G.D. Crawford, W.D. Le, R. Smith, W.J. Xie, E. Stefani, and S.H. Appel A novel N18TG2x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin J. Neurosci. 12 9 1992 3392 3398
-
(1992)
J. Neurosci.
, vol.12
, Issue.9
, pp. 3392-3398
-
-
Crawford, G.D.1
Le, W.D.2
Smith, R.3
Xie, W.J.4
Stefani, E.5
Appel, S.H.6
-
7
-
-
69049119262
-
Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons
-
J.P. Daher, M. Ying, R. Banerjee, R.S. McDonald, M.D. Hahn, L. Yang, M. Flint Beal, B. Thomas, V.L. Dawson, T.M. Dawson, and D.J. Moore Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons Mol. Neurodegener. 4 2009 34
-
(2009)
Mol. Neurodegener.
, vol.4
, pp. 34
-
-
Daher, J.P.1
Ying, M.2
Banerjee, R.3
McDonald, R.S.4
Hahn, M.D.5
Yang, L.6
Flint Beal, M.7
Thomas, B.8
Dawson, V.L.9
Dawson, T.M.10
Moore, D.J.11
-
8
-
-
34250832784
-
Calpain-cleavage of α-synuclein: Connecting proteolytic processing to disease-linked aggregation
-
DOI 10.2353/ajpath.2007.061232
-
B.M. Dufty, L.R. Warner, S.T. Hou, S.X. Jiang, T. Gomez-Isla, K.M. Leenhouts, J.T. Oxford, M.B. Feany, E. Masliah, and T.T. Rohn Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation Am. J. Pathol. 170 5 2007 1725 1738 (Pubitemid 47339316)
-
(2007)
American Journal of Pathology
, vol.170
, Issue.5
, pp. 1725-1738
-
-
Dufty, B.M.1
Warner, L.R.2
Hou, S.T.3
Jiang, S.X.4
Gomez-Isla, T.5
Leenhouts, K.M.6
Oxford, J.T.7
Feany, M.B.8
Masliah, E.9
Rohn, T.T.10
-
9
-
-
75949120541
-
Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology
-
A.R. Esteves, D.M. Arduíno, R.H. Swerdlow, C.R. Oliveira, and S.M. Cardoso Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology Neurobiol. Dis. 37 3 2010 723 730
-
(2010)
Neurobiol. Dis.
, vol.37
, Issue.3
, pp. 723-730
-
-
Esteves, A.R.1
Arduíno, D.M.2
Swerdlow, R.H.3
Oliveira, C.R.4
Cardoso, S.M.5
-
10
-
-
2642607011
-
Low frequency of α-synuclein mutations in familial Parkinson's disease
-
DOI 10.1002/ana.410430320
-
M. Farrer, F. Wavrant-De Vrieze, R. Crook, L. Boles, J. Perez-Tur, J. Hardy, W.G. Johnson, J. Steele, D. Maraganore, K. Gwinn, and T. Lynch Low frequency of alpha-synuclein mutations in familial Parkinson's disease Ann. Neurol. 43 3 1998 394 397 (Pubitemid 28113605)
-
(1998)
Annals of Neurology
, vol.43
, Issue.3
, pp. 394-397
-
-
Farrer, M.1
Wavrant-De Vrieze, F.2
Crook, R.3
Boles, L.4
Perez-Tur, J.5
Hardy, J.6
Johnson, W.G.7
Steele, J.8
Maraganore, D.9
Gwinn, K.10
Lynch, T.11
-
11
-
-
0038456964
-
Nuclear localization of α-synuclein and its interaction with histones
-
DOI 10.1021/bi0341152
-
J. Goers, A.B. Manning-Bog, A.L. McCormack, I.S. Millett, S. Doniach, D.A. Di Monte, V.N. Uversky, and A.L. Fink Nuclear localization of alpha-synuclein and its interaction with histones Biochemistry 42 28 2003 8465 8471 (Pubitemid 36875412)
-
(2003)
Biochemistry
, vol.42
, Issue.28
, pp. 8465-8471
-
-
Goers, J.1
Manning-Bog, A.B.2
McCormack, A.L.3
Millett, I.S.4
Doniach, S.5
Di Monte, D.A.6
Uversky, V.N.7
Fink, A.L.8
-
12
-
-
78650142376
-
Protein oxidative modifications in the ageing brain: Consequence for the onset of neurodegenerative disease
-
S. Grimm, A. Hoehn, K.J. Davies, and T. Grune Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease Free Radic. Res. 45 1 2011 73 88
-
(2011)
Free Radic. Res.
, vol.45
, Issue.1
, pp. 73-88
-
-
Grimm, S.1
Hoehn, A.2
Davies, K.J.3
Grune, T.4
-
13
-
-
0033890821
-
α-synuclein promotes mitochondrial deficit and oxidative stress
-
L.J. Hsu, Y. Sagara, A. Arroyo, E. Rockenstein, A. Sisk, M. Mallory, J. Wong, T. Takenouchi, M. Hashimoto, and E. Masliah α-Synuclein promotes mitochondrial deficit and oxidative stress Am. J. Pathol. 157 2 2000 401 410 (Pubitemid 30627559)
-
(2000)
American Journal of Pathology
, vol.157
, Issue.2
, pp. 401-410
-
-
Hsu, L.J.1
Sagara, Y.2
Arroyo, A.3
Rockenstein, E.4
Sisk, A.5
Mallory, M.6
Wong, J.7
Takenouchi, T.8
Hashimoto, M.9
Masliah, E.10
-
14
-
-
0032500599
-
Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
-
DOI 10.1074/jbc.273.41.26292
-
P.H. Jensen, M.S. Nielsen, R. Jakes, C.G. Dotti, and M. Goedert Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation J. Biol. Chem. 273 41 1998 26292 26294 (Pubitemid 28471629)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.41
, pp. 26292-26294
-
-
Jensen, P.H.1
Nielsen, M.S.2
Jakes, R.3
Dotti, C.G.4
Goedert, M.5
-
15
-
-
0142242238
-
Parkin Cleaves Intracellular α-Synuclein Inclusions via the Activation of Calpain
-
DOI 10.1074/jbc.M306017200
-
S.J. Kim, J.Y. Sung, J.W. Um, N. Hattori, Y. Mizuno, K. Tanaka, S.R. Paik, J. Kim, and K.C. Chung Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain J. Biol. Chem. 278 43 2003 41890 41899 (Pubitemid 37310450)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.43
, pp. 41890-41899
-
-
Kim, S.J.1
Sung, J.Y.2
Um, J.W.3
Hattori, N.4
Mizuno, Y.5
Tanaka, K.6
Paik, S.R.7
Kim, J.8
Chung, K.C.9
-
16
-
-
84856583036
-
Calpain in the CNS: From synaptic function to neurotoxicity
-
J. Liu, M.C. Liu, and K.K. Wang Calpain in the CNS: from synaptic function to neurotoxicity Sci. Signal. 1 14 2008 re1
-
(2008)
Sci. Signal.
, vol.1
, Issue.14
, pp. 1
-
-
Liu, J.1
Liu, M.C.2
Wang, K.K.3
-
17
-
-
81355123205
-
Conventional calpains and programmed cell death
-
P. Łopatniuk, and J.M. Witkowski Conventional calpains and programmed cell death Acta Biochim. Pol. 58 3 2011 287 296
-
(2011)
Acta Biochim. Pol.
, vol.58
, Issue.3
, pp. 287-296
-
-
Łopatniuk, P.1
Witkowski, J.M.2
-
18
-
-
84857716290
-
Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons
-
M. Lundblad, M. Decressac, B. Mattsson, and A. Björklund Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons Proc. Nat. Acad. Sci. U.S.A. 109 9 2012 3213 3219
-
(2012)
Proc. Nat. Acad. Sci. U.S.A.
, vol.109
, Issue.9
, pp. 3213-3219
-
-
Lundblad, M.1
Decressac, M.2
Mattsson, B.3
Björklund, A.4
-
19
-
-
0023722437
-
Synuclein: A neuronspecific protein localized to the nucleus and presynaptic nerve terminal
-
L. Maroteaux, J.T. Campanelli, and R.H. Scheller Synuclein: a neuronspecific protein localized to the nucleus and presynaptic nerve terminal J. Neurosci. 8 1988 2804 2815
-
(1988)
J. Neurosci.
, vol.8
, pp. 2804-2815
-
-
Maroteaux, L.1
Campanelli, J.T.2
Scheller, R.H.3
-
20
-
-
19644371237
-
Cleavage of α-synuclein by calpain: Potential role in degradation of fibrillized and nitrated species of α-synuclein
-
DOI 10.1021/bi047846q
-
A.J. Mishizen-Eberz, E.H. Norris, B.I. Giasson, R. Hodara, H. Ischiropoulos, V.M. Lee, J.Q. Trojanowski, and D.R. Lynch Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein Chemistry 44 21 2005 7818 7829 (Pubitemid 40740765)
-
(2005)
Biochemistry
, vol.44
, Issue.21
, pp. 7818-7829
-
-
Mishizen-Eberz, A.J.1
Norris, E.H.2
Giasson, B.I.3
Hodara, R.4
Ischiropoulos, H.5
Lee, V.M.-Y.6
Trojanowski, J.Q.7
Lynch, D.R.8
-
21
-
-
0043233011
-
Distinct cleavage patterns of normal and pathologic forms of α-synuclein by calpain I in vitro
-
DOI 10.1046/j.1471-4159.2003.01878.x
-
A.J. Mishizen-Eberz, R.P. Guttmann, B.I. Giasson, G.A. Day 3rd, R. Hodara, H. Ischiropoulos, V.M. Lee, J.Q. Trojanowski, and D.R. Lynch Distinct cleavage patterns of normal and pathologic forms of α-synuclein by calpain I in vitro J. Neurochem. 86 4 2003 836 847 (Pubitemid 36988796)
-
(2003)
Journal of Neurochemistry
, vol.86
, Issue.4
, pp. 836-847
-
-
Mishizen-Eberz, A.J.1
Guttmann, R.P.2
Giasson, B.I.3
Day III, G.A.4
Hodara, R.5
Ischiropoulos, H.6
Lee, V.M.-Y.7
Trojanowski, J.Q.8
Lynch, D.R.9
-
22
-
-
0029882525
-
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: A role in nerve cell death?
-
DOI 10.1016/0306-4522(96)00100-5
-
A. Mouatt-Prigent, J.O. Karlsson, Y. Agid, and E.C. Hirsch Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? Neuroscience 73 4 1996 979 987 (Pubitemid 26194324)
-
(1996)
Neuroscience
, vol.73
, Issue.4
, pp. 979-987
-
-
Mouatt-Prigent, A.1
Karlsson, J.O.2
Agid, Y.3
Hirsch, E.C.4
-
23
-
-
73549085595
-
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
-
V.M. Nemani, W. Lu, V. Berge, K. Nakamura, B. Onoa, M.K. Lee, F.A. Chaudhry, R.A. Nicoll, and R.H. Edwards Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis Neuron 65 1 2010 66 79
-
(2010)
Neuron
, vol.65
, Issue.1
, pp. 66-79
-
-
Nemani, V.M.1
Lu, W.2
Berge, V.3
Nakamura, K.4
Onoa, B.5
Lee, M.K.6
Chaudhry, F.A.7
Nicoll, R.A.8
Edwards, R.H.9
-
24
-
-
63449129338
-
Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; The role of a putative iron-responsive element
-
D. Olivares, X. Huang, L. Branden, N.H. Greig, and J.T. Rogers Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; The role of a putative iron-responsive element Int. J. Mol. Sci. 10 3 2009 1226 1260
-
(2009)
Int. J. Mol. Sci.
, vol.10
, Issue.3
, pp. 1226-1260
-
-
Olivares, D.1
Huang, X.2
Branden, L.3
Greig, N.H.4
Rogers, J.T.5
-
26
-
-
84864658791
-
Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease
-
A.T. Simões, N. Gonçalves, A. Koeppen, N. Déglon, S. Kügler, C.B. Duarte, and L. Pereira de Almeida Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease Brain 135 8 2012 2428 2439
-
(2012)
Brain
, vol.135
, Issue.8
, pp. 2428-2439
-
-
Simões, A.T.1
Gonçalves, N.2
Koeppen, A.3
Déglon, N.4
Kügler, S.5
Duarte, C.B.6
Pereira De Almeida, L.7
-
27
-
-
0031452173
-
Structure and physiological function of calpains
-
H. Sorimachi, S. Ishiura, and K. Suzuki Structure and physiological function of calpains Biochem. J. 328 Pt 3 1997 721 732 (Pubitemid 28005767)
-
(1997)
Biochemical Journal
, vol.328
, Issue.3
, pp. 721-732
-
-
Sorimachi, H.1
Ishiura, S.2
Suzuki, K.3
-
28
-
-
13444254033
-
Subcellular localisation of recombinant α- and γ-synuclein
-
DOI 10.1016/j.mcn.2004.09.017
-
C.G. Specht, C.M. Tigaret, G.F. Rast, A. Thalhammer, Y. Rudhard, and R. Schoepfer Subcellular localisation of recombinant alpha- and gamma-synuclein Mol. Cell. Neurosci. 28 2 2005 326 334 (Pubitemid 40202593)
-
(2005)
Molecular and Cellular Neuroscience
, vol.28
, Issue.2
, pp. 326-334
-
-
Specht, C.G.1
Tigaret, C.M.2
Rast, G.F.3
Thalhammer, A.4
Rudhard, Y.5
Schoepfer, R.6
-
29
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
M.G. Spillantini, M.L. Schmidt, V.M. Lee, J.Q. Trojanowski, R. Jakes, and M. Goedert Alpha-synuclein in Lewy bodies Nature 388 6645 1997 839 840
-
(1997)
Nature
, vol.388
, Issue.6645
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
30
-
-
0033966487
-
α-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
-
DOI 10.1046/j.1471-4159.2000.740721.x
-
M. Vila, S. Vukosavic, V. Jackson-Lewis, M. Neystat, M. Jakowec, and S. Przedborski α-Synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the Parkinsonian toxin MPTP J. Neurochem. 74 2 2000 721 729 (Pubitemid 30053745)
-
(2000)
Journal of Neurochemistry
, vol.74
, Issue.2
, pp. 721-729
-
-
Vila, M.1
Vukosavic, S.2
Jackson-Lewis, V.3
Neystat, M.4
Jakowec, M.5
Przedborski, S.6
-
31
-
-
70350041314
-
Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization
-
E.A. Waxman, J.R. Mazzulli, and B.I. Giasson Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization Biochemistry 48 40 2009 9427 9436
-
(2009)
Biochemistry
, vol.48
, Issue.40
, pp. 9427-9436
-
-
Waxman, E.A.1
Mazzulli, J.R.2
Giasson, B.I.3
-
32
-
-
79955844395
-
The histone chaperon FACT: Structural insights and mechanisms for nucleosome reorganization
-
D.D. Winkler, and K. Luger The histone chaperon FACT: structural insights and mechanisms for nucleosome reorganization J. Biol. Chem. 286 21 2011 18369 18374
-
(2011)
J. Biol. Chem.
, vol.286
, Issue.21
, pp. 18369-18374
-
-
Winkler, D.D.1
Luger, K.2
-
33
-
-
32644467781
-
Oxidative stress induces nuclear translocation of C-terminus of α-synuclein in dopaminergic cells
-
DOI 10.1016/j.bbrc.2006.01.148, PII S0006291X06001793
-
S. Xu, M. Zhou, S. Yu, Y. Cai, A. Zhang, K. Uéda, and P. Chan Oxidative stress induces nuclear translocation of C-terminus of alpha-synuclein in dopaminergic cells Biochem. Biophys. Res. Commun. 342 1 2006 330 335 (Pubitemid 43247395)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.342
, Issue.1
, pp. 330-335
-
-
Xu, S.1
Zhou, M.2
Yu, S.3
Cai, Y.4
Zhang, A.5
Ueda, K.6
Chan, P.7
-
34
-
-
33847649977
-
Extensive nuclear localization of α-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody
-
DOI 10.1016/j.neuroscience.2006.12.028, PII S0306452206016915
-
S. Yu, X. Li, G. Liu, J. Han, C. Zhang, Y. Li, S. Xu, C. Liu, Y. Gao, H. Yang, K. Uéda, and P. Chan Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody Neurosicience 145 2 2007 539 555 (Pubitemid 46350815)
-
(2007)
Neuroscience
, vol.145
, Issue.2
, pp. 539-555
-
-
Yu, S.1
Li, X.2
Liu, G.3
Han, J.4
Zhang, C.5
Li, Y.6
Xu, S.7
Liu, C.8
Gao, Y.9
Yang, H.10
Ueda, K.11
Chan, P.12
-
35
-
-
10744230149
-
The New Mutation, E46K, of α-Synuclein Causes Parkinson and Lewy Body Dementia
-
DOI 10.1002/ana.10795
-
J.J. Zarranz, J. Alegre, J.C. Gómez-Esteban, E. Lezcano, R. Ros, I. Ampuero, L. Vidal, J. Hoenicka, O. Rodriguez, B. Atarés, V. Llorens, E. Gomez Tortosa, T. del Ser, D.G. Muñoz, and J.G. de Yebenes The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia Ann. Neurol. 55 2 2004 164 173 (Pubitemid 38166992)
-
(2004)
Annals of Neurology
, vol.55
, Issue.2
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atares, B.10
Llorens, V.11
Gomez Tortosa, E.12
Del Ser, T.13
Munoz, D.G.14
De Yebenes, J.G.15
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