A functional role for intra-axonal protein synthesis during axonal regeneration from adult sensory neurons

Journal of Neuroscience

Volumn 21, Issue 23, 2001, Pages 9291-9303

  Zheng, J Q ^a   Kelly, T K ^a   Chang, B ^a   Ryazantsev, S ^a   Rajasekaran, A K ^a   Martin, K C ^a   Twiss, J L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Axonal regeneration; Conditioned neuron; Local protein synthesis; MRNA localization; Nerve regeneration

Indexed keywords

CELL PROTEIN; INITIATION FACTOR; MESSENGER RNA; RIBOSOME PROTEIN; RIBOSOME RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL GROWTH; CONDITIONING; CONTROLLED STUDY; GROWTH CONE; IMMUNOFLUORESCENCE; NERVE CELL LESION; NERVE FIBER REGENERATION; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RNA TRANSLATION; SENSORY NERVE CELL; TRANSLATION INITIATION; VENTRAL ROOT;

EID: 0035575854     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-23-09291.2001     Document Type: Article

References (89)

1. Protein synthesis in axons and terminals: Significance for maintenance, plasticity and regulation of phenotype. With a critique of slow transport theory
2. Sorting of beta-actin mRNA and protein to neurites and growth cones in culture
3. Coordinate expression of ribosomal protein genes during Xenopus development
4. Substitution of just five nucleotides at and around the transcription start site of rat beta-actin promoter is sufficient to render the resulting transcript a subject for translational control
5. Long-term survival of anucleate axons and its implications for nerve regeneration
6. Axonal transport of actin: Slow component b is the principal source of actin for the axon
7. Slow components of axonal transport: Two cytoskeletal networks
8. Neuronal polarity: Vectorial cytoplasmic flow precedes axon formation
9. Development of sympathetic neurons in compartmentalized cultures. II. Local control of neurite survival by nerve growth factor
10. Delivery of newly synthesized tubulin to rapidly growing distal axons of sympathetic neurons in compartmented cultures
11. Occurrence and complexity of polyadenylated RNA in squid axoplasm
12. Wallerian degeneration in peripheral nerve disease
13. Single-step method of RNA isolation by guanidine isothiocyanate-phenol-chloroform extraction
14. Molecular characterization of the dendritic growth cone: Regulated mRNA transport and local protein synthesis
15. Protein synthesis within neuronal growth cones
16. Nerve growth factor activates Thy-1 and neurofilament gene transcription in rat PC12 cells
17. Early regeneration in vitro of adult mouse sciatic axons is dependent on local protein synthesis but may not involve neurotrophins
18. Lupus autoantibodies target ribosomal P proteins
19. Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus
20. Synthesis of β-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures
21. Nucleotide sequence of the human gamma cytoskeletal actin mRNA: Anomalous evolution of vertebrate non-muscle actin genes
22. Regenerating axons of the rat require a local source of proteins
23. Protein masking of a ribosomal RNA epitope is an early event in afferent deprivation-induced neuronal death
24. Active polysomes in the axoplasm of the squid giant axon
25. Beta and gamma actin mRNAs are differentially located within myoblasts
26. Murine HIP/L29 is a heparin-binding protein with a restricted pattern of expression in adult tissues
27. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression
28. Messenger RNA coding for oxytocin is present in axons of the hypothalamoneurohypophysial tract
29. A requirement of local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity
30. β-actin and β-tubulin are components of a heterogeneous mRNA population present in the squid giant axon
31. Determinants of mRNA localization
32. Isoform-specific 3′-untranslated sequences sort alpha-cardiac and beta-cytoplasmic actin messenger RNAs to different cytoplasmic compartments
33. Sequences responsible for intracellular localization of beta-actin messenger RNA also affect cell phenotype
34. Development of subcellular mRNA compartmentation in hippocampal neurons in culture
35. Neurotrophin-3 signals redistribute RNA in neurons
36. Translocation of RNA granules in living neurons
37. 35S]methionine labeling of proteins in goldfish retinal ganglion cell axons in vitro
38. Evaluation of local synthesis of axonal proteins in the goldfish Mauthner cell axon and axons of dorsal and ventral roots of the rat in vitro
39. Cortical plaque-like structures identify ribosome-containing domains in the Mauthner cell axon
40. Cryptic peripheral ribosomal domains distributed intermittently along mammalian myelinated axons
41. Identification of an amino acid-regulated mRNA from rat liver as the mammalian equivalent of bacterial ribosomal protein L22
42. Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion
43. Transfer of newly synthesized proteins from Schwann cells to the squid giant axon
44. Monoclonal antibodies to nucleic acid-containing cellular constituents: Probes for molecular biology and autoimmune disease
45. Nerve growth factors (NGFBDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons
46. cDNA cloning and expression of HIP, a novel cell surface heparin sulfate/heparin-binding protein of human uterine epithelial cells and cell lines
47. Synapse-specific, long-term facilitation of Aplysia sensory to motor synapses: A function for local protein synthesis in memory storage
48. Local protein synthesis and its role in synapse-specific plasticity
49. Visualization of polysomes in the postsynaptic area of the squid giant synapse by electron spectroscopic imaging
50. Amplification of cDNA ends based on template-switching effect and step-out PCR
51. Effect of condition lesion on optic nerve regeneration in goldfish
52. Protein synthesis and axonal transport in goldfish retinal ganglion cells during regeneration accelerated by a conditioning lesion
53. Diversity of messenger RNAs in the axonal compartment of peptidergic neurons in the rat
54. Neurotrophin-3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons
55. Temporal expression pattern of peripheral myelin protein 22 during in vivo and in vitro myelination
56. The nucleotide sequence of the rat cytoplasmic beta-actin gene
57. Turnover of fluorescently labeled tubulin and actin in the axon
58. Actin dynamics in growth cones
59. Localization and active transport of mRNA in axons of sympathetic neurons in culture
60. Ribosomes in myelinated axons of the rabbit spinal ganglion neurons
61. Sprouting and synapse formation by motor axons separated from their cell bodies
62. NMDA receptormediated control of protein synthesis at developing synapses
63. Fate of GAP-43 in ascending spinal axons of DRG neurons after peripheral nerve injury: Delayed accumulation and correlation with regenerative potential
64. mRNA trafficking and local protein synthesis at the synapse
65. The initial period of peripheral nerve regeneration and the importance of the local environment for the conditioning lesion effect
66. A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth
67. Neurofilament mRNAs are present and translated in normal and severed sciatic nerve
68. Targeting of mRNAs to subsynaptic microdomains in dendrites
69. mRNA localization in neurons: A multipurpose mechanism?
70. Lamina-specific synaptic activation causes domain-specific alterations in dendritic immunostaining for MAP2 and CAM kinase II
71. Transport of BC1 RNA in hypothalamo-neurohypophyseal axons
72. Influence of nerve cell body and neurolemma cell on local axonal protein synthesis following neurotomy
73. Demonstration of local protein synthesis within dendrites using a new cell culture system that permits the isolation of living axons and dendrites from their cell bodies
74. Nerve growth factor promotes neurite regeneration in PC12 cells by translational control
75. Translational control of ribosomal protein L4 is required for rapid neurite extension
76. Glial polypeptides transferred into the squid giant axon
77. RNA in the axonal domain: A new dimension in neuronal functioning?
78. De novo protein synthesis in isolated axons of identified neurons
79. Metabotropic glutamate receptors trigger postsynaptic protein synthesis
80. Medium weight neurofilament mRNA in goldfish Mauthner axoplasm
81. Olfactory marker protein mRNA is found in axons of olfactory receptor neurons
82. Extraribosomal functions of ribosomal proteins
83. Regulation of mRNA utilization in mouse erythroleukemia cells induced to differentiate by exposure to dimethyl sulfoxide
84. Ribosome-like particles in myelinated axons of the rat
85. Ribosomes in myelinated axons of dorsal root ganglia
86. Neurotrophin regulation of beta-actin mRNA and protein localization within growth cones