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Volumn 4, Issue JAN, 2014, Pages

Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity

Author keywords

Bayesian learning; Cell morphogenesis; Image analysis; RNAi screening

Indexed keywords

RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 84901044347     PISSN: None     EISSN: 20462441     Source Type: Journal    
DOI: 10.1098/rsob.130132     Document Type: Article
Times cited : (49)

References (45)
  • 2
    • 42149177825 scopus 로고    scopus 로고
    • The regulation of cell motility and chemotaxis by phospholipid signaling
    • DOI 10.1242/jcs.023333
    • Kolsch V, Charest PG, Firtel RA 2008 The regulation of cell motility and chemotaxis by phospholipid signaling. J. Cell Sci. 121, 551-559. (doi:10.1242/jcs.023333) (Pubitemid 351524153)
    • (2008) Journal of Cell Science , vol.121 , Issue.5 , pp. 551-559
    • Kolsch, V.1    Charest, P.G.2    Firtel, R.A.3
  • 3
    • 70849098888 scopus 로고    scopus 로고
    • Actin, a Central player in cell shape and movement
    • (doi:10.1126/science.1175862)
    • Pollard TD, Cooper JA 2009 Actin, a central player in cell shape and movement. Science 326, 1208-1212. (doi:10.1126/science.1175862)
    • (2009) Science , vol.326 , pp. 1208-1212
    • Pollard, T.D.1    Cooper, J.A.2
  • 4
    • 84866882608 scopus 로고    scopus 로고
    • Actin cortex mechanics and cellular morphogenesis
    • (doi:10.1016/j.tcb.2012.07.001)
    • Salbreux G, Charras G, Paluch E. 2012 Actin cortex mechanics and cellular morphogenesis. Trends Cell Biol. 22, 536-545. (doi:10.1016/j.tcb.2012.07.001)
    • (2012) Trends Cell Biol. , vol.22 , pp. 536-545
    • Salbreux, G.1    Charras, G.2    Paluch, E.3
  • 5
    • 0030045346 scopus 로고    scopus 로고
    • Cell migration: A physically integrated molecular process
    • DOI 10.1016/S0092-8674(00)81280-5
    • Lauffenburger DA, Horwitz AF 1996 Cell migration: a physically integrated molecular process. Cell 84, 359-369. (doi:10.1016/S0092-8674(00)81280-5) (Pubitemid 26058561)
    • (1996) Cell , vol.84 , Issue.3 , pp. 359-369
    • Lauffenburger, D.A.1    Horwitz, A.F.2
  • 6
    • 69949156933 scopus 로고    scopus 로고
    • The shape of motile cells
    • (doi:10.1016/j.cub.2009.06.053)
    • Mogilner A, Keren K. 2009 The shape of motile cells. Curr. Biol. 19, R762-R771. (doi:10.1016/j.cub.2009.06.053)
    • (2009) Curr. Biol. , vol.19
    • Mogilner, A.1    Keren, K.2
  • 7
    • 84880328076 scopus 로고    scopus 로고
    • A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes
    • (doi:10.1038/ncb2764)
    • Yin Z et al. 2013 A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat. Cell Biol. 15, 860-871. (doi:10.1038/ncb2764)
    • (2013) Nat. Cell Biol. , vol.15 , pp. 860-871
    • Yin, Z.1
  • 8
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • DOI 10.1146/annurev.cellbio.21.020604.150721
    • Jaffe AB, Hall A. 2005 Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247-269. (doi:10.1146/annurev.cellbio.21.020604.150721) (Pubitemid 41740635)
    • (2005) Annual Review of Cell and Developmental Biology , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 9
    • 79959677602 scopus 로고    scopus 로고
    • Life at the leading edge
    • (doi:10.1016/j.cell.2011.06.010)
    • Ridley AJ. 2011 Life at the leading edge. Cell 145, 1012-1022. (doi:10.1016/j.cell.2011.06.010)
    • (2011) Cell , vol.145 , pp. 1012-1022
    • Ridley, A.J.1
  • 11
    • 84856116174 scopus 로고    scopus 로고
    • Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration
    • (doi:10.1016/j.cell.2011.10.050)
    • Houk AR, Jilkine A, Mejean CO, Boltyanskiy R., Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD 2012 Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell 148, 175-188. (doi:10.1016/j.cell.2011.10.050)
    • (2012) Cell , vol.148 , pp. 175-188
    • Houk, A.R.1    Jilkine, A.2    Mejean, C.O.3    Boltyanskiy, R.4    Dufresne, E.R.5    Angenent, S.B.6    Altschuler, S.J.7    Wu, L.F.8    Weiner, O.D.9
  • 12
    • 77749233738 scopus 로고    scopus 로고
    • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    • (doi:10.1073/pnas.0913860107)
    • Alexander A et al. 2009 ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc. Natl Acad. Sci. USA 107, 4153-4158. (doi:10.1073/pnas.0913860107)
    • (2009) Proc. Natl Acad. Sci. USA , vol.107 , pp. 4153-4158
    • Alexander, A.1
  • 13
    • 44349186015 scopus 로고    scopus 로고
    • Mechanism of shape determination in motile cells
    • DOI 10.1038/nature06952, PII NATURE06952
    • Keren K, Pincus Z, Allen GM, Barnhart EL, Marriott G, Mogilner A, Theriot JA 2008 Mechanism of shape determination in motile cells. Nature 453, 475-480. (doi:10.1038/nature06952) (Pubitemid 351733321)
    • (2008) Nature , vol.453 , Issue.7194 , pp. 475-480
    • Keren, K.1    Pincus, Z.2    Allen, G.M.3    Barnhart, E.L.4    Marriott, G.5    Mogilner, A.6    Theriot, J.A.7
  • 14
    • 69949185998 scopus 로고    scopus 로고
    • Coordination of rho GTPase activities during cell protrusion
    • (doi:10.1038/nature08242)
    • Machacek M et al. 2009 Coordination of Rho GTPase activities during cell protrusion. Nature 461, 99-103. (doi:10.1038/nature08242)
    • (2009) Nature , vol.461 , pp. 99-103
    • Machacek, M.1
  • 15
    • 0032100809 scopus 로고    scopus 로고
    • A role for Cdc42 in macrophage chemotaxis
    • DOI 10.1083/jcb.141.5.1147
    • Allen WE, Zicha D, Ridley AJ, Jones GE 1998 A role for Cdc42 in macrophage chemotaxis. J. Cell Biol. 141, 1147-1157. (doi:10.1083/jcb.141.5. 1147) (Pubitemid 28265609)
    • (1998) Journal of Cell Biology , vol.141 , Issue.5 , pp. 1147-1157
    • Allen, W.E.1    Zicha, D.2    Ridley, A.J.3    Jones, G.E.4
  • 16
    • 52449120635 scopus 로고    scopus 로고
    • Synthetic activation of endogenous PI3K and rac identifies an AND-gate switch for cell polarization and migration
    • (doi:10.1371/journal.pone.0003068)
    • Inoue T, Meyer T. 2008 Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS ONE 3, e3068. (doi:10.1371/journal.pone.0003068)
    • (2008) PLoS ONE , vol.3
    • Inoue, T.1    Meyer, T.2
  • 18
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: Turning on Rho GTPases with guanine nucleotide-exchange factors
    • DOI 10.1038/nrm1587
    • Rossman KL, Der CJ, Sondek J. 2005 GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6, 167-180. (doi:10.1038/nrm1587) (Pubitemid 40215811)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.2 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 19
    • 33846969965 scopus 로고    scopus 로고
    • Current knowledge of the large RhoGAP family of proteins
    • DOI 10.1042/BC20060086
    • Tcherkezian J, Lamarche-Vane N. 2007 Current knowledge of the large RhoGAP family of proteins. Biol. Cell 99, 67-86. (doi:10.1042/BC20060086) (Pubitemid 46242033)
    • (2007) Biology of the Cell , vol.99 , Issue.2 , pp. 67-86
    • Tcherkezian, J.1    Lamarche-Vane, N.2
  • 20
    • 0035158377 scopus 로고    scopus 로고
    • RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity
    • Arthur WT, Burridge K. 2001 RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity. Mol. Biol. Cell 12, 2711-2720. (doi:10.1091/mbc.12.9.2711) (Pubitemid 33051936)
    • (2001) Molecular Biology of the Cell , vol.12 , Issue.9 , pp. 2711-2720
    • Arthur, W.T.1    Burridge, K.2
  • 21
    • 54149096498 scopus 로고    scopus 로고
    • Coordination of rho and rac GTPase function via p190B RhoGAP
    • (doi:10.1016/j.cub.2008.09.019)
    • Bustos RI, Forget MA, Settleman JE, Hansen SH 2008 Coordination of Rho and Rac GTPase function via p190B RhoGAP. Curr. Biol. 18, 1606-1611. (doi:10.1016/j.cub.2008.09.019)
    • (2008) Curr. Biol. , vol.18 , pp. 1606-1611
    • Bustos, R.I.1    Forget, M.A.2    Settleman, J.E.3    Hansen, S.H.4
  • 22
    • 0037341905 scopus 로고    scopus 로고
    • Redox-dependent downregulation of Rho by Rac
    • DOI 10.1038/ncb938
    • Nimnual AS, Taylor LJ, Bar-Sagi D. 2003 Redox-dependent downregulation of Rho by Rac. Nat. Cell Biol. 5, 236-241. (doi:10.1038/ncb938) (Pubitemid 36322251)
    • (2003) Nature Cell Biology , vol.5 , Issue.3 , pp. 236-241
    • Nimnual, A.S.1    Taylor, L.J.2    Bar-Sagi, D.3
  • 23
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • (doi:10.1016/0092-8674(92) 90164-8)
    • Ridley AJ, Paterson HF, Johnston CL, Diekmann D., Hall A. 1992 The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410. (doi:10.1016/0092-8674(92) 90164-8)
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 24
    • 1842477355 scopus 로고    scopus 로고
    • Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor dbs by rac1
    • DOI 10.1074/jbc.M313099200
    • Cheng L, Mahon GM, Kostenko EV, Whitehead IP 2004 Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1. J. Biol. Chem. 279, 12786-12793. (doi:10.1074/jbc. M313099200) (Pubitemid 38445851)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.13 , pp. 12786-12793
    • Cheng, L.1    Mahon, G.M.2    Kostenko, E.V.3    Whitehead, I.P.4
  • 26
    • 34250882643 scopus 로고    scopus 로고
    • Quantitative morphological signatures define local signaling networks regulating cell morphology
    • DOI 10.1126/science.1140324
    • Bakal C, Aach J, Church G., Perrimon N. 2007 Quantitative morphological signatures define local signaling networks regulating cell morphology. Science 316, 1753-1756. (doi:10.1126/science.1140324) (Pubitemid 46988551)
    • (2007) Science , vol.316 , Issue.5832 , pp. 1753-1756
    • Bakal, C.1    Aach, J.2    Church, G.3    Perrimon, N.4
  • 28
    • 0032549766 scopus 로고    scopus 로고
    • Laminin-dependent integrin clustering with tyrosine-phosphorylated molecules in a Drosophila neuronal cell line
    • DOI 10.1016/S0304-3940(98)00145-1, PII S0304394098001451
    • Takagi Y, Ui-Tei K, Miyake T., Hirohashi S. 1998 Laminin-dependent integrin clustering with tyrosine-phosphorylated molecules in a Drosophila neuronal cell line. Neurosci. Lett. 244, 149-152. (doi:10.1016/S0304-3940(98) 00145-1) (Pubitemid 28226313)
    • (1998) Neuroscience Letters , vol.244 , Issue.3 , pp. 149-152
    • Takagi, Y.1    Ui-Tei, K.2    Miyake, T.3    Hirohashi, S.4
  • 29
    • 1642365541 scopus 로고    scopus 로고
    • Cascade pathway of filopodia formation downstream of SCAR
    • DOI 10.1242/jcs.00921
    • Biyasheva A, Svitkina T, Kunda P., Baum B, Borisy G. 2004 Cascade pathway of filopodia formation downstream of SCAR. J. Cell Sci. 117, 837-848. (doi:10.1242/jcs.00921) (Pubitemid 38396712)
    • (2004) Journal of Cell Science , vol.117 , Issue.6 , pp. 837-848
    • Biyasheva, A.1    Svitkina, T.2    Kunda, P.3    Baum, B.4    Borisy, G.5
  • 30
    • 77952474987 scopus 로고    scopus 로고
    • Cellular heterogeneity: Do differences make a difference?
    • (doi:10.1016/j.cell.2010.04.033)
    • Altschuler SJ, Wu LF 2010 Cellular heterogeneity: do differences make a difference? Cell 141, 559-563. (doi:10.1016/j.cell.2010.04.033)
    • (2010) Cell , vol.141 , pp. 559-563
    • Altschuler, S.J.1    Wu, L.F.2
  • 31
    • 84860171972 scopus 로고    scopus 로고
    • Using cell-to-cell variability - A new era in molecular biology
    • (doi:10.1126/science.1222161)
    • Pelkmans L. 2012 Using cell-to-cell variability - a new era in molecular biology. Science 336, 425-426. (doi:10.1126/science.1222161)
    • (2012) Science , vol.336 , pp. 425-426
    • Pelkmans, L.1
  • 32
    • 58049200628 scopus 로고    scopus 로고
    • Characterizing heterogeneous cellular responses to perturbations
    • (doi:10.1073/pnas.0807038105)
    • Slack MD, Martinez ED, Wu LF, Altschuler SJ 2008 Characterizing heterogeneous cellular responses to perturbations. Proc. Natl Acad. Sci. USA 105, 19306-19311. (doi:10.1073/pnas.0807038105)
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 19306-19311
    • Slack, M.D.1    Martinez, E.D.2    Wu, L.F.3    Altschuler, S.J.4
  • 33
    • 0015609281 scopus 로고
    • The logical analysis of continuous, non-linear biochemical control networks
    • (doi:10.1016/0022-5193(73)90208-7)
    • Glass L, Kauffman SA 1973 The logical analysis of continuous, non-linear biochemical control networks. J. Theor. Biol. 39, 103-129. (doi:10.1016/0022- 5193(73)90208-7)
    • (1973) J. Theor. Biol. , vol.39 , pp. 103-129
    • Glass, L.1    Kauffman, S.A.2
  • 34
    • 81355148858 scopus 로고    scopus 로고
    • Rho protein crosstalk: Another social network?
    • (doi:10.1016/j.tcb.2011.08.002)
    • Guilluy C, Garcia-Mata R, Burridge K. 2011 Rho protein crosstalk: another social network? Trends Cell Biol. 21, 718-726. (doi:10.1016/j.tcb.2011.08.002)
    • (2011) Trends Cell Biol. , vol.21 , pp. 718-726
    • Guilluy, C.1    Garcia-Mata, R.2    Burridge, K.3
  • 35
    • 79953303384 scopus 로고    scopus 로고
    • Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for beta-pix in negative regulation of focal adhesion maturation
    • (doi:10.1038/ncb2216)
    • Kuo JC, Han X, Hsiao CT, Yates 3rd JR, Waterman CM. 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for beta-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13, 383-393. (doi:10.1038/ncb2216)
    • (2011) Nat. Cell Biol. , vol.13 , pp. 383-393
    • Kuo, J.C.1    Han, X.2    Hsiao, C.T.3    Yates III, J.R.4    Waterman, C.M.5
  • 36
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • (doi:10.1016/0092-8674(95)90370-4)
    • Nobes CD, Hall A. 1995 Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62. (doi:10.1016/0092-8674(95)90370-4)
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 37
    • 0031443277 scopus 로고    scopus 로고
    • The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation
    • DOI 10.1016/S0092-8674(00)80482-1
    • Barrett K, Leptin M, Settleman J. 1997 The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell 91, 905-915. (doi:10.1016/S0092-8674(00)80482-1) (Pubitemid 28027825)
    • (1997) Cell , vol.91 , Issue.7 , pp. 905-915
    • Barrett, K.1    Leptin, M.2    Settleman, J.3
  • 38
    • 0029097186 scopus 로고
    • CDC42 and rac1 control different actin-dependent processes in the drosophila wing disc epithelium
    • (doi:10.1083/jcb.131.1.151)
    • Eaton S, Auvinen P, Luo L., Jan YN, Simons K. 1995 CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. J. Cell Biol. 131, 151-164. (doi:10.1083/jcb.131.1.151)
    • (1995) J. Cell Biol. , vol.131 , pp. 151-164
    • Eaton, S.1    Auvinen, P.2    Luo, L.3    Jan, Y.N.4    Simons, K.5
  • 40
    • 0842288337 scopus 로고    scopus 로고
    • Inferring cellular networks using probabilistic graphical models
    • DOI 10.1126/science.1094068
    • Friedman N. 2004 Inferring cellular networks using probabilistic graphical models. Science 303, 799-805. (doi:10.1126/science.1094068) (Pubitemid 38174650)
    • (2004) Science , vol.303 , Issue.5659 , pp. 799-805
    • Friedman, N.1
  • 41
    • 34547840242 scopus 로고    scopus 로고
    • Nested effects models for high-dimensional phenotyping screens
    • DOI 10.1093/bioinformatics/btm178
    • Markowetz F, Kostka D, Troyanskaya OG, Spang R. 2007 Nested effects models for high-dimensional phenotyping screens. Bioinformatics 23, i305-i312. (doi:10.1093/bioinformatics/btm178) (Pubitemid 47244414)
    • (2007) Bioinformatics , vol.23 , Issue.13
    • Markowetz, F.1    Kostka, D.2    Troyanskaya, O.G.3    Spang, R.4
  • 42
    • 17644427718 scopus 로고    scopus 로고
    • Causal protein-signaling networks derived from multiparameter single-cell data
    • DOI 10.1126/science.1105809
    • Sachs K, Perez O, Pe'er D, Lauffenburger DA, Nolan GP. 2005 Causal protein-signaling networks derived from multiparameter single-cell data. Science 308, 523-529. (doi:10.1126/science.1105809) (Pubitemid 40570578)
    • (2005) Science , vol.308 , Issue.5721 , pp. 523-529
    • Sachs, K.1    Perez, O.2    Pe'er, D.3    Lauffenburger, D.A.4    Nolan, G.P.5
  • 43
    • 18144442687 scopus 로고    scopus 로고
    • Inferring subnetworks from perturbed expression profiles
    • Pe'er D, Regev A, Elidan G, Friedman N. 2001 Inferring subnetworks from perturbed expression profiles. Bioinformatics 17(Suppl. 1), S215-S224. (doi:10.1093/bioinformatics/17.suppl-1.S215) (Pubitemid 33793513)
    • (2001) Bioinformatics , vol.17 , Issue.SUPPL. 1
    • Pe'er, D.1    Regev, A.2    Elidan, G.3    Friedman, N.4
  • 44
    • 49649089500 scopus 로고    scopus 로고
    • On the spontaneous emergence of cell polarity
    • (doi:10.1038/nature07119)
    • Altschuler SJ, Angenent SB, Wang Y, Wu LF 2008 On the spontaneous emergence of cell polarity. Nature 454, 886-889. (doi:10.1038/nature07119)
    • (2008) Nature , vol.454 , pp. 886-889
    • Altschuler, S.J.1    Angenent, S.B.2    Wang, Y.3    Wu, L.F.4
  • 45
    • 24944577909 scopus 로고    scopus 로고
    • Cdc42 and Par6-PKCη regulate the spatially localized association of Dlg1 and APC to control cell polarization
    • DOI 10.1083/jcb.200412172
    • Etienne-Manneville S., Manneville JB, Nicholls S, Ferenczi MA, Hall A. 2005 Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization. J. Cell Biol. 170, 895-901. (doi:10.1083/jcb.200412172) (Pubitemid 41306289)
    • (2005) Journal of Cell Biology , vol.170 , Issue.6 , pp. 895-901
    • Etienne-Manneville, S.1    Manneville, J.-B.2    Nicholls, S.3    Ferenczi, M.A.4    Hall, A.5


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